KEGG   ENZYME: 2.6.1.74Help
Entry
EC 2.6.1.74                 Enzyme                                 

Name
cephalosporin-C transaminase;
cephalosporin C aminotransferase;
L-alanine:cephalosporin-C aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
cephalosporin-C:2-oxoglutarate aminotransferase
Reaction(IUBMB)
(7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate + D-glutamate = cephalosporin C + 2-oxoglutarate [RN:R03063]
Reaction(KEGG)
Substrate
(7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate [CPD:C04712];
D-glutamate [CPD:C00217]
Product
cephalosporin C [CPD:C00916];
2-oxoglutarate [CPD:C00026]
Comment
A number of D-amino acids, including D-alanine, D-aspartate and D-methionine can also act as amino-group donors. Although this enzyme acts on several free D-amino acids, it differs from EC 2.6.1.21, D-alanine transaminase, in that it can use cephalosporin C as an amino donor.
History
EC 2.6.1.74 created 1992, modified 2005
Pathway
ec00311  Penicillin and cephalosporin biosynthesis
ec01130  Biosynthesis of antibiotics
Reference
1  [PMID:3228235]
  Authors
Aretz W, Sauber K.
  Title
Novel D-amino acid transaminase.
  Journal
Ann N Y Acad Sci 542:366-70 (1988)
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.74
IUBMB Enzyme Nomenclature: 2.6.1.74
ExPASy - ENZYME nomenclature database: 2.6.1.74
BRENDA, the Enzyme Database: 2.6.1.74
CAS: 122096-91-7

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