KEGG   ENZYME: 2.6.1.84Help
Entry
EC 2.6.1.84                 Enzyme                                 

Name
arginine---pyruvate transaminase;
arginine:pyruvate transaminase;
AruH;
ATase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-arginine:pyruvate aminotransferase
Reaction(IUBMB)
L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine [RN:R08197]
Reaction(KEGG)
Substrate
L-arginine [CPD:C00062];
pyruvate [CPD:C00022]
Product
5-guanidino-2-oxopentanoate [CPD:C03771];
L-alanine [CPD:C00041]
Comment
A pyridoxal-phosphate protein. While L-arginine is the best substrate, the enzyme exhibits broad substrate specificity, with L-lysine, L-methionine, L-leucine, L-ornithine and L-glutamine also able to act as substrates, but more slowly. Pyruvate cannot be replaced by 2-oxoglutarate as amino-group acceptor. This is the first catalytic enzyme of the arginine transaminase pathway for L-arginine utilization in Pseudomonas aeruginosa. This pathway is only used when the major route of arginine catabolism, i.e. the arginine succinyltransferase pathway, is blocked.
History
EC 2.6.1.84 created 2007
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K12252  arginine:pyruvate transaminase
Genes
PAE: PA4976(aruH)
PAEV: N297_5148
PAEI: N296_5148
PAU: PA14_65770(aspC)
PAP: PSPA7_5709(aspC)
PAG: PLES_53641(aruH)
PAF: PAM18_5087(aruH)
PNC: NCGM2_0542(aspC)
PAEB: NCGM1900_5724(aspC)
PDK: PADK2_26370
PAEP: PA1S_26990
PAEM: U769_27255
PAEL: T223_27450
PAEU: BN889_05521(aruH)
PAEG: AI22_07005
PAEC: M802_5146
PAEO: M801_5013
PCQ: PcP3B5_02230(aruH)
PPU: PP_3721(aruH)
PPF: Pput_2042
PPT: PPS_3189
PPB: PPUBIRD1_2041(aspC)
PPI: YSA_09437
PPX: T1E_1732(aspC)
PPUH: B479_15825
PPUT: L483_19365
PPUN: PP4_21010(aspC)
PPUD: DW66_3460
PMON: X969_15335
PMOT: X970_14980
PPRC: PFLCHA0_c27760(aspC2) PFLCHA0_c33840(aspC3) PFLCHA0_c49990(yugH)
PFB: VO64_0254
PEN: PSEEN3003(aspC)
PKC: PKB_0124(aspc1)
PSEC: CCOS191_2783(aruH)
PANR: A7J50_2814
PSIL: PMA3_15850
AAUS: EP12_18740
SAGA: M5M_04555
MICC: AUP74_01586(aruH_1) AUP74_02850(aruH_2)
GAI: IMCC3135_11970(aruH_1) IMCC3135_23615(aruH_2)
CSA: Csal_0536
HEL: HELO_2764(aruH)
HBE: BEI_1553(aruH)
BCEN: DM39_3804
BCT: GEM_4550
BPSL: WS57_08055
BXE: Bxe_B1173
BXB: DR64_6490
BFN: OI25_6931
MLO: mlr1282
MES: Meso_1479
AMIH: CO731_02952(aruH)
SME: SMc02262
SMX: SM11_chr0192(aspC)
SMEL: SM2011_c02262(aspC)
SMER: DU99_02980
SMD: Smed_0178
SFD: USDA257_c01790(aspC2)
SAME: SAMCFNEI73_Ch0558(aspC)
EAD: OV14_1495
RHT: NT26_2963(aspC)
NGL: RG1141_CH32880(aruH)
SHZ: shn_00815
MMED: Mame_04622(aruH)
SIL: SPO2132(aspC-3) SPOA0066
JAN: Jann_1956
RDE: RD1_3185(aspC)
RLI: RLO149_c024100(aspC)
PGD: Gal_03952
OAT: OAN307_c22570(aspC)
OAR: OA238_c22200(aspC)
OTM: OSB_16290(aruH)
PTP: RCA23_c16670(aspC3)
MALG: MALG_01400
SPSE: SULPSESMR1_01753(aruH)
RMM: ROSMUCSMR3_01198(aruH)
LVS: LOKVESSMR4R_02264(aruH)
AHT: ANTHELSMS3_03017(aruH)
 » show all
Taxonomy
Reference
1  [PMID:17416668]
  Authors
Yang Z, Lu CD.
  Title
Characterization of an arginine:pyruvate transaminase in arginine catabolism of Pseudomonas aeruginosa PAO1.
  Journal
J Bacteriol 189:3954-9 (2007)
DOI:10.1128/JB.00262-07
  Sequence
[pae:PA4976]
Reference
2  [PMID:17416670]
  Authors
Yang Z, Lu CD.
  Title
Functional genomics enables identification of genes of the arginine transaminase pathway in Pseudomonas aeruginosa.
  Journal
J Bacteriol 189:3945-53 (2007)
DOI:10.1128/JB.00261-07
  Sequence
[pae:PA4976]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.84
IUBMB Enzyme Nomenclature: 2.6.1.84
ExPASy - ENZYME nomenclature database: 2.6.1.84
BRENDA, the Enzyme Database: 2.6.1.84

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