KEGG   ENZYME: 2.5.1.84Help
Entry
EC 2.5.1.84                 Enzyme                                 

Name
all-trans-nonaprenyl diphosphate synthase [geranyl-diphosphate specific];
nonaprenyl diphosphate synthase (ambiguous);
solanesyl diphosphate synthase (ambiguous);
SolPP synthase (ambiguous);
SPP-synthase (ambiguous);
SPP synthase (ambiguous);
solanesyl-diphosphate synthase (ambiguous);
OsSPS2
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 7 isopentenyl units)
Reaction(IUBMB)
geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate [RN:R09250]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
all-trans-nonaprenyl diphosphate [CPD:C04145]
Comment
(2E,6E)-Farnesyl diphosphate and geranylgeranyl diphosphate are less effective as substrates than geranyl diphosphate. The enzyme is involved in the synthesis of the side chain of menaquinone-9 [1]. In Oryza sativa the enzyme SPS2 is involved in providing solanesyl diphosphate for plastoquinone-9 formation [3].
History
EC 2.5.1.84 created 1972 as EC 2.5.1.11, part transferred 2010 to EC 2.5.1.84
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K05356  all-trans-nonaprenyl-diphosphate synthase
Genes
ATH: AT1G17050(SPS2) AT1G78510(SPS1)
ALY: ARALYDRAFT_494049 ARALYDRAFT_895751
CRB: 17894671 17896965
CSAT: 104702634 104713531 104740392 104751747 104756029 104775809
EUS: EUTSA_v10007715mg EUTSA_v10018616mg
BRP: 103832329 103872491
BNA: 106346730 106354554 106354696 106365558
BOE: 106301071 106343305
THJ: 104810419 104812299 104813301 104813987 104822586
CPAP: 110811666
CIT: 102612772
TCC: 18594463
DZI: 111298875
VRA: 106762491
VAR: 108334430
CCAJ: 109790225
CAM: 101502183
LJA: Lj0g3v0072399.1(Lj0g3v0072399.1) Lj0g3v0072399.2(Lj0g3v0072399.2)
ADU: 107459857
AIP: 107613812
FVE: 101297041
PPER: 18778932
PMUM: 103325805
PAVI: 110772576
ZJU: 107414345
CSV: 101214140
CMO: 103492962
MCHA: 111012845
RCU: 8258714
JCU: 105641085
POP: 7459128
JRE: 108994345
VVI: 100246988
SLY: 101253007(SppS)
SPEN: 107026209
SOT: 102593674
CANN: 107878554
NSY: 104243529
NTO: 104101158
LSV: 111904475
CCAV: 112516899
BVG: 104899063
SOE: 110783766
DOSA: Os05t0582300-01(Os05g0582300)
ATS: 109748254(LOC109748254)
SBI: 8155346
PDA: 103712684
MUS: 103989203
DCT: 110112294
PEQ: 110032238
AOF: 109842749
ATR: 18430924
OLU: OSTLU_51700(clpR2)
APRO: F751_0189
SMIN: v1.2.008416.t1(symbB.v1.2.008416.t1)
SYN: slr0611(sds)
SYZ: MYO_110(sds)
SYY: SYNGTS_0001(sds)
SYT: SYNGTI_0001(sds)
SYS: SYNPCCN_0001(sds)
SYQ: SYNPCCP_0001(sds)
SYJ: D082_04480(sds)
SYO: C7I86_00005(sds)
SYW: SYNW1011(sds)
SYC: syc1741_c(sds)
SYG: sync_1551
SYR: SynRCC307_1159(preA)
SYX: SynWH7803_1038(preA)
SYP: SYNPCC7002_A0580(sdsA)
CYA: CYA_2276(sds)
CYB: CYB_0451(sds)
SYNR: KR49_03240
SYND: KR52_10950
SYNW: SynWH8103_01143(sds)
TEL: tlr1757(sds)
THN: NK55_05445(sdsA)
CYI: CBM981_0715(preA)
LET: O77CONTIG1_01361(hepT)
HHG: XM38_031750(preA)
PMA: Pro_1042(crtE)
PMM: PMM0618(sds)
PMT: PMT_0392
PMB: A9601_06741(sds)
PMC: P9515_06831(sds)
PMF: P9303_18951(sds)
PMG: P9301_06441(sds)
PMH: P9215_07001(sds)
PMJ: P9211_10311(sds)
PME: NATL1_06761(sds)
PRC: EW14_0663
PRM: EW15_0718
AMR: AM1_4909(sds)
MAR: MAE_00010(sds)
MPK: VL20_2046
CYL: AA637_04100(sds)
CYT: cce_2465(sds)
TER: Tery_0157
ARP: NIES39_N00440(sds)
GVI: gvip084(sds)
GLJ: GKIL_2127(sds)
ANA: alr0096(sds)
NOE: CLI64_12930(sds)
AVA: Ava_1469
NAZ: Aazo_0858
ANB: ANA_C12807(sds)
CALH: IJ00_17620
NSP: BMF81_03890(hepT)
CTHE: Chro_0646
CEO: ETSB_0422(sds)
 » show all
Taxonomy
Reference
1  [PMID:911777]
  Authors
Sagami H, Ogura K, Seto S
  Title
Solanesyl pyrophosphate synthetase from Micrococcus lysodeikticus.
  Journal
Biochemistry 16:4616-22 (1977)
Reference
2  [PMID:7447947]
  Authors
Fujii H, Sagami H, Koyama T, Ogura K, Seto S, Baba T, Allen CM.
  Title
Variable product specificity of solanesyl pyrophosphate synthetase.
  Journal
Biochem Biophys Res Commun 96:1648-53 (1980)
DOI:10.1016/0006-291X(80)91363-7
Reference
3  [PMID:20421194]
  Authors
Ohara K, Sasaki K, Yazaki K
  Title
Two solanesyl diphosphate synthases with different subcellular localizations and  their respective physiological roles in Oryza sativa.
  Journal
J Exp Bot 61:2683-92 (2010)
DOI:10.1093/jxb/erq103
  Sequence
[osa:4341844]
Reference
4  [PMID:1748647]
  Authors
Ohnuma S, Koyama T, Ogura K
  Title
Purification of solanesyl-diphosphate synthase from Micrococcus luteus. A new class of prenyltransferase.
  Journal
J Biol Chem 266:23706-13 (1991)
Reference
5  [PMID:1429508]
  Authors
Gotoh T, Koyama T, Ogura K
  Title
Farnesyl diphosphate synthase and solanesyl diphosphate synthase reactions of diphosphate-modified allylic analogs: the significance of the diphosphate linkage involved in the allylic substrates for prenyltransferase.
  Journal
J Biochem 112:20-7 (1992)
Reference
6  [PMID:8226825]
  Authors
Teclebrhan H, Olsson J, Swiezewska E, Dallner G
  Title
Biosynthesis of the side chain of ubiquinone:trans-prenyltransferase in rat liver microsomes.
  Journal
J Biol Chem 268:23081-6 (1993)
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.84
IUBMB Enzyme Nomenclature: 2.5.1.84
ExPASy - ENZYME nomenclature database: 2.5.1.84
BRENDA, the Enzyme Database: 2.5.1.84

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