| Entry |
|
|---|
| Name |
diacylglycerol kinase (ATP);
diglyceride kinase (ambiguous);
1,2-diacylglycerol kinase (phosphorylating) (ambiguous);
1,2-diacylglycerol kinase (ambiguous);
sn-1,2-diacylglycerol kinase (ambiguous);
DG kinase (ambiguous);
DGK (ambiguous);
ATP:diacylglycerol phosphotransferase;
arachidonoyl-specific diacylglycerol kinase;
diacylglycerol:ATP kinase;
ATP:1,2-diacylglycerol 3-phosphotransferase;
diacylglycerol kinase (ATP dependent)
|
|---|
| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
|---|
| Sysname |
ATP:1,2-diacyl-sn-glycerol 3-phosphotransferase
|
|---|
| Reaction(IUBMB) |
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate [RN: R02240]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
ADP [CPD: C00008];
1,2-diacyl-sn-glycerol 3-phosphate [CPD: C00416]
|
|---|
| Comment |
Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. Activity is stimulated by certain phospholipids [4,7]. In plants and animals the product 1,2-diacyl-sn-glycerol 3-phosphate is an important second messenger. cf. EC 2.7.1.174, diacylglycerol kinase (CTP).
|
|---|
| History |
EC 2.7.1.107 created 1984, modified 2013
|
|---|
| Pathway |
| ec00564 | Glycerophospholipid metabolism |
| ec01110 | Biosynthesis of secondary metabolites |
|
|---|
| Orthology |
| K00901 | diacylglycerol kinase (ATP) |
| K07029 | diacylglycerol kinase (ATP) |
|
|---|
| Genes |
» show all
 |
|---|
| Reference |
|
|---|
| Authors |
HOKIN LE, HOKIN MR. |
|---|
| Title |
Diglyceride kinase and other path ways for phosphatidic acid synthesis in the erythrocyte membrane. |
|---|
| Journal |
Biochim Biophys Acta 67:470-84 (1963) |
|---|
| Reference |
|
|---|
| Authors |
Weissbach H, Thomas E, Kaback HR. |
|---|
| Title |
Studies on the metabolism of ATP by isolated bacterial membranes: formation and metabolism of membrane-bound phosphatidic acid. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Daleo GR, Piras MM, Piras R. |
|---|
| Title |
Diglyceride kinase activity of microtubules. Characterization and comparison with the protein kinase and ATPase activities associated with vinblastine-isolated tubulin of chick embryonic muscles. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Walsh JP, Bell RM |
|---|
| Title |
sn-1,2-Diacylglycerol kinase of Escherichia coli. Structural and kinetic analysis of the lipid cofactor dependence. |
|---|
| Journal |
J Biol Chem 261:15062-9 (1986) |
|---|
| Reference |
|
|---|
| Authors |
Russ E, Kaiser U, Sandermann H Jr |
|---|
| Title |
Lipid-dependent membrane enzymes. Purification to homogeneity and further characterization of diacylglycerol kinase from Escherichia coli. |
|---|
| Journal |
Eur J Biochem 171:335-42 (1988) |
|---|
| Reference |
|
|---|
| Authors |
Walsh JP, Bell RM |
|---|
| Title |
Diacylglycerol kinase from Escherichia coli. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Wissing JB, Wagner KG |
|---|
| Title |
Diacylglycerol kinase from suspension cultured plant cells : characterization and subcellular localization. |
|---|
| Journal |
Plant Physiol 98:1148-53 (1992) |
|---|
| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.7.1.107 |
|
|---|
