KEGG   ENZYME: 2.5.1.82Help
Entry
EC 2.5.1.82                 Enzyme                                 

Name
hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific];
HexPS(ambiguous);
(all-E) hexaprenyl diphosphate synthase;
(all-trans) hexaprenyl diphosphate synthase;
hexaprenyl pyrophosphate synthase (ambiguous);
HexPPs (ambiguous);
hexaprenyl diphosphate synthase (ambiguous)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units)
Reaction(IUBMB)
geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate [RN:R09246]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
all-trans-hexaprenyl diphosphate [CPD:C01230]
Comment
The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate. Requires Mg2+ [1].
History
EC 2.5.1.82 created 1984 as EC 2.5.1.33, part transferred 2010 to EC 2.5.1.82
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K05355  hexaprenyl-diphosphate synthase
K21268  hexaprenyl diphosphate synthase
Genes
CME: CYME_CMJ246C
SCE: YBR003W(COQ1)
AGO: AGOS_AER004W
ERC: Ecym_5300
KLA: KLLA0_E17183g
KMX: KLMA_60114(COQ1)
LTH: KLTH0G16368g
VPO: Kpol_1036p41
ZRO: ZYRO0A04620g
CGR: CAGL0C04257g
NCS: NCAS_0I01970(NCAS0I01970)
NDI: NDAI_0A06570(NDAI0A06570)
TPF: TPHA_0A04460(TPHA0A04460)
TBL: TBLA_0F00560(TBLA0F00560)
TDL: TDEL_0D04200(TDEL0D04200)
KAF: KAFR_0F02550(KAFR0F02550)
PIC: PICST_86778(COQ1)
CAL: CAALFM_CR00570WA(CaO19.7478)
CAUR: QG37_01534
SLB: AWJ20_394(COQ1)
NCR: NCU02305
NTE: NEUTE1DRAFT124027(NEUTE1DRAFT_124027)
MGR: MGG_03343
SSCK: SPSK_04068
MAW: MAC_09061
MAJ: MAA_03330
CMT: CCM_00496
MBE: MBM_07123
ANG: ANI_1_1348094(An11g10370)
ABE: ARB_07252
TVE: TRV_03960
PTE: PTT_13690
ZTR: MYCGRDRAFT_73426(COQ1)
SPO: SPBPJ4664.01(dps1)
CNE: CNI01740
CNB: CNBH1650
ABP: AGABI1DRAFT117445(AGABI1DRAFT_117445) AGABI1DRAFT121951(AGABI1DRAFT_121951)
ABV: AGABI2DRAFT123328(AGABI2DRAFT_123328) AGABI2DRAFT214023(AGABI2DRAFT_214023)
MGL: MGL_1241
DFA: DFA_03641(coq1)
STO: STK_04870
SSO: SSO2345(gdS-2)
SOL: Ssol_0157
SSOA: SULA_0149
SSOL: SULB_0150
SSOF: SULC_0149
SAI: Saci_0995
SID: M164_0161
SII: LD85_0146
SIH: SiH_0146
SIR: SiRe_0142
SIC: SiL_0133
MSE: Msed_0691
MCN: Mcup_1409
AHO: Ahos_2145
 » show all
Taxonomy
Reference
1  [PMID:11790729]
  Authors
Hemmi H, Ikejiri S, Yamashita S, Nishino T
  Title
Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus.
  Journal
J Bacteriol 184:615-20 (2002)
DOI:10.1128/JB.184.3.615-620.2002
  Sequence
[sso:SSO2345]
Reference
2  [PMID:12372398]
  Authors
Hemmi H, Noike M, Nakayama T, Nishino T
  Title
Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus  solfataricus by introducing mimetic mutations.
  Journal
Biochem Biophys Res Commun 297:1096-101 (2002)
DOI:10.1016/S0006-291X(02)02348-3
Reference
3  [PMID:16291686]
  Authors
Sun HY, Ko TP, Kuo CJ, Guo RT, Chou CC, Liang PH, Wang AH
  Title
Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures.
  Journal
J Bacteriol 187:8137-48 (2005)
DOI:10.1128/JB.187.23.8137-8148.2005
  Sequence
[sso:SSO2345]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.82
IUBMB Enzyme Nomenclature: 2.5.1.82
ExPASy - ENZYME nomenclature database: 2.5.1.82
BRENDA, the Enzyme Database: 2.5.1.82

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