KEGG   ENZYME: 2.6.1.7Help
Entry
EC 2.6.1.7                  Enzyme                                 

Name
kynurenine---oxoglutarate transaminase;
kynurenine transaminase (cyclizing);
kynurenine 2-oxoglutarate transaminase;
kynurenine aminotransferase;
L-kynurenine aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-kynurenine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate [RN:R01956]
Reaction(KEGG)
R01956;
(other) R04171
Show
Substrate
L-kynurenine [CPD:C00328];
2-oxoglutarate [CPD:C00026]
Product
4-(2-aminophenyl)-2,4-dioxobutanoate [CPD:C01252];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
History
EC 2.6.1.7 created 1961, modified 1983
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K00816  kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase
K00825  kynurenine/2-aminoadipate aminotransferase
K14264  kynurenine aminotransferase
Genes
HSA: 51166(AADAT) 56267(KYAT3) 883(KYAT1)
PTR: 456999(KYAT3) 461601(AADAT) 473069(KYAT1)
PPS: 100980672(KYAT1) 100993985(KYAT3) 100995091(AADAT)
GGO: 101128027(KYAT3) 101137144(KYAT1) 101151419(AADAT)
PON: 100435746(AADAT) 100436953(KYAT3) 100452866(KYAT1)
NLE: 100579800(KYAT3) 100584784(AADAT) 100598335(KYAT1)
MCC: 694023(KYAT3) 695264(AADAT) 717142(KYAT1)
MCF: 101925086(KYAT3) 102122792(AADAT) 102142392(KYAT1)
CSAB: 103224481(KYAT3) 103236521(AADAT) 103239781(KYAT1)
RRO: 104660517(KYAT1) 104662870(AADAT) 104664603(KYAT3)
RBB: 108512836(KYAT1) 108514569(KYAT3) 108522848(AADAT)
CJC: 100390682(KYAT1) 100392205(KYAT3) 100403876(AADAT)
SBQ: 101034905(CCBL1) 101047103(AADAT) 101049363(CCBL2)
MMU: 229905(Kyat3) 23923(Aadat) 70266(Kyat1)
RNO: 29416(Aadat) 311844(Kyat1) 541589(Kyat3)
CGE: 100769821(Kyat1) 100771070(Kyat3) 100771752
NGI: 103727134(Aadat) 103730106(Kyat3) 103742867(Kyat1)
HGL: 101701445(Kyat3) 101707012(Aadat) 101714047(Ccbl1)
CCAN: 109677660(Aadat) 109682136(Kyat3) 109697703(Kyat1)
OCU: 100351221(KYAT1) 100355602(AADAT) 100358799(KYAT3)
TUP: 102479498(AADAT) 102484200(KYAT3) 102492301(KYAT1)
CFA: 479959(KYAT3) 486059(AADAT) 491310(KYAT1)
AML: 100466080(KYAT3) 100469458(AADAT) 100484335(KYAT1)
UMR: 103658154(AADAT) 103662922(KYAT3) 103670433(KYAT1)
ORO: 101379355(CCBL2) 101379671(AADAT) 101381784(CCBL1)
FCA: 101082171(KYAT3) 101082605(KYAT1) 101091616(AADAT)
PTG: 102949681(AADAT) 102956075(KYAT1) 102960707(KYAT3)
AJU: 106966305(KYAT1) 106968046(KYAT3) 106985264(AADAT)
BTA: 104968656 508712(KYAT3) 508929(AADAT) 520638 528582(CCBL1)
BOM: 102268017(KYAT3) 102269904(AADAT) 102270370 102274277(KYAT1) 102274974
BIU: 109556093(KYAT3) 109562758 109562760 109563538 109566527(KYAT1)
PHD: 102319020(KYAT3) 102326511 102328319(KYAT1)
CHX: 102180605(KYAT1) 102182368(KYAT3) 102190411(AADAT)
OAS: 101117485 101119265(KYAT3) 101121661 114108697 114113035 114113690
SSC: 100152011(AADAT) 100157176(KYAT3) 100515071(KYAT1)
CFR: 102514713(KYAT1) 102515842(AADAT) 102522240(KYAT3)
CDK: 105084526(KYAT3) 105092558(KYAT1) 105101723(AADAT)
BACU: 103001193(KYAT3) 103002075(AADAT) 103002354 103010164(KYAT1)
LVE: 103071573 103073927(KYAT1) 103077196(AADAT) 103090268(KYAT3)
OOR: 101279076 101279329 101285560(CCBL2) 101290033(CCBL1)
ECB: 100052141(KYAT3) 100067095(AADAT) 100070151(KYAT1)
EPZ: 103550870(KYAT1) 103554076(AADAT) 103557170(KYAT3)
EAI: 106831581(KYAT3) 106843200(AADAT) 106845422(KYAT1)
MYB: 102246710(KYAT1) 102246937(KYAT3) 102255657(AADAT)
MYD: 102764566(AADAT) 102770113(KYAT1) 102774189(KYAT3)
HAI: 109373938 109373940 109376722(KYAT3) 109382267(KYAT1)
RSS: 109436541(AADAT) 109445910(KYAT1) 109458284(KYAT3)
PALE: 102885606(KYAT3) 102886879(AADAT) 102890346(KYAT1)
LAV: 100653952(AADAT) 100674418(KYAT1) 100676040(KYAT3)
TMU: 101356269 101356623 101358316 101358802
MDO: 100013642(KYAT1) 100027687(KYAT3) 100031005
SHR: 100913887(AADAT) 100925132(KYAT1) 100928200(KYAT3)
PCW: 110193638(KYAT1) 110210007(KYAT3) 110216000(AADAT)
OAA: 100074153(CCBL1) 100074828(KYAT3) 100076580(AADAT)
GGA: 417202(CCBL1) 424517(KYAT3) 428728(AADAT)
MGP: 100539859(AADAT) 100545698(KYAT1) 100546759(KYAT3)
CJO: 107313054(AADAT) 107317420(KYAT3) 107321728(KYAT1)
APLA: 101796959(KYAT3) 101797673(AADAT) 101804188(KYAT1)
ACYG: 106032348(AADAT) 106034104(CCBL2) 106047313(CCBL1)
TGU: 100223564(KYAT3) 100226378(KYAT1) 100228964(AADAT)
SCAN: 103814906(KYAT3) 103819020(KYAT1) 103825924(AADAT)
GFR: 102038773(AADAT) 102043066(KYAT3) 102045568(KYAT1)
FAB: 101809203(KYAT1) 101816765(KYAT3) 101817402(AADAT)
PHI: 102108384(KYAT3) 102109435(KYAT1) 102114032(AADAT)
PMAJ: 107203407(AADAT) 107207980(KYAT3) 107212063(KYAT1)
CCAE: 111927908(AADAT) 111932822(KYAT3) 111936982(KYAT1)
CCW: 104688281(KYAT1) 104690544(AADAT) 104695321(KYAT3)
FPG: 101916601(AADAT) 101923826(KYAT3) 101924602(KYAT1)
FCH: 102052592(KYAT1) 102055107(KYAT3) 102059338(AADAT)
CLV: 102087961(AADAT) 102092812(KYAT3) 102097970(KYAT1)
EGZ: 104122512(CCBL1) 104122910(CCBL2) 104123112(AADAT)
NNI: 104015478(CCBL2) 104021266(AADAT) 104023148(CCBL1)
ACUN: 113479346(AADAT) 113482894(KYAT3) 113486546(KYAT1)
AAM: 106484015(AADAT) 106490298(KYAT1) 106499802(KYAT3)
ASN: 102377511(KYAT3) 102381063(KYAT1) 102384291
AMJ: 102564187(KYAT1) 102573373(AADAT) 102574637(KYAT3)
PSS: 102443615 102446036(KYAT1) 102459761(KYAT3) 102463594(AADAT)
CMY: 102931085(KYAT1) 102933210(AADAT) 102947846(KYAT3)
CPIC: 101933473(AADAT) 101948590(KYAT3) 101949101 101949140(KYAT1)
ACS: 100551617 100551817 100555601(kyat3)
PVT: 110079452(KYAT3) 110079688(KYAT1) 110085380(AADAT) 110085384
PBI: 103050097(AADAT) 103054557(KYAT3) 103058068(KYAT1)
PMUR: 107286149(AADAT) 107296247 107298201(CCBL2) 107299327 107301622
GJA: 107107125(AADAT) 107107127 107115481(KYAT1) 107126241(KYAT3)
XLA: 108715667(kyat3.S) 380432(kyat3.L) 398787(aadat.L) 432067(aadat.S) 734936(kyat1.L)
XTR: 496662(aadat) 496736(kyat1)
NPR: 108789894(AADAT) 108791027(KYAT3) 108794311(KYAT1)
DRE: 393315(ccbl2) 557979(aadat) 791592(kyat1)
SRX: 107726298 107731000 107736118 107747859(aadat) 107749985 107749986
SANH: 107691018 107692820(aadat) 107696739 107698888
SGH: 107553806(aadat) 107587404 107593160(ccbl2) 107596979
CCAR: 109055696 109090139 109091225
IPU: 108260319 108260321 108260322 108267547(aadat) 108271869(kyat3)
PHYP: 113531568 113531574 113531633 113532395(kyat3) 113539769(aadat)
AMEX: 103027162(kyat3) 103040807(aadat) 103046817(kyat1)
EEE: 113570275 113584540(kyat3) 113585158(aadat)
TRU: 101064758(kyat1) 101066451(kyat3) 101078353(aadat)
TNG: GSTEN00004861G001 GSTEN00014385G001 GSTEN00025714G001
LCO: 104931917(kyat3) 104938006(aadat) 104939087(kyat1)
NCC: 104946129(ccbl1) 104951126(aadat) 104955761(ccbl2)
MZE: 101466800(kyat1) 101486988(kyat3) 101487147(aadat)
OLA: 101156284(aadat) 101164171(kyat1) 101173380
XMA: 102233774(aadat) 102235261(kyat3) 102237088(kyat1)
PRET: 103463971(kyat3) 103473416(kyat1) 103475938(aadat)
NFU: 107374788(ccbl1) 107377046(aadat) 107397216(ccbl2)
KMR: 108231028(kyat1) 108241208(kyat3) 108249082(aadat)
CSEM: 103376809(kyat3) 103388590(aadat) 103390101(kyat1)
LCF: 108874059 108874060(kyat1) 108878962(kyat3) 108903085(aadat)
SDU: 111231920(kyat3) 111235631(aadat) 111237361(kyat1)
HCQ: 109508374(aadat) 109517170(kyat1) 109529744(kyat3)
BPEC: 110154758 110154910 110157436(kyat1) 110170749(aadat)
MALB: 109965770(kyat3) 109971345(kyat1) 109971451(aadat)
SASA: 100195431(kat3) 106569847 106608880(aadat)
OTW: 112214602(aadat) 112220099(kyat1) 112251473(kyat3)
SALP: 111952834(aadat) 111961864(kyat1) 112071986(kyat3)
ELS: 105015286(kyat1) 105026755(aadat) 105030533(kyat3)
SFM: 108921052(aadat) 108921915
PKI: 111841854(kyat1) 111850985(aadat) 111854627(kyat3)
LCM: 102348380(KYAT1) 102363875(AADAT) 102366870(KYAT3)
CMK: 103171755(kyat1) 103174679(kyat3) 103180238(aadat)
BFO: BRAFLDRAFT_118927 BRAFLDRAFT_63603 BRAFLDRAFT_69573
CIN: 100175167 100177655 100186481
SPU: 100891652 592969 593717
APLC: 110975863 110980482 110981090
SKO: 102808740
DME: Dmel_CG6950(CG6950)
DPO: Dpse_GA19977
DAN: Dana_GF23062
DER: 6553988
DPE: 6594315
DSE: Dsec_GM26066
DSI: Dsimw501_GD20629(Dsim_GD20629)
DWI: 6650503
DYA: Dyak_GE10079
DGR: Dgri_GH19404
DMO: Dmoj_GI22608
DVI: Dvir_GJ23853
MDE: 101891461
AGA: AgaP_AGAP011158
AAG: 5564787
CQU: CpipJ_CPIJ008201
AME: 724239 724811 725529
BIM: 100741457 100744283 100749289
BTER: 100644987 100645702 100649409
SOC: 105192855 105199937 105199950
MPHA: 105834301 105839488 105839941
AEC: 105146733 105149700 105153713
ACEP: 105617700 105618986 105626664
PBAR: 105422611 105428467 105429534 105433236
HST: 105180580 105188712 105191261
DQU: 106741108 106748643 106750486
CFO: 105248140 105248141 105252539 105256158 105259526 112638491
LHU: 105669318 105673051 105674064
PGC: 109852229 109856505 109862736
OBO: 105276089 105276822 105278388
PCF: 106788265 106788958 106789106
NVI: 100119206 100120227 100122641
MDL: 103571015 103571150
TCA: 655252 656125 662228
DPA: 109532996 109533718
NVL: 108561682 108565563
BMOR: 101738563 101742893
DPL: KGM_208814 KGM_212650 KGM_212651 KGM_212652
PMAC: 106710609 106711437
PRAP: 110992721 110999630
HAW: 110378047 110381053
TNL: 113494547 113494548 113495871
PXY: 105380713 105390263
API: 100159163 100160464 100164839 100569638 103310723
DNX: 107161360 107161381 107170518 107171505 107172258
AGS: 114127271 114127273 114132211
CLEC: 106666336
PHU: Phum_PHUM007560 Phum_PHUM210690
ZNE: 110837661
FCD: 110851920 110852399 110852512 110857982
DPX: DAPPUDRAFT_211037 DAPPUDRAFT_299942 DAPPUDRAFT_317235
ISC: IscW_ISCW012663 IscW_ISCW012664
TUT: 107360001 107371477
DPTE: 113793296
CEL: CELE_F28H6.3(nkat-1) CELE_R03A10.4(nkat-3)
CBR: CBG07704(Cbr-nkat-3) CBG10259
NAI: NECAME_03852
BMY: Bm1_10490
LOA: LOAG_06544
TSP: Tsp_07645 Tsp_12549
HRO: HELRODRAFT_108146 HELRODRAFT_161542 HELRODRAFT_188198 HELRODRAFT_188199 HELRODRAFT_65967
LGI: LOTGIDRAFT_146236 LOTGIDRAFT_202579 LOTGIDRAFT_208411 LOTGIDRAFT_213992 LOTGIDRAFT_214715 LOTGIDRAFT_224237
PCAN: 112573243 112574088 112576260
CRG: 105325199 105325285 105325286 105327675
MYI: 110458623 110459674 110461123 110466096
OBI: 106876997 106879841 106879849
LAK: 106160078 106165407 106165650 106173073 106173407 106177683 106178615 106178619 106178625 106178728 106178736
SMM: Smp_123750
SHX: MS3_06559
OVI: T265_13324
NVE: NEMVE_v1g173158
EPA: 110244036
PDAM: 113686698
SPIS: 111323701
HMG: 100208716 101238570 105845275
TAD: TRIADDRAFT_20976
AQU: 100641141
QSU: 111983314 112019006
CSL: COCSUDRAFT_44586
CVR: CHLNCDRAFT_133915 CHLNCDRAFT_144288
APRO: F751_0981
CME: CYME_CME121C
GSL: Gasu_10540
SCE: YJL060W(BNA3)
AGO: AGOS_AEL170C
ERC: Ecym_6292 Ecym_6319
KLA: KLLA0_F01617g
KMX: KLMA_50067(BNA3)
LTH: KLTH0H10648g
VPO: Kpol_1035p23
ZRO: ZYRO0G20636g
CGR: CAGL0J05126g
NCS: NCAS_0A09200(NCAS0A09200)
NDI: NDAI_0G05760(NDAI0G05760)
TPF: TPHA_0O01450(TPHA0O01450)
TDL: TDEL_0D01900(TDEL0D01900)
KAF: KAFR_0A01710(KAFR0A01710)
PPA: PAS_chr3_1132
DHA: DEHA2A04818g
PIC: PICST_45065
PGU: PGUG_00188
SPAA: SPAPADRAFT_60769
LEL: LELG_00731
CAL: CAALFM_C202640CA CAALFM_C202950WA(CaO19.5809)
CTP: CTRG_01368
COT: CORT_0A10090
CDU: CD36_17430 CD36_17720
CTEN: CANTEDRAFT_114548
YLI: YALI0E28787g
CLU: CLUG_00635
CLUS: A9F13_17g00143
CAUR: QG37_00211
SLB: AWJ20_1268(BNA3)
NCR: NCU03347(nic-4)
NTE: NEUTE1DRAFT84478(NEUTE1DRAFT_84478)
SMP: SMAC_04085
PAN: PODANSg6426
TTT: THITE_2156589
MTM: MYCTH_2311651
CTHR: CTHT_0001820
MGR: MGG_03264
TMN: UCRPA7_8043 UCRPA7_882
SSCK: SPSK_04279
FGR: FGSG_01560
FPU: FPSE_00774
FVR: FVEG_09641
FOX: FOXG_11148
NHE: NECHADRAFT_56943
TRE: TRIREDRAFT_108299 TRIREDRAFT_122820
MAW: MAC_05770
MAJ: MAA_01732
CMT: CCM_08981
PLJ: VFPFJ_07310
VAL: VDBG_05822
VDA: VDAG_07756
CFJ: CFIO01_07923
ELA: UCREL1_2763
PFY: PFICI_06462 PFICI_08822
SSL: SS1G_14365
BFU: BCIN_14g04940(Bcbna3)
MBE: MBM_06522
PSCO: LY89DRAFT_684139
GLZ: GLAREA_09638
ANI: AN5616.2
AFM: AFUA_4G11190
AOR: AO090003001103
ANG: ANI_1_908184(An04g05490)
AFV: AFLA_027170
ACT: ACLA_050280
NFI: NFIA_105110
PCS: Pc22g06360
PDP: PDIP_33670
CIM: CIMG_01500
CPW: CPC735_049450
PBL: PAAG_02644
PBN: PADG_01665
URE: UREG_05097
ABE: ARB_02285
TVE: TRV_04968
AJE: HCAG_01655
PNO: SNOG_07678
PTE: PTT_12703
BZE: COCCADRAFT_9164
BSC: COCSADRAFT_357023
BOR: COCMIDRAFT_87908
AALT: CC77DRAFT_1057041
ZTR: MYCGRDRAFT_109456
PFJ: MYCFIDRAFT_209990
BCOM: BAUCODRAFT_144231
NPA: UCRNP2_8162 UCRNP2_9323
TML: GSTUM_00008190001
SPO: SPAC6B12.04c
CNE: CNA00190
CNB: CNBA0180
CGI: CGB_B0190C
TMS: TREMEDRAFT_28961
TVS: TRAVEDRAFT_34780 TRAVEDRAFT_73288
DSQ: DICSQDRAFT_137660 DICSQDRAFT_150331
SHS: STEHIDRAFT_54103
HIR: HETIRDRAFT_416268
PSQ: PUNSTDRAFT_112390
ADL: AURDEDRAFT_53416
FME: FOMMEDRAFT_135437
GTR: GLOTRDRAFT_108338 GLOTRDRAFT_125628
LBC: LACBIDRAFT_292948
MPR: MPER_11854
MRR: Moror_17546
CCI: CC1G_00425
SCM: SCHCODRAFT_12771
ABP: AGABI1DRAFT38406(AGABI1DRAFT_38406)
ABV: AGABI2DRAFT67810(AGABI2DRAFT_67810)
CPUT: CONPUDRAFT_89836
SLA: SERLADRAFT_460803
WSE: WALSEDRAFT_61441
WIC: J056_002546
UMA: UMAG_10703
PFP: PFL1_04474
MGL: MGL_1970
PGR: PGTG_10514
MLR: MELLADRAFT_56822
MBR: MONBRDRAFT_33510 MONBRDRAFT_33534
SRE: PTSG_07452 PTSG_09009
DDI: DDB_G0287269(ccbl) DDB_G0287711
DPP: DICPUDRAFT_153380 DICPUDRAFT_159551 DICPUDRAFT_37021 DICPUDRAFT_44091 DICPUDRAFT_78310
DFA: DFA_03567 DFA_11928(ccbl)
ACAN: ACA1_112320 ACA1_112450 ACA1_255550 ACA1_255670
TET: TTHERM_00140940 TTHERM_00661530 TTHERM_00661540
PTM: GSPATT00006017001 GSPATT00023607001
SMIN: v1.2.018754.t1(symbB.v1.2.018754.t1)
PTI: PHATRDRAFT_10073 PHATR_10257
FCY: FRACYDRAFT_157973 FRACYDRAFT_195837
TPS: THAPSDRAFT_34647 THAPSDRAFT_460
AAF: AURANDRAFT_11479 AURANDRAFT_22616 AURANDRAFT_27554 AURANDRAFT_31446 AURANDRAFT_34539
NGD: NGA_0728200(CCBL) NGA_2018300(AADAT)
PIF: PITG_03678 PITG_10590
PSOJ: PHYSODRAFT_492501 PHYSODRAFT_552309
SPAR: SPRG_06585 SPRG_07237 SPRG_14332
EHX: EMIHUDRAFT_103493 EMIHUDRAFT_452800 EMIHUDRAFT_470587 EMIHUDRAFT_68512 EMIHUDRAFT_95037
GTT: GUITHDRAFT_159025
TBR: Tb10.389.1810
LMA: LMJF_33_1330
LIF: LINJ_33_1410
LDO: LDBPK_331410
LMI: LMXM_32_1330
LBZ: LBRM_33_1600
NGR: NAEGRDRAFT_32036 NAEGRDRAFT_76772
 » show all
Taxonomy
Reference
1  [PMID:13357462]
  Authors
BONNER DM, JAKOBY WB.
  Title
Kynurenine transaminase from neurospora.
  Journal
J Biol Chem 221:689-95 (1956)
Reference
2  [PMID:13449053]
  Authors
MASON M.
  Title
Kynurenine transaminase of rat kidney; a study of coenzyme dissociation.
  Journal
J Biol Chem 227:61-8 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.7
IUBMB Enzyme Nomenclature: 2.6.1.7
ExPASy - ENZYME nomenclature database: 2.6.1.7
BRENDA, the Enzyme Database: 2.6.1.7
CAS: 9030-38-0

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