KEGG   ENZYME: 2.6.1.27Help
Entry
EC 2.6.1.27                 Enzyme                                 

Name
tryptophan transaminase;
L-phenylalanine-2-oxoglutarate aminotransferase;
tryptophan aminotransferase;
5-hydroxytryptophan-ketoglutaric transaminase;
hydroxytryptophan aminotransferase;
L-tryptophan aminotransferase;
L-tryptophan transaminase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-tryptophan:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate [RN:R00684]
Reaction(KEGG)
R00684;
(other) R02700
Show
Substrate
L-tryptophan [CPD:C00078];
2-oxoglutarate [CPD:C00026]
Product
(indol-3-yl)pyruvate [CPD:C00331];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. Also acts on 5-hydroxytryptophan and, to a lesser extent, on the phenyl amino acids.
History
EC 2.6.1.27 created 1972
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K00838  aromatic amino acid aminotransferase I / 2-aminoadipate transaminase
K14265  tryptophan aminotransferase
Genes
MNG: MNEG_3800
SCE: YGL202W(ARO8)
AGO: AGOS_AFR548C
ERC: Ecym_7228
KLA: KLLA0_F10021g
KMX: KLMA_20259(ARO8) KLMA_50151(ARO8)
LTH: KLTH0E07678g KLTH0G02002g
VPO: Kpol_278p2
ZRO: ZYRO0C06028g
CGR: CAGL0G01254g
NCS: NCAS_0E00670(NCAS0E00670)
NDI: NDAI_0I02830(NDAI0I02830)
TPF: TPHA_0D03370(TPHA0D03370)
TDL: TDEL_0D05790(TDEL0D05790)
KAF: KAFR_0D01420(KAFR0D01420)
PIC: PICST_66767(ARO8)
CAL: CAALFM_C200340CA(ARO8)
CAUR: QG37_05344
SLB: AWJ20_1088(ARO8)
NCR: NCU09116
SSCK: SPSK_08879
MBE: MBM_09282
ANG: ANI_1_1292134(An15g02460) ANI_1_2088024(An02g00030) ANI_1_766024(An02g05540)
PTE: PTT_08476
ABP: AGABI1DRAFT113513(AGABI1DRAFT_113513) AGABI1DRAFT75541(AGABI1DRAFT_75541) AGABI1DRAFT75553(AGABI1DRAFT_75553)
ABV: AGABI2DRAFT191531(AGABI2DRAFT_191531) AGABI2DRAFT191838(AGABI2DRAFT_191838) AGABI2DRAFT201971(AGABI2DRAFT_201971)
MGL: MGL_2601
SMIN: v1.2.016220.t1(symbB.v1.2.016220.t1)
NGD: NGA_2105700(ARO8)
 » show all
Taxonomy
Reference
1  [PMID:5722279]
  Authors
George H, Gabay S.
  Title
Brain aromatic aminotransferase. I. Purification and some properties of pig brain L-phenylalanine-2-oxoglutarate aminotransferase.
  Journal
Biochim Biophys Acta 167:555-66 (1968)
DOI:10.1016/0005-2744(68)90045-4
Reference
2  [PMID:5697992]
  Authors
O'Neil SR, DeMoss RD.
  Title
Tryptophan transaminase from Clostridium sporogenes.
  Journal
Arch Biochem Biophys 127:361-9 (1968)
DOI:10.1016/0003-9861(68)90237-3
Reference
3  [PMID:14285270]
  Authors
TANGEN O, FONNUM F, HAAVALDSEN R.
  Title
SEPARATION AND PURIFICATION OF AROMATIC AMINO ACID TRANSAMINASES FROM RAT BRAIN.
  Journal
Biochim Biophys Acta 96:82-90 (1965)
DOI:10.1016/0005-2787(65)90612-X
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.27
IUBMB Enzyme Nomenclature: 2.6.1.27
ExPASy - ENZYME nomenclature database: 2.6.1.27
BRENDA, the Enzyme Database: 2.6.1.27
CAS: 9022-98-4

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