KEGG   ENZYME: 2.6.1.40Help
Entry
EC 2.6.1.40                 Enzyme                                 

Name
(R)-3-amino-2-methylpropionate---pyruvate transaminase;
D-3-aminoisobutyrate---pyruvate transaminase;
beta-aminoisobutyrate-pyruvate aminotransferase;
D-3-aminoisobutyrate-pyruvate aminotransferase;
D-3-aminoisobutyrate-pyruvate transaminase;
(R)-3-amino-2-methylpropionate transaminase;
D-beta-aminoisobutyrate:pyruvate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase
Reaction(IUBMB)
(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine [RN:R02050]
Reaction(KEGG)
Substrate
(R)-3-amino-2-methylpropanoate [CPD:C01205];
pyruvate [CPD:C00022]
Product
2-methyl-3-oxopropanoate [CPD:C00349];
L-alanine [CPD:C00041]
Comment
The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.22, (S)-3-amino-2-methylpropionate transaminase, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.
History
EC 2.6.1.40 created 1972 (EC 2.6.1.61 created 1982, incorporated 2004) modified 2004
Pathway
ec00280  Valine, leucine and isoleucine degradation
Orthology
K00827  alanine-glyoxylate transaminase / (R)-3-amino-2-methylpropionate-pyruvate transaminase
Genes
HSA: 64902(AGXT2)
PTR: 471573(AGXT2)
PPS: 100982568(AGXT2)
GGO: 101147587(AGXT2)
PON: 100171524(AGXT2)
NLE: 100607531(AGXT2)
MCC: 699250(AGXT2)
MCF: 102140666(AGXT2)
CSAB: 103215117(AGXT2)
RRO: 104678746(AGXT2)
RBB: 108543800(AGXT2)
CJC: 100403023(AGXT2)
SBQ: 101045858(AGXT2)
MMU: 268782(Agxt2)
RNO: 83784(Agxt2)
CGE: 100759906(Agxt2)
NGI: 103735910(Agxt2)
HGL: 101714498(Agxt2)
CCAN: 109690881(Agxt2)
OCU: 100352336(AGXT2)
TUP: 102501713(AGXT2)
CFA: 612589(AGXT2)
AML: 100482092(AGXT2)
UMR: 103664720(AGXT2)
ORO: 101375130(AGXT2)
FCA: 101097947(AGXT2)
PTG: 102966139(AGXT2)
AJU: 106980604(AGXT2)
BTA: 521553(AGXT2)
BOM: 102269782(AGXT2)
BIU: 109575007(AGXT2)
PHD: 102320044(AGXT2)
CHX: 102176828(AGXT2)
OAS: 101111660(AGXT2)
SSC: 100513890(AGXT2)
CFR: 102515152(AGXT2)
CDK: 105087007(AGXT2)
BACU: 103010921(AGXT2)
LVE: 103080731(AGXT2)
OOR: 101275910(AGXT2)
ECB: 100053849(AGXT2)
EPZ: 103545309(AGXT2)
EAI: 106824782(AGXT2)
MYB: 102239222(AGXT2)
MYD: 102773052(AGXT2)
HAI: 109385510(AGXT2)
RSS: 109450224(AGXT2)
PALE: 102888844(AGXT2)
LAV: 100668434(AGXT2)
TMU: 101347029
MDO: 100020759(AGXT2)
SHR: 100917044(AGXT2)
OAA: 100078063(AGXT2)
GGA: 431666(AGXT2)
MGP: 100541842(AGXT2)
CJO: 107305776(AGXT2)
APLA: 101799853(AGXT2)
ACYG: 106036349(AGXT2)
TGU: 100230972(AGXT2)
GFR: 102033340(AGXT2)
FAB: 101810573(AGXT2)
PHI: 102109437(AGXT2)
PMAJ: 107198191(AGXT2)
CCAE: 111941074(AGXT2)
CCW: 104686756(AGXT2)
FPG: 101911080(AGXT2)
FCH: 102052632(AGXT2)
CLV: 102087277(AGXT2)
EGZ: 104133922(AGXT2)
AAM: 106499541(AGXT2)
ASN: 102375742(AGXT2)
AMJ: 102559340(AGXT2)
PSS: 102449032(AGXT2)
CMY: 102930944(AGXT2)
CPIC: 101937486(AGXT2)
ACS: 100565387(agxt2)
PVT: 110080093(AGXT2)
PBI: 103060614(AGXT2)
GJA: 107107502(AGXT2)
XLA: 108705425(agxt2.S) 108718414(agxt2.L)
XTR: 100491739(agxt2)
NPR: 108792653(AGXT2)
DRE: 619269(agxt2)
SANH: 107662137
CCAR: 109069820(agxt2)
IPU: 108279281(agxt2)
AMEX: 103047265(agxt2)
TRU: 101075075(agxt2)
MZE: 101477079(agxt2)
OLA: 111948298(agxt2)
XMA: 102217588(agxt2)
PRET: 103473873(agxt2)
NFU: 107374696(agxt2)
KMR: 108231105(agxt2)
CSEM: 103390290(agxt2)
LCF: 108873989(agxt2) 108873991
SDU: 111234697(agxt2) 111234704
HCQ: 109523626(agxt2)
BPEC: 110160563(agxt2)
MALB: 109960590(agxt2)
SASA: 106568486(agxt2)
OTW: 112257351(agxt2)
ELS: 105007583(agxt2)
SFM: 108935619(agxt2)
LCM: 102356225(AGXT2)
CIN: 100178847
SPU: 594821
APLC: 110989783
DME: Dmel_CG11241(CG11241)
DSI: Dsimw501_GD12056(Dsim_GD12056)
MDE: 101893078
AAG: 5565436
AME: 100576186
BIM: 100748967
BTER: 100645336
PCF: 106791427
NVI: 100123739
MDL: 103568860
TCA: 658321
DPA: 109536139
NVL: 108565425
PRAP: 111003467
HAW: 110375501
PXY: 105394913
API: 100163196
CLEC: 106663150
ZNE: 110828279
FCD: 110855892
TUT: 107366508
CEL: CELE_T09B4.8(T09B4.8)
CBR: CBG12888
CRG: 105338391
MYI: 110453623
OBI: 106882838
LAK: 106163654
EPA: 110243940
HMG: 100197706
AQU: 100631942
ATH: AT2G38400(AGT3) AT3G08860(PYD4) AT4G39660(AGT2)
LJA: Lj1g3v2444980.1(Lj1g3v2444980.1) Lj4g3v2800580.1(Lj4g3v2800580.1)
DOSA: Os03t0171900-01(Os03g0171900) Os03t0338000-01(Os03g0338000) Os05t0475400-01(Os05g0475400)
ATS: 109754438(LOC109754438) 109772808(LOC109772808) 109784440(LOC109784440)
PPP: 112287430
CRE: CHLREDRAFT_133057(AGT2)
MNG: MNEG_7082
APRO: F751_4530
 » show all
Taxonomy
Reference
1  [PMID:5773299]
  Authors
Kakimoto Y, Taniguchi K, Sano I.
  Title
D-beta-aminoisobutyrate:pyruvate aminotransferase in mammalian liver and excretion of beta-aminoisobutyrate by man.
  Journal
J Biol Chem 244:335-40 (1969)
Reference
2  [PMID:10989446]
  Authors
Tamaki N, Sakata SF, Matsuda K.
  Title
Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver.
  Journal
Methods Enzymol 324:376-89 (2000)
DOI:10.1016/S0076-6879(00)24247-X
  Sequence
[rno:83784]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.40
IUBMB Enzyme Nomenclature: 2.6.1.40
ExPASy - ENZYME nomenclature database: 2.6.1.40
BRENDA, the Enzyme Database: 2.6.1.40
CAS: 37279-00-8

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