KEGG   ENZYME: 2.5.1.88Help
Entry
EC 2.5.1.88                 Enzyme                                 

Name
trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 9--11 isopentenyl units)
Reaction(IUBMB)
(2Z,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + trans,polycis-polyprenyl diphosphate (n = 9--11) [RN:R09731]
Reaction(KEGG)
Substrate
(2Z,6E)-farnesyl diphosphate [CPD:C16826];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
trans,polycis-polyprenyl diphosphate [CPD:C19853]
Comment
Highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate. Broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product [1].
History
EC 2.5.1.88 created 2010
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K21273  trans,polycis-polyprenyl diphosphate synthase
Genes
TFU: Tfu_0853
NDA: Ndas_0730
TCU: Tcur_3231
SRO: Sros_2336
STP: Strop_3446
SAQ: Sare_3825
MAU: Micau_4838
MIL: ML5_3461
VMA: VAB18032_28301
AMS: AMIS_11890
ASE: ACPL_1421
ACTN: L083_1597
AFS: AFR_08000
SNA: Snas_2041
TBI: Tbis_1177
 » show all
Taxonomy
Reference
1  [PMID:19447338]
  Authors
Ambo T, Noike M, Kurokawa H, Koyama T
  Title
Cloning and functional analysis of cis-prenyltransferase from Thermobifida fusca.
  Journal
J Biosci Bioeng 107:620-2 (2009)
DOI:10.1016/j.jbiosc.2009.02.006
  Sequence
[tfu:Tfu_0853]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.88
IUBMB Enzyme Nomenclature: 2.5.1.88
ExPASy - ENZYME nomenclature database: 2.5.1.88
BRENDA, the Enzyme Database: 2.5.1.88

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