KEGG   ENZYME: 2.5.1.41Help
Entry
EC 2.5.1.41                 Enzyme                                 

Name
phosphoglycerol geranylgeranyltransferase;
glycerol phosphate geranylgeranyltransferase;
geranylgeranyl-transferase (ambiguous);
prenyltransferase (ambiguous);
(S)-3-O-geranylgeranylglyceryl phosphate synthase;
(S)-geranylgeranylglyceryl phosphate synthase;
GGGP synthase;
(S)-GGGP synthase;
GGGPS;
geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase;
geranylgeranyl diphosphate:sn-glycerol-1-phosphate geranylgeranyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranylgeranyl-diphosphate:sn-glycerol-1-phosphate geranylgeranyltransferase
Reaction(IUBMB)
geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate [RN:R04158]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353];
sn-glycerol 1-phosphate [CPD:C00623]
Product
diphosphate [CPD:C00013];
3-(O-geranylgeranyl)-sn-glycerol 1-phosphate [CPD:C04590]
Comment
This cytosolic enzyme catalyses the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria [2]. Requires Mg2+ for maximal activity [2]. It catalyses the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate [2]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase) and EC 2.7.7.67 (CDP-archaeol synthase), which lead to the formation of CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [5].
History
EC 2.5.1.41 created 1992, modified 2009
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K17104  phosphoglycerol geranylgeranyltransferase
Genes
STRT: A8713_30305
SLS: SLINC_6335
MJA: MJ_1250
MFE: Mefer_0372
MVU: Metvu_0909
MFS: MFS40622_0685
MIF: Metin_0740
MJH: JH146_0475
MIG: Metig_1082
MMP: MMP0007
MMD: GYY_00040
MAE: Maeo_1165
MVO: Mvol_1417
MTH: MTH_552
METC: MTCT_0480
METE: tca_00524(pcrB)
MST: Msp_1291(pcrB)
MSI: Msm_0124
MRU: mru_1102
MEB: Abm4_0883
MMIL: sm9_0933
MEYE: TL18_05650
MOL: YLM1_0765
METH: MBMB1_0428
MFC: BRM9_1833
MCUB: MCBB_0391
MFV: Mfer_0282
MKA: MK0642
AFU: AF_0403
FPL: Ferp_2022
GAC: GACE_1575
GAH: GAH_00156
TAC: Ta0995
TVO: TVG0750626(TVG0750626)
PTO: PTO0183
FAI: FAD_1427
CDIV: CPM_1185
MARC: AR505_1588
ABI: Aboo_0770
PHO: PH1124(PH1124)
PAB: PAB0735
PFU: PF1039
PFI: PFC_04430
PYN: PNA2_1786
PYS: Py04_0956
TKO: TK1026
TON: TON_1065
TGA: TGAM_1175(gggPS)
TSI: TSIB_0683
THE: GQS_10240
THA: TAM4_2030
THM: CL1_1622
TLT: OCC_02732
THS: TES1_1095
TNU: BD01_0972
TEU: TEU_10660
PPAC: PAP_08105
MAC: MA_3969
MBAR: MSBR2_3210
MBAK: MSBR3_3195
MMA: MM_0943
MMAC: MSMAC_0379
METM: MSMTP_0421
MTHE: MSTHC_1743
MTHR: MSTHT_1546
MHOR: MSHOH_0454
MBU: Mbur_1652
MMET: MCMEM_2137
MMH: Mmah_1962
MPY: Mpsy_1329
MTP: Mthe_1238
MCJ: MCON_1916
MHI: Mhar_0199
MHU: Mhun_1010
MLA: Mlab_1138
MEMA: MMAB1_3107
MPI: Mpet_1935
MBN: Mboo_0860
MPL: Mpal_1300
MEZ: Mtc_2486
HSL: OE_1398R(pcrB1) OE_3699R(pcrB2)
HHB: Hhub_1410(pcrB)
HALH: HTSR_1475
HHSR: HSR6_1547
HMA: rrnAC1650(pcrB)
HHI: HAH_2191(pcrB)
NPH: NP_1224A(pcrB)
NMO: Nmlp_2072(pcrB)
HUT: Huta_2960
HTI: HTIA_2549
HWA: HQ_1269A(pcrB)
HWC: Hqrw_1298(pcrB)
HVO: HVO_0680(pcrB1) HVO_1086(pcrB2)
HLA: Hlac_0199
NMG: Nmag_1070(pcrB1) Nmag_2771(pcrB2)
NAT: NJ7G_1988
SALI: L593_04125
ACJ: ACAM_0473
SMR: Smar_0993
IHO: Igni_0425
IIS: EYM_04315
DKA: DKAM_1191
TAG: Tagg_0823
IAG: Igag_0058
HBU: Hbut_0005
STO: STK_03100
SSO: SSO0259
SOL: Ssol_1237
SSOA: SULA_1279
SSOL: SULB_1280
SSOF: SULC_1278
SAI: Saci_0728
SID: M164_1886
SII: LD85_2100
SIH: SiH_1816
SIR: SiRe_1736
SIC: SiL_1728
MSE: Msed_2291
MCN: Mcup_2034
AHO: Ahos_0786
PAI: PAE3045
PIS: Pisl_0443
PCL: Pcal_0985
PAS: Pars_1793
PYR: P186_1474
POG: Pogu_0338
TNE: Tneu_1677
CMA: Cmaq_0928
TUZ: TUZN_1798
TTN: TTX_1714
VDI: Vdis_0768
VMO: VMUT_1616
TPE: Tpen_0633
ASC: ASAC_1045
ACIA: SE86_06355
NMR: Nmar_1795
NCT: NMSP_1711
NEV: NTE_00080
TAA: NMY3_00623(pcrB)
NCV: NCAV_1797
NBV: T478_1498
NDV: NDEV_0006
MARH: Mia14_0378
KCR: Kcr_1391
BARC: AOA65_2367
BARB: AOA66_1442
 » show all
Taxonomy
Reference
1
  Authors
Zhang, D.-L., Daniels, L. and Poulter, C.D.
  Title
Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction.
  Journal
J Am Chem Soc 112:1264-1265 (1990)
Reference
2  [PMID:8408023]
  Authors
Chen A, Zhang D, Poulter CD
  Title
(S)-geranylgeranylglyceryl phosphate synthase. Purification and characterization of the first pathway-specific enzyme in archaebacterial membrane lipid biosynthesis.
  Journal
J Biol Chem 268:21701-5 (1993)
  Sequence
Reference
3  [PMID:12801917]
  Authors
Nemoto N, Oshima T, Yamagishi A
  Title
Purification and characterization of geranylgeranylglyceryl phosphate synthase from a thermoacidophilic archaeon, Thermoplasma acidophilum.
  Journal
J Biochem 133:651-7 (2003)
  Sequence
[tac:Ta0995]
Reference
4  [PMID:16377641]
  Authors
Payandeh J, Fujihashi M, Gillon W, Pai EF
  Title
The crystal structure of (S)-3-O-geranylgeranylglyceryl phosphate synthase reveals an ancient fold for an ancient enzyme.
  Journal
J Biol Chem 281:6070-8 (2006)
DOI:10.1074/jbc.M509377200
  Sequence
[afu:AF_0403]
Reference
5  [PMID:10960477]
  Authors
Morii H, Nishihara M, Koga Y
  Title
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus.
  Journal
J Biol Chem 275:36568-74 (2000)
DOI:10.1074/jbc.M005925200
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.41
IUBMB Enzyme Nomenclature: 2.5.1.41
ExPASy - ENZYME nomenclature database: 2.5.1.41
BRENDA, the Enzyme Database: 2.5.1.41
CAS: 124650-69-7

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