KEGG   ENZYME: 2.5.1.60Help
Entry
EC 2.5.1.60                 Enzyme                                 

Name
protein geranylgeranyltransferase type II;
GGTaseII;
Rab geranylgeranyltransferase;
RabGGTase;
geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranylgeranyl-diphosphate:protein-cysteine geranyltransferase
Reaction(IUBMB)
geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
Substrate
geranylgeranyl diphosphate [CPD:C00353];
protein-cysteine [CPD:C20119]
Product
S-geranylgeranyl-protein;
diphosphate [CPD:C00013]
Comment
This enzyme, along with protein farnesyltransferase (EC 2.5.1.58) and protein geranylgeranyltransferase type I (EC 2.5.1.59), constitutes the protein prenyltransferase family of enzymes. Attaches geranylgeranyl groups to two C-terminal cysteines in Ras-related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs. Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion [5].
History
EC 2.5.1.60 created 2003
Orthology
K05956  geranylgeranyl transferase type-2 subunit beta
K14050  geranylgeranyl transferase type-2 subunit alpha
Genes
HSA: 5875(RABGGTA) 5876(RABGGTB)
PTR: 100614714(RABGGTB) 452815(RABGGTA)
PPS: 100978858(RABGGTA) 100987085(RABGGTB)
GGO: 101140684(RABGGTB) 101152486(RABGGTA)
PON: 100174130(RABGGTA) 100440764(RABGGTB)
NLE: 100585898(RABGGTA) 100602152(RABGGTB)
MCC: 705421(RABGGTB) 714521(RABGGTA)
MCF: 102119899(RABGGTA) 102126317(RABGGTB)
CSAB: 103224591(RABGGTB) 103228733(RABGGTA)
RRO: 104662681(RABGGTA) 104666523(RABGGTB)
RBB: 108515016(RABGGTB) 108540942(RABGGTA)
CJC: 100394620(RABGGTB) 100412872(RABGGTA)
SBQ: 101034050(RABGGTB) 101047538(RABGGTA)
MMU: 19352(Rabggtb) 56187(Rabggta)
RNO: 25533(Rabggtb) 58983(Rabggta)
CGE: 100757505(Rabggta) 100762868(Rabggtb)
NGI: 103739418(Rabggta) 103746469(Rabggtb)
HGL: 101709927(Rabggtb) 101722509(Rabggta)
CCAN: 109685844(Rabggta) 109687809 109687817
OCU: 100345858(RABGGTB) 100349944(RABGGTA)
TUP: 102474188(RABGGTB) 102501477(RABGGTA)
CFA: 608407(RABGGTA) 612683(RABGGTB)
AML: 100473122(RABGGTA) 100480827(RABGGTB)
UMR: 103662997(RABGGTB) 103679328(RABGGTA)
ORO: 101367487(RABGGTB) 101375757(RABGGTA)
FCA: 101082319(RABGGTA) 101090281(RABGGTB)
PTG: 102962034(RABGGTB) 102963179(RABGGTA)
AJU: 106979048(RABGGTB) 106987871(RABGGTA)
BTA: 516619(RABGGTA) 533276(RABGGTB)
BOM: 102264837(RABGGTA) 102288371(RABGGTB)
BIU: 109556839(RABGGTB) 109564769(RABGGTA)
PHD: 102338947(RABGGTB) 102339491(RABGGTA) 102343581
CHX: 102183383(RABGGTB) 102187051(RABGGTA)
OAS: 100302071(RABGGTB) 101103163 101114020(RABGGTA)
SSC: 100049679(RABGGTA) 733698(RABGGTB)
CFR: 102505171(RABGGTB) 102523014(RABGGTA)
CDK: 105096687(RABGGTB) 105102443(RABGGTA)
BACU: 102998347(RABGGTA) 103019854(RABGGTB)
LVE: 103078134(RABGGTB) 103078888(RABGGTA)
OOR: 101269753(RABGGTA) 101288253(RABGGTB)
ECB: 100051161(RABGGTA) 100067295(RABGGTB)
EPZ: 103549429(RABGGTB) 103561042(RABGGTA)
EAI: 106836537(RABGGTB) 106848609(RABGGTA)
MYB: 102250484(RABGGTA) 102252699(RABGGTB)
MYD: 102752362(RABGGTA) 102754047 102758789(RABGGTB)
HAI: 109383512(RABGGTB) 109393696(RABGGTA)
RSS: 109436130(RABGGTA) 109443000 109453758(RABGGTB)
PALE: 102891613(RABGGTA) 102893188(RABGGTB)
LAV: 100673002(RABGGTB) 100674668(RABGGTA)
MDO: 100030822(RABGGTA) 100616945(RABGGTB)
SHR: 100915544(RABGGTA) 100927615(RABGGTB)
GGA: 424723(RABGGTB)
MGP: 100542594(RABGGTB)
CJO: 107317786(RABGGTB)
APLA: 101796884(RABGGTB)
ACYG: 106043586(RABGGTB)
TGU: 100220901(RABGGTB)
GFR: 102035992(RABGGTB)
FAB: 101814646(RABGGTA) 101819375(RABGGTB)
PHI: 102101133(RABGGTA) 102106763 102112837(RABGGTB)
PMAJ: 107207945(RABGGTB) 107214961
CCAE: 111939647(RABGGTB)
CCW: 104695113(RABGGTB)
FPG: 101919112(RABGGTB)
FCH: 102055652(RABGGTB)
CLV: 102094150(RABGGTB)
EGZ: 104123851(RABGGTB)
AAM: 106486517(RABGGTB)
ASN: 102374627(RABGGTA) 102384192(RABGGTB)
AMJ: 102575873(RABGGTB) 102576818(RABGGTA)
PSS: 102463096(RABGGTB)
CMY: 102944402(RABGGTA) 102944974(RABGGTB)
CPIC: 101938263(RABGGTA) 101945307(RABGGTB)
ACS: 100552203(rabggtb) 100555882(rabggta)
PVT: 110079527(RABGGTB) 110088296(RABGGTA)
PBI: 103059520(RABGGTB) 103062832(RABGGTA)
GJA: 107106254(RABGGTA) 107113027(RABGGTB)
XLA: 108707005(rabggta.S) 108714201 446590(rabggta.L) 734339(rabggtb.S)
XTR: 100127877(rabggtb) 448385(rabggta)
NPR: 108787188(RABGGTA) 108804941(RABGGTB)
DRE: 406386(rabggtb) 767725(rabggta)
IPU: 108275915(rabggta) 108278059(rabggtb)
AMEX: 103042989(rabggtb) 103045164(rabggta)
TRU: 101074084(rabggtb) 101076217(rabggta)
LCO: 104919155(rabggta) 104938824(rabggtb)
NCC: 104947093(rabggta) 104961287(rabggtb) 104966389
MZE: 101473837(rabggtb) 101477764(rabggta)
OLA: 101169143(rabggtb) 101169923(rabggta)
XMA: 102223776(rabggtb) 102235170(rabggta)
PRET: 103463817(rabggta) 103479931(rabggtb)
NFU: 107383506(rabggtb) 107393404(rabggta)
KMR: 108232796(rabggtb) 108243368(rabggta)
CSEM: 103376686(rabggta) 103396704(rabggtb)
LCF: 108879094(rabggta) 108884274(rabggtb)
SDU: 111226359(rabggta) 111231245(rabggtb)
HCQ: 109516872(rabggtb) 109532155(rabggta)
BPEC: 110154803(rabggta) 110155717(rabggtb)
MALB: 109955470(rabggtb) 109962136(rabggta)
SASA: 100195142(rabggtb) 100196776(rabggta)
OTW: 112248533(rabggta)
ELS: 105006062(rabggtb) 105006958(rabggta)
SFM: 108923709(rabggtb) 108929571(rabggta)
LCM: 102354536(RABGGTB) 102355599(RABGGTA)
CMK: 103174735(rabggtb)
SPU: 100887959 588843(rabggtb)
DME: Dmel_CG12007(CG12007) Dmel_CG18627(betaggt-II)
DSI: Dsimw501_GD19760(Dsim_GD19760) Dsimw501_GD23193(Dsim_GD23193)
PCF: 106792180
CEL: CELE_B0280.1(ggtb-1) CELE_M57.2(M57.2)
TSP: Tsp_09299
SHX: MS3_00120
ATH: AT3G12070(RGTB2) AT4G24490(RGTA1) AT5G12210(RGTB1) AT5G41820(RGTA2)
LJA: Lj1g3v1548830.1(Lj1g3v1548830.1) Lj4g3v2603650.1(Lj4g3v2603650.1) Lj4g3v2616110.1(Lj4g3v2616110.1) Lj4g3v2616110.2(Lj4g3v2616110.2)
DOSA: Os06t0677500-01(Os06g0677500) Os08t0512300-01(Os08g0512300) Os11t0523500-00(Os11g0523500)
ATS: 109741368(LOC109741368) 109781403(LOC109781403)
ZMA: 100193289(AY104360) 100285137 100501641
SCE: YJL031C(BET4) YPR176C(BET2)
KMX: KLMA_20502(BET2) KLMA_20695(BET4)
NCS: NCAS_0A15160(NCAS0A15160) NCAS_0F02080(NCAS0F02080)
NDI: NDAI_0C03710(NDAI0C03710) NDAI_0J00320(NDAI0J00320)
TPF: TPHA_0I03230(TPHA0I03230) TPHA_0N00960(TPHA0N00960)
TBL: TBLA_0D03430(TBLA0D03430) TBLA_0E00790(TBLA0E00790)
TDL: TDEL_0E03830(TDEL0E03830) TDEL_0H00380(TDEL0H00380)
KAF: KAFR_0B00380(KAFR0B00380) KAFR_0J01090(KAFR0J01090)
PIC: PICST_32799(BET4) PICST_37880(BET2.2)
SLB: AWJ20_640(BET2)
NTE: NEUTE1DRAFT122935(NEUTE1DRAFT_122935) NEUTE1DRAFT88828(NEUTE1DRAFT_88828)
MAJ: MAA_05663
BFU: BCIN_04g04630(Bcbet4) BCIN_06g05320(Bcbet2)
ANG: ANI_1_148114(An13g01040) ANI_1_1942184(An04g06090)
ABE: ARB_02255
ABP: AGABI1DRAFT131406(AGABI1DRAFT_131406) AGABI1DRAFT78756(AGABI1DRAFT_78756) AGABI1DRAFT89514(AGABI1DRAFT_89514)
ABV: AGABI2DRAFT211583(AGABI2DRAFT_211583) AGABI2DRAFT216711(AGABI2DRAFT_216711)
MGL: MGL_3422
DDI: DDB_G0269570(rabggta) DDB_G0290671(rabggtb)
DFA: DFA_00234(rabggta) DFA_05375(rabggtb)
EHI: EHI_023180(25.t00001) EHI_025110(505.t00003)
PYO: PY17X_0102900(PY07078) PY17X_1310200(PY02453)
PCB: PCHAS_010200(PC301049.00.0) PCHAS_130960
TPV: TP03_0500
BBO: BBOV_I004600(19.m02085) BBOV_III009610(17.m07834) BBOV_IV001440(21.m02925)
SMIN: v1.2.019508.t1(symbB.v1.2.019508.t1) v1.2.024704.t1(symbB.v1.2.024704.t1)
RBA: RB10641
PSL: Psta_1729
PLM: Plim_3681
TTF: THTE_2308
 » show all
Taxonomy
Reference
1  [PMID:8621375]
  Authors
Casey PJ, Seabra MC.
  Title
Protein prenyltransferases.
  Journal
J Biol Chem 271:5289-92 (1996)
DOI:10.1074/jbc.271.10.5289
Reference
2  [PMID:9677305]
  Authors
Wilson AL, Erdman RA, Castellano F, Maltese WA.
  Title
Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases.
  Journal
Biochem J 333 ( Pt 3):497-504 (1998)
Reference
3  [PMID:10745007]
  Authors
Zhang H, Seabra MC, Deisenhofer J.
  Title
Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution.
  Journal
Structure Fold Des 8:241-51 (2000)
  Sequence
[rno:58983 25533]
Reference
4  [PMID:11591706]
  Authors
Thoma NH, Niculae A, Goody RS, Alexandrov K.
  Title
Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate.
  Journal
J Biol Chem 276:48631-6 (2001)
DOI:10.1074/jbc.M106470200
Reference
5  [PMID:12071695]
  Authors
Rak A, Niculae A, Kalinin A, Thoma NH, Sidorovitch V, Goody RS, Alexandrov K.
  Title
In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex.
  Journal
Protein Expr Purif 25:23-30 (2002)
DOI:10.1006/prep.2001.1605
Reference
6
  Authors
Gibbs, R.A.
  Title
Prenyl transfer and the enzymes of terpenoid and steroid biosynthesis.
  Journal
In: Sinnott, M. (Ed.), Comprehensive Biological Catalysis. A Mechanistic Reference, vol. 1, Academic Press, San Diego, CA, 1998, p. 31-118.
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.60
IUBMB Enzyme Nomenclature: 2.5.1.60
ExPASy - ENZYME nomenclature database: 2.5.1.60
BRENDA, the Enzyme Database: 2.5.1.60
CAS: 135371-29-8

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