KEGG   ENZYME: 2.6.1.88Help
Entry
EC 2.6.1.88                 Enzyme                                 

Name
methionine transaminase;
methionine-oxo-acid transaminase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-methionine:2-oxo-acid aminotransferase
Reaction(IUBMB)
L-methionine + a 2-oxo carboxylate = 4-(methylsulfanyl)-2-oxobutanoate + an L-amino acid [RN:R08618]
Reaction(KEGG)
Substrate
L-methionine [CPD:C00073];
2-oxo carboxylate [CPD:C00161]
Product
4-(methylsulfanyl)-2-oxobutanoate [CPD:C01180];
L-amino acid [CPD:C00151]
Comment
The enzyme is most active with L-methionine. It participates in the L-methionine salvage pathway from S-methyl-5'-thioadenosine, a by-product of polyamine biosynthesis. The enzyme from the bacterium Klebsiella pneumoniae can use several different amino acids as amino donor, with aromatic amino acids being the most effective [1]. The enzyme from the plant Arabidopsis thaliana is also a part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates [3].
History
EC 2.6.1.88 created 2011
Pathway
ec00966  Glucosinolate biosynthesis
Orthology
K14287  methionine transaminase
K21346  methionine transaminase
Genes
ATH: AT3G19710(BCAT4)
ALY: ARALYDRAFT_898360(BCAT4)
CRB: 17892217
CSAT: 104765840
EUS: EUTSA_v10021016mg
BRP: 103859824(BCAT4-1) 103869425(BCAT4-2)
BNA: 106385828 106425083
BOE: 106292635 106332286
ECO: b0600(ybdL)
ECJ: JW0593(ybdL)
ECD: ECDH10B_0561(ybdL) ECDH10B_0669(ybdL)
EBW: BWG_0474(ybdL)
ECOK: ECMDS42_0462(ybdL)
ECE: Z0743(ybdL)
ECS: ECs0639
ETW: ECSP_0655(ybdL)
EOJ: ECO26_0676(ybdL)
EOI: ECO111_0631(ybdL)
EOH: ECO103_0609(ybdL)
ECOO: ECRM13514_0624(ybdL)
ECOH: ECRM13516_0568(ybdL)
ECG: E2348C_0503(ybdL)
EOK: G2583_0764(ybdL)
ESO: O3O_06710
ESM: O3M_18565
ESL: O3K_18585
ELH: ETEC_0630
EUN: UMNK88_634(ybdL)
ECC: c0688(ybdL)
ECP: ECP_0633
ECI: UTI89_C0603(ybdL)
ECV: APECO1_1449(ybdL)
ECY: ECSE_0668
ECR: ECIAI1_0585(ybdL)
ECQ: ECED1_0599(ybdL)
ECK: EC55989_0593(ybdL)
ECT: ECIAI39_0578(ybdL)
EOC: CE10_0601(ybdL)
EUM: ECUMN_0695(ybdL)
ESE: ECSF_0542
EBR: ECB_00568(ybdL)
EBD: ECBD_3053
EKF: KO11_20660(ybdL)
EAB: ECABU_c06510(ybdL)
EDJ: ECDH1ME8569_0571(ybdL)
ENA: ECNA114_0544(ybdL)
ELW: ECW_m0656(ybdL)
ELL: WFL_03260(ybdL)
ELC: i14_0662(ybdL)
ELD: i02_0662(ybdL)
ELP: P12B_c0585(ybdL)
EBL: ECD_00568(ybdL)
EBE: B21_00557(ybdL)
ELF: LF82_2589(ybdL)
ECOI: ECOPMV1_00619(ybdL)
ECOJ: P423_02950
ECOS: EC958_0721(ybdL)
EFE: EFER_2493(ybdL)
STY: STY0647
STT: t2265
STM: STM0603(ybdL)
SEO: STM14_0702(ybdL)
SEY: SL1344_0591(ybdL)
SEJ: STMUK_0608(ybdL)
SEB: STM474_0623(ybdL)
SENI: CY43_03300
SPT: SPA2131(ybdL)
SEK: SSPA1981
SEI: SPC_0615(ybdL)
SEC: SCH_0634(ybdL)
SHB: SU5_01293
SENS: Q786_02945
SED: SeD_A0700
SEG: SG0607(ybdL)
SEL: SPUL_2363(ybdL)
SEGA: SPUCDC_2349(ybdL)
SET: SEN0572(ybdL)
SENA: AU38_02925
SENO: AU37_02920
SENV: AU39_02925
SENQ: AU40_03215
SENL: IY59_02980
SEEP: I137_10775
SENB: BN855_5950
SENE: IA1_03160
SBG: SBG_0511
SBZ: A464_576
SFL: SF0515(ybdL)
SFX: S0520(ybdL)
SFV: SFV_0549(ybdL)
SFE: SFxv_0568(ybdL)
SFN: SFy_0670
SFS: SFyv_0709
SFT: NCTC1_00537(ybdL)
SSN: SSON_0552(ybdL)
ENC: ECL_03085
ECLO: ENC_21160
EEC: EcWSU1_01190(ybdL)
ECLX: LI66_05775
ECLY: LI62_06675
ECLZ: LI64_06275
ESA: ESA_02723
CSK: ES15_2793(ybdL)
CTU: CTU_12390(ybdL)
KPN: KPN_00645(ybdL)
KPU: KP1_1596(ybdL)
KPP: A79E_3595
KPE: KPK_3929
KPR: KPR_3931(ybdL)
KPX: PMK1_02978(ybdL)
KPNU: LI86_18875
KPNK: BN49_1703(ybdL)
KVA: Kvar_3722
KOX: KOX_14120
KOE: A225_1642
EAE: EAE_13740
EAR: CCG31223
CKO: CKO_02559
EBF: D782_3234
PSTS: E05_47260
YPS: YPTB0873(ybdL)
YPO: BZ17_1673
YPY: YPK_3322
YPB: YPTS_0914
YPQ: DJ40_1492
YPU: BZ21_118
YPR: BZ20_1174
YPC: BZ23_395
YPF: BZ19_231
YEN: YE3234(mntE)
YEY: Y11_21621
YEW: CH47_2602
YET: CH48_2604
YEE: YE5303_36911(mntE)
YAL: AT01_1545
YFR: AW19_2213
YIN: CH53_2774
YKR: CH54_3573
YRO: CH64_3494
SPE: Spro_0941
SRL: SOD_c07960(ybdL1)
SPLY: Q5A_004235(ybdL_1)
SMAF: D781_0891
SMW: SMWW4_v1c08670(ybdL)
SMAR: SM39_0246
SERF: L085_24095
RAA: Q7S_04470
ECA: ECA3488
PATR: EV46_17270
PATO: GZ59_35020
PCT: PC1_3304
PEC: W5S_3594
SOD: Sant_3153
DDD: Dda3937_00920(ybdL)
DDQ: DDI_3218
ETA: ETA_26110
EPY: EpC_27350
EPR: EPYR_02972(ybdL)
EAM: EAMY_0870(ybdL)
EAY: EAM_0882
EBI: EbC_08680
EGE: EM595_0863(ybdL1)
PAM: PANA_0870(ybdL)
PLF: PANA5342_3437(ybdL)
PAJ: PAJ_0205(ybdL)
PVA: Pvag_0263(ybdL)
PSTW: DSJ_19565
TPTY: NCTC11468_02959(ybdL_2)
PSX: DR96_2902
XFT: PD_1474(aspC)
XCC: XCC2218(ybdL)
XCB: XC_1899
XCA: xcc-b100_1962(aspC2)
XCP: XCR_2486
XCV: XCV2521
XAX: XACM_2330
XAC: XAC2322(ybdL)
XCI: XCAW_01987(ybdL)
XOO: XOO2156(ybdL)
XOM: XOO2025(XOO2025)
XOR: XOC_2718
XAL: XALC_1299
XPH: XppCFBP6546_01410(XppCFBP6546P_01410)
SML: Smlt3267
SMT: Smal_2698
SMZ: SMD_2841
PSUW: WQ53_00975
PSD: DSC_09235
LAQ: GLA29479_2738(ybdL)
LEZ: GLE_2824
LEM: LEN_2206
DKO: I596_1470
PAE: PA3798
PAEV: N297_3923
PAEI: N296_3923
PAU: PA14_14940(ybdL)
PNC: NCGM2_4985(ybdL)
PAEB: NCGM1900_1179(ybdL)
PAEP: PA1S_06065
PAEM: U769_05880
PAEL: T223_05785
PAEG: AI22_27530
PAEC: M802_3921
PAEO: M801_3789
PMY: Pmen_3495
PMK: MDS_3760
PPSE: BN5_3252
PCQ: PcP3B5_49780(ybdL)
PPU: PP_0858
PPF: Pput_0888
PPT: PPS_0924
PPI: YSA_06800
PPX: T1E_4182(ybdL)
PPUH: B479_04790
PPUT: L483_04340
PPUN: PP4_44160
PPUD: DW66_0887
PMON: X969_02865
PMOT: X970_02840
PSB: Psyr_1253
PSYR: N018_19430
PFL: PFL_4949(ybdL)
PPRC: PFLCHA0_c49340(ybdL)
PPRO: PPC_4959(ybdL)
PFS: PFLU_5052
PFC: PflA506_4359(ybdL)
PFW: PF1751_v1c45370(ybdL)
PFB: VO64_1933
PMAN: OU5_4661
PEN: PSEEN1026
PSA: PST_3025
PSTT: CH92_15365
PKC: PKB_1054(ybdL)
PSES: PSCI_0551
PSEM: TO66_25245
PSEC: CCOS191_0947(ybdL)
PSOS: POS17_4928(ybdL)
PANR: A7J50_4820
PSET: THL1_1201
PSIL: PMA3_24170
AVN: Avin_40190(pvdH)
AVL: AvCA_40190(pvdH)
AVD: AvCA6_40190(pvdH)
ACB: A1S_3370
ABY: ABAYE0111
ABN: AB57_3823
ABX: ABK1_3621
ABH: M3Q_118
ABAD: ABD1_32730
ABAZ: P795_0545
ABAU: IX87_13920
ABAA: IX88_01675
ACC: BDGL_002841(ybdL)
ACI: ACIAD3553
SWD: Swoo_0852
SVO: SVI_0692
SPSW: Sps_02660
PSM: PSM_A3021
PSEO: OM33_15855
PPHE: PP2015_167
PEA: PESP_a3744(ybdL)
PSPO: PSPO_b0244(ybdL)
PART: PARC_a0120(ybdL)
PTU: PTUN_a0120(ybdL)
PTD: PTET_a3411(ybdL)
PSEN: PNC201_16970(ybdL)
FTU: FTT_1413
FTQ: RO31_1658
FTF: FTF1413
FTW: FTW_0471
FTT: FTV_1350
FTG: FTU_1434
FTL: FTL_0648
FTM: FTM_0607
FTN: FTN_1380
FTX: AW25_622
FTD: AS84_1130
FTY: CH70_560
FPH: Fphi_1305
FPT: BZ13_696
FPI: BF30_1554
FPM: LA56_872
FPX: KU46_5
FPZ: LA55_1569
FPJ: LA02_964
FNA: OOM_0875
APAC: S7S_16200
PSPI: PS2015_107
RSO: RSc2011
RSE: F504_1962
RPI: Rpic_2166
REH: H16_A1104(h16_A1104)
CNC: CNE_1c10480(ybdL1)
RME: Rmet_0976(ybdL)
CTI: RALTA_A1089(ybdL)
CGD: CR3_0901(ybdL)
BMA: BMA1801
BMAL: DM55_2635
BMAE: DM78_2346
BMAQ: DM76_2620
BMAI: DM57_604
BMAF: DM51_1479
BMAZ: BM44_2570
BMAB: BM45_2136
BPS: BPSL1239
BPSE: BDL_788
BPSM: BBQ_2218
BPSU: BBN_2343
BPSD: BBX_2729
BPK: BBK_294
BPSH: DR55_3370
BPSA: BBU_965
BPSO: X996_2978
BUT: X994_1495
BTE: BTH_I1088
BTQ: BTQ_1112
BTJ: BTJ_1320
BTZ: BTL_2550
BTD: BTI_2609
BTV: BTHA_2823
BTHE: BTN_2100
BTHM: BTRA_2915
BTHA: DR62_2341
BTHL: BG87_2804
BOK: DM82_652
BOC: BG90_366
BVE: AK36_1657
BCN: Bcen_1613
BCJ: BCAL2320
BCEN: DM39_2324
BCEW: DM40_2875
BCEO: I35_2244
BAM: Bamb_2263
BMU: Bmul_1052
BMJ: BMULJ_02211(aspB)
BMK: DM80_2739
BMUL: NP80_2346
BCT: GEM_1186
BCED: DM42_2837
BDL: AK34_885
BCON: NL30_29165
BUB: BW23_2637
BLAT: WK25_10845
BTEI: WS51_21505
BSEM: WJ12_11270
BPSL: WS57_29925
BMEC: WJ16_11570
BSTG: WT74_11765
BGU: KS03_11
BGO: BM43_360
BUK: MYA_2017
BUL: BW21_2737
BXE: Bxe_A3182
BXB: DR64_883
BPH: Bphy_1981
BFN: OI25_403
PNU: Pnuc_0752
PNE: Pnec_1069
PPNO: DA70_06865
PPNM: LV28_23820
PPUL: RO07_18105
PSPU: NA29_19070
PAPI: SG18_16850
PLG: NCTC10937_01368(ybdL)
HYF: DTO96_102497(ybdL)
BPE: BP3870
BPC: BPTD_3813
BPER: BN118_3745
BPET: B1917_3881
BPEU: Q425_39190
BPA: BPP4424
BPAR: BN117_4557
BBR: BB5012
BPT: Bpet4979
BAV: BAV3423
BHO: D560_1384
BHM: D558_1374
BHZ: ACR54_04648(ybdL)
BTRM: SAMEA390648701221(ybdL)
AXY: AXYL_06502(ybdL)
AXX: ERS451415_06192(ybdL)
PUT: PT7_2922
AMIM: MIM_c40790
AFQ: AFA_18435
ODI: ODI_R0154
RFR: Rfer_2111
POL: Bpro_2403
PNA: Pnap_2174
AAV: Aave_3167
AJS: Ajs_1915
AAA: Acav_2088
ACRA: BSY15_3361
VEI: Veis_4927
DAC: Daci_3534
CTES: O987_17330
RTA: Rta_19370
LIM: L103DPR2_01732(ybdL)
LIH: L63ED372_01332(ybdL)
HYB: Q5W_12665
CBAA: SRAA_0412
CBAB: SMCB_0296
MPT: Mpe_A1947
MMS: mma_1383(aspB2)
JAG: GJA_2128
CFU: CFU_1583
CARE: LT85_3157
LCH: Lcho_2600
TIN: Tint_2583
THI: THI_2985(ybdL)
RGE: RGE_29190(ybdL)
PBH: AAW51_3111(ybdL)
EBA: ebA3890
DSU: Dsui_3376
DAR: Daro_3334
AZO: azo3359(ybdL)
AZA: AZKH_3928
AOA: dqs_3498
TCL: Tchl_1810
BPRC: D521_1018
SCL: sce8802
BMX: BMS_1675
BLQ: L21SP5_01998(ybdL)
CPI: Cpin_0778
FLN: FLA_5691
SGN: SGRA_3312
PHE: Phep_2072
MUC: MuYL_2641
MGOT: MgSA37_02640(ybdL)
CHU: CHU_0694(ybdL)
DFE: Dfer_2834
SLI: Slin_4804
LBY: Lbys_2742
FAE: FAES_3067
PSEZ: HME7025_00225(ybdL)
HSW: Hsw_3781
GFO: GFO_3151
GFL: GRFL_1237
FJO: Fjoh_0009
FJG: BB050_02505(ybdL)
FIN: KQS_09830
MARM: YQ22_08710
DDO: I597_0428(ybdL)
MLT: VC82_1434
NDO: DDD_1539
EAO: BD94_2283
ELB: VO54_00418(ybdL)
CHZ: CHSO_2340(ccbl) CHSO_3014(ccbl1)
WIN: WPG_1625
TJE: TJEJU_2067(ybdL)
AALG: AREALGSMS7_01472(ybdL)
SPON: HME9304_01615(ybdL)
KOS: KORDIASMS9_01567(ybdL)
MARF: CJ739_1170
FBA: FIC_00915
IAL: IALB_1859
CABY: Cabys_3305
 » show all
Taxonomy
Reference
1  [PMID:10074065]
  Authors
Heilbronn J, Wilson J, Berger BJ.
  Title
Tyrosine aminotransferase catalyzes the final step of methionine recycling in Klebsiella pneumoniae.
  Journal
J Bacteriol 181:1739-47 (1999)
  Sequence
Reference
2  [PMID:15280032]
  Authors
Dolzan M, Johansson K, Roig-Zamboni V, Campanacci V, Tegoni M, Schneider G, Cambillau C
  Title
Crystal structure and reactivity of YbdL from Escherichia coli identify a methionine aminotransferase function.
  Journal
FEBS Lett 571:141-6 (2004)
DOI:10.1016/j.febslet.2004.06.075
  Sequence
[eco:b0600]
Reference
3  [PMID:17056707]
  Authors
Schuster J, Knill T, Reichelt M, Gershenzon J, Binder S
  Title
Branched-chain aminotransferase4 is part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates in Arabidopsis.
  Journal
Plant Cell 18:2664-79 (2006)
DOI:10.1105/tpc.105.039339
  Sequence
[ath:AT3G19710]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.88
IUBMB Enzyme Nomenclature: 2.6.1.88
ExPASy - ENZYME nomenclature database: 2.6.1.88
BRENDA, the Enzyme Database: 2.6.1.88

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