KEGG   ENZYME: 2.5.1.85Help
Entry
EC 2.5.1.85                 Enzyme                                 

Name
all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific];
nonaprenyl diphosphate synthase (ambiguous);
solanesyl diphosphate synthase (ambiguous);
At-SPS2;
At-SPS1;
SPS1;
SPS2
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 5 isopentenyl units)
Reaction(IUBMB)
geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate [RN:R09251]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
all-trans-nonaprenyl diphosphate [CPD:C04145]
Comment
Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate [1]. The plant Arabidopsis thaliana has two different enzymes that catalyse this reaction. SPS1 contributes to the biosynthesis of the ubiquinone side-chain while SPS2 supplies the precursor of the plastoquinone side-chains [2].
History
EC 2.5.1.85 created 1972 as EC 2.5.1.11, part transferred 2010 to EC 2.5.1.85
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K05356  all-trans-nonaprenyl-diphosphate synthase
Genes
ATH: AT1G17050(SPS2) AT1G78510(SPS1)
ALY: ARALYDRAFT_494049 ARALYDRAFT_895751
CRB: 17894671 17896965
CSAT: 104702634 104713531 104740392 104751747 104756029 104775809
EUS: EUTSA_v10007715mg EUTSA_v10018616mg
BRP: 103832329 103872491
BNA: 106346730 106354554 106354696 106365558
BOE: 106301071 106343305
THJ: 104810419 104812299 104813301 104813987 104822586
CPAP: 110811666
CIT: 102612772
TCC: 18594463
DZI: 111298875
VRA: 106762491
VAR: 108334430
CCAJ: 109790225
CAM: 101502183
LJA: Lj0g3v0072399.1(Lj0g3v0072399.1) Lj0g3v0072399.2(Lj0g3v0072399.2)
ADU: 107459857
AIP: 107613812
FVE: 101297041
PPER: 18778932
PMUM: 103325805
PAVI: 110772576
ZJU: 107414345
CSV: 101214140
CMO: 103492962
MCHA: 111012845
RCU: 8258714
JCU: 105641085
POP: 7459128
JRE: 108994345
VVI: 100246988
SLY: 101253007(SppS)
SPEN: 107026209
SOT: 102593674
CANN: 107878554
NSY: 104243529
NTO: 104101158
LSV: 111904475
BVG: 104899063
SOE: 110783766
DOSA: Os05t0582300-01(Os05g0582300)
ATS: 109748254(LOC109748254)
SBI: 8155346
PDA: 103712684
MUS: 103989203
DCT: 110112294
AOF: 109842749
ATR: 18430924
OLU: OSTLU_51700(clpR2)
APRO: F751_0189
SMIN: v1.2.008416.t1(symbB.v1.2.008416.t1)
SYN: slr0611(sds)
SYZ: MYO_110(sds)
SYY: SYNGTS_0001(sds)
SYT: SYNGTI_0001(sds)
SYS: SYNPCCN_0001(sds)
SYQ: SYNPCCP_0001(sds)
SYJ: D082_04480(sds)
SYO: C7I86_00005(sds)
SYW: SYNW1011(sds)
SYC: syc1741_c(sds)
SYG: sync_1551
SYR: SynRCC307_1159(preA)
SYX: SynWH7803_1038(preA)
SYP: SYNPCC7002_A0580(sdsA)
CYA: CYA_2276(sds)
CYB: CYB_0451(sds)
SYNR: KR49_03240
SYND: KR52_10950
SYNW: SynWH8103_01143(sds)
TEL: tlr1757(sds)
THN: NK55_05445(sdsA)
CYI: CBM981_0715(preA)
LET: O77CONTIG1_01361(hepT)
HHG: XM38_031750(preA)
PMA: Pro_1042(crtE)
PMM: PMM0618(sds)
PMT: PMT_0392
PMB: A9601_06741(sds)
PMC: P9515_06831(sds)
PMF: P9303_18951(sds)
PMG: P9301_06441(sds)
PMH: P9215_07001(sds)
PMJ: P9211_10311(sds)
PME: NATL1_06761(sds)
PRC: EW14_0663
PRM: EW15_0718
AMR: AM1_4909(sds)
MAR: MAE_00010(sds)
MPK: VL20_2046
CYL: AA637_04100(sds)
CYT: cce_2465(sds)
TER: Tery_0157
ARP: NIES39_N00440(sds)
GVI: gvip084(sds)
GLJ: GKIL_2127(sds)
ANA: alr0096(sds)
NOE: CLI64_12930(sds)
AVA: Ava_1469
NAZ: Aazo_0858
ANB: ANA_C12807(sds)
CALH: IJ00_17620
NSP: BMF81_03890(hepT)
CTHE: Chro_0646
CEO: ETSB_0422(sds)
 » show all
Taxonomy
Reference
1  [PMID:12437513]
  Authors
Hirooka K, Bamba T, Fukusaki E, Kobayashi A
  Title
Cloning and kinetic characterization of Arabidopsis thaliana solanesyl diphosphate synthase.
  Journal
Biochem J 370:679-86 (2003)
DOI:10.1042/BJ20021311
  Sequence
[ath:AT1G78510]
Reference
2  [PMID:15784989]
  Authors
Hirooka K, Izumi Y, An CI, Nakazawa Y, Fukusaki E, Kobayashi A
  Title
Functional analysis of two solanesyl diphosphate synthases from Arabidopsis thaliana.
  Journal
Biosci Biotechnol Biochem 69:592-601 (2005)
DOI:10.1271/bbb.69.592
  Sequence
[ath:AT1G17050]
Reference
3  [PMID:15653808]
  Authors
Jun L, Saiki R, Tatsumi K, Nakagawa T, Kawamukai M
  Title
Identification and subcellular localization of two solanesyl diphosphate synthases from Arabidopsis thaliana.
  Journal
Plant Cell Physiol 45:1882-8 (2004)
DOI:10.1093/pcp/pch211
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.85
IUBMB Enzyme Nomenclature: 2.5.1.85
ExPASy - ENZYME nomenclature database: 2.5.1.85
BRENDA, the Enzyme Database: 2.5.1.85

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