KEGG   ENZYME: 2.6.1.34Help
Entry
EC 2.6.1.34                 Enzyme                                 

Name
UDP-N-acetylbacillosamine transaminase;
uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase;
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase;
UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase;
pglE (gene name);
UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
UDP-N-acetylbacillosamine + 2-oxoglutarate = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + L-glutamate [RN:R04529]
Reaction(KEGG)
Substrate
UDP-N-acetylbacillosamine [CPD:C04630];
2-oxoglutarate [CPD:C00026]
Product
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose [CPD:C04613];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. The enzyme is involved in biosynthesis of UDP-N,N'-diacetylbacillosamine, an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species [2-4] and O-linked glycosylation of certain L-serine residues in Neisseria species [5].
History
EC 2.6.1.34 created 1972, modified 2013
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
Orthology
K15910  UDP-N-acetylbacillosamine transaminase
Genes
CJE: Cj1121c(pglE)
CJB: BN148_1121c(pglE)
CJJ: CJJ81176_1139(pglE)
CJU: C8J_1062(wlaK)
CJN: ICDCCJ07001_1077
CJI: CJSA_1063(pglE)
CJM: CJM1_1100(pglE)
CJS: CJS3_1168
CJP: A911_05430
CJEJ: N564_01089
CJEU: N565_01132
CJEN: N755_01125
CJEI: N135_01158
CJER: H730_06580
CJV: MTVDSCj20_1125(pglE)
CJY: QZ67_01198(pglE)
CJQ: UC78_1079(pglE)
CJR: CJE1264(pglE)
CJD: JJD26997_0599(pglE)
CFT: CFF04554_1371(pglE)
CFV: CFVI03293_1394(pglE)
CFX: CFV97608_1494(pglE)
CFZ: CSG_14940
CAMP: CFT03427_1319(pglE)
CCV: CCV52592_1203(pglE)
CCO: CCC13826_0448(pglE)
CCOC: CCON33237_1461(pglE)
CLA: Cla_1257(pglE)
CLR: UPTC16701_1240(pglE)
CLM: UPTC16712_1258(pglE)
CLQ: UPTC4110_1242(pglE)
CLN: UPTC3659_1477(pglE)
CLL: CONCH_1208(pglE)
CCQ: N149_1063
CCF: YSQ_03360
CCY: YSS_06075
CCOI: YSU_03395
CCOF: VC76_05505(pglE)
CCOO: ATE51_01360(pglE)
CAJ: CIG1485E_1366(pglE)
CIS: CINS_1222(pglE)
CVO: CVOL_1236(pglE)
CPEL: CPEL_1363(pglE)
CAMR: CAQ16704_1268(pglE)
CSM: CSUB8521_1444(pglE)
CSF: CSUB8523_1540(pglE)
CGRA: CGRAC_1486(pglE)
CURE: CUREO_1369(pglE)
CHYO: CHH_1360(pglE)
CHV: CHELV3228_0574(pglE)
CSPF: CSF_1367(pglE)
CPIN: CPIN18020_1229(pglE)
CCUN: CCUN_1175(pglE)
CLX: CLAN_1156(pglE)
CAVI: CAV_0412(pglE)
 » show all
Taxonomy
Reference
1  [PMID:4381351]
  Authors
Distler J, Kaufman B, Roseman S.
  Title
Enzymic synthesis of a diamino sugar nucleotide by extracts of type XIV Diplococcus pneumoniae.
  Journal
Arch Biochem Biophys 116:466-78 (1966)
DOI:10.1016/0003-9861(66)90054-3
Reference
2  [PMID:17087520]
  Authors
Olivier NB, Chen MM, Behr JR, Imperiali B
  Title
In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system.
  Journal
Biochemistry 45:13659-69 (2006)
DOI:10.1021/bi061456h
Reference
3  [PMID:16286454]
  Authors
Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM
  Title
Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways.
  Journal
J Biol Chem 281:723-32 (2006)
DOI:10.1074/jbc.M511021200
  Sequence
[cje:Cj1121c]
Reference
4  [PMID:18198901]
  Authors
Rangarajan ES, Ruane KM, Sulea T, Watson DC, Proteau A, Leclerc S, Cygler M, Matte A, Young NM
  Title
Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter  jejuni.
  Journal
Biochemistry 47:1827-36 (2008)
DOI:10.1021/bi702032r
Reference
5  [PMID:21542610]
  Authors
Hartley MD, Morrison MJ, Aas FE, Borud B, Koomey M, Imperiali B
  Title
Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N'-diacetylbacillosamine.
  Journal
Biochemistry 50:4936-48 (2011)
DOI:10.1021/bi2003372
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.34
IUBMB Enzyme Nomenclature: 2.6.1.34
ExPASy - ENZYME nomenclature database: 2.6.1.34
BRENDA, the Enzyme Database: 2.6.1.34
CAS: 37277-89-7

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