KEGG   ENZYME: 2.7.1.1
Entry
EC 2.7.1.1                  Enzyme                                 

Name
hexokinase;
hexokinase type IV glucokinase;
hexokinase D;
hexokinase type IV;
hexokinase (phosphorylating);
ATP-dependent hexokinase;
glucose ATP phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:D-hexose 6-phosphotransferase
Reaction(IUBMB)
ATP + D-hexose = ADP + D-hexose 6-phosphate [RN:R02848]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
D-hexose [CPD:C00738]
Product
ADP [CPD:C00008];
D-hexose 6-phosphate [CPD:C02965]
Comment
D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
History
EC 2.7.1.1 created 1961
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec00051  Fructose and mannose metabolism
ec00052  Galactose metabolism
ec00500  Starch and sucrose metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
ec00521  Streptomycin biosynthesis
ec00524  Neomycin, kanamycin and gentamicin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00844  hexokinase
Genes
HSA: 3098(HK1) 3099(HK2) 3101(HK3) 80201(HKDC1)
PTR: 450504(HKDC1) 450505(HK1) 462298(HK3) 741291(HK2)
PPS: 100969639(HKDC1) 100969975(HK1) 100983149(HK2) 100990081(HK3)
GGO: 101125395(HK2) 101127052(HKDC1) 101131029(HK1) 101146050(HK3)
PON: 100172246(HK1) 100433183(HKDC1) 100458288(HK3) 100460834(HK2)
NLE: 100591401(HK3) 100593006(HK2) 100595352(HKDC1) 100595917(HK1)
MCC: 698120(HK3) 710479(HK2) 711922(HK1) 711995(HKDC1)
MCF: 102121518(HK2) 102145864(HK1) 102147228(HKDC1) 107126374(HK3)
CSAB: 103216074(HK1) 103216076(HKDC1) 103220012(HK2) 103245036(HK3)
RRO: 104661961(HKDC1) 104661963(HK1) 104674833(HK2) 104680441(HK3)
RBB: 108530364(HK1) 108530366(HKDC1) 108531690(HK2) 108544799(HK3)
CJC: 100385141(HKDC1) 100396473(HK2) 100413117(HK1) 100415061(HK3)
SBQ: 101029285(HK3) 101047051(HK1) 101047634(HK2) 101049162(HKDC1)
MMU: 15275(Hk1) 15277(Hk2) 212032(Hk3) 216019(Hkdc1)
MCAL: 110296267(Hk2) 110302692(Hk1) 110303354(Hkdc1) 110307543(Hk3)
MPAH: 110314383(Hk2) 110326557(Hkdc1) 110326866(Hk1) 110334200(Hk3)
RNO: 100364027 25058(Hk1) 25059(Hk2) 25060(Hk3)
MUN: 110549757(Hk3) 110561607(Hk2) 110563779(Hk1) 110563780(Hkdc1)
CGE: 100765413(Hk1) 100765703(Hkdc1) 100765901(Hk3) 100772205(Hk2)
NGI: 103726981(Hk2) 103729731(Hk1) 103729733(Hkdc1) 103745389(Hk3)
HGL: 101706410(Hk3) 101708521(Hkdc1) 101709130(Hk1) 101722401(Hk2)
CCAN: 109684938(Hkdc1) 109685239(Hk1) 109685772(Hk3) 109697922(Hk2)
OCU: 100338214(HK2) 100340945(HK1) 100340994(HK3) 100345105(HKDC1)
TUP: 102479777(HK3) 102493365(HK1) 102494607(HKDC1) 102499175(HK2)
CFA: 100856448(HK2) 479234(HK1) 489019(HKDC1) 489096(HK3)
VVP: 112916701(HK2) 112923912(HKDC1) 112923920(HK1) 112925741(HK3)
AML: 100470774(HK2) 100475939(HKDC1) 100483014(HK3) 100483319(HK1)
UMR: 103664456(HK3) 103667783(HKDC1) 103668004(HK1) 103671429(HK2)
UAH: 113243430(HK2) 113259127(HKDC1) 113259128(HK1) 113264133(HK3)
ORO: 101373969(HK1) 101374267(HKDC1) 101383196(HK3) 101384043(HK2)
FCA: 101080358(HK3) 101089344(HK2) 101094295(HKDC1) 101098403(HK1)
PTG: 102952730(HK3) 102955671(HK1) 102956632(HKDC1) 102962533(HK2)
PPAD: 109263394(HK2) 109264349(HK1) 109264350(HKDC1) 109267563(HK3)
AJU: 106967150(HKDC1) 106967151(HK1) 106972962(HK2) 106975401(HK3)
BTA: 280817(HK1) 614824(HKDC1) 788926(HK2)
BOM: 102268099(HKDC1) 102270322(HK1) 102274810(HK2) 102275095(HK3)
BBUB: 102406489(HK1) 102407034(HKDC1) 102408948(HK3) 102414046(HK2)
CHX: 102168356(HK2) 102182403(HK3) 102189736(HKDC1) 102190759(HK1)
OAS: 100036759(HK1) 101107690(HK2) 101107841(HKDC1) 101119209(HK3)
SSC: 100152344(HK1) 100153520(HKDC1) 100522855(HK3) 494561(HK2)
CFR: 102509660(HK1) 102509897(HKDC1) 102511221(HK3) 102518387(HK2)
CDK: 105085304(HK2) 105099579(HK3) 105099882(HK1) 105099884(HKDC1)
BACU: 103000123(HK1) 103000583(HKDC1) 103005558(HK2) 103011120(HK3)
LVE: 103077114(HK3) 103078924(HK2) 103085238(HK1) 103085507(HKDC1)
OOR: 101271458(HK1) 101271708(HKDC1) 101278255(HK2) 101281461(HK3)
DLE: 111169081(HK2) 111169843(HK3) 111183455(HKDC1) 111183456(HK1)
ECB: 100009677(HK2) 100068725(HK3) 100072686(HKDC1) 100072687(HK1)
EPZ: 103549373(HK1) 103549388(HKDC1) 103557323(HK3) 103557674(HK2)
EAI: 106821924(HK3) 106835132(HK2) 106845014(HKDC1) 106845016(HK1)
MYB: 102243213(HK1) 102246049(HK2) 102259488(HK3) 102263651(HKDC1)
MYD: 102760926(HK3) 102762722(HKDC1) 102763004(HK1) 102767710(HK2)
MNA: 107525054(HK3) 107526031(HK1) 107526078(HKDC1) 107529247(HK2)
HAI: 109371220(HK2) 109372136(HKDC1) 109372148(HK1) 109389785(HK3)
DRO: 112302963(HK2) 112305499(HK1) 112305506(HKDC1) 112320357(HK3)
PALE: 102878115(HK3) 102892478(HK2) 102894665(HKDC1) 102898766(HK1)
RAY: 107502916(HK2) 107504088(HK1) 107504095(HKDC1) 107517523(HK3)
LAV: 100660114(HK2) 100661681(HK3) 100669094(HK1) 100677445(HKDC1)
MDO: 100015984(HKDC1) 100031311(HK1) 100031793(HK3) 100032849(HK2)
SHR: 100919294(HK3) 100926799(HK1) 100930478 116421983(HKDC1)
PCW: 110200049(HK1) 110200090(HKDC1) 110207611(HK2) 110216727(HK3)
OAA: 100074718(HK2) 100079843(HK3) 100085443(HK1) 100088018(HKDC1)
GGA: 373889(HK1) 374044(HK2) 423698(HKDC1) 768421(HK3)
SCAN: 103817507(HK3) 103822724 103823724(HKDC1) 103823725(HK1)
GFR: 102031971(HK1) 102032137(HKDC1) 102042831(HK2) 102044178(HK3)
FAB: 101810322(HK2) 101813440(HK3) 101814475(HKDC1) 101814878(HK1)
PHI: 102099289(HKDC1) 102099472(HK1) 102100727(HK3) 102107271(HK2)
FPG: 101917382(HK3) 101918504(HK1) 101918678(HKDC1) 101919932(HK2)
FCH: 102055063(HK1) 102055236(HKDC1) 102055764(HK3) 102056548
EGZ: 104124621(HK1) 104124622(HKDC1) 104128868(HK3) 104130346(HK2)
NNI: 104013489(HKDC1) 104013490(HK1) 104017587(HK2) 104018992(HK3)
PADL: 103918476(HK1) 103918477(HKDC1) 103918816(HK3) 103919658(HK2)
CMY: 102930728 102933769(HKDC1) 102934001(HK1)
CPIC: 101931154(HK1) 101931432(HKDC1) 101943345(HK2) 101948904(HK3)
ACS: 100560089(hk3) 100564618 100566564(hkdc1) 100566756(hk1)
DRE: 321224(hkdc1) 406339(hk2) 406791(hk1)
IPU: 108255852 108263365(hk1) 108263366(hkdc1)
AMEX: 103028521(hk1) 103036666(hk3) 103047009
LCM: 102359026(HK3) 102363536(HK2) 102364429(HKDC1) 102364683(HK1)
BFO: 118414727
DME: Dmel_CG3001(Hex-A) Dmel_CG32849(Hex-t2) Dmel_CG33102(Hex-t1) Dmel_CG8094(Hex-C)
DSI: Dsimw501_GD21281(Dsim_Hex-t1) Dsimw501_GD21282(Dsim_Hex-t2) Dsimw501_GD24777(Dsim_GD24777) Dsimw501_GD25630(Dsim_GD25630)
DYA: Dyak_GE12255(Dyak_Hex-C) Dyak_GE17799(Dyak_Hex-A) Dyak_GE23668(Dyak_Hex-t1) Dyak_GE23669(Dyak_Hex-t2)
AAG: 5571932
OBB: 114872100
NVI: 100121683
CSOL: 105368881
NVL: 108565519
CLEC: 106661784
CEL: CELE_F14B4.2(hxk-1)
CBR: CBG19465
TSP: Tsp_08386
SHX: MS3_10478
NVE: 5515074
EPA: 110238574
ADF: 107330418
AMIL: 114975924
DGT: 114516190
HMG: 100212254
AQU: 100639704
ATH: AT1G47840(HXK3) AT1G50460(HKL1) AT2G19860(HXK2) AT3G20040(ATHXK4) AT4G29130(HXK1) AT4G37840(HKL3)
LJA: Lj0g3v0022069.1(Lj0g3v0022069.1) Lj0g3v0022669.1(Lj0g3v0022669.1) Lj0g3v0323989.1(Lj0g3v0323989.1) Lj1g3v1302660.1(Lj1g3v1302660.1) Lj2g3v0852070.1(Lj2g3v0852070.1) Lj2g3v0852070.2(Lj2g3v0852070.2) Lj2g3v2089780.3(Lj2g3v2089780.3) Lj2g3v2537560.1(Lj2g3v2537560.1) Lj3g3v2318220.1(Lj3g3v2318220.1) Lj4g3v3043790.1(Lj4g3v3043790.1) Lj4g3v3043790.2(Lj4g3v3043790.2) Lj5g3v0186690.1(Lj5g3v0186690.1)
SLY: 101249034 101256649 543638(Hxk2) 543779(hxk1) 778210(HXK3) 778211(HXK4)
DOSA: Os01t0190400-01(Os01g0190400) Os01t0722700-01(Os01g0722700) Os01t0742500-01(Os01g0742500) Os01t0940100-01(Os01g0940100) Os05t0187100-01(Os05g0187100) Os05t0375100-00(Os05g0375100) Os05t0522500-01(Os05g0522500) Os07t0446800-00(Os07g0446800)
ATS: 109733490(LOC109733490) 109736761(LOC109736761) 109737843(LOC109737843) 109742409(LOC109742409) 109759197(LOC109759197) 109770855(LOC109770855) 109775221(LOC109775221) 109781800(LOC109781800) 109783982(LOC109783982)
CRE: CHLREDRAFT_21582(HXK1)
VCN: VOLCADRAFT_67129(hxk1)
APRO: F751_3201
SCE: YCL040W(GLK1) YDR516C(EMI2) YFR053C(HXK1) YGL253W(HXK2) YLR446W
KMX: KLMA_10051(GLK1) KLMA_60412(RAG5)
NCS: NCAS_0A00340(NCAS0A00340) NCAS_0B08930(NCAS0B08930) NCAS_0E00180(NCAS0E00180) NCAS_0F04080(NCAS0F04080)
NDI: NDAI_0A00320(NDAI0A00320) NDAI_0B06350(NDAI0B06350) NDAI_0F04460(NDAI0F04460) NDAI_0I03320(NDAI0I03320) NDAI_0J02790(NDAI0J02790)
TPF: TPHA_0B01640(TPHA0B01640) TPHA_0B04850(TPHA0B04850) TPHA_0E03770(TPHA0E03770) TPHA_0G03730(TPHA0G03730)
TBL: TBLA_0A05050(TBLA0A05050) TBLA_0A07540(TBLA0A07540) TBLA_0B06320(TBLA0B06320) TBLA_0E00110(TBLA0E00110) TBLA_0I03540(TBLA0I03540)
TDL: TDEL_0C06700(TDEL0C06700) TDEL_0D06490(TDEL0D06490)
KAF: KAFR_0D00310(KAFR0D00310) KAFR_0E04210(KAFR0E04210) KAFR_0G01260(KAFR0G01260) KAFR_0J00110(KAFR0J00110) KAFR_0J02970(KAFR0J02970)
PIC: PICST_32526(NAG5) PICST_73701(GLK1) PICST_85453(HXK1)
SLB: AWJ20_2590(HXK2) AWJ20_361(GLK1) AWJ20_4024(HXK2)
NTE: NEUTE1DRAFT119084(NEUTE1DRAFT_119084) NEUTE1DRAFT126829(NEUTE1DRAFT_126829) NEUTE1DRAFT87040(NEUTE1DRAFT_87040)
ANG: ANI_1_1030104(An12g08610) ANI_1_1984024(An02g14380) ANI_1_378054(An06g00380) ANI_1_66114(An13g00510)
SPO: SPAC24H6.04(hxk1) SPAC4F8.07c(hxk2)
ABP: AGABI1DRAFT114620(AGABI1DRAFT_114620) AGABI1DRAFT57808(AGABI1DRAFT_57808)
ABV: AGABI2DRAFT184646(AGABI2DRAFT_184646) AGABI2DRAFT194802(AGABI2DRAFT_194802)
MGL: MGL_1289
MRT: MRET_2854
EHI: EHI_098290(77.t00021) EHI_098560(19.t00020)
PCB: PCHAS_112240(PC301118.00.0)
BBO: BBOV_I000860(16.m00773)
CPV: cgd6_3800
SCL: sce6033(hxk)
CCE: Ccel_3221
DRM: Dred_1810
DAE: Dtox_3946
HMO: HM1_0763
MHG: MHY_04720
PUF: UFO1_4440
PFT: JBW_00035
TPA: TP_0505
TPP: TPASS_0505(hxk)
TPB: TPFB_0505
TDE: TDE2469
TPED: TPE_0072
BTH: BT_2430
BFR: BF2523
BXY: BXY_18040
PDI: BDI_1250
DORI: FH5T_05565
 » show all
Reference
1  [PMID:16748250]
  Authors
Bailey K, Webb EC.
  Title
Purification of yeast hexokinase and its reaction with betabeta'-dichlorodiethyl sulphide.
  Journal
Biochem J 42:60-8 (1948)
DOI:10.1042/bj0420060
Reference
2  [PMID:19873467]
  Authors
Berger L, Slein MW, Colowick SP, Cori CF
  Title
ISOLATION OF HEXOKINASE FROM BAKER'S YEAST.
  Journal
J Gen Physiol 29:379-91 (1946)
Reference
3  [PMID:19873468]
  Authors
Kunitz M, McDonald MR
  Title
CRYSTALLINE HEXOKINASE (HETEROPHOSPHATESE) : METHOD OF ISOLATION AND PROPERTIES.
  Journal
J Gen Physiol 29:393-412 (1946)
Reference
4  [PMID:7048063]
  Authors
Pollard-Knight D, Cornish-Bowden A.
  Title
Mechanism of liver glucokinase.
  Journal
Mol Cell Biochem 44:71-80 (1982)
DOI:10.1007/bf00226892
Reference
5  [PMID:233226]
  Authors
Ureta T, Radojkovic J, Lagos R, Guixe V, Nunez L.
  Title
Phylogenetic and ontogenetic studies of glucose phosphorylating isozymes of vertebrates.
  Journal
Arch Biol Med Exp (Santiago) 12:587-604 (1979)
Reference
6  [PMID:6477520]
  Authors
Cardenas ML, Rabajille E, Niemeyer H.
  Title
Fructose is a good substrate for rat liver 'glucokinase' (hexokinase D).
  Journal
Biochem J 222:363-70 (1984)
DOI:10.1042/bj2220363
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.1
IUBMB Enzyme Nomenclature: 2.7.1.1
ExPASy - ENZYME nomenclature database: 2.7.1.1
UM-BBD (Biocatalysis/Biodegradation Database): 2.7.1.1
BRENDA, the Enzyme Database: 2.7.1.1
CAS: 9001-51-8

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