KEGG   ENZYME: 2.6.1.58Help
Entry
EC 2.6.1.58                 Enzyme                                 

Name
phenylalanine(histidine) transaminase;
phenylalanine (histidine) aminotransferase;
phenylalanine(histidine):pyruvate aminotransferase;
histidine:pyruvate aminotransferase;
L-phenylalanine(L-histidine):pyruvate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-phenylalanine:pyruvate aminotransferase
Reaction(IUBMB)
L-phenylalanine + pyruvate = phenylpyruvate + L-alanine [RN:R00692]
Reaction(KEGG)
R00692;
(other) R09254
Show
Substrate
L-phenylalanine [CPD:C00079];
pyruvate [CPD:C00022]
Product
phenylpyruvate [CPD:C00166];
L-alanine [CPD:C00041]
Comment
L-Histidine and L-tyrosine can act instead of L-phenylalanine; in the reverse reaction, L-methionine, L-serine and L-glutamine can replace L-alanine.
History
EC 2.6.1.58 created 1978
Pathway
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K05821  aromatic amino acid aminotransferase II
Genes
SCE: YHR137W(ARO9)
KLA: KLLA0_D11110g
KMX: KLMA_60423(ARO9)
LTH: KLTH0B06270g
VPO: Kpol_1035p30
ZRO: ZYRO0G05346g
CGR: CAGL0G06028g
NCS: NCAS_0B07220(NCAS0B07220)
NDI: NDAI_0B04550(NDAI0B04550)
TPF: TPHA_0O01520(TPHA0O01520)
TBL: TBLA_0B00990(TBLA0B00990)
TDL: TDEL_0F00900(TDEL0F00900)
PIC: PICST_34099(ARO9.1)
CAL: CAALFM_C405560CA(ARO9)
CAUR: QG37_02082
 » show all
Taxonomy
Reference
1  [PMID:14070]
  Authors
Minatogawa Y, Noguchi T, Kido R.
  Title
Species distribution and properties of hepatic phenylalanine (histidine):pyruvate aminotransferase.
  Journal
Hoppe Seylers Z Physiol Chem 358:59-67 (1977)
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.58
IUBMB Enzyme Nomenclature: 2.6.1.58
ExPASy - ENZYME nomenclature database: 2.6.1.58
BRENDA, the Enzyme Database: 2.6.1.58
CAS: 72560-98-6

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