KEGG   ENZYME: 2.5.1.42Help
Entry
EC 2.5.1.42                 Enzyme                                 

Name
geranylgeranylglycerol-phosphate geranylgeranyltransferase;
geranylgeranyloxyglycerol phosphate geranylgeranyltransferase;
geranylgeranyltransferase II;
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase;
DGGGP synthase;
DGGGPS;
geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranylgeranyl diphosphate:3-(O-geranylgeranyl)-sn-glycerol 1-phosphate geranylgeranyltransferase
Reaction(IUBMB)
geranylgeranyl diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate [RN:R04520]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353];
3-(O-geranylgeranyl)-sn-glycerol 1-phosphate [CPD:C04590]
Product
diphosphate [CPD:C00013];
2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
Comment
This enzyme is an integral-membrane protein that carries out the second prenyltransfer reaction involved in the formation of polar membrane lipids in Archaea. Requires a divalent metal cation, such as Mg2+ or Mn2+, for activity [2]. 4-Hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate and alpha-glycerophosphate cannot act as prenyl-acceptor substrates [2]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.41 (phosphoglycerol geranylgeranyltransferase), which, together with this enzyme, alkylates the hydroxy groups of glycerol 1-phosphate to yield unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 (CDP-archaeol synthase) to form CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [3]. Belongs in the UbiA prenyltransferase family [2].
History
EC 2.5.1.42 created 1992, modified 2009
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K17105  geranylgeranylglycerol-phosphate geranylgeranyltransferase
Genes
LFA: LFA_1197
DOR: Desor_2061
DMI: Desmer_2108
HMO: HM1_3117(ubiA)
NTP: CRH09_14125
SVL: Strvi_5133
SRC: M271_47045
SAUO: BV401_04850
SMAL: SMALA_0222
SEN: SACE_4647
ALL: CRK61972
ACTN: L083_7158
RXY: Rxyl_2757
AMR: AM1_D0196(ubiA)
CTHE: Chro_3310
CTE: CT1291
CTS: Ctha_2526
IAL: IALB_0629(ubiA)
CABY: Cabys_1573
MJA: MJ_0279
MMP: MMP1677
MMD: GYY_09240
MAE: Maeo_1040
MVO: Mvol_1278
MTH: MTH_1098
METC: MTCT_0992
METE: tca_01055
MST: Msp_0634
METB: AW729_04545(ubiA)
MSI: Msm_0941
MRU: mru_1885
MEB: Abm4_0306
MMIL: sm9_1892
MEYE: TL18_08915(ubiA)
MOL: YLM1_1336
METH: MBMB1_1509
MFC: BRM9_0738
MCUB: MCBB_1754
MFV: Mfer_0640
MKA: MK0953(ubiA)
AFU: AF_0404
FPL: Ferp_2021
GAC: GACE_1576
GAH: GAH_00157
TAC: Ta0996
TVO: TVG0751384(TVG0751384)
PTO: PTO0182
FAI: FAD_1222
CDIV: CPM_1186
MARC: AR505_1587
ABI: Aboo_0771
PHO: PH0027(PH0027)
PAB: PAB0018(ubiA-like)
PFU: PF1963
PFI: PFC_08765(ubiA)
PYN: PNA2_0551
PYS: Py04_0089
PYC: TQ32_06920(ubiA)
TKO: TK1957
TON: TON_1950
TGA: TGAM_1764
TSI: TSIB_0711
THE: GQS_05375(ubiA)
THA: TAM4_1485
TLT: OCC_02582(ubiA)
THS: TES1_1952
TNU: BD01_2040
TEU: TEU_04265(ubiA)
TGY: X802_01740(ubiA)
TPEP: A0127_04680(ubiA)
TGG: A3K92_03080(ubiA)
TCE: A3L02_06675(ubiA)
TSL: A3L11_04245(ubiA)
TTD: A3L14_01860(ubiA)
TPRF: A3L09_05275(ubiA)
TRL: A3L10_10205(ubiA)
TPAF: A3L08_03605(ubiA)
PPAC: PAP_00080(ubiA)
MAC: MA_0961(ubiA)
MMA: MM_2075
MMAC: MSMAC_1809
MTHE: MSTHC_1961
MTHR: MSTHT_1331
MBU: Mbur_1679
MMET: MCMEM_2160
MMH: Mmah_1979
MPY: Mpsy_1283(ubiA) Mpsy_1441(ubiA2)
MTP: Mthe_1142
MHI: Mhar_1249
MHU: Mhun_0625
MLA: Mlab_0795
MBG: BN140_0748(ubiA1)
MEMA: MMAB1_0967
MPI: Mpet_0930
MBN: Mboo_1843
MPD: MCP_2782
MEZ: Mtc_2488
RCI: LRC477(ubiA-1) RCIX579(ubiA-2)
HAL: VNG_0610G(hhoA)
HSL: OE_1921R(ubiA2)
HDL: HALDL1_07245(ubiA)
HHB: Hhub_1691
HJE: HacjB3_11200(ubiA)
HALH: HTSR_1199
HHSR: HSR6_1234
NPH: NP_4470A(ubiA2)
NMO: Nmlp_2958(ubiA2)
HWA: HQ_1884A(ubiA2)
HWC: Hqrw_2024(ubiA2)
HVO: HVO_1436(ubiA2)
HME: HFX_1501(ubiA)
HGI: ABY42_06985(ubiA)
HLA: Hlac_2079
HTU: Htur_1016
NMG: Nmag_3192(ubiA2)
NAT: NJ7G_3597
SALI: L593_14740(ubiA)
HLR: HALLA_10005(ubiA)
APE: APE_0159
ACJ: ACAM_0126
SMR: Smar_1155
IHO: Igni_0416
IIS: EYM_02685
DKA: DKAM_1012
TAG: Tagg_0063
IAG: Igag_1473
HBU: Hbut_0025
STO: STK_14510
SSO: SSO0583(ubiA-2)
SOL: Ssol_1647
SSOA: SULA_1675
SSOL: SULB_1676
SSOF: SULC_1674
SAI: Saci_1565
SID: M164_1546
SII: LD85_1756
SIH: SiH_1515
SIR: SiRe_1424
SIC: SiL_1427
MSE: Msed_1933
MCN: Mcup_0351
AHO: Ahos_1160
PAI: PAE1784
PIS: Pisl_1733
PCL: Pcal_0555
PAS: Pars_0740
PYR: P186_0096
POG: Pogu_1603
TNE: Tneu_0749
CMA: Cmaq_0958
TUZ: TUZN_2035
TTN: TTX_1501(ubiA)
VDI: Vdis_0353
VMO: VMUT_1279
ASC: ASAC_0782
ACIA: SE86_05850
NDV: NDEV_0648
MARH: Mia14_0921
KCR: Kcr_1480
BARB: AOA66_0405
 » show all
Taxonomy
Reference
1
  Authors
Zhang, D.-L., Daniels, L. and Poulter, C.D.
  Title
Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction.
  Journal
J Am Chem Soc 112:1264-1265 (1990)
Reference
2  [PMID:15356000]
  Authors
Hemmi H, Shibuya K, Takahashi Y, Nakayama T, Nishino T
  Title
(S)-2,3-Di-O-geranylgeranylglyceryl phosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus. Molecular cloning and characterization of a membrane-intrinsic prenyltransferase involved in the biosynthesis of archaeal ether-linked membrane lipids.
  Journal
J Biol Chem 279:50197-203 (2004)
DOI:10.1074/jbc.M409207200
  Sequence
[sso:SSO0583]
Reference
3  [PMID:10960477]
  Authors
Morii H, Nishihara M, Koga Y
  Title
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus.
  Journal
J Biol Chem 275:36568-74 (2000)
DOI:10.1074/jbc.M005925200
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.42
IUBMB Enzyme Nomenclature: 2.5.1.42
ExPASy - ENZYME nomenclature database: 2.5.1.42
BRENDA, the Enzyme Database: 2.5.1.42
CAS: 124650-68-6

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