KEGG   ENZYME: 2.5.1.57Help
Entry
EC 2.5.1.57                 Enzyme                                 

Name
N-acylneuraminate-9-phosphate synthase;
N-acetylneuraminate 9-phosphate lyase;
N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase;
N-acetylneuraminate 9-phosphate synthetase;
N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating);
sialic acid 9-phosphate synthetase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase
Reaction(IUBMB)
phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + phosphate [RN:R02769]
Reaction(KEGG)
Substrate
phosphoenolpyruvate [CPD:C00074];
N-acyl-D-mannosamine 6-phosphate [CPD:C00686];
H2O [CPD:C00001]
Product
N-acylneuraminate 9-phosphate [CPD:C01200];
phosphate [CPD:C00009]
Comment
Acts on N-glycoloyl and N-acetyl-derivatives.
History
EC 2.5.1.57 created 1972 as EC 4.1.3.20, transferred 2002 to EC 2.5.1.57
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K05304  sialic acid synthase
Genes
HSA: 54187(NANS)
PTR: 743934(NANS)
PPS: 100982112(NANS)
GGO: 101124502(NANS)
PON: 100446862(NANS)
NLE: 100596073 100603154(NANS)
MCC: 715459(NANS)
MCF: 102120030(NANS)
CSAB: 103219150(NANS)
RRO: 104657773(NANS)
RBB: 108539113(NANS)
CJC: 100411585(NANS)
SBQ: 101027621(NANS)
MMU: 94181(Nans)
RNO: 298071(Nans)
CGE: 100767837(Nans)
NGI: 103749137(Nans)
HGL: 101721582(Nans)
CCAN: 109697287(Nans)
OCU: 100356934(NANS)
TUP: 102496776(NANS)
CFA: 481624(NANS)
AML: 100471912(NANS)
UMR: 103678504(NANS)
ORO: 101377441(NANS)
FCA: 101092303(NANS)
PTG: 102952743(NANS)
AJU: 106981299(NANS)
BTA: 540602(NANS)
BOM: 102266035(NANS)
BIU: 109563072(NANS)
PHD: 102326794(NANS)
CHX: 102171423(NANS)
OAS: 101104048(NANS)
SSC: 100155883(NANS)
CFR: 102511644(NANS)
CDK: 105086903(NANS)
BACU: 103016138(NANS)
LVE: 103074242(NANS)
OOR: 101286113(NANS)
ECB: 100064126(NANS)
EPZ: 103550229(NANS)
EAI: 106842931(NANS)
MYB: 102254698(NANS)
MYD: 102770256(NANS)
HAI: 109386412(NANS)
RSS: 109446100(NANS)
PALE: 102882391(NANS)
LAV: 100659127(NANS)
TMU: 101361417
MDO: 100014569(NANS)
SHR: 100915225(NANS)
OAA: 100074951(NANS)
GGA: 427283(NANS)
MGP: 100540972(NANS)
CJO: 107306381(NANS)
APLA: 101793548(NANS)
ACYG: 106046483(NANS)
TGU: 100227675(NANS)
GFR: 102036907(NANS)
FAB: 101817049(NANS)
PHI: 102108606(NANS)
PMAJ: 107198262(NANS)
CCAE: 111940921(NANS)
CCW: 104689769(NANS)
FPG: 101910977(NANS)
FCH: 102058691(NANS)
CLV: 102088004(NANS)
EGZ: 104135026(NANS)
AAM: 106487451(NANS)
ASN: 102371122(NANS)
AMJ: 102562418(NANS)
CMY: 102930222(NANS)
CPIC: 101940249(NANS)
ACS: 100558551(nans)
PVT: 110077827(NANS)
PBI: 103051012(NANS)
GJA: 107122992(NANS)
XLA: 432051 447417(nans.L)
XTR: 100492893(nans)
NPR: 108783786(NANS)
DRE: 322780(nansa)
IPU: 100528493(nans) 108260162
AMEX: 111195185(nans)
TRU: 778024(nans)
LCO: 104922341(nans)
NCC: 104951104(nans)
OLA: 101166198(nans)
XMA: 102234709(nans)
PRET: 103467988(nans) 103472627
MALB: 109953770(nans)
ELS: 105022900(nans)
SFM: 108920829
CMK: 103177631(nans) 103177633
SPU: 577884(nans)
DME: Dmel_CG5232(NANS)
DSI: Dsimw501_GD18832(Dsim_GD18832)
MDE: 101899077
AAG: 5563645
TCA: 103312199
DPA: 109539228
NVL: 108567369
BMOR: 101744099
PRAP: 110994857
HAW: 110380482
PXY: 105391284
DNX: 107161705
CLEC: 106666066
ZNE: 110829049
FCD: 110842189
TUT: 107368038
CRG: 105324122
DGG: DGI_4066
DAS: Daes_2970
DPI: BN4_12645
RLG: Rleg_0440
BVR: BVIR_1970
RCE: RC1_3771(nans)
SLAU: SLA_6887
 » show all
Taxonomy
Reference
1  [PMID:13743311]
  Authors
ROSEMAN S, JOURDIAN GW, WATSON D, ROOD R.
  Title
Enzymatic synthesis of sialic acid 9-phosphates.
  Journal
Proc Natl Acad Sci U S A 47:958-61 (1961)
Reference
2  [PMID:5928202]
  Authors
Watson DR, Jourdian GW, Roseman S.
  Title
The sialic acids. 8. Sialic acid 9-phosphate synthetase.
  Journal
J Biol Chem 241:5627-36 (1966)
Reference
3  [PMID:10873658]
  Authors
Nakata D, Close BE, Colley KJ, Matsuda T, Kitajima K.
  Title
Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity.
  Journal
Biochem Biophys Res Commun 273:642-8 (2000)
DOI:10.1006/bbrc.2000.2983
  Sequence
[mmu:94181]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.57
IUBMB Enzyme Nomenclature: 2.5.1.57
ExPASy - ENZYME nomenclature database: 2.5.1.57
BRENDA, the Enzyme Database: 2.5.1.57
CAS: 9031-58-7

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