KEGG   ENZYME: 2.5.1.89Help
Entry
EC 2.5.1.89                 Enzyme                                 

Name
tritrans,polycis-undecaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranylgeranyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 7 isopentenyl units)
Reaction(IUBMB)
geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate [RN:R09730]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
tritrans,heptacis-undecaprenyl diphosphate [CPD:C19852]
Comment
This enzyme is involved in the biosynthesis of the glycosyl carrier lipid in some archaebacteria. Unlike EC 2.5.1.31, its counterpart in most bacteria, it prefers geranylgeranyl diphosphate to farnesyl diphosphate as the allylic substrate, resulting in production of a tritrans,polycis variant of undecaprenyl diphosphate [1].
History
EC 2.5.1.89 created 2010, modified 2011
Pathway
ec00900  Terpenoid backbone biosynthesis
Orthology
K15888  tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]
Genes
MJA: MJ_1372
MFE: Mefer_0013
MVU: Metvu_0730
MFS: MFS40622_0557
MIF: Metin_0747
MJH: JH146_0409
MIG: Metig_0007
MMP: MMP1345
MMQ: MmarC5_0233
MMX: MmarC6_1328
MMD: GYY_07550
MAE: Maeo_1136
MVO: Mvol_0149
MTH: MTH_232
MMG: MTBMA_c06810(uppS)
METC: MTCT_0194
MWO: MWSIV6_0644(uppS)
METE: tca_00212
MST: Msp_1182(uppS)
MSI: Msm_0096
MRU: mru_1005(uppS)
MEB: Abm4_0676(uppS)
MMIL: sm9_0974(uppS)
MEYE: TL18_05495
MOL: YLM1_0546
METH: MBMB1_0608(uppS)
MFC: BRM9_1627(uppS)
MFI: DSM1535_2322(uppS)
MCUB: MCBB_0494(uppS)
MFV: Mfer_0595
MKA: MK0767(uppS)
AFU: AF_1219
FPL: Ferp_1985
GAC: GACE_0233
GAH: GAH_00064
TAC: Ta0546
TVO: TVG0591988(TVG0591988)
PTO: PTO1378
FAI: FAD_0573
CDIV: CPM_0361
MEAR: Mpt1_c12690(uppS)
MARC: AR505_1636
ABI: Aboo_0417
PHO: PH1590(PH1590)
PAB: PAB0394(hypoth)
PFU: PF1599
PFI: PFC_07225
PYN: PNA2_0175
PYS: Py04_1477
TKO: TK1173
TON: TON_0373
TGA: TGAM_0719(uppS)
TSI: TSIB_1513
THE: GQS_03365
THA: TAM4_934
THM: CL1_0304
TLT: OCC_03007
THS: TES1_0768
TNU: BD01_0338
TEU: TEU_07395
THH: CDI07_02520(uppS)
PPAC: PAP_02925
MAC: MA_3723(uppS)
MBAR: MSBR2_2648
MBAK: MSBR3_2777
MMA: MM_0618
MMAC: MSMAC_0692
METM: MSMTP_0756
MTHE: MSTHC_0884
MTHR: MSTHT_2395
MHOR: MSHOH_0806
MBU: Mbur_0041
MMET: MCMEM_0626
MMH: Mmah_1238
MPY: Mpsy_1109
MTP: Mthe_0589
MCJ: MCON_0296(uppS)
MHI: Mhar_2350
MHU: Mhun_0785
MLA: Mlab_0118
MBG: BN140_0601(uppS)
MEMA: MMAB1_0780(uppS)
MPI: Mpet_0736
MBN: Mboo_2063
MPL: Mpal_0107
MPD: MCP_1817(uppS)
MEZ: Mtc_1306(uppS-2)
RCI: RRC441(uppS-2)
HAL: VNG_1779C
HSL: OE_3503F(uppS1)
HHB: Hhub_3075(uppS1)
HALH: HTSR_0407
HHSR: HSR6_0392(uppS2)
HSU: HLASF_1850(uppS1)
HSF: HLASA_1836(uppS1)
HMA: rrnAC1716(uppS)
HHI: HAH_2250(uppS1)
NPH: NP_4550A(uppS1)
NMO: Nmlp_2341(uppS1)
HUT: Huta_2829
HTI: HTIA_2734
HMU: Hmuk_1548
HARC: HARCEL1_06025(uppS)
HWA: HQ_3332A(uppS2)
HWC: Hqrw_3861(uppS2)
HVO: HVO_2315(uppS1)
HME: HFX_2325(uppS)
HAQ: DU484_16985(uppS)
HAJ: DU500_00030(uppS)
HLA: Hlac_2063
SRUB: C2R22_16735(uppS)
HTU: Htur_3250
NMG: Nmag_1224(uppS1)
NAT: NJ7G_2495
SALI: L593_09975
SMR: Smar_1245
IHO: Igni_0586
IIS: EYM_01550
DKA: DKAM_0927
TAG: Tagg_0145
IAG: Igag_0013
HBU: Hbut_1087
STO: STK_01890(uppS)
SSO: SSO0163
SOL: Ssol_1140
SSOA: SULA_1176
SSOL: SULB_1177
SSOF: SULC_1175
SAI: Saci_0757
SID: M164_1983
SII: LD85_2238
SIH: SiH_1921
SIR: SiRe_1848
SIC: SiL_1830
MSE: Msed_0171
MCN: Mcup_1902
MHK: DFR87_05955(uppS)
AHO: Ahos_0890
ABRI: DFR85_06545(uppS)
ASUL: DFR86_07315(uppS)
PYR: P186_1582
POG: Pogu_0896
VDI: Vdis_0938
VMO: VMUT_1786
TPE: Tpen_0762
ASC: ASAC_1265
ACIA: SE86_07500
NMR: Nmar_1416
NID: NPIRD3C_2077(uppS)
NIN: NADRNF5_0463(uppS)
NCT: NMSP_0329(uppS)
NGA: Ngar_c35510(uppS)
NEV: NTE_00400
NCV: NCAV_0511(uppS)
NBV: T478_0360(uppS)
NDV: NDEV_1710(uppS)
NAA: Nps_02790
MARH: Mia14_0585
KCR: Kcr_0245
BARC: AOA65_0926(uppS)
BARB: AOA66_0322(uppS)
LOKI: Lokiarch_02280(uppS_1)
 » show all
Taxonomy
Reference
1  [PMID:11114943]
  Authors
Hemmi H, Yamashita S, Shimoyama T, Nakayama T, Nishino T
  Title
Cloning, expression, and characterization of cis-polyprenyl diphosphate synthase  from the thermoacidophilic archaeon Sulfolobus acidocaldarius.
  Journal
J Bacteriol 183:401-4 (2001)
DOI:10.1128/JB.183.1.401-404.2001
  Sequence
[sai:Saci_0757]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.89
IUBMB Enzyme Nomenclature: 2.5.1.89
ExPASy - ENZYME nomenclature database: 2.5.1.89
BRENDA, the Enzyme Database: 2.5.1.89

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