KEGG   ENZYME: 2.5.1.51Help
Entry
EC 2.5.1.51                 Enzyme                                 

Name
beta-pyrazolylalanine synthase;
beta-(1-pyrazolyl)alanine synthase;
beta-pyrazolealanine synthase;
beta-pyrazolylalanine synthase (acetylserine);
O3-acetyl-L-serine acetate-lyase (adding pyrazole);
BPA-synthase;
pyrazolealanine synthase;
pyrazolylalaninase;
3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase;
O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase
Reaction(IUBMB)
O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate [RN:R03134]
Reaction(KEGG)
Substrate
O-acetyl-L-serine [CPD:C00979];
pyrazole [CPD:C00481]
Product
3-(pyrazol-1-yl)-L-alanine [CPD:C01162];
acetate [CPD:C00033]
Comment
The enzyme is highly specific for acetylserine and pyrazole. Not identical with EC 2.5.1.52 L-mimosine synthase.
History
EC 2.5.1.51 created 1989 as EC 4.2.99.14 (EC 4.2.99.17 incorporated 1992), transferred 2002 to EC 2.5.1.51
Reference
1
  Authors
Murakoshi, I., Ikegami, F., Hinuma, Y. and Hanma, Y.
  Title
Purification and characterization of beta-(pyrazol-1-yl)-L-alanine synthase from Citrullus vulgaris.
  Journal
Phytochemistry 23:973-977 (1984)
Reference
2
  Authors
Murakoshi, I., Ikegami, F., Hinuma, Y. and Hanma, Y.
  Title
Purification and characterization of L-mimosine synthase from Leucaena leucocephala.
  Journal
Phytochemistry 23:1905-1908 (1984)
Reference
3
  Authors
Murakoshi, I., Kuramoto, H. and Haginiwa, J.
  Title
The enzymic synthesis of beta-substituted alanines.
  Journal
Phytochemistry 11:177-182 (1972)
Reference
4  [PMID:8280125]
  Authors
Noji M, Murakoshi I, Saito K.
  Title
Evidence for identity of beta-pyrazolealanine synthase with cysteine synthase in watermelon: formation of beta-pyrazole-alanine by cloned cysteine synthase in vitro and in vivo.
  Journal
Biochem Biophys Res Commun 197:1111-7 (1993)
DOI:10.1006/bbrc.1993.2592
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.51
IUBMB Enzyme Nomenclature: 2.5.1.51
ExPASy - ENZYME nomenclature database: 2.5.1.51
BRENDA, the Enzyme Database: 2.5.1.51
CAS: 37290-81-6

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