KEGG   ENZYME: 2.7.1.140Help
Entry
EC 2.7.1.140                Enzyme                                 

Name
inositol-tetrakisphosphate 5-kinase;
1D-myo-inositol-tetrakisphosphate 5-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase
Reaction(IUBMB)
ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:R03478]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1D-myo-inositol 1,3,4,6-tetrakisphosphate [CPD:C04477]
Product
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:C01284]
Comment
The enzyme from plants and yeast can also use Ins(1,2,3,4,6)P5 as a substrate [2].
History
EC 2.7.1.140 created 1992
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K00915  inositol-polyphosphate multikinase
Genes
HSA: 253430(IPMK)
PTR: 450471(IPMK)
PPS: 100973083(IPMK)
GGO: 101154364(IPMK)
PON: 100462505(IPMK)
NLE: 100592716(IPMK)
MCC: 703630(IPMK)
MCF: 102143477(IPMK)
CSAB: 103216169(IPMK)
RRO: 104665616(IPMK)
RBB: 108540730(IPMK)
CJC: 100415637(IPMK)
SBQ: 101051501(IPMK)
MMU: 69718(Ipmk)
RNO: 171458(Ipmk)
CGE: 100772629(Ipmk)
NGI: 103730748(Ipmk)
HGL: 101700113(Ipmk)
CCAN: 109696228(Ipmk)
OCU: 100355723(IPMK)
TUP: 102483332(IPMK)
AML: 100478367(IPMK)
UMR: 103667727(IPMK)
ORO: 101366273(IPMK)
FCA: 101098826(IPMK)
PTG: 102959812(IPMK)
AJU: 106973131(IPMK)
BTA: 615135(IPMK)
BOM: 102287037(IPMK)
BIU: 109553141(IPMK)
PHD: 102317812(IPMK)
CHX: 102177585(IPMK)
OAS: 101120714(IPMK)
SSC: 100623323(IPMK)
CFR: 102520396(IPMK)
CDK: 105093838(IPMK)
BACU: 103013713(IPMK)
LVE: 103080830(IPMK)
OOR: 101280269(IPMK)
ECB: 100072153(IPMK)
EPZ: 103550049(IPMK)
EAI: 106838737(IPMK)
MYB: 102254091(IPMK)
MYD: 102753565 102755711(IPMK)
HAI: 109377792 109380619(IPMK)
RSS: 109447447(IPMK)
PALE: 102888012(IPMK)
LAV: 100665963(IPMK)
TMU: 101348316
MDO: 100024450(IPMK)
SHR: 100931610(IPMK)
OAA: 100076322(IPMK)
GGA: 101751177(IPMK)
MGP: 100539865(IPMK)
CJO: 107315641(IPMK)
APLA: 101804228(IPMK)
ACYG: 106030987(IPMK)
TGU: 100225175(IPMK)
GFR: 102036262(IPMK)
FAB: 101808343(IPMK)
PHI: 102102225(IPMK)
PMAJ: 107215911(IPMK)
CCAE: 111931648(IPMK)
CCW: 104695108(IPMK)
FPG: 101922653(IPMK)
FCH: 102053151(IPMK)
CLV: 102098297(IPMK)
EGZ: 104128403(IPMK)
AAM: 106498578(IPMK)
ASN: 102379224(IPMK)
AMJ: 102574742(IPMK)
PSS: 102448749(IPMK)
CMY: 102934554(IPMK)
CPIC: 101949940(IPMK)
ACS: 100560539(ipmk)
PVT: 110073675(IPMK)
PBI: 103050503(IPMK)
GJA: 107124655(IPMK)
XLA: 108697359(ipmk.S) 447535(ipmk.L)
XTR: 100485175(ipmk)
NPR: 108788857(IPMK)
DRE: 100151036(ipmka) 790916(ipmkb)
IPU: 108263300 108274002(ipmk)
AMEX: 103031896 103035921(ipmk)
TRU: 101068659(ipmk)
LCO: 104938069(ipmk) 109136905
NCC: 104954473(ipmk)
MZE: 101484766(ipmk)
OLA: 101168158(ipmk)
XMA: 102236019(ipmk)
PRET: 103482182(ipmk)
NFU: 107396954(ipmk)
CSEM: 103381652(ipmk)
LCF: 108876813(ipmk)
SDU: 111237040(ipmk)
HCQ: 109529284(ipmk)
BPEC: 110154216(ipmk)
MALB: 109966674(ipmk)
ELS: 105006191(ipmk)
SFM: 108932688 108939714(ipmk)
LCM: 102351435(IPMK)
CMK: 103180913(ipmk)
CIN: 100181124
SPU: 576026
APLC: 110988184
DME: Dmel_CG13688(Ipk2)
DSI: Dsimw501_GD22857(Dsim_GD22857)
MDE: 101890959
AAG: 5576218
AME: 724909
BIM: 100741069
BTER: 100647372
SOC: 105194884
AEC: 105153183
ACEP: 105621350
PBAR: 105427938
HST: 105184462
DQU: 106743474
CFO: 105253694
LHU: 105671661
PGC: 109861092
PCF: 106789901
NVI: 100121919
MDL: 103576872
TCA: 661775
DPA: 109544545
NVL: 108558778
BMOR: 101740910
PMAC: 106713113
PRAP: 110999112
HAW: 110380263
API: 100166192
CLEC: 106674014
ZNE: 110831036
FCD: 110853922
TUT: 107360338
CEL: CELE_ZK795.1(ipmk-1)
CBR: CBG13522
BMY: Bm1_39650
TSP: Tsp_05937
CRG: 105329464
MYI: 110449876
OBI: 106870575
LAK: 106156040
ADF: 107358834
HMG: 101241397
ATH: AT5G07370(IPK2a) AT5G61760(IPK2BETA)
THJ: 104818295
CPAP: 110820479
CIT: 102615927
TCC: 18605232
DZI: 111291280
GMX: 100127407(IPK2)
VRA: 106756308
CAM: 101499122
LJA: Lj3g3v0463560.1(Lj3g3v0463560.1)
ADU: 107463105
AIP: 107612848
FVE: 101314526
PPER: 18776852
PMUM: 103337905
PAVI: 110757800
ZJU: 107423333
CSV: 101222676
CMO: 103494615
MCHA: 111015224
CMAX: 111479614
CMOS: 111457968
CPEP: 111790999
RCU: 8275463
JCU: 105648688
HBR: 110659725
JRE: 108999223
VVI: 100250912(IPK2)
SOT: 102577543(IPMK) 102599548
INI: 109183005
SIND: 105158271
OSA: 4329509
DOSA: Os02t0523800-01(Os02g0523800)
OBR: 102703374
BDI: 100838319
ATS: 109732235(LOC109732235)
SBI: 8059604
SITA: 101764096
MUS: 103971160
DCT: 110100476
PEQ: 110032183
ATR: 18434574
PPP: 112287121
MNG: MNEG_1909
APRO: F751_5641
SCE: YDR173C(ARG82)
ERC: Ecym_4203
KMX: KLMA_50536(ARG82)
NCS: NCAS_0B03200(NCAS0B03200)
NDI: NDAI_0A01200(NDAI0A01200)
TPF: TPHA_0C02470(TPHA0C02470)
TBL: TBLA_0H01030(TBLA0H01030)
TDL: TDEL_0F04950(TDEL0F04950)
KAF: KAFR_0B06020(KAFR0B06020)
CAL: CAALFM_C209730CA(IPK2)
CAUR: QG37_05990
SLB: AWJ20_3593(ARG82)
NCR: NCU06315
NTE: NEUTE1DRAFT60460(NEUTE1DRAFT_60460)
MGR: MGG_14150
SSCK: SPSK_09096
CMT: CCM_08832
MBE: MBM_03256
ANI: AN0156.2
ANG: ANI_1_1358164(An18g04520)
ABE: ARB_03060
TVE: TRV_06092
PTE: PTT_17736
CNE: CNN02250
CNB: CNBN2290
ABP: AGABI1DRAFT121474(AGABI1DRAFT_121474)
ABV: AGABI2DRAFT209575(AGABI2DRAFT_209575)
MGL: MGL_0277
SPAR: SPRG_07163
 » show all
Taxonomy
Reference
1  [PMID:2584198]
  Authors
Shears SB.
  Title
The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase.
  Journal
J Biol Chem 264:19879-86 (1989)
Reference
2  [PMID:12226109]
  Authors
Stevenson-Paulik J, Odom AR, York JD.
  Title
Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.
  Journal
J Biol Chem 277:42711-8 (2002)
DOI:10.1074/jbc.M209112200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.140
IUBMB Enzyme Nomenclature: 2.7.1.140
ExPASy - ENZYME nomenclature database: 2.7.1.140
BRENDA, the Enzyme Database: 2.7.1.140
CAS: 123940-40-9

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