KEGG   ENZYME: 2.7.1.134Help
Entry
EC 2.7.1.134                Enzyme                                 

Name
inositol-tetrakisphosphate 1-kinase;
1D-myo-inositol-tetrakisphosphate 1-kinase;
inositol-trisphosphate 6-kinase;
1D-myo-inositol-trisphosphate 6-kinase;
ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase;
inositol-trisphosphate 5-kinase;
1D-myo-inositol-trisphosphate 5-kinase;
ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase
Reaction(IUBMB)
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:R03479]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1D-myo-inositol 3,4,5,6-tetrakisphosphate [CPD:C04520]
Product
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:C01284]
Comment
This enzyme also phosphorylates Ins(1,3,4)P3 on O-5 and O-6. The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. It can also catalyse an isomerization between Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP.
History
EC 2.7.1.134 created 1990, (EC 2.7.1.133 created 1989, incorporated 2002; EC 2.7.1.139 created 1992, incorporated 2002), modified 2002
Pathway
ec00562  Inositol phosphate metabolism
Orthology
K00913  inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase
Genes
HSA: 3705(ITPK1)
PTR: 453121(ITPK1)
PPS: 100980755(ITPK1)
GGO: 101134664(ITPK1)
PON: 100448118(ITPK1)
NLE: 100590495(ITPK1)
MCC: 698756(ITPK1)
MCF: 102119398(ITPK1)
CSAB: 103229579(ITPK1)
RRO: 104679048(ITPK1)
RBB: 108519106(ITPK1)
CJC: 100396941(ITPK1)
SBQ: 101039869(ITPK1)
MMU: 217837(Itpk1)
RNO: 500709(Itpk1)
CGE: 100768438(Itpk1)
NGI: 103724593(Itpk1)
HGL: 101700462(Itpk1)
CCAN: 109693572(Itpk1)
OCU: 100345790(ITPK1)
TUP: 102479480(ITPK1)
CFA: 490591(ITPK1)
AML: 100484787(ITPK1)
UMR: 103673773(ITPK1)
ORO: 101385854(ITPK1)
FCA: 101087672(ITPK1)
PTG: 102951160(ITPK1)
AJU: 106980827(ITPK1)
BTA: 518488(ITPK1)
BOM: 102279411(ITPK1)
BIU: 109575578(ITPK1)
PHD: 102333268(ITPK1)
CHX: 102183460(ITPK1)
OAS: 101115161(ITPK1)
SSC: 100152339(ITPK1)
CFR: 102508931(ITPK1)
CDK: 105095826(ITPK1)
BACU: 103011955(ITPK1)
LVE: 103084508(ITPK1)
OOR: 101270326(ITPK1)
ECB: 100063828(ITPK1)
EPZ: 103556533(ITPK1)
EAI: 106825383(ITPK1)
MYB: 102246792(ITPK1)
MYD: 102764458(ITPK1) 102773325
HAI: 109376793(ITPK1)
RSS: 109442311 109454623(ITPK1)
PALE: 102877958(ITPK1)
LAV: 100668527(ITPK1)
TMU: 101341573
MDO: 100014342(ITPK1)
SHR: 100924957(ITPK1) 111719345
OAA: 100079832(ITPK1)
GGA: 423421(ITPK1)
MGP: 100541150(ITPK1)
CJO: 107315185(ITPK1)
APLA: 101801656(ITPK1)
ACYG: 106033487(ITPK1)
TGU: 100222999(ITPK1)
GFR: 102034047(ITPK1)
FAB: 101819235(ITPK1)
PHI: 102106037(ITPK1)
PMAJ: 107205493(ITPK1)
CCAE: 111929864(ITPK1)
CCW: 104688688(ITPK1)
FPG: 101920131(ITPK1)
FCH: 102048369(ITPK1)
CLV: 102088692(ITPK1)
EGZ: 104135355(ITPK1)
AAM: 106483074(ITPK1)
ASN: 102373418(ITPK1) 112548809
AMJ: 102575334(ITPK1) 109280689
PSS: 102452019(ITPK1) 112546611
CMY: 102932685 102933310(ITPK1)
CPIC: 101948262(ITPK1) 101949054
ACS: 100566274(itpk1)
PVT: 110083634(ITPK1)
PBI: 103054635(ITPK1)
GJA: 107123858(ITPK1)
XLA: 108698651 108700483(itpk1.S) 379828(itpk1.L)
XTR: 100144987 549890(itpk1)
NPR: 108788675(ITPK1) 108804962
DRE: 100148744(itpk1b) 406290(itpk1a)
TRU: 101069194(itpk1) 101072928
NCC: 104941855(itpk1) 104945354
MZE: 101469029(itpk1) 101485309
OLA: 101157334(itpk1)
XMA: 102220593(itpk1)
PRET: 103458928(itpk1)
NFU: 107392041(itpk1)
KMR: 108237618(itpk1)
CSEM: 103377198(itpk1) 103378259
SDU: 111225701(itpk1) 111232797
HCQ: 109510866 109516026(itpk1)
BPEC: 110153603 110155270(itpk1)
MALB: 109955064(itpk1)
ELS: 105015588(itpk1) 105017670
SFM: 108919611(itpk1)
LCM: 102351625(ITPK1) 102366649
CMK: 103174155 103185398(itpk1)
CIN: 100181853
SPU: 580408
APLC: 110977634
SKO: 102806915
AME: 551726
BIM: 100740014
BTER: 100647743
SOC: 105195554
AEC: 105150186
ACEP: 105618310
PBAR: 105426206
HST: 105181094
DQU: 106743443
CFO: 105250081
LHU: 105673912
PGC: 109863770
PCF: 106784291
NVI: 100117094
MDL: 103578390
TCA: 660348
NVL: 108567762
BMOR: 101744563
PMAC: 106719950
PRAP: 110991381
HAW: 110378751
API: 100159102
DNX: 107163234
CLEC: 106662859
ZNE: 110837839
FCD: 110844108
CRG: 105337850
MYI: 110440574
OBI: 106874910
EPA: 110247170
LJA: Lj1g3v2095610.1(Lj1g3v2095610.1) Lj2g3v1495070.1(Lj2g3v1495070.1) Lj4g3v1107900.1(Lj4g3v1107900.1) Lj4g3v1477230.1(Lj4g3v1477230.1) Lj5g3v2063140.1(Lj5g3v2063140.1) Lj5g3v2063140.2(Lj5g3v2063140.2)
DOSA: Os02t0466400-01(Os02g0466400) Os03t0230500-01(Os03g0230500) Os03t0726200-01(Os03g0726200) Os10t0103800-01(Os10g0103800) Os10t0576100-01(Os10g0576100)
ATS: 109732807(LOC109732807) 109748791(LOC109748791) 109751093(LOC109751093) 109759444(LOC109759444) 109773428(LOC109773428)
ZMA: 100194132 100282774 100282992(si618046c10b) 103627151 732818(lpa2)
APRO: F751_4717
DDI: DDB_G0269746(ITPK1)
DFA: DFA_02662(ITPK1)
EHI: EHI_042120(11.t00022) EHI_100310(151.t00008)
 » show all
Taxonomy
Reference
1  [PMID:2829850]
  Authors
Stephens LR, Hawkins PT, Morris AJ, Downes PC.
  Title
L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase.
  Journal
Biochem J 249:283-92 (1988)
Reference
2  [PMID:3497156]
  Authors
Balla T, Guillemette G, Baukal AJ, Catt KJ.
  Title
Metabolism of inositol 1,3,4-trisphosphate to a new tetrakisphosphate isomer in angiotensin-stimulated adrenal glomerulosa cells.
  Journal
J Biol Chem 262:9952-5 (1987)
Reference
3  [PMID:2823793]
  Authors
Shears SB, Parry JB, Tang EK, Irvine RF, Michell RH, Kirk CJ.
  Title
Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate.
  Journal
Biochem J 246:139-47 (1987)
Reference
4  [PMID:2584198]
  Authors
Shears SB.
  Title
The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase.
  Journal
J Biol Chem 264:19879-86 (1989)
Reference
5  [PMID:11042108]
  Authors
Yang X, Shears SB.
  Title
Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase.
  Journal
Biochem J 351 Pt 3:551-5 (2000)
  Sequence
[hsa:3705]
Reference
6  [PMID:11909533]
  Authors
Ho MW, Yang X, Carew MA, Zhang T, Hua L, Kwon YU, Chung SK, Adelt S, Vogel G, Riley AM, Potter BV, Shears SB.
  Title
Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase.
  Journal
Curr Biol 12:477-82 (2002)
DOI:10.1016/S0960-9822(02)00713-3
  Sequence
[hsa:3705]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.134
IUBMB Enzyme Nomenclature: 2.7.1.134
ExPASy - ENZYME nomenclature database: 2.7.1.134
BRENDA, the Enzyme Database: 2.7.1.134
CAS: 187175-98-0

KEGG   ENZYME: 2.7.1.159Help
Entry
EC 2.7.1.159                Enzyme                                 

Name
inositol-1,3,4-trisphosphate 5/6-kinase;
Ins(1,3,4)P3 5/6-kinase;
inositol trisphosphate 5/6-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase
Reaction(IUBMB)
(1) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate [RN:R03428];
(2) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate [RN:R03429]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1D-myo-inositol 1,3,4-trisphosphate [CPD:C01243]
Product
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5-tetrakisphosphate [CPD:C01272];
1D-myo-inositol 1,3,4,6-tetrakisphosphate [CPD:C04477]
Comment
In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6). InsP6 is involved in many cellular processes, including mRNA export from the nucleus [2]. Yeasts do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by the actions of EC 2.7.1.151 (inositol-polyphosphate multikinase) and EC 2.7.1.158 (inositol-pentakisphosphate 2-kinase) [2].
History
EC 2.7.1.159 created 2006
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K00913  inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase
K01765  inositol-1,3,4-trisphosphate 5/6-kinase
Genes
HSA: 3705(ITPK1)
PTR: 453121(ITPK1)
PPS: 100980755(ITPK1)
GGO: 101134664(ITPK1)
PON: 100448118(ITPK1)
NLE: 100590495(ITPK1)
MCC: 698756(ITPK1)
MCF: 102119398(ITPK1)
CSAB: 103229579(ITPK1)
RRO: 104679048(ITPK1)
RBB: 108519106(ITPK1)
CJC: 100396941(ITPK1)
SBQ: 101039869(ITPK1)
MMU: 217837(Itpk1)
RNO: 500709(Itpk1)
CGE: 100768438(Itpk1)
NGI: 103724593(Itpk1)
HGL: 101700462(Itpk1)
CCAN: 109693572(Itpk1)
OCU: 100345790(ITPK1)
TUP: 102479480(ITPK1)
CFA: 490591(ITPK1)
AML: 100484787(ITPK1)
UMR: 103673773(ITPK1)
ORO: 101385854(ITPK1)
FCA: 101087672(ITPK1)
PTG: 102951160(ITPK1)
AJU: 106980827(ITPK1)
BTA: 518488(ITPK1)
BOM: 102279411(ITPK1)
BIU: 109575578(ITPK1)
PHD: 102333268(ITPK1)
CHX: 102183460(ITPK1)
OAS: 101115161(ITPK1)
SSC: 100152339(ITPK1)
CFR: 102508931(ITPK1)
CDK: 105095826(ITPK1)
BACU: 103011955(ITPK1)
LVE: 103084508(ITPK1)
OOR: 101270326(ITPK1)
ECB: 100063828(ITPK1)
EPZ: 103556533(ITPK1)
EAI: 106825383(ITPK1)
MYB: 102246792(ITPK1)
MYD: 102764458(ITPK1) 102773325
HAI: 109376793(ITPK1)
RSS: 109442311 109454623(ITPK1)
PALE: 102877958(ITPK1)
LAV: 100668527(ITPK1)
TMU: 101341573
MDO: 100014342(ITPK1)
SHR: 100924957(ITPK1) 111719345
OAA: 100079832(ITPK1)
GGA: 423421(ITPK1)
MGP: 100541150(ITPK1)
CJO: 107315185(ITPK1)
APLA: 101801656(ITPK1)
ACYG: 106033487(ITPK1)
TGU: 100222999(ITPK1)
GFR: 102034047(ITPK1)
FAB: 101819235(ITPK1)
PHI: 102106037(ITPK1)
PMAJ: 107205493(ITPK1)
CCAE: 111929864(ITPK1)
CCW: 104688688(ITPK1)
FPG: 101920131(ITPK1)
FCH: 102048369(ITPK1)
CLV: 102088692(ITPK1)
EGZ: 104135355(ITPK1)
AAM: 106483074(ITPK1)
ASN: 102373418(ITPK1) 112548809
AMJ: 102575334(ITPK1) 109280689
PSS: 102452019(ITPK1) 112546611
CMY: 102932685 102933310(ITPK1)
CPIC: 101948262(ITPK1) 101949054
ACS: 100566274(itpk1)
PVT: 110083634(ITPK1)
PBI: 103054635(ITPK1)
GJA: 107123858(ITPK1)
XLA: 108698651 108700483(itpk1.S) 379828(itpk1.L)
XTR: 100144987 549890(itpk1)
NPR: 108788675(ITPK1) 108804962
DRE: 100148744(itpk1b) 406290(itpk1a)
TRU: 101069194(itpk1) 101072928
NCC: 104941855(itpk1) 104945354
MZE: 101469029(itpk1) 101485309
OLA: 101157334(itpk1)
XMA: 102220593(itpk1)
PRET: 103458928(itpk1)
NFU: 107392041(itpk1)
KMR: 108237618(itpk1)
CSEM: 103377198(itpk1) 103378259
SDU: 111225701(itpk1) 111232797
HCQ: 109510866 109516026(itpk1)
BPEC: 110153603 110155270(itpk1)
MALB: 109955064(itpk1)
ELS: 105015588(itpk1) 105017670
SFM: 108919611(itpk1)
LCM: 102351625(ITPK1) 102366649
CMK: 103174155 103185398(itpk1)
CIN: 100181853
SPU: 580408
APLC: 110977634
SKO: 102806915
AME: 551726
BIM: 100740014
BTER: 100647743
SOC: 105195554
AEC: 105150186
ACEP: 105618310
PBAR: 105426206
HST: 105181094
DQU: 106743443
CFO: 105250081
LHU: 105673912
PGC: 109863770
PCF: 106784291
NVI: 100117094
MDL: 103578390
TCA: 660348
NVL: 108567762
BMOR: 101744563
PMAC: 106719950
PRAP: 110991381
HAW: 110378751
API: 100159102
DNX: 107163234
CLEC: 106662859
ZNE: 110837839
FCD: 110844108
CRG: 105337850
MYI: 110440574
OBI: 106874910
EPA: 110247170
LJA: Lj1g3v2095610.1(Lj1g3v2095610.1) Lj2g3v1495070.1(Lj2g3v1495070.1) Lj4g3v1107900.1(Lj4g3v1107900.1) Lj4g3v1477230.1(Lj4g3v1477230.1) Lj4g3v1882000.1(Lj4g3v1882000.1) Lj4g3v1882000.2(Lj4g3v1882000.2) Lj4g3v1882010.1(Lj4g3v1882010.1) Lj5g3v2063140.1(Lj5g3v2063140.1) Lj5g3v2063140.2(Lj5g3v2063140.2)
DOSA: Os02t0466400-01(Os02g0466400) Os03t0230500-01(Os03g0230500) Os03t0726200-01(Os03g0726200) Os09t0518700-01(Os09g0518700) Os10t0103800-01(Os10g0103800) Os10t0576100-01(Os10g0576100)
ATS: 109732807(LOC109732807) 109748791(LOC109748791) 109751093(LOC109751093) 109759444(LOC109759444) 109764293(LOC109764293) 109773428(LOC109773428)
DDI: DDB_G0269746(ITPK1)
DFA: DFA_02662(ITPK1)
EHI: EHI_042120(11.t00022) EHI_100310(151.t00008)
SPAR: SPRG_04523
 » show all
Taxonomy
Reference
1  [PMID:8662638]
  Authors
Wilson MP, Majerus PW.
  Title
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.
  Journal
J Biol Chem 271:11904-10 (1996)
DOI:10.1074/jbc.271.20.11904
  Sequence
[bta:518488]
Reference
2  [PMID:15531582]
  Authors
Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW.
  Title
The pathway for the production of inositol hexakisphosphate in human cells.
  Journal
J Biol Chem 280:1911-20 (2005)
DOI:10.1074/jbc.M411528200
Reference
3  [PMID:15837423]
  Authors
Miller GJ, Wilson MP, Majerus PW, Hurley JH.
  Title
Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.
  Journal
Mol Cell 18:201-12 (2005)
DOI:10.1016/j.molcel.2005.03.016
  Sequence
[ehi:EHI_100310] [hsa:3705]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.159
IUBMB Enzyme Nomenclature: 2.7.1.159
ExPASy - ENZYME nomenclature database: 2.7.1.159
BRENDA, the Enzyme Database: 2.7.1.159
CAS: 288307-53-9

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