KEGG   ENZYME: 2.5.1.86Help
Entry
EC 2.5.1.86                 Enzyme                                 

Name
trans,polycis-decaprenyl diphosphate synthase;
Rv2361c;
(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesylcistransferase (adding 7 isopentenyl units)
Reaction(IUBMB)
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + trans,octacis-decaprenyl diphosphate [RN:R09244]
Reaction(KEGG)
Substrate
(2Z,6E)-farnesyl diphosphate [CPD:C16826];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
trans,octacis-decaprenyl diphosphate [CPD:C18321]
Comment
The enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan [2].
History
EC 2.5.1.86 created 2010
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K14215  trans,polycis-decaprenyl diphosphate synthase
Genes
MTU: Rv2361c(uppS)
MTV: RVBD_2361c
MTC: MT2430(uppS-2)
MRA: MRA_2385
MTF: TBFG_12387
MTB: TBMG_01614
MTK: TBSG_01623
MTZ: TBXG_001599
MTG: MRGA327_14530
MTI: MRGA423_14675
MTUR: CFBS_2500
MTD: UDA_2361c
MTUC: J113_16365
MTUE: J114_12645
MTUH: I917_16605
MTUL: TBHG_02300
MTUT: HKBT1_2491
MTUU: HKBT2_2494
MBB: BCG_2375c
MBT: JTY_2369
MBM: BCGMEX_2364c(uppS)
MBX: BCGT_2185
MAF: MAF_23750
MMIC: RN08_2617
MLE: ML0634
MLB: MLBr00634
MPA: MAP_2141c
MAO: MAP4_1681
MAVI: RC58_08405
MAVU: RE97_08405
MAV: MAV_2034(uppS)
MAVD: NF84_09140
MAVR: LA63_09325
MAVA: LA64_09345
MIT: OCO_20180
MIA: OCU_20280
MID: MIP_02839
MYO: OEM_18010
MIR: OCQ_18850
MLP: MLM_2658
MUL: MUL_3614
MMC: Mmcs_3449
MKM: Mkms_3512
MJL: Mjls_3460
MMI: MMAR_3671
MMM: W7S_09455
MLI: MULP_03919(uppS)
MHAD: B586_09310
MSM: MSMEG_4490(uppS)
MSG: MSMEI_4379(uppS)
MVA: Mvan_3822
MGI: Mflv_2714
MPHL: MPHLCCUG_03461(uppS_1)
MVQ: MYVA_3646
MTHN: 4412656_02789(uppS)
MAB: MAB_1676
MABB: MASS_1769
MABO: NF82_08480
MCHE: BB28_09115
MSTE: MSTE_01676
MTER: 4434518_01468(uppS_2)
 » show all
Taxonomy
Reference
1  [PMID:15516568]
  Authors
Kaur D, Brennan PJ, Crick DC
  Title
Decaprenyl diphosphate synthesis in Mycobacterium tuberculosis.
  Journal
J Bacteriol 186:7564-70 (2004)
DOI:10.1128/JB.186.22.7564-7570.2004
  Sequence
[mtu:Rv2361c]
Reference
2  [PMID:18597781]
  Authors
Wang W, Dong C, McNeil M, Kaur D, Mahapatra S, Crick DC, Naismith JH
  Title
The structural basis of chain length control in Rv1086.
  Journal
J Mol Biol 381:129-40 (2008)
DOI:10.1016/j.jmb.2008.05.060
  Sequence
[mtu:Rv2361c]
Reference
3  [PMID:11004176]
  Authors
Crick DC, Schulbach MC, Zink EE, Macchia M, Barontini S, Besra GS, Brennan PJ
  Title
Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis.
  Journal
J Bacteriol 182:5771-8 (2000)
DOI:10.1128/JB.182.20.5771-5778.2000
  Sequence
[mtu:Rv2361c] [msm:MSMEG_4490]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.86
IUBMB Enzyme Nomenclature: 2.5.1.86
ExPASy - ENZYME nomenclature database: 2.5.1.86
BRENDA, the Enzyme Database: 2.5.1.86

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