KEGG   ENZYME: 2.6.1.99Help
Entry
EC 2.6.1.99                 Enzyme                                 

Name
L-tryptophan---pyruvate aminotransferase;
TAA1 (gene name);
vt2 (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-tryptophan:pyruvate aminotransferase
Reaction(IUBMB)
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine [RN:R10180]
Reaction(KEGG)
Substrate
L-tryptophan [CPD:C00078];
pyruvate [CPD:C00022]
Product
indole-3-pyruvate [CPD:C00331];
L-alanine [CPD:C00041]
Comment
This plant enzyme, along with EC 1.14.13.168, indole-3-pyruvate monooxygenase, is responsible for the biosynthesis of the plant hormone indole-3-acetate from L-tryptophan.
History
EC 2.6.1.99 created 2012
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K16903  L-tryptophan---pyruvate aminotransferase
Genes
ATH: AT1G23320(TAR1) AT1G70560(TAA1) AT4G24670(TAR2)
ALY: ARALYDRAFT_335577 ARALYDRAFT_476182 ARALYDRAFT_492374
CRB: 17877519 17894004 17900474
CSAT: 104701697 104712605 104720137 104722517 104730979 104743484 104750895 104759380 104778836
EUS: EUTSA_v10009685mg EUTSA_v10018719mg EUTSA_v10025236mg
BRP: 103831591 103840774 103840776 103852664 103862382 108869691
BNA: 106353777 106374472 106375778 106395273 106400436 106400463 106404922 106430840 106442204 111207310
BOE: 106294041 106294077 106299425 106321880 106322583 106325109
THJ: 104809038 104809260 104822161 104822981
CPAP: 110813115 110816856
LJA: Lj1g3v0318800.1(Lj1g3v0318800.1) Lj1g3v0318800.2(Lj1g3v0318800.2) Lj1g3v0329870.1(Lj1g3v0329870.1) Lj2g3v1415340.1(Lj2g3v1415340.1) Lj2g3v1415360.1(Lj2g3v1415360.1) Lj2g3v1415390.1(Lj2g3v1415390.1) Lj4g3v1451990.1(Lj4g3v1451990.1)
DOSA: Os01t0169800-01(Os01g0169800) Os05t0169300-01(Os05g0169300)
ATS: 109740802(LOC109740802) 109749870(LOC109749870) 109779434(LOC109779434)
ATR: 18422576
 » show all
Taxonomy
Reference
1  [PMID:18394996]
  Authors
Tao Y, Ferrer JL, Ljung K, Pojer F, Hong F, Long JA, Li L, Moreno JE, Bowman ME, Ivans LJ, Cheng Y, Lim J, Zhao Y, Ballare CL, Sandberg G, Noel JP, Chory J
  Title
Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants.
  Journal
Cell 133:164-76 (2008)
DOI:10.1016/j.cell.2008.01.049
  Sequence
Reference
2  [PMID:22025724]
  Authors
Mashiguchi K, Tanaka K, Sakai T, Sugawara S, Kawaide H, Natsume M, Hanada A, Yaeno T, Shirasu K, Yao H, McSteen P, Zhao Y, Hayashi K, Kamiya Y, Kasahara H
  Title
The main auxin biosynthesis pathway in Arabidopsis.
  Journal
Proc Natl Acad Sci U S A 108:18512-7 (2011)
DOI:10.1073/pnas.1108434108
  Sequence
[ath:AT1G70560]
Reference
3  [PMID:21335375]
  Authors
Phillips KA, Skirpan AL, Liu X, Christensen A, Slewinski TL, Hudson C, Barazesh S, Cohen JD, Malcomber S, McSteen P
  Title
vanishing tassel2 encodes a grass-specific tryptophan aminotransferase required for vegetative and reproductive development in maize.
  Journal
Plant Cell 23:550-66 (2011)
DOI:10.1105/tpc.110.075267
  Sequence
[zma:103634861]
Reference
4  [PMID:22155950]
  Authors
Zhao Y
  Title
Auxin biosynthesis: a simple two-step pathway converts tryptophan to indole-3-acetic acid in plants.
  Journal
Mol Plant 5:334-8 (2012)
DOI:10.1093/mp/ssr104
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.99
IUBMB Enzyme Nomenclature: 2.6.1.99
ExPASy - ENZYME nomenclature database: 2.6.1.99
BRENDA, the Enzyme Database: 2.6.1.99

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