KEGG   ENZYME: 2.5.1.56Help
Entry
EC 2.5.1.56                 Enzyme                                 

Name
N-acetylneuraminate synthase;
(NANA)condensing enzyme;
N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating);
NeuAc synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
Reaction(IUBMB)
phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate [RN:R01804]
Reaction(KEGG)
R01804;
(other) R04435
Show
Substrate
phosphoenolpyruvate [CPD:C00074];
N-acetyl-D-mannosamine [CPD:C00645];
H2O [CPD:C00001]
Product
phosphate [CPD:C00009];
N-acetylneuraminate [CPD:C00270]
History
EC 2.5.1.56 created 1972 as EC 4.1.3.19, transferred 2002 to EC 2.5.1.56
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K01654  N-acetylneuraminate synthase
K05304  sialic acid synthase
Genes
HSA: 54187(NANS)
PTR: 743934(NANS)
PPS: 100982112(NANS)
GGO: 101124502(NANS)
PON: 100446862(NANS)
NLE: 100596073 100603154(NANS)
MCC: 715459(NANS)
MCF: 102120030(NANS)
CSAB: 103219150(NANS)
RRO: 104657773(NANS)
RBB: 108539113(NANS)
CJC: 100411585(NANS)
SBQ: 101027621(NANS)
MMU: 94181(Nans)
RNO: 298071(Nans)
CGE: 100767837(Nans)
NGI: 103749137(Nans)
HGL: 101721582(Nans)
CCAN: 109697287(Nans)
OCU: 100356934(NANS)
TUP: 102496776(NANS)
CFA: 481624(NANS)
AML: 100471912(NANS)
UMR: 103678504(NANS)
ORO: 101377441(NANS)
FCA: 101092303(NANS)
PTG: 102952743(NANS)
AJU: 106981299(NANS)
BTA: 540602(NANS)
BOM: 102266035(NANS)
BIU: 109563072(NANS)
PHD: 102326794(NANS)
CHX: 102171423(NANS)
OAS: 101104048(NANS)
SSC: 100155883(NANS)
CFR: 102511644(NANS)
CDK: 105086903(NANS)
BACU: 103016138(NANS)
LVE: 103074242(NANS)
OOR: 101286113(NANS)
ECB: 100064126(NANS)
EPZ: 103550229(NANS)
EAI: 106842931(NANS)
MYB: 102254698(NANS)
MYD: 102770256(NANS)
HAI: 109386412(NANS)
RSS: 109446100(NANS)
PALE: 102882391(NANS)
LAV: 100659127(NANS)
TMU: 101361417
MDO: 100014569(NANS)
SHR: 100915225(NANS)
OAA: 100074951(NANS)
GGA: 427283(NANS)
MGP: 100540972(NANS)
CJO: 107306381(NANS)
APLA: 101793548(NANS)
ACYG: 106046483(NANS)
TGU: 100227675(NANS)
GFR: 102036907(NANS)
FAB: 101817049(NANS)
PHI: 102108606(NANS)
PMAJ: 107198262(NANS)
CCAE: 111940921(NANS)
CCW: 104689769(NANS)
FPG: 101910977(NANS)
FCH: 102058691(NANS)
CLV: 102088004(NANS)
EGZ: 104135026(NANS)
AAM: 106487451(NANS)
ASN: 102371122(NANS)
AMJ: 102562418(NANS)
CMY: 102930222(NANS)
CPIC: 101940249(NANS)
ACS: 100558551(nans)
PVT: 110077827(NANS)
PBI: 103051012(NANS)
GJA: 107122992(NANS)
XLA: 432051 447417(nans.L)
XTR: 100492893(nans)
NPR: 108783786(NANS)
DRE: 322780(nansa)
IPU: 100528493(nans) 108260162
AMEX: 111195185(nans)
TRU: 778024(nans)
LCO: 104922341(nans)
NCC: 104951104(nans)
OLA: 101166198(nans)
XMA: 102234709(nans)
PRET: 103467988(nans) 103472627
MALB: 109953770(nans)
ELS: 105022900(nans)
SFM: 108920829
CMK: 103177631(nans) 103177633
SPU: 577884(nans)
DME: Dmel_CG5232(NANS)
DSI: Dsimw501_GD18832(Dsim_GD18832)
MDE: 101899077
AAG: 5563645
TCA: 103312199
DPA: 109539228
NVL: 108567369
BMOR: 101744099
PRAP: 110994857
HAW: 110380482
PXY: 105391284
DNX: 107161705
CLEC: 106666066
ZNE: 110829049
FCD: 110842189
TUT: 107368038
CRG: 105324122
ECOO: ECRM13514_2762(nnaB)
ECOH: ECRM13516_2630(nnaB)
ESO: O3O_16390
ESM: O3M_09195
ESL: O3K_09230
ECI: UTI89_C3372(neuB)
ECV: APECO1_3471(neuB)
ECM: EcSMS35_3232(neuB)
ECT: ECIAI39_3443(neuB)
EOC: CE10_3481(neuB)
ECZ: ECS88_3330(neuB)
EIH: ECOK1_3369(neuB)
ECOI: ECOPMV1_03252(spsE)
SBZ: A464_2222
ENC: ECL_03360
EBF: D782_1589
PEC: W5S_3015
ETR: ETAE_1207(neuB)
ETD: ETAF_1122
ETE: ETEE_3151(neuB)
HPR: PARA_02850(nnaB)
MHT: D648_18140(neuB)
MHQ: D650_8020(neuB)
MHAT: B824_18220(neuB)
MHX: MHH_c26670(nnaB)
MHAE: F382_04090
MHAM: J450_03120
MHAO: J451_04330
MHAL: N220_10190
MHAQ: WC39_04015
MHAY: VK67_04015
MVR: X781_5990
MVE: X875_5510
VVU: VV1_0808
VVY: VV0312
VPA: VP0200
VFI: VF_0143(neuB)
VFM: VFMJ11_0175(pseI)
PPR: PBPRA2707(CJ1317)
PMK: MDS_1970
PPF: Pput_1483
PFL: PFL_1625(pseI)
PSA: PST_3835
PPUU: PputUW4_03891(pseI)
ABM: ABSDF0070
ABX: ABK1_0091
SON: SO_3261
SAZ: Sama_2331
SBL: Sbal_2958
SLO: Shew_1329
SSE: Ssed_3100
SPL: Spea_0049
SHL: Shal_1403
SWD: Swoo_1582
ILO: IL0519(siaC) IL0551
CPS: CPS_2097
PAT: Patl_3076
MHC: MARHY2541(rkpQ)
MAD: HP15_2393
TCX: Tcr_1458
NHL: Nhal_0399
HCH: HCH_04835 HCH_05266(neuB)
AHA: AHA_4180(nueB)
ASA: ASA_0148(neuB)
ASR: WL1483_1781(pseI)
NME: NMB0068(siaC)
NMP: NMBB_0073(siaC)
NMQ: NMBM04240196_0082(siaC)
NMZ: NMBNZ0533_0074(siaC)
NMC: NMC0052(siaC)
NMN: NMCC_0076(siaC)
NMT: NMV_0069(siaC)
CVI: CV_4031(neuB)
BPH: Bphy_3008
PNE: Pnec_0333
BPT: Bpet2307(neuB)
BPSI: IX83_06875
VEI: Veis_4853
CTES: O987_16645
HAR: HEAR1126
JAG: GJA_936
TIN: Tint_2652
NEU: NE1570
NET: Neut_1549
DSU: Dsui_0079
DAR: Daro_1248
HAC: Hac_1271(neuB)
CJE: Cj1141(neuB1)
CJB: BN148_1141(neuB1)
CJU: C8J_1339
CJI: CJSA_1083(neuB1)
CJEJ: N564_01107
CJEU: N565_01150
CJEN: N755_01145
CJEI: N135_01178
CCY: YSS_07645
CIS: CINS_1205(neuB)
CSM: CSUB8521_1427(neuB)
GSU: GSU1970(neuB)
GME: Gmet_0455
GUR: Gura_4086
GLO: Glov_3405
GBM: Gbem_3726
PCA: Pcar_1140 Pcar_1277(neuB)
DVU: DVU0349
DDS: Ddes_1890
DGG: DGI_4066
DAS: Daes_2970
DPI: BN4_12645
DBA: Dbac_0367
DRT: Dret_0614
DAT: HRM2_36740(neuB)
HOH: Hoch_0346
DBR: Deba_1027
BBA: Bd1683(neuB)
PACA: ID47_09690
SMI: BN406_06051(rkpQ)
RHI: NGR_b09490(rkpQ)
SFH: SFHH103_06314(rkpQ)
RLG: Rleg_0440
RPB: RPB_1534
RPE: RPE_4236
NHA: Nham_1196
BVR: BVIR_1970
CCR: CC_2868
CSE: Cseg_0922
PZU: PHZ_c2601
RCP: RCAP_rcc02960(neuB)
RDE: RD1_4205
PDE: Pden_3556
HBA: Hbal_0198
RCE: RC1_3771(nans)
MGM: Mmc1_0562
BAY: RBAM_035120(spsE)
BCG: BCG9842_B1724(pseI)
BPU: BPUM_3432
GKA: GK3123
LSP: Bsph_1163
BBE: BBR47_53260(neuB)
SAG: SAG1161(neuB)
SAN: neuB
SAK: SAK_1250(neuB)
SGC: A964_1134(neuB)
SAGS: SaSA20_0983(neuB)
SAGL: GBS222_0993(neuB)
SAGM: BSA_12390
SAGI: MSA_12810
SAGR: SAIL_12810
SAGP: V193_05425
SAGC: DN94_05425
SAGE: EN72_06455
SAGG: EN73_05990
SAGN: W903_1244(neuB)
SSB: SSUBM407_1280(neuB)
SSI: SSU0535(neuB)
SSS: SSUSC84_0517(neuB)
SUP: YYK_02535
SSUT: TL13_1188(neuB)
SSUI: T15_1401(neuB)
CTC: CTC_01711
CBO: CBO2680
CBA: CLB_2621
CBH: CLC_2553
CBY: CLM_3044
CBL: CLK_2067
CBB: CLD_1885
CBI: CLJ_B2910
CBT: CLH_1466
CKL: CKL_2472
CKR: CKR_2186
BPB: bpr_I2559(neuB2)
SWO: Swol_0210
HMO: HM1_1244
MTA: Moth_0756
SCO: SCO4881(2SCK8.07)
SMA: SAVERM_3373(neuB)
SGR: SGR_2659
SLAU: SLA_6887
JDE: Jden_0843
MPH: MLP_28480
KFL: Kfla_0513
TFU: Tfu_0010
SRO: Sros_1204
GOB: Gobs_4334
SYW: SYNW0394
SYG: sync_0174
SYNR: KR49_06605
SYND: KR52_04985
PMB: A9601_14241(spsE)
PMF: P9303_01101(spsE)
PMG: P9301_14081(spsE)
PMH: P9215_14811(spsE)
PMJ: P9211_12451(spsE)
PME: NATL1_08721(spsE)
CYT: cce_4481
RCA: Rcas_0774
PUV: PUV_16450(spsE)
WCH: wcw_0976(neuB)
LIL: LA_1613(spsE)
LIE: LIF_A1300(spsE)
LIC: LIC_12169(sas)
LBJ: LBJ_1114(neuB-2)
LBL: LBL_1168(neuB-2)
LBF: LBF_1974(neuB-3)
BHY: BHWA1_01436(spsE)
BRM: Bmur_1664
BPO: BP951000_1153(spsE)
SUS: Acid_2246
FNU: FN1684
TAI: Taci_0643
BVU: BVU_4040
SRU: SRU_0605(spsE)
SRM: SRM_00699(spsE)
PHE: Phep_3942
CHU: CHU_2758(neuB)
DFE: Dfer_3363
SLI: Slin_4269
GFO: GFO_0569
FJO: Fjoh_0305
FPS: FP1256(neuB)
ZPR: ZPR_1117
CTE: CT0825
CPC: Cpar_0852
CCH: Cag_1072
CLI: Clim_0797
PVI: Cvib_1025
PLT: Plut_1274
PPH: Ppha_1574
PAA: Paes_0910
CTS: Ctha_2574
TNP: Tnap_0417
KOL: Kole_1281
NDE: NIDE2999
MJA: MJ_1065
MAE: Maeo_0420
MRU: mru_1878(neuB)
MBU: Mbur_1586
MHU: Mhun_3098
HMU: Hmuk_1456
NMG: Nmag_0151(neuB)
 » show all
Taxonomy
Reference
1  [PMID:13971393]
  Authors
BLACKLOW RS, WARREN L.
  Title
Biosynthesis of sialic acids by Neisseria meningitidis.
  Journal
J Biol Chem 237:3520-6 (1962)
Reference
2  [PMID:9438985]
  Authors
Komaki E, Ohta Y, Tsukada Y.
  Title
Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1-M12.
  Journal
Biosci Biotechnol Biochem 61:2046-50 (1997)
DOI:10.1271/bbb.61.2046
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.56
IUBMB Enzyme Nomenclature: 2.5.1.56
ExPASy - ENZYME nomenclature database: 2.5.1.56
BRENDA, the Enzyme Database: 2.5.1.56
CAS: 37290-66-7

KEGG   ENZYME: 2.5.1.57Help
Entry
EC 2.5.1.57                 Enzyme                                 

Name
N-acylneuraminate-9-phosphate synthase;
N-acetylneuraminate 9-phosphate lyase;
N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase;
N-acetylneuraminate 9-phosphate synthetase;
N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating);
sialic acid 9-phosphate synthetase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase
Reaction(IUBMB)
phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + phosphate [RN:R02769]
Reaction(KEGG)
Substrate
phosphoenolpyruvate [CPD:C00074];
N-acyl-D-mannosamine 6-phosphate [CPD:C00686];
H2O [CPD:C00001]
Product
N-acylneuraminate 9-phosphate [CPD:C01200];
phosphate [CPD:C00009]
Comment
Acts on N-glycoloyl and N-acetyl-derivatives.
History
EC 2.5.1.57 created 1972 as EC 4.1.3.20, transferred 2002 to EC 2.5.1.57
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K05304  sialic acid synthase
Genes
HSA: 54187(NANS)
PTR: 743934(NANS)
PPS: 100982112(NANS)
GGO: 101124502(NANS)
PON: 100446862(NANS)
NLE: 100596073 100603154(NANS)
MCC: 715459(NANS)
MCF: 102120030(NANS)
CSAB: 103219150(NANS)
RRO: 104657773(NANS)
RBB: 108539113(NANS)
CJC: 100411585(NANS)
SBQ: 101027621(NANS)
MMU: 94181(Nans)
RNO: 298071(Nans)
CGE: 100767837(Nans)
NGI: 103749137(Nans)
HGL: 101721582(Nans)
CCAN: 109697287(Nans)
OCU: 100356934(NANS)
TUP: 102496776(NANS)
CFA: 481624(NANS)
AML: 100471912(NANS)
UMR: 103678504(NANS)
ORO: 101377441(NANS)
FCA: 101092303(NANS)
PTG: 102952743(NANS)
AJU: 106981299(NANS)
BTA: 540602(NANS)
BOM: 102266035(NANS)
BIU: 109563072(NANS)
PHD: 102326794(NANS)
CHX: 102171423(NANS)
OAS: 101104048(NANS)
SSC: 100155883(NANS)
CFR: 102511644(NANS)
CDK: 105086903(NANS)
BACU: 103016138(NANS)
LVE: 103074242(NANS)
OOR: 101286113(NANS)
ECB: 100064126(NANS)
EPZ: 103550229(NANS)
EAI: 106842931(NANS)
MYB: 102254698(NANS)
MYD: 102770256(NANS)
HAI: 109386412(NANS)
RSS: 109446100(NANS)
PALE: 102882391(NANS)
LAV: 100659127(NANS)
TMU: 101361417
MDO: 100014569(NANS)
SHR: 100915225(NANS)
OAA: 100074951(NANS)
GGA: 427283(NANS)
MGP: 100540972(NANS)
CJO: 107306381(NANS)
APLA: 101793548(NANS)
ACYG: 106046483(NANS)
TGU: 100227675(NANS)
GFR: 102036907(NANS)
FAB: 101817049(NANS)
PHI: 102108606(NANS)
PMAJ: 107198262(NANS)
CCAE: 111940921(NANS)
CCW: 104689769(NANS)
FPG: 101910977(NANS)
FCH: 102058691(NANS)
CLV: 102088004(NANS)
EGZ: 104135026(NANS)
AAM: 106487451(NANS)
ASN: 102371122(NANS)
AMJ: 102562418(NANS)
CMY: 102930222(NANS)
CPIC: 101940249(NANS)
ACS: 100558551(nans)
PVT: 110077827(NANS)
PBI: 103051012(NANS)
GJA: 107122992(NANS)
XLA: 432051 447417(nans.L)
XTR: 100492893(nans)
NPR: 108783786(NANS)
DRE: 322780(nansa)
IPU: 100528493(nans) 108260162
AMEX: 111195185(nans)
TRU: 778024(nans)
LCO: 104922341(nans)
NCC: 104951104(nans)
OLA: 101166198(nans)
XMA: 102234709(nans)
PRET: 103467988(nans) 103472627
MALB: 109953770(nans)
ELS: 105022900(nans)
SFM: 108920829
CMK: 103177631(nans) 103177633
SPU: 577884(nans)
DME: Dmel_CG5232(NANS)
DSI: Dsimw501_GD18832(Dsim_GD18832)
MDE: 101899077
AAG: 5563645
TCA: 103312199
DPA: 109539228
NVL: 108567369
BMOR: 101744099
PRAP: 110994857
HAW: 110380482
PXY: 105391284
DNX: 107161705
CLEC: 106666066
ZNE: 110829049
FCD: 110842189
TUT: 107368038
CRG: 105324122
DGG: DGI_4066
DAS: Daes_2970
DPI: BN4_12645
RLG: Rleg_0440
BVR: BVIR_1970
RCE: RC1_3771(nans)
SLAU: SLA_6887
 » show all
Taxonomy
Reference
1  [PMID:13743311]
  Authors
ROSEMAN S, JOURDIAN GW, WATSON D, ROOD R.
  Title
Enzymatic synthesis of sialic acid 9-phosphates.
  Journal
Proc Natl Acad Sci U S A 47:958-61 (1961)
Reference
2  [PMID:5928202]
  Authors
Watson DR, Jourdian GW, Roseman S.
  Title
The sialic acids. 8. Sialic acid 9-phosphate synthetase.
  Journal
J Biol Chem 241:5627-36 (1966)
Reference
3  [PMID:10873658]
  Authors
Nakata D, Close BE, Colley KJ, Matsuda T, Kitajima K.
  Title
Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity.
  Journal
Biochem Biophys Res Commun 273:642-8 (2000)
DOI:10.1006/bbrc.2000.2983
  Sequence
[mmu:94181]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.57
IUBMB Enzyme Nomenclature: 2.5.1.57
ExPASy - ENZYME nomenclature database: 2.5.1.57
BRENDA, the Enzyme Database: 2.5.1.57
CAS: 9031-58-7

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