KEGG   ENZYME: 2.6.1.5Help
Entry
EC 2.6.1.5                  Enzyme                                 

Name
tyrosine transaminase;
tyrosine aminotransferase;
glutamic-hydroxyphenylpyruvic transaminase;
glutamic phenylpyruvic aminotransferase;
L-phenylalanine 2-oxoglutarate aminotransferase;
L-tyrosine aminotransferase;
phenylalanine aminotransferase;
phenylalanine transaminase;
phenylalanine-alpha-ketoglutarate transaminase;
phenylpyruvate transaminase;
phenylpyruvic acid transaminase;
tyrosine-alpha-ketoglutarate aminotransferase;
tyrosine-alpha-ketoglutarate transaminase;
tyrosine-2-ketoglutarate aminotransferase;
TyrAT
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-tyrosine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate [RN:R00734]
Reaction(KEGG)
R00734;
(other) R00694 R07396
Show
Substrate
L-tyrosine [CPD:C00082];
2-oxoglutarate [CPD:C00026]
Product
4-hydroxyphenylpyruvate [CPD:C01179];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. L-Phenylalanine can act instead of L-tyrosine. The mitochondrial enzyme may be identical with EC 2.6.1.1 (aspartate transaminase). The three isoenzymic forms are interconverted by EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33 (fruit bromelain). The enzyme can also catalyse the final step in the methionine-salvage pathway of Klebsiella pneumoniae [8].
History
EC 2.6.1.5 created 1961
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec00270  Cysteine and methionine metabolism
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec00401  Novobiocin biosynthesis
ec00950  Isoquinoline alkaloid biosynthesis
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K00815  tyrosine aminotransferase
K00838  aromatic amino acid aminotransferase I / 2-aminoadipate transaminase
Genes
HSA: 6898(TAT)
PTR: 454227(TAT)
PPS: 100987430(TAT)
GGO: 101140743(TAT)
PON: 100446283(TAT)
NLE: 100583147(TAT)
MCC: 708005(TAT)
MCF: 102144775(TAT)
CSAB: 103233171(TAT)
RRO: 104654756(TAT)
RBB: 108527460(TAT)
CJC: 100410667(TAT)
SBQ: 101027620(TAT)
MMU: 234724(Tat)
RNO: 24813(Tat)
CGE: 100754678(Tat)
NGI: 103735627(Tat)
HGL: 101698939(Tat)
CCAN: 109694288(Tat)
OCU: 100356286(TAT)
TUP: 102487558(TAT)
CFA: 479665(TAT)
AML: 100483605(TAT)
UMR: 103673588(TAT)
ORO: 101362086(TAT)
FCA: 101080599(TAT)
PTG: 102948951(TAT)
AJU: 106987553(TAT)
BTA: 533481(TAT)
BOM: 102267424(TAT)
BIU: 109572867(TAT)
PHD: 102334447(TAT)
CHX: 102180419(TAT)
OAS: 101104679(TAT)
SSC: 100511756(TAT)
CFR: 102517380(TAT)
CDK: 105088375(TAT)
BACU: 103012502(TAT)
LVE: 103088482(TAT)
OOR: 101275770(TAT)
ECB: 100068116(TAT)
EPZ: 103551742(TAT)
EAI: 106830905(TAT)
MYB: 102255659(TAT)
MYD: 102760497(TAT)
HAI: 109390344(TAT)
RSS: 109441614 109461299(TAT)
PALE: 102892915(TAT)
LAV: 100670549(TAT)
TMU: 101360712
MDO: 100020832(TAT)
SHR: 100925059(TAT)
OAA: 100077699(TAT)
GGA: 415884(TAT)
MGP: 100549583(TAT)
CJO: 107319455(TAT)
APLA: 101789874(TAT)
ACYG: 106046587(TAT)
TGU: 100230394(TAT)
GFR: 102031842(TAT)
FAB: 101817231(TAT)
PHI: 102107453(TAT)
PMAJ: 107209884(TAT)
CCW: 104691865(TAT)
FPG: 101910928(TAT)
FCH: 102058698(TAT)
CLV: 102092900(TAT)
EGZ: 104126324(TAT)
AAM: 106498813(TAT)
ASN: 102386962(TAT)
AMJ: 102557908(TAT)
PSS: 102447335(TAT)
CMY: 102947455(TAT)
CPIC: 101940425(TAT)
ACS: 100559092(tat)
PVT: 110076298(TAT)
PBI: 103062948(TAT)
GJA: 107124716(TAT)
XLA: 108714054(tat.L) 443707(tat.S)
XTR: 448486(tat)
NPR: 108786562(TAT)
DRE: 561410(tat)
CCAR: 109110169(tat)
IPU: 108264225(tat)
AMEX: 103039201(tat)
TRU: 101067692(tat)
LCO: 104938146(tat)
MZE: 101484403(tat)
OLA: 101171329(tat)
XMA: 102225669(tat)
PRET: 103466840(tat)
NFU: 107389299(tat)
CSEM: 103379743(tat)
LCF: 108902254(tat)
HCQ: 109513048(tat)
BPEC: 110169335(tat)
ELS: 105018571(tat)
SFM: 108926574(tat)
CMK: 103188097(tat)
CIN: 100183684
SPU: 592114
APLC: 110983037
DME: Dmel_CG1461(CG1461)
DSI: Dsimw501_GD17166(Dsim_GD17166)
MDE: 101888064
AAG: 5571325
AME: 725204
BIM: 100740664
BTER: 100647939
SOC: 105197229
AEC: 105153437
ACEP: 105623421
PBAR: 105424455
HST: 105186474
CFO: 105254667
LHU: 105674354
PGC: 109851780
NVI: 100119866
TCA: 659321
BMOR: 101742749
PMAC: 106719845
PRAP: 111000348
PXY: 105385896
ZNE: 110833486
TUT: 107363316
CEL: CELE_F42D1.2(tatn-1)
CBR: CBG07591
BMY: Bm1_31005
CRG: 105345822
MYI: 110450801
OBI: 106871819
EPA: 110253040
AQU: 100635686
CAM: 101501656
LJA: Lj0g3v0064019.1(Lj0g3v0064019.1) Lj3g3v0428970.1(Lj3g3v0428970.1)
CMO: 103490501 103501785(ArAT1)
DOSA: Os02t0302200-01(Os02g0302200) Os02t0302700-01(Os02g0302700) Os06t0345200-01(Os06g0345200) Os11t0552000-01(Os11g0552000) Os11t0644800-00(Os11g0644800)
ATS: 109736601(LOC109736601) 109746718(LOC109746718) 109749918(LOC109749918) 109779912(LOC109779912) 109785695(LOC109785695)
PPP: 112275296
MNG: MNEG_3800
MIS: MICPUN_113229(TAT)
SCE: YGL202W(ARO8)
ERC: Ecym_7228
KMX: KLMA_20259(ARO8) KLMA_50151(ARO8)
NCS: NCAS_0E00670(NCAS0E00670)
NDI: NDAI_0I02830(NDAI0I02830)
TPF: TPHA_0D03370(TPHA0D03370)
TDL: TDEL_0D05790(TDEL0D05790)
KAF: KAFR_0D01420(KAFR0D01420)
PIC: PICST_66767(ARO8)
CAL: CAALFM_C200340CA(ARO8)
CAUR: QG37_05344
SLB: AWJ20_1088(ARO8)
NCR: NCU09116
MGR: MGG_09919
SSCK: SPSK_08879
MBE: MBM_09282
ANG: ANI_1_1292134(An15g02460) ANI_1_2088024(An02g00030) ANI_1_766024(An02g05540)
PTE: PTT_08476
ABP: AGABI1DRAFT113513(AGABI1DRAFT_113513)
ABV: AGABI2DRAFT191838(AGABI2DRAFT_191838)
DDI: DDB_G0287515(tat)
DFA: DFA_00865(tat)
SMIN: v1.2.016220.t1(symbB.v1.2.016220.t1) v1.2.017044.t1(symbB.v1.2.017044.t1)
NGD: NGA_2105700(ARO8)
SPAR: SPRG_06771
LMA: LMJF_36_2360(TAT)
LIF: LINJ_36_2490(TAT)
LBZ: LBRM_35_2580(TAT)
 » show all
Taxonomy
Reference
1  [PMID:13366978]
  Authors
CANELLAKIS ZN, COHEN PP.
  Title
Purification studies of tyrosine-alpha-ketoglutaric acid transaminase.
  Journal
J Biol Chem 222:53-62 (1956)
Reference
2  [PMID:13366979]
  Authors
CANELLAKIS ZN, COHEN PP.
  Title
Kinetic and substrate specificity study of tyrosine-alpha-ketoglutaric acid transaminase.
  Journal
J Biol Chem 222:63-71 (1956)
Reference
3  [PMID:14171223]
  Authors
JACOBY GA, LADU BN.
  Title
STUDIES ON THE SPECIFICITY OF TYROSINE-ALPHA-KETOGLUTARATE TRANSAMINASE.
  Journal
J Biol Chem 239:419-24 (1964)
Reference
4  [PMID:14408534]
  Authors
KENNEY FT.
  Title
Properties of partially purified tyrosine-alpha-ketoglutarate transaminase from rat liver.
  Journal
J Biol Chem 234:2707-12 (1959)
Reference
5  [PMID:4396841]
  Authors
Miller JE, Litwack G.
  Title
Purification, properties, and identity of liver mitochondrial tyrosine aminotransferase.
  Journal
J Biol Chem 246:3234-40 (1971)
Reference
6  [PMID:13363833]
  Authors
ROWSELL EV.
  Title
Transaminations with L-glutamate and alpha-oxoglutarate in fresh extracts of animal tissues.
  Journal
Biochem J 64:235-45 (1956)
Reference
7  [PMID:13750129]
  Authors
SENTHESHANMUGANATHAN S.
  Title
The purification and properties of the tyrosine-2-oxoglutarate transaminase of Saccharomyces cerevisiae.
  Journal
Biochem J 77:619-25 (1960)
Reference
8  [PMID:10074065]
  Authors
Heilbronn J, Wilson J, Berger BJ.
  Title
Tyrosine aminotransferase catalyzes the final step of methionine recycling in Klebsiella pneumoniae.
  Journal
J Bacteriol 181:1739-47 (1999)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.5
IUBMB Enzyme Nomenclature: 2.6.1.5
ExPASy - ENZYME nomenclature database: 2.6.1.5
UM-BBD (Biocatalysis/Biodegradation Database): 2.6.1.5
BRENDA, the Enzyme Database: 2.6.1.5
CAS: 9014-55-5

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