KEGG   ENZYME: 2.6.1.7Help
Entry
EC 2.6.1.7                  Enzyme                                 

Name
kynurenine---oxoglutarate transaminase;
kynurenine transaminase (cyclizing);
kynurenine 2-oxoglutarate transaminase;
kynurenine aminotransferase;
L-kynurenine aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-kynurenine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate [RN:R01956]
Reaction(KEGG)
R01956;
(other) R04171
Show
Substrate
L-kynurenine [CPD:C00328];
2-oxoglutarate [CPD:C00026]
Product
4-(2-aminophenyl)-2,4-dioxobutanoate [CPD:C01252];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
History
EC 2.6.1.7 created 1961, modified 1983
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K00816  kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase
K00825  kynurenine/2-aminoadipate aminotransferase
K14264  kynurenine aminotransferase
Genes
HSA: 51166(AADAT) 56267(KYAT3) 883(KYAT1)
PTR: 456999(KYAT3) 461601(AADAT) 473069(KYAT1)
PPS: 100980672(KYAT1) 100993985(KYAT3) 100995091(AADAT)
GGO: 101128027(KYAT3) 101137144(KYAT1) 101151419(AADAT)
PON: 100435746(AADAT) 100436953(KYAT3) 100452866(KYAT1)
NLE: 100579800(KYAT3) 100584784(AADAT) 100598335(KYAT1)
MCC: 694023(KYAT3) 695264(AADAT) 717142(KYAT1)
MCF: 101925086(KYAT3) 102122792(AADAT) 102142392(KYAT1)
CSAB: 103224481(KYAT3) 103236521(AADAT) 103239781(KYAT1)
RRO: 104660517(KYAT1) 104662870(AADAT) 104664603(KYAT3)
RBB: 108512836(KYAT1) 108514569(KYAT3) 108522848(AADAT)
CJC: 100390682(KYAT1) 100392205(KYAT3) 100403876(AADAT)
SBQ: 101034905(CCBL1) 101047103(AADAT) 101049363(CCBL2)
MMU: 229905(Kyat3) 23923(Aadat) 70266(Kyat1)
RNO: 29416(Aadat) 311844(Kyat1) 541589(Kyat3)
CGE: 100769821(Kyat1) 100771070(Kyat3) 100771752
NGI: 103727134(Aadat) 103730106(Kyat3) 103742867(Kyat1)
HGL: 101701445(Kyat3) 101707012(Aadat) 101714047(Ccbl1)
CCAN: 109677660(Aadat) 109682136(Kyat3) 109697703(Kyat1)
OCU: 100351221(KYAT1) 100355602(AADAT) 100358799(KYAT3)
TUP: 102479498(AADAT) 102484200(KYAT3) 102492301(KYAT1)
CFA: 479959(KYAT3) 486059(AADAT) 491310(KYAT1)
AML: 100466080(KYAT3) 100469458(AADAT) 100484335(KYAT1)
UMR: 103658154(AADAT) 103662922(KYAT3) 103670433(KYAT1)
ORO: 101379355(CCBL2) 101379671(AADAT) 101381784(CCBL1)
FCA: 101082171(KYAT3) 101082605(KYAT1) 101091616(AADAT)
PTG: 102949681(AADAT) 102956075(KYAT1) 102960707(KYAT3)
AJU: 106966305(KYAT1) 106968046(KYAT3) 106985264(AADAT)
BTA: 104968656 508712(KYAT3) 508929(AADAT) 520638 528582(CCBL1)
BOM: 102268017(KYAT3) 102269904(AADAT) 102270370 102274277(KYAT1) 102274974
BIU: 109556093(KYAT3) 109562758 109562760 109563538 109566527(KYAT1)
PHD: 102319020(KYAT3) 102326511 102328319(KYAT1)
CHX: 102180605(KYAT1) 102182368(KYAT3) 102190411(AADAT)
OAS: 101117485(CCBL1) 101119265(CCBL2) 101121661(AADAT)
SSC: 100152011(AADAT) 100157176(KYAT3) 100515071(KYAT1)
CFR: 102514713(KYAT1) 102515842(AADAT) 102522240(KYAT3)
CDK: 105084526(KYAT3) 105092558(KYAT1) 105101723(AADAT)
BACU: 103001193(KYAT3) 103002075(AADAT) 103002354 103010164(KYAT1)
LVE: 103071573 103073927(KYAT1) 103077196(AADAT) 103090268(KYAT3)
OOR: 101279076 101279329 101285560(CCBL2) 101290033(CCBL1)
ECB: 100052141(KYAT3) 100067095(AADAT) 100070151(KYAT1)
EPZ: 103550870(KYAT1) 103554076(AADAT) 103557170(KYAT3)
EAI: 106831581(KYAT3) 106843200(AADAT) 106845422(KYAT1)
MYB: 102246710(KYAT1) 102246937(KYAT3) 102255657(AADAT)
MYD: 102764566(AADAT) 102770113(KYAT1) 102774189(KYAT3)
HAI: 109373938 109373940 109376722(KYAT3) 109382267(KYAT1)
RSS: 109436541(AADAT) 109445910(KYAT1) 109458284(KYAT3)
PALE: 102885606(KYAT3) 102886879(AADAT) 102890346(KYAT1)
LAV: 100653952(AADAT) 100674418(KYAT1) 100676040(KYAT3)
TMU: 101356269 101356623 101358316 101358802
MDO: 100013642(KYAT1) 100027687(KYAT3) 100031005
SHR: 100913887(AADAT) 100925132(KYAT1) 100928200(KYAT3)
OAA: 100074153(CCBL1) 100074828(KYAT3) 100076580(AADAT)
GGA: 417202(CCBL1) 424517(KYAT3) 428728(AADAT)
MGP: 100539859(AADAT) 100545698(KYAT1) 100546759(KYAT3)
CJO: 107313054(AADAT) 107317420(KYAT3) 107321728(KYAT1)
APLA: 101796959(KYAT3) 101797673(AADAT) 101804188(KYAT1)
ACYG: 106032348(AADAT) 106034104(CCBL2) 106047313(CCBL1)
TGU: 100223564(KYAT3) 100226378(KYAT1) 100228964(AADAT)
GFR: 102038773(AADAT) 102043066(KYAT3) 102045568(KYAT1)
FAB: 101809203(KYAT1) 101816765(KYAT3) 101817402(AADAT)
PHI: 102108384(KYAT3) 102109435(KYAT1) 102114032(AADAT)
PMAJ: 107203407(AADAT) 107207980(KYAT3) 107212063(KYAT1)
CCAE: 111927908(AADAT) 111932822(KYAT3) 111936982(KYAT1)
CCW: 104688281(KYAT1) 104690544(AADAT) 104695321(KYAT3)
FPG: 101916601(AADAT) 101923826(KYAT3) 101924602(KYAT1)
FCH: 102052592(KYAT1) 102055107(KYAT3) 102059338(AADAT)
CLV: 102087961(AADAT) 102092812(KYAT3) 102097970(KYAT1)
EGZ: 104122512(CCBL1) 104122910(CCBL2) 104123112(AADAT)
AAM: 106484015(AADAT) 106490298(KYAT1) 106499802(KYAT3)
ASN: 102377511(KYAT3) 102381063(KYAT1) 102384291
AMJ: 102564187(KYAT1) 102573373(AADAT) 102574637(KYAT3)
PSS: 102443615 102446036(KYAT1) 102459761(KYAT3) 102463594(AADAT)
CMY: 102931085(KYAT1) 102933210(AADAT) 102947846(KYAT3)
CPIC: 101933473(AADAT) 101948590(KYAT3) 101949101 101949140(KYAT1)
ACS: 100551617 100551817 100555601(kyat3)
PVT: 110079452(KYAT3) 110079688(KYAT1) 110085380(AADAT) 110085384
PBI: 103050097(AADAT) 103054557(KYAT3) 103058068(KYAT1)
GJA: 107107125(AADAT) 107107127 107115481(KYAT1) 107126241(KYAT3)
XLA: 108715667(kyat3.S) 380432(kyat3.L) 398787(aadat.L) 432067(aadat.S) 734936(kyat1.L)
XTR: 496662(aadat) 496736(kyat1)
NPR: 108789894(AADAT) 108791027(KYAT3) 108794311(KYAT1)
DRE: 393315(ccbl2) 557979(aadat) 791592(kyat1)
SRX: 107726298 107731000 107736118 107747859(aadat) 107749985 107749986
SANH: 107691018 107692820(aadat) 107696739 107698888
SGH: 107553806(aadat) 107587404 107593160(ccbl2) 107596979
CCAR: 109055696 109090139 109091225
IPU: 108260319 108260321 108260322 108267547(aadat) 108271869(kyat3)
AMEX: 103027162(kyat3) 103040807(aadat) 103046817(kyat1)
TRU: 101064758(kyat1) 101066451(kyat3) 101078353(aadat)
TNG: GSTEN00004861G001 GSTEN00014385G001 GSTEN00025714G001
LCO: 104931917(kyat3) 104938006(aadat) 104939087(kyat1)
NCC: 104946129(ccbl1) 104951126(aadat) 104955761(ccbl2)
MZE: 101466800(kyat1) 101486988(kyat3) 101487147(aadat)
OLA: 101156284(aadat) 101164171(kyat1) 101173380
XMA: 102233774(aadat) 102235261(kyat3) 102237088(kyat1)
PRET: 103463971(kyat3) 103473416(kyat1) 103475938(aadat)
NFU: 107374788(ccbl1) 107377046(aadat) 107397216(ccbl2)
KMR: 108231028(kyat1) 108241208(kyat3) 108249082(aadat)
CSEM: 103376809(kyat3) 103388590(aadat) 103390101(kyat1)
LCF: 108874059 108874060(kyat1) 108878962(kyat3) 108903085(aadat)
SDU: 111231920(kyat3) 111235631(aadat) 111237361(kyat1)
HCQ: 109508374(aadat) 109517170(kyat1) 109529744(kyat3)
BPEC: 110154758 110154910 110157436(kyat1) 110170749(aadat)
MALB: 109965770(kyat3) 109971345(kyat1) 109971451(aadat)
SASA: 100195431(kat3) 106569847 106608880(aadat)
OTW: 112214602(aadat) 112220099(kyat1) 112251473(kyat3)
ELS: 105015286(kyat1) 105026755(aadat) 105030533(kyat3)
SFM: 108921052(aadat) 108921915
LCM: 102348380(KYAT1) 102363875(AADAT) 102366870(KYAT3)
CMK: 103171755(kyat1) 103174679(kyat3) 103180238(aadat)
BFO: BRAFLDRAFT_118927 BRAFLDRAFT_63603 BRAFLDRAFT_69573
CIN: 100175167 100177655 100186481
SPU: 100891652 592969 593717
APLC: 110975863 110980482 110981090
SKO: 102808740
DME: Dmel_CG6950(CG6950)
DPO: Dpse_GA19977
DAN: Dana_GF23062
DER: 6553988
DPE: 6594315
DSE: Dsec_GM26066
DSI: Dsimw501_GD20629(Dsim_GD20629)
DYA: Dyak_GE10079
DGR: Dgri_GH19404
DMO: Dmoj_GI22608
DVI: Dvir_GJ23853
MDE: 101891461
AGA: AgaP_AGAP011158
AAG: 5564787
CQU: CpipJ_CPIJ008201
AME: 724239 724811 725529
BIM: 100741457 100744283 100749289
BTER: 100644987 100645702 100649409
SOC: 105192855 105199937 105199950
AEC: 105146733 105149700 105153713
ACEP: 105617700 105618986 105626664
PBAR: 105422611 105428467 105429534 105433236
HST: 105180580 105188712 105191261
DQU: 106741108 106748643 106750486
CFO: 105248140 105248141 105252539 105256158 105259526 112638491
LHU: 105669318 105673051 105674064
PGC: 109852229 109856505 109862736
PCF: 106788265 106788958 106789106
NVI: 100119206 100120227 100122641
MDL: 103571015 103571150
TCA: 655252 656125 662228
DPA: 109532996 109533718
NVL: 108561682 108565563
BMOR: 101738563 101742893
DPL: KGM_208814 KGM_212650 KGM_212651 KGM_212652
PMAC: 106710609 106711437
PRAP: 110992721 110999630
HAW: 110378047 110381053
PXY: 105380713 105390263
API: 100159163 100160464 100164839 100569638 103310723
DNX: 107161360 107161381 107170518 107171505 107172258
CLEC: 106666336
PHU: Phum_PHUM007560 Phum_PHUM210690
ZNE: 110837661
FCD: 110851920 110852399 110852512 110857982
DPX: DAPPUDRAFT_211037 DAPPUDRAFT_299942 DAPPUDRAFT_317235
ISC: IscW_ISCW012663 IscW_ISCW012664
TUT: 107360001 107371477
CEL: CELE_F28H6.3(nkat-1) CELE_R03A10.4(nkat-3)
CBR: CBG07704(Cbr-nkat-3) CBG10259
NAI: NECAME_03852
BMY: Bm1_10490
LOA: LOAG_06544
TSP: Tsp_07645 Tsp_12549
HRO: HELRODRAFT_108146 HELRODRAFT_161542 HELRODRAFT_188198 HELRODRAFT_188199 HELRODRAFT_65967
LGI: LOTGIDRAFT_146236 LOTGIDRAFT_202579 LOTGIDRAFT_208411 LOTGIDRAFT_213992 LOTGIDRAFT_214715 LOTGIDRAFT_224237
CRG: 105325199 105325285 105325286 105327675
MYI: 110458623 110459674 110461123 110466096
OBI: 106876997 106879841 106879849
LAK: 106160078 106165407 106165650 106173073 106173407 106177683 106178615 106178619 106178625 106178728 106178736
SMM: Smp_123750
SHX: MS3_06559
OVI: T265_13324
NVE: NEMVE_v1g173158
EPA: 110244036
HMG: 100208716 101238570 105845275
TAD: TRIADDRAFT_20976
AQU: 100641141
CSL: COCSUDRAFT_44586
CVR: CHLNCDRAFT_133915 CHLNCDRAFT_144288
APRO: F751_0981
CME: CYME_CME121C
GSL: Gasu_10540
SCE: YJL060W(BNA3)
AGO: AGOS_AEL170C
ERC: Ecym_6292 Ecym_6319
KLA: KLLA0_F01617g
KMX: KLMA_50067(BNA3)
LTH: KLTH0H10648g
VPO: Kpol_1035p23
ZRO: ZYRO0G20636g
CGR: CAGL0J05126g
NCS: NCAS_0A09200(NCAS0A09200)
NDI: NDAI_0G05760(NDAI0G05760)
TPF: TPHA_0O01450(TPHA0O01450)
TDL: TDEL_0D01900(TDEL0D01900)
KAF: KAFR_0A01710(KAFR0A01710)
PPA: PAS_chr3_1132
DHA: DEHA2A04818g
PIC: PICST_45065
PGU: PGUG_00188
SPAA: SPAPADRAFT_60769
LEL: LELG_00731
CAL: CAALFM_C202640CA CAALFM_C202950WA(CaO19.5809)
CTP: CTRG_01368
COT: CORT_0A10090
CDU: CD36_17430 CD36_17720
CTEN: CANTEDRAFT_114548
YLI: YALI0E28787g
CLU: CLUG_00635
CLUS: A9F13_17g00143
CAUR: QG37_00211
SLB: AWJ20_1268(BNA3)
NCR: NCU03347(nic-4)
NTE: NEUTE1DRAFT84478(NEUTE1DRAFT_84478)
SMP: SMAC_04085
PAN: PODANSg6426
TTT: THITE_2156589
MTM: MYCTH_2311651
CTHR: CTHT_0001820
MGR: MGG_03264
TMN: UCRPA7_8043 UCRPA7_882
SSCK: SPSK_04279
FGR: FGSG_01560
FPU: FPSE_00774
FVR: FVEG_09641
FOX: FOXG_11148
NHE: NECHADRAFT_56943
TRE: TRIREDRAFT_108299 TRIREDRAFT_122820
MAW: MAC_05770
MAJ: MAA_01732
CMT: CCM_08981
PLJ: VFPFJ_07310
VAL: VDBG_05822
VDA: VDAG_07756
CFJ: CFIO01_07923
ELA: UCREL1_2763
PFY: PFICI_06462 PFICI_08822
SSL: SS1G_14365
BFU: BCIN_14g04940(Bcbna3)
MBE: MBM_06522
PSCO: LY89DRAFT_684139
GLZ: GLAREA_09638
ANI: AN5616.2
AFM: AFUA_4G11190
AOR: AO090003001103
ANG: ANI_1_908184(An04g05490)
AFV: AFLA_027170
ACT: ACLA_050280
NFI: NFIA_105110
PCS: Pc22g06360
PDP: PDIP_33670
CIM: CIMG_01500
CPW: CPC735_049450
PBL: PAAG_02644
PBN: PADG_01665
URE: UREG_05097
ABE: ARB_02285
TVE: TRV_04968
AJE: HCAG_01655
PNO: SNOG_07678
PTE: PTT_12703
BZE: COCCADRAFT_9164
BSC: COCSADRAFT_357023
BOR: COCMIDRAFT_87908
AALT: CC77DRAFT_1057041
ZTR: MYCGRDRAFT_109456
PFJ: MYCFIDRAFT_209990
BCOM: BAUCODRAFT_144231
NPA: UCRNP2_8162 UCRNP2_9323
TML: GSTUM_00008190001
SPO: SPAC6B12.04c
CNE: CNA00190
CNB: CNBA0180
CGI: CGB_B0190C
TMS: TREMEDRAFT_28961
TVS: TRAVEDRAFT_34780 TRAVEDRAFT_73288
DSQ: DICSQDRAFT_137660 DICSQDRAFT_150331
SHS: STEHIDRAFT_54103
HIR: HETIRDRAFT_416268
PSQ: PUNSTDRAFT_112390
ADL: AURDEDRAFT_53416
FME: FOMMEDRAFT_135437
GTR: GLOTRDRAFT_108338 GLOTRDRAFT_125628
LBC: LACBIDRAFT_292948
MPR: MPER_11854
MRR: Moror_17546
CCI: CC1G_00425
SCM: SCHCODRAFT_12771
ABP: AGABI1DRAFT38406(AGABI1DRAFT_38406)
ABV: AGABI2DRAFT67810(AGABI2DRAFT_67810)
CPUT: CONPUDRAFT_89836
SLA: SERLADRAFT_460803
WSE: WALSEDRAFT_61441
WIC: J056_002546
UMA: UMAG_10703
PFP: PFL1_04474
MGL: MGL_1970
PGR: PGTG_10514
MLR: MELLADRAFT_56822
MBR: MONBRDRAFT_33510 MONBRDRAFT_33534
SRE: PTSG_07452 PTSG_09009
DDI: DDB_G0287269(ccbl) DDB_G0287711
DPP: DICPUDRAFT_153380 DICPUDRAFT_159551 DICPUDRAFT_37021 DICPUDRAFT_44091 DICPUDRAFT_78310
DFA: DFA_03567 DFA_11928(ccbl)
ACAN: ACA1_112320 ACA1_112450 ACA1_255550 ACA1_255670
TET: TTHERM_00140940 TTHERM_00661530 TTHERM_00661540
PTM: GSPATT00006017001 GSPATT00023607001
SMIN: v1.2.018754.t1(symbB.v1.2.018754.t1)
PTI: PHATRDRAFT_10073 PHATR_10257
FCY: FRACYDRAFT_157973 FRACYDRAFT_195837
TPS: THAPSDRAFT_34647 THAPSDRAFT_460
AAF: AURANDRAFT_11479 AURANDRAFT_22616 AURANDRAFT_27554 AURANDRAFT_31446 AURANDRAFT_34539
NGD: NGA_0728200(CCBL) NGA_2018300(AADAT)
PIF: PITG_03678 PITG_10590
PSOJ: PHYSODRAFT_492501 PHYSODRAFT_552309
SPAR: SPRG_06585 SPRG_07237 SPRG_14332
EHX: EMIHUDRAFT_103493 EMIHUDRAFT_452800 EMIHUDRAFT_470587 EMIHUDRAFT_68512 EMIHUDRAFT_95037
GTT: GUITHDRAFT_159025
TBR: Tb10.389.1810
LMA: LMJF_33_1330
LIF: LINJ_33_1410
LDO: LDBPK_331410
LMI: LMXM_32_1330
LBZ: LBRM_33_1600
NGR: NAEGRDRAFT_32036 NAEGRDRAFT_76772
 » show all
Taxonomy
Reference
1  [PMID:13357462]
  Authors
BONNER DM, JAKOBY WB.
  Title
Kynurenine transaminase from neurospora.
  Journal
J Biol Chem 221:689-95 (1956)
Reference
2  [PMID:13449053]
  Authors
MASON M.
  Title
Kynurenine transaminase of rat kidney; a study of coenzyme dissociation.
  Journal
J Biol Chem 227:61-8 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.7
IUBMB Enzyme Nomenclature: 2.6.1.7
ExPASy - ENZYME nomenclature database: 2.6.1.7
BRENDA, the Enzyme Database: 2.6.1.7
CAS: 9030-38-0

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Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (6629)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (722)   
   KEGG MGENES (393)   
   RefGene (5440)   
   EGENES (71)   
Protein sequence (275)   
   UniProt (109)   
   SWISS-PROT (26)   
   RefSeq(pep) (78)   
   PDBSTR (61)   
   PMD (1)   
DNA sequence (303)   
   RefSeq(nuc) (202)   
   GenBank (58)   
   EMBL (43)   
3D Structure (27)   
   PDB (27)   
Protein domain (2)   
   InterPro (2)   
All databases (7250)   

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