KEGG   ENZYME: 2.6.1.82Help
Entry
EC 2.6.1.82                 Enzyme                                 

Name
putrescine---2-oxoglutarate transaminase;
putrescine-alpha-ketoglutarate transaminase;
YgjG;
putrescine:alpha-ketoglutarate aminotransferase;
PAT;
putrescine transaminase (ambiguous);
putrescine aminotransferase (ambiguous);
butane-1,4-diamine:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
putrescine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
putrescine + 2-oxoglutarate = 1-pyrroline + L-glutamate + H2O (overall reaction) [RN:R10064];
(1a) putrescine + 2-oxoglutarate = 4-aminobutanal + L-glutamate [RN:R01155];
(1b) 4-aminobutanal = 1-pyrroline + H2O (spontaneous) [RN:R07408]
Reaction(KEGG)
Substrate
putrescine [CPD:C00134];
2-oxoglutarate [CPD:C00026];
4-aminobutanal [CPD:C00555]
Product
1-pyrroline [CPD:C15668];
L-glutamate [CPD:C00025];
H2O [CPD:C00001];
4-aminobutanal [CPD:C00555]
Comment
A pyridoxal 5'-phosphate protein [3]. The product, 4-aminobutanal, spontaneously cyclizes to form 1-pyrroline, which is a substrate for EC 1.2.1.19, aminobutyraldehyde dehydrogenase. Cadaverine and spermidine can also act as substrates [3]. Forms part of the arginine-catabolism pathway [2]. cf. EC 2.6.1.113, putrescine---pyruvate transaminase.
History
EC 2.6.1.82 created 2006, modified 2017
Pathway
ec00310  Lysine degradation
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K09251  putrescine aminotransferase
Genes
ECO: b3073(patA)
ECJ: JW5510(ygjG)
ECD: ECDH10B_3248(ygjG)
EBW: BWG_2783(ygjG)
ECOK: ECMDS42_2542(ygjG)
ECE: Z4426(ygjG)
ECS: ECs3955
ECF: ECH74115_4387(ygjG)
ETW: ECSP_4047(ygjG)
ELX: CDCO157_3696
EOJ: ECO26_4174(ygjG)
EOI: ECO111_3895(ygjG)
EOH: ECO103_3818(ygjG)
ECOO: ECRM13514_4033(ygjG)
ECOH: ECRM13516_3836(ygjG)
ECG: E2348C_3366(ygjG)
EOK: G2583_3797(ygjG)
ESO: O3O_22055
ESM: O3M_03630
ESL: O3K_03590
ECW: EcE24377A_3540(rocD)
ELH: ETEC_3343
EUN: UMNK88_3827(ygjG)
ECC: c3828(ygjG)
ECP: ECP_3163
ECI: UTI89_C3511(ygjG)
ECV: APECO1_3343(ygjG)
ECX: EcHS_A3255(ygjG)
ECM: EcSMS35_3367(ygjG)
ECY: ECSE_3354
ECR: ECIAI1_3220(ygjG)
ECQ: ECED1_3741(ygjG)
ECK: EC55989_3487(ygjG)
ECT: ECIAI39_3571(ygjG)
EOC: CE10_3604(patA)
EUM: ECUMN_3556(ygjG)
ECZ: ECS88_3470(ygjG)
ESE: ECSF_2916
EBR: ECB_02942(ygjG)
EBD: ECBD_0669
EKF: KO11_07355(ygjG)
EAB: ECABU_c34930(ygjG)
EDJ: ECDH1ME8569_2968(ygjG)
EIH: ECOK1_3505(rocD)
ENA: ECNA114_3166(ygjG)
ELW: ECW_m3340(ygjG)
ELL: WFL_16320(ygjG)
ELC: i14_3520(ygjG)
ELD: i02_3520(ygjG)
ELP: P12B_c3190(ygjG)
EBL: ECD_02942(patA)
EBE: B21_02892(ygjG)
ELF: LF82_3225(ygjG)
ECOI: ECOPMV1_03391(patA)
ECOJ: P423_17360
ECOS: EC958_3479(ygjG)
EFE: EFER_3025(ygjG)
EAL: EAKF1_ch2857c(ygjG)
EMA: C1192_19755(ygjG)
STY: STY3396
STT: t3138
STM: STM3218(oat)
SEO: STM14_3896(oat)
SEY: SL1344_3191(oat)
SEJ: STMUK_3207(oat)
SEB: STM474_3372(oat)
SENI: CY43_16775
SPT: SPA3086(oat)
SEK: SSPA2882
SEI: SPC_3294(oat)
SEC: SCH_3165(oat)
SEH: SeHA_C3513(ygjG)
SHB: SU5_03713
SEE: SNSL254_A3479(ygjG)
SEW: SeSA_A3409(ygjG)
SEA: SeAg_B3405(ygjG)
SENS: Q786_15695
SED: SeD_A3575(rocD)
SEG: SG3114(oat)
SEL: SPUL_3231(oat)
SEGA: SPUCDC_3217(oat)
SET: SEN3060(oat)
SENA: AU38_15575
SENO: AU37_15775
SENV: AU39_15775
SENQ: AU40_17555
SENL: IY59_16180
SEEP: I137_15415
SENB: BN855_32980(ygjG)
SENE: IA1_15565
SBG: SBG_2853
SBZ: A464_3296
SFL: SF3114(ygjG)
SFX: S3320(ygjG)
SFV: SFV_3114(ygjG)
SFE: SFxv_3420(ygjG)
SFN: SFy_4444
SFS: SFyv_4521
SFT: NCTC1_03374(ygjG)
SSN: SSON_3211(ygjG)
SBO: SBO_2932(ygjG)
ENC: ECL_04458
ECLO: ENC_33220
ECLX: LI66_19490
ECLY: LI62_21450
ECLZ: LI64_18630
EEC: EcWSU1_03889(patA)
ECAN: CWI88_03060(ygjG)
ESA: ESA_03492
CSK: ES15_3449
CTU: CTU_04740(patA)
KPN: KPN_03501(ygjG)
KPU: KP1_4798(ygjG)
KPP: A79E_0616
KPT: VK055_3967(ygjG)
KPE: KPK_0611(ygjG)
KPR: KPR_4705(patA)
KPJ: N559_0670
KPX: PMK1_01019(patA)
KPNU: LI86_03245
KPNK: BN49_0606(patA)
KVA: Kvar_0599
KOX: KOX_03220
KOE: A225_5093
EAE: EAE_03880
EAR: CCG33216
KQV: B8P98_03285(ygjG)
CKO: CKO_04486
CRO: ROD_48051
CBRA: A6J81_20490(ygjG)
CWE: CO701_01070(ygjG)
CYO: CD187_03150(ygjG)
CAMA: F384_24635
CAF: AL524_23390(ygjG)
CIF: AL515_20310(ygjG)
CFAR: CI104_03360(ygjG)
CIR: C2U53_06125(ygjG)
CIE: AN232_07815(ygjG)
EBT: EBL_c04700(ygjG)
RAO: DSD31_03330(ygjG)
CLAP: NCTC11466_04014(patA)
KOT: EH164_02855(ygjG)
LEH: C3F35_15085(ygjG)
LNI: CWR52_15710(ygjG)
LEW: DAI21_07800(ygjG)
BUF: D8682_18550(ygjG)
METY: MRY16398_06840(patA)
AHN: NCTC12129_00716(patA)
EBF: D782_0607
EBC: C2U52_11820(ygjG)
EBU: CUC76_18795(ygjG)
SERA: Ser39006_017225(ygjG)
RAA: Q7S_09650
ECA: ECA1543
PATR: EV46_07805
PATO: GZ59_15810
PEC: W5S_1732
SOD: Sant_1573
DDQ: DDI_1242
LBQ: CKQ53_11500(ygjG)
HPAR: AL518_18710(ygjG)
PFC: PflA506_2598(patA)
BGP: BGL_2c09700(argD) BGL_2c11910(patA)
DBA: Dbac_2006
DSF: UWK_00860
DOL: Dole_1070
CCX: COCOR_03198(argD)
BMR: BMI_II845
BTM: MC28_0591
BWW: bwei_3644(ygjG)
BMYO: BG05_4537(ygjG)
BMYC: DJ92_4003
BMQ: BMQ_0863(rocD)
BMD: BMD_0864(rocD)
BMH: BMWSH_4378(ygjG)
BMEG: BG04_3159
BAG: Bcoa_3317
GEA: GARCT_01452(patA_2)
PMS: KNP414_07440(patA2)
PMW: B2K_35280
ASOC: CB4_00046(patA_1)
BTS: Btus_0600
LLK: LLKF_1589
LLJ: LG36_0894
CBE: Cbei_4934
CBZ: Cbs_4934
CSR: Cspa_c29400(patA)
CACE: CACET_c35030(patA)
AMT: Amet_4317
AOE: Clos_2419
CCE: Ccel_1814
RUM: CK1_29070
CPRO: CPRO_14640(patA_3)
SLP: Slip_1325
DRM: Dred_2058
DAE: Dtox_1194
PTH: PTH_1726(ArgD)
DAU: Daud_0653
HMO: HM1_1941(oat)
SAY: TPY_1764(rocD) TPY_2989
CTHM: CFE_1259
TTE: TTE2339(ArgD)
THX: Thet_2097
TIT: Thit_2031
TKI: TKV_c21020(patA)
CHY: CHY_1436
MTA: Moth_1785
ADG: Adeg_1419
TPZ: Tph_c13270(argD1)
TOC: Toce_0940
TTM: Tthe_0388
TSH: Tsac_0964
PFT: JBW_01313
MANA: MAMMFC1_03699(patA_3)
PFAC: PFJ30894_01719(patA_2)
MAB: MAB_2279
MABB: MASS_2203
MSTE: MSTE_02492
NCY: NOCYR_5148(patA)
SCO: SCO1284(2SCG18.31c)
SMA: SAVERM_2285(rocD3)
SGR: SGR_2290
SCT: SCAT_5590(patA)
SBH: SBI_01944
SHY: SHJG_0313
SVE: SVEN_4888
SALS: SLNWT_4936
STRE: GZL_09114
SAMB: SAM23877_1365(patA)
SRW: TUE45_02122(patA)
SLE: sle_03180(sle_03180)
SFK: KY5_0298c
MPH: MLP_04660
NML: Namu_5127
AMI: Amir_3615
ALO: CRK58238
ACTN: L083_2318
DFC: DFI_07035
TRA: Trad_2914
TTH: TT_C0553
TTJ: TTHA0909
TSC: TSC_c09430(patA)
TAQ: TO73_0717
MRB: Mrub_1580
 » show all
Taxonomy
Reference
1  [PMID:3510672]
  Authors
Prieto-Santos MI, Martin-Checa J, Balana-Fouce R, Garrido-Pertierra A.
  Title
A pathway for putrescine catabolism in Escherichia coli.
  Journal
Biochim Biophys Acta 880:242-4 (1986)
DOI:10.1016/0304-4165(86)90085-1
Reference
2  [PMID:16023116]
  Authors
Samsonova NN, Smirnov SV, Novikova AE, Ptitsyn LR.
  Title
Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase.
  Journal
FEBS Lett 579:4107-12 (2005)
DOI:10.1016/j.febslet.2005.06.038
Reference
3  [PMID:12617754]
  Authors
Samsonova NN, Smirnov SV, Altman IB, Ptitsyn LR.
  Title
Molecular cloning and characterization of Escherichia coli K12 ygjG gene.
  Journal
BMC Microbiol 3:2 (2003)
DOI:10.1186/1471-2180-3-2
  Sequence
[eco:b3073]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.82
IUBMB Enzyme Nomenclature: 2.6.1.82
ExPASy - ENZYME nomenclature database: 2.6.1.82
BRENDA, the Enzyme Database: 2.6.1.82
CAS: 98982-73-1

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