Entry |
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Name |
kynurenine---oxoglutarate transaminase;
kynurenine transaminase (cyclizing);
kynurenine 2-oxoglutarate transaminase;
kynurenine aminotransferase;
L-kynurenine aminotransferase
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Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
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Sysname |
L-kynurenine:2-oxoglutarate aminotransferase
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Reaction(IUBMB) |
L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O (overall reaction) [RN: R12688];
(1a) L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate [RN: R01956];
(1b) 4-(2-aminophenyl)-2,4-dioxobutanoate + H2O (spontaneous) [RN: R03445]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
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History |
EC 2.6.1.7 created 1961, modified 1983
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Pathway |
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Orthology |
K00816 | kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase |
K00825 | kynurenine/2-aminoadipate aminotransferase |
K14264 | kynurenine aminotransferase |
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Genes |
» show all
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Reference |
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Authors |
BONNER DM, JAKOBY WB. |
Title |
Kynurenine transaminase from neurospora. |
Journal |
J Biol Chem 221:689-95 (1956) |
Reference |
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Authors |
MASON M. |
Title |
Kynurenine transaminase of rat kidney; a study of coenzyme dissociation. |
Journal |
J Biol Chem 227:61-8 (1957) |
Reference |
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Authors |
Noguchi T, Minatogawa Y, Okuno E, Nakatani M, Morimoto M. |
Title |
Purification and characterization of kynurenine--2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats. |
Journal |
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Reference |
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Authors |
Han Q, Robinson H, Cai T, Tagle DA, Li J. |
Title |
Biochemical and structural properties of mouse kynurenine aminotransferase III. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 2.6.1.7 |
ExPASy - ENZYME nomenclature database: | 2.6.1.7 |
BRENDA, the Enzyme Database: | 2.6.1.7 |
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