KEGG   ENZYME: 2.5.1.76Help
Entry
EC 2.5.1.76                 Enzyme                                 

Name
cysteate synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
sulfite:O-phospho-L-serine sulfotransferase (phosphate-hydrolysing, L-cysteate-forming)
Reaction(IUBMB)
O-phospho-L-serine + sulfite = L-cysteate + phosphate [RN:R09530]
Reaction(KEGG)
Substrate
O-phospho-L-serine [CPD:C01005];
sulfite [CPD:C00094]
Product
L-cysteate [CPD:C00506];
phosphate [CPD:C00009]
Comment
A pyridoxal-phosphate protein. It is highly specific for O-phospho-L-serine and sulfite. The reaction proceeds through a dehydroalanine (2-aminoacrylic acid) intermediate. The enzyme from Methanosarcina acetivorans is evolutionarily related to threonine synthase (EC 4.2.3.1), but the reaction is more similar to that of O-phosphoserine sulfhydrylase (EC 2.5.1.65).
History
EC 2.5.1.76 created 2009
Orthology
K15527  cysteate synthase
Genes
SBH: SBI_01127(thrC1)
SLS: SLINC_0745
KAU: B6264_25020
SESP: BN6_58880(sam27)
MPRO: BJP34_24920
BACC: BRDCF_p1063
OSP: Odosp_0306
AFD: Alfi_3017
RBC: BN938_1527
DORI: FH5T_07005
MBAS: ALGA_4376
FPL: Ferp_0996
GAC: GACE_0966
GAH: GAH_01909
MAC: MA_3297(thrC)
MBAR: MSBR2_0111
MBAK: MSBR3_0082
MMA: MM_0133
MMAC: MSMAC_2537
METM: MSMTP_1160
MTHE: MSTHC_0614
MTHR: MSTHT_0114
MHOR: MSHOH_1390
MBU: Mbur_1454
MMET: MCMEM_1953
MMH: Mmah_1753
MPY: Mpsy_2145
MTP: Mthe_0680
MCJ: MCON_0195
MHI: Mhar_1114
MHU: Mhun_2977
MLA: Mlab_0503
MBG: BN140_0055(thrC1)
MEMA: MMAB1_0058
MPI: Mpet_0280
MBN: Mboo_2116
MPL: Mpal_2734
MPD: MCP_1992
MEZ: Mtc_1468
RCI: LRC440(thrC-2)
 » show all
Taxonomy
Reference
1  [PMID:19761441]
  Authors
Graham DE, Taylor SM, Wolf RZ, Namboori SC
  Title
Convergent evolution of coenzyme M biosynthesis in the Methanosarcinales: cysteate synthase evolved from an ancestral threonine synthase.
  Journal
Biochem J 424:467-78 (2009)
DOI:10.1042/BJ20090999
  Sequence
[mac:MA_3297]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.76
IUBMB Enzyme Nomenclature: 2.5.1.76
ExPASy - ENZYME nomenclature database: 2.5.1.76
BRENDA, the Enzyme Database: 2.5.1.76

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