KEGG   ENZYME: 2.6.1.98Help
Entry
EC 2.6.1.98                 Enzyme                                 

Name
UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase;
WbpE;
WlbC
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate:2-oxoglutarate aminotransferase
Reaction(IUBMB)
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate + 2-oxoglutarate = UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + L-glutamate [RN:R10141]
Reaction(KEGG)
Substrate
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate [CPD:C20359];
2-oxoglutarate [CPD:C00026]
Product
UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate [CPD:C20395];
L-glutamate [CPD:C00025]
Comment
A pyridoxal 5'-phosphate protein. This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide. The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the previous enzyme in the pathway, EC 1.1.1.335 (UDP-N-acetyl-2-amino-2-deoxyglucuronate oxidase).
History
EC 2.6.1.98 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
Orthology
K13017  UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase
Genes
PLU: plu4799(wblD)
PLUM: A4R40_23870
PAY: PAU_04314(wblD)
PTT: VY86_07530
XBO: XBJ1_4316
XNE: XNC1_0114
XNM: XNC2_0116
MSU: MS1498(wecE)
ASU: Asuc_0108
AAZ: ADJ80_05785
PAE: PA3155(wbpE)
PAEV: N297_3266(wbpE)
PAEI: N296_3266(wbpE)
PAEM: U769_09137
PAEC: M802_3264(wbpE)
PAEO: M801_3131(wbpE)
PMY: Pmen_1860
PPUH: B479_06915
PSES: PSCI_2868
PSOS: POS17_4989
PSET: THL1_1979
PALI: A3K91_0721
ACB: A1S_0055
ACC: BDGL_002974(degT)
CBU: CBU_0825
CBD: CBUD_0890
CBG: CbuG_1176
CBC: CbuK_0693
LPN: lpg1424
LPH: LPV_1541
LPO: LPO_1421
LPM: LP6_1405(dnrJ)
LPF: lpl1375
LPP: lpp1379
LPC: LPC_0840
LPA: lpa_02088
LPE: lp12_1362
LLO: LLO_1795
LFA: LFA_1370(wbpE)
LHA: LHA_1875(degT)
LOK: Loa_02109
LCD: clem_05795(wbpE)
LLG: 44548918_01052(arnB_1)
TMC: LMI_1805(degT)
TIG: THII_3198
TNI: TVNIR_0691(degT_[H])
HCO: LOKO_02147(wbpE)
ADI: B5T_01710
SALN: SALB1_3707
ENM: EBS_1934
CVI: CV_4124
LHK: LHK_02803
PSE: NH8B_0416
REH: H16_B0031(wbpE)
PPNO: DA70_17280
BPE: BP0091(bplC)
BPC: BPTD_0087(bplC)
BPER: BN118_0160(wlbC)
BPET: B1917_0094(bplC)
BPEU: Q425_2040(bplC)
BPA: BPP0153(bplC)
BPAR: BN117_0151(wlbC)
BBR: BB0153(bplC)
BBM: BN115_0142(wlbC)
BBH: BN112_3258(wlbC)
BBX: BBS798_0152(bplC)
BPT: Bpet4818(wlbC)
BAV: BAV0096(wlbC)
BHO: D560_1330(wbpE)
BHM: D558_1319(wbpE)
BHZ: ACR54_00108(wbpE)
BTRM: SAMEA390648701340(wlbC)
AXX: ERS451415_06025(arnB_1)
TEA: KUI_0410
TEG: KUK_0144
ODI: ODI_R2824
PNA: Pnap_3126
AAV: Aave_0952
AJS: Ajs_3018
CTES: O987_08020
HYB: Q5W_21485
HSE: Hsero_4197(wecE)
LCH: Lcho_0293
RGE: RGE_41550
HHE: HH_0627(wlaK)
HMS: HMU06610
HCP: HCN_0250(wlaK)
HCB: HCBAA847_0255(wlaK)
WSU: WS2186(WLBC)
CJI: CJSA_0475
CJM: CJM1_0483(degT)
CJS: CJS3_0498
CJEJ: N564_00492
CJEU: N565_00540
CJEN: N755_00539
CJEI: N135_00555
CJER: H730_03415
CJY: QZ67_00515(wbpE)
CJQ: UC78_0492(wbpE)
CCQ: N149_0497
CCF: YSQ_07315
CCY: YSS_02340
CCOI: YSU_06325
CCOF: VC76_02655(wbpE)
CCOO: ATE51_03192(wbpE)
CIS: CINS_1035
CVO: CVOL_1045
CPEL: CPEL_1175
CCUN: CCUN_0150
CAVI: CAV_0737
ABU: Abu_0664
SULJ: SJPD1_2062
NIS: NIS_1315
SUN: SUN_0095
GLO: Glov_1506
GEB: GM18_1435
DOL: Dole_1837
BBAT: Bdt_1685
BBAC: EP01_04625
BEX: A11Q_1879
PUV: PUV_00150(degT)
WCH: wcw_1823(wbpE)
BRM: Bmur_0965
BPW: WESB_0221
BIP: Bint_0303
ACA: ACP_3532
ABAS: ACPOL_2417
FSC: FSU_0637
ZGA: ZOBELLIA_1739(fdtB)
TTK: TST_1661(wbpE)
 » show all
Taxonomy
Reference
1  [PMID:19282284]
  Authors
Westman EL, McNally DJ, Charchoglyan A, Brewer D, Field RA, Lam JS
  Title
Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the  biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas  aeruginosa.
  Journal
J Biol Chem 284:11854-62 (2009)
DOI:10.1074/jbc.M808583200
  Sequence
[pae:PA3155]
Reference
2  [PMID:19348502]
  Authors
Larkin A, Imperiali B
  Title
Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1.
  Journal
Biochemistry 48:5446-55 (2009)
DOI:10.1021/bi900186u
  Sequence
[pae:PA3155]
Reference
3  [PMID:20604544]
  Authors
Larkin A, Olivier NB, Imperiali B
  Title
Structural analysis of WbpE from Pseudomonas aeruginosa PAO1: a nucleotide sugar  aminotransferase involved in O-antigen assembly.
  Journal
Biochemistry 49:7227-37 (2010)
DOI:10.1021/bi100805b
  Sequence
[pae:PA3155]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.98
IUBMB Enzyme Nomenclature: 2.6.1.98
ExPASy - ENZYME nomenclature database: 2.6.1.98
BRENDA, the Enzyme Database: 2.6.1.98

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