KEGG   ENZYME: 2.5.1.38Help
Entry
EC 2.5.1.38                 Enzyme                                 

Name
isonocardicin synthase;
nocardicin aminocarboxypropyltransferase;
S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:nocardicin-G 3-amino-3-carboxypropyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + nocardicin G = S-methyl-5'-thioadenosine + isonocardicin C [RN:R10881]
Reaction(KEGG)
R10881;
(other) R03072
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Substrate
S-adenosyl-L-methionine [CPD:C00019];
nocardicin G [CPD:C17355]
Product
S-methyl-5'-thioadenosine [CPD:C00170];
isonocardicin C [CPD:C17352]
Comment
The enzyme, characterized from the bacterium Nocardia uniformis, is involved in the biosynthesis of the beta-lactam antibiotic nocardicin A. The enzyme can act on nocardicin E, F, and G, producing isonocardicin A, B, and C, respectively. However, the in vivo substrate is believed to be nocardicin G [3].
History
EC 2.5.1.38 created 1992, modified 2016
Pathway
ec00261  Monobactam biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K19104  isonocardicin synthase
Genes
AMI: Amir_4587
Taxonomy
Reference
1
  Authors
Wilson, B.A., Bantia, S., Salituro, G.M., Reeve, A.M. and Townsend, C.A.
  Title
Cell-free biosynthesis of nocardicin A from nocardicin E and S-adenosylmethionine.
  Journal
J Am Chem Soc 110:8238-8239 (1988)
Reference
2  [PMID:9804844]
  Authors
Reeve AM, Breazeale SD, Townsend CA.
  Title
Purification, characterization, and cloning of an S-adenosylmethionine-dependent  3-amino-3-carboxypropyltransferase in nocardicin biosynthesis.
  Journal
J Biol Chem 273:30695-703 (1998)
DOI:10.1074/jbc.273.46.30695
Reference
3  [PMID:15629944]
  Authors
Kelly WL, Townsend CA.
  Title
Mutational analysis of nocK and nocL in the nocardicin a producer Nocardia uniformis.
  Journal
J Bacteriol 187:739-46 (2005)
DOI:10.1128/JB.187.2.739-746.2005
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.38
IUBMB Enzyme Nomenclature: 2.5.1.38
ExPASy - ENZYME nomenclature database: 2.5.1.38
BRENDA, the Enzyme Database: 2.5.1.38
CAS: 118246-74-5

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