KEGG   ENZYME: 2.7.1.157Help
Entry
EC 2.7.1.157                Enzyme                                 

Name
N-acetylgalactosamine kinase;
GALK2;
GK2;
GalNAc kinase;
N-acetylgalactosamine (GalNAc)-1-phosphate kinase;
ATP:N-acetyl-D-galactosamine 1-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:N-acetyl-alpha-D-galactosamine 1-phosphotransferase
Reaction(IUBMB)
ATP + N-acetyl-alpha-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate [RN:R08967]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
N-acetyl-alpha-D-galactosamine
Product
ADP [CPD:C00008];
N-acetyl-alpha-D-galactosamine 1-phosphate [CPD:C18060]
Comment
The enzyme is highly specific for GalNAc as substrate, but has slight activity with D-galactose [2]. Requires Mg2+, Mn2+ or Co2+ for activity, with Mg2+ resulting in by far the greatest stimulation of enzyme activity.
History
EC 2.7.1.157 created 2005
Orthology
K18674  N-acetylgalactosamine kinase
Genes
HSA: 2585(GALK2)
PTR: 744911(GALK2)
PPS: 100993695(GALK2)
GGO: 101128070(GALK2)
PON: 100173519(GALK2)
NLE: 100580277(GALK2)
MCC: 714866(GALK2)
MCF: 102133835(GALK2)
CSAB: 103245645(GALK2)
RRO: 104656916(GALK2)
RBB: 108530100(GALK2)
CJC: 100398615(GALK2) 103789124(GALK2)
SBQ: 101030526(GALK2)
MMU: 69976(Galk2)
RNO: 296117(Galk2)
CGE: 100752083(Galk2)
NGI: 103733040(Galk2)
HGL: 101714414(Galk2)
CCAN: 109684254 109684265(Galk2)
OCU: 100349778(GALK2)
TUP: 102477172(GALK2)
CFA: 487548(GALK2)
AML: 100474626(GALK2)
UMR: 103676726(GALK2)
ORO: 101377084(GALK2)
FCA: 101097562(GALK2)
PTG: 102956946(GALK2)
AJU: 106967224(GALK2)
BTA: 536133(GALK2)
BOM: 102285422(GALK2)
BIU: 109565141(GALK2)
PHD: 102324705(GALK2)
CHX: 102177984(GALK2)
OAS: 101108754(GALK2)
SSC: 100152312(GALK2)
CFR: 102518566(GALK2)
CDK: 105104776(GALK2)
BACU: 103019442(GALK2)
LVE: 103086640(GALK2)
OOR: 101287500(GALK2)
ECB: 100070040(GALK2)
EPZ: 103551850(GALK2)
EAI: 106838512(GALK2)
MYB: 102261265(GALK2)
MYD: 102759909(GALK2)
HAI: 109394504(GALK2)
RSS: 109441111 109446871(GALK2)
PALE: 102887362(GALK2)
LAV: 100673716(GALK2) 104846861
TMU: 101357245
MDO: 100025887(GALK2)
SHR: 100927973(GALK2)
OAA: 100092828
GGA: 415596(GALK2)
MGP: 100541570(GALK2)
CJO: 107318733(GALK2)
APLA: 101800821(GALK2)
ACYG: 106033610(GALK2)
TGU: 100220666(GALK2)
GFR: 102040707(GALK2)
FAB: 101809065(GALK2)
PHI: 102104028(GALK2)
PMAJ: 107209247(GALK2)
CCAE: 111934110(GALK2)
CCW: 104683987(GALK2)
FPG: 101914646(GALK2)
FCH: 102056200(GALK2)
CLV: 102088209(GALK2)
EGZ: 104130922(GALK2)
AAM: 106496574(GALK2)
ASN: 102386197(GALK2)
AMJ: 102566502(GALK2)
PSS: 102462792(GALK2)
CMY: 102935480(GALK2)
CPIC: 101943695(GALK2)
ACS: 100560349(galk2)
PVT: 110077234(GALK2)
PBI: 103054405(GALK2)
GJA: 107124464(GALK2)
XLA: 380379(galk2.L)
XTR: 448280(galk2)
NPR: 108792192(GALK2)
DRE: 792268(galk2)
SRX: 107712518(galk2) 107739099
CCAR: 109050785(galk2) 109058485
IPU: 108275233(galk2)
AMEX: 103026995(galk2)
TRU: 101066943(galk2)
LCO: 104940594(galk2)
NCC: 104960092(galk2)
MZE: 101474367(galk2)
OLA: 101171825(galk2)
XMA: 102218065(galk2)
PRET: 103466438(galk2)
KMR: 108230033(galk2)
CSEM: 103380462(galk2)
LCF: 108876666(galk2)
SDU: 111229735(galk2)
HCQ: 109507570(galk2)
BPEC: 110169595(galk2)
MALB: 109972807(galk2)
SASA: 100194982(galk2)
ELS: 105018363(galk2)
SFM: 108942064(galk2)
LCM: 102351584(GALK2)
CMK: 103186962(galk2)
CIN: 100178740
SPU: 591788
APLC: 110984721
SKO: 100376157
DME: Dmel_CG5288(Galk)
DSI: Dsimw501_GD12949(Dsim_GD12949)
MDE: 101899814
AAG: 5565716
AME: 551581
BIM: 100749831
BTER: 100648022
SOC: 105202170
AEC: 105145674
ACEP: 105627945
PBAR: 105426814
HST: 105192639
DQU: 106742033
CFO: 105248693
LHU: 105677111
PGC: 109854402
PCF: 106792561
NVI: 100116833
MDL: 103575647
TCA: 660592
DPA: 109539373
BMOR: 101745110
PMAC: 106716876
PRAP: 111000806
HAW: 110380006
PXY: 105393024
API: 100168735
DNX: 107165780
CLEC: 106673886
ZNE: 110841302
FCD: 110858073
CEL: CELE_M01D7.4(tag-96)
CBR: CBG22217(Cbr-tag-96)
BMY: Bm1_16455
CRG: 105327634
OBI: 106875465
SHX: MS3_04825
EPA: 110238219
ADF: 107331877
AQU: 100635641
ATH: AT3G06580(GALK)
CRB: 17891124
THJ: 104818876
CPAP: 110821277
TCC: 18603687
DZI: 111280004
EGR: 104415246
CAM: 101496906
LJA: Lj0g3v0357339.1(Lj0g3v0357339.1) Lj4g3v2263880.1(Lj4g3v2263880.1)
ADU: 107462750
AIP: 107639344
FVE: 101301951
PPER: 18790144
PMUM: 103323208
PAVI: 110752320
PXB: 103961282
CSV: 101222674
CMO: 103483903
MCHA: 111009231
RCU: 8258843
JCU: 105643566
VVI: 100244839
SLY: 101267552
SPEN: 107008513
SOT: 102597452
CANN: 107878649
NSY: 104236621
INI: 109176233
HAN: 110940986
BVG: 104887933
NNU: 104598734
OSA: 4334679
DOSA: Os03t0832600-01(Os03g0832600)
OBR: 102720420
BDI: 100824538
ATS: 109744798(LOC109744798)
SBI: 8079681
ZMA: 100284953(pco060326)
SITA: 101761856
EGU: 105039960
MUS: 103976564
DCT: 110106124
PEQ: 110021877
ATR: 18431449
CRE: CHLREDRAFT_122621(GAL1)
APRO: F751_4029
DDI: DDB_G0292112(galK)
DFA: DFA_05675(galK)
FCY: FRACYDRAFT_264529(GALK2_1)
SACI: Sinac_5476
PBAS: SMSP2_01028(galK_1)
 » show all
Taxonomy
Reference
1  [PMID:8702831]
  Authors
Pastuszak I, Drake R, Elbein AD.
  Title
Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation.
  Journal
J Biol Chem 271:20776-82 (1996)
DOI:10.1074/jbc.271.34.20776
Reference
2  [PMID:8798585]
  Authors
Pastuszak I, O'Donnell J, Elbein AD.
  Title
Identification of the GalNAc kinase amino acid sequence.
  Journal
J Biol Chem 271:23653-6 (1996)
DOI:10.1074/jbc.271.39.23653
  Sequence
[hsa:2585]
Reference
3  [PMID:16006554]
  Authors
Thoden JB, Holden HM.
  Title
The molecular architecture of human N-acetyl galactosamine kinase.
  Journal
J Biol Chem (2005)
DOI:10.1074/jbc.M505730200
  Sequence
[hsa:2585]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.157
IUBMB Enzyme Nomenclature: 2.7.1.157
ExPASy - ENZYME nomenclature database: 2.7.1.157
BRENDA, the Enzyme Database: 2.7.1.157

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