KEGG   ENZYME: 2.7.1.158Help
Entry
EC 2.7.1.158                Enzyme                                 

Name
inositol-pentakisphosphate 2-kinase;
IP5 2-kinase;
Gsl1p;
Ipk1p;
inositol polyphosphate kinase;
inositol 1,3,4,5,6-pentakisphosphate 2-kinase;
Ins(1,3,4,5,6)P5 2-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase
Reaction(IUBMB)
ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate [RN:R05202]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:C01284]
Product
ADP [CPD:C00008];
1D-myo-inositol hexakisphosphate [CPD:C01204]
Comment
The enzyme can also use Ins(1,4,5,6)P4 [2] and Ins(1,4,5)P3 [3] as substrate. Inositol hexakisphosphate (phytate) accumulates in storage protein bodies during seed development and, when hydrolysed, releases stored nutrients to the developing seedling before the plant is capable of absorbing nutrients from its environment [5].
History
EC 2.7.1.158 created 2006
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K10572  inositol-pentakisphosphate 2-kinase
K19786  inositol-pentakisphosphate 2-kinase
Genes
HSA: 64768(IPPK)
PTR: 740083(IPPK)
PPS: 100976952(IPPK) 100990623
GGO: 101146670(IPPK)
PON: 100445346(IPPK)
NLE: 100598766(IPPK) 101178222
MCC: 705937(IPPK)
MCF: 102125417(IPPK)
CSAB: 103219752(IPPK)
RRO: 104671586(IPPK)
RBB: 108516298(IPPK)
CJC: 100414925(IPPK)
SBQ: 101043044(IPPK)
MMU: 75678(Ippk)
RNO: 306808(Ippk)
CGE: 100755765(Ippk)
NGI: 103749954(Ippk)
HGL: 101698360(Ippk)
CCAN: 109682934(Ippk)
OCU: 100351214(IPPK)
TUP: 102501070(IPPK)
CFA: 484215(IPPK)
AML: 100472139(IPPK)
UMR: 103663296
ORO: 101379090(IPPK)
FCA: 101083117
PTG: 102954516(IPPK)
AJU: 106982579(IPPK)
BTA: 521083(IPPK)
BOM: 102279192(IPPK)
BIU: 109562573(IPPK) 109563258
PHD: 102322548(IPPK)
CHX: 102189953(IPPK)
OAS: 101107928(IPPK)
SSC: 100739651(IPPK)
CFR: 102507284(IPPK)
CDK: 105084710(IPPK)
BACU: 103006293(IPPK)
LVE: 103081103(IPPK)
OOR: 101286512(IPPK)
ECB: 100055987(IPPK)
EPZ: 103560339(IPPK)
EAI: 106846186(IPPK)
MYB: 102248998(IPPK)
MYD: 102761154(IPPK)
LAV: 100656538(IPPK)
TMU: 101357235
MDO: 100030309(IPPK)
SHR: 111719635(IPPK) 111721689
OAA: 100082269(IPPK) 100090496
GGA: 415951(IPPK)
MGP: 100539260(IPPK)
CJO: 107319660(IPPK)
APLA: 101797545(IPPK)
ACYG: 106049184(IPPK)
TGU: 100232713(IPPK)
GFR: 102040718(IPPK)
FAB: 101814368(IPPK)
PHI: 102102622(IPPK)
PMAJ: 107210141(IPPK)
CCAE: 111935335(IPPK)
CCW: 104683418(IPPK)
FPG: 101918249(IPPK)
FCH: 102058004(IPPK)
CLV: 102089388(IPPK)
EGZ: 104124326(IPPK)
AAM: 106486648(IPPK)
ASN: 102367780(IPPK)
AMJ: 102560753(IPPK)
PSS: 102449945(IPPK)
CMY: 102944728(IPPK)
CPIC: 101954054(IPPK)
ACS: 100554094(ippk)
PVT: 110085973(IPPK)
PBI: 103059819(IPPK)
GJA: 107124131(IPPK)
XLA: 108714575(ippk.L) 108715809(ippk.S)
XTR: 780205(ippk)
NPR: 108791091(IPPK)
DRE: 541511(ippk)
SRX: 107731322(ippk) 107755999
SANH: 107658385 107704449(ippk)
IPU: 108254826(ippk)
AMEX: 103024038(ippk)
TRU: 101061368(ippk)
LCO: 104930699(ippk) 109140708
NCC: 104941719(ippk)
MZE: 101472215(ippk)
OLA: 101165130(ippk)
XMA: 102229641(ippk)
PRET: 103464283(ippk)
NFU: 107384818(ippk)
CSEM: 103386439(ippk)
LCF: 108889780(ippk)
SDU: 111219461(ippk)
HCQ: 109510281(ippk)
BPEC: 110174830(ippk)
MALB: 109966393(ippk)
ELS: 105013487(ippk)
SFM: 108925514 108929817(ippk)
LCM: 102365442(IPPK)
CMK: 103188780(ippk)
CIN: 100177443
SPU: 100890290
APLC: 110986924
SKO: 102801216
DME: Dmel_CG30295(Ipk1)
DER: 6547608
DSI: Dsimw501_GD11544(Dsim_GD11544)
MDE: 101895533
AAG: 5565328
AME: 100576733
BIM: 100748798
BTER: 100648958
SOC: 105197674
AEC: 105147568
ACEP: 105623178
PBAR: 105429334
HST: 105191745
DQU: 106751941
CFO: 105251231
LHU: 105679102
PGC: 109857105
PCF: 106791892
MDL: 103575460
TCA: 657223
DPA: 109539188
NVL: 108566435
PRAP: 110994958
API: 103311901
DNX: 107163853
ZNE: 110828228
FCD: 110861830
TUT: 107370322
TSP: Tsp_05169
CRG: 105340067
MYI: 110443333
OBI: 106881623
SHX: MS3_08141
EPA: 110233378
ADF: 107354595
HMG: 101237508
CIT: 102620706
TCC: 18591431
EGR: 104448999
LJA: Lj1g3v2127260.1(Lj1g3v2127260.1) Lj5g3v0109820.1(Lj5g3v0109820.1) Lj5g3v0109820.2(Lj5g3v0109820.2) Lj5g3v0110920.1(Lj5g3v0110920.1)
FVE: 101291401
PXB: 103955368
ZJU: 107403694
RCU: 8275762
JCU: 105633830
JRE: 108991378
VVI: 100243814
SLY: 101263310
SPEN: 107017691
SOT: 102599880
CANN: 107866973
NSY: 104239920
NTO: 104112995
SIND: 105166115
BVG: 104889576
NNU: 104595636
OSA: 4337286
DOSA: Os04t0661200-01(Os04g0661200)
OBR: 102721267
BDI: 100821360
ATS: 109752213(LOC109752213)
SBI: 110436526
ZMA: 100126363(cl9911_2) 100501721
SITA: 101770113
PDA: 103711547
EGU: 105058765
DCT: 110094659
AOF: 109830592
ATR: 18422511
APRO: F751_4886
SCE: YDR315C(IPK1)
ERC: Ecym_3221
KMX: KLMA_70370(IPK1)
NCS: NCAS_0F02820(NCAS0F02820)
NDI: NDAI_0C04280(NDAI0C04280)
TPF: TPHA_0D02010(TPHA0D02010)
TBL: TBLA_0A03060(TBLA0A03060)
TDL: TDEL_0E02850(TDEL0E02850)
KAF: KAFR_0K02240(KAFR0K02240)
CAL: CAALFM_C403330WA(IPK1)
CAUR: QG37_03740
SLB: AWJ20_466
NCR: NCU00358
NTE: NEUTE1DRAFT146520(NEUTE1DRAFT_146520)
MGR: MGG_05177
SSCK: SPSK_10631
MAW: MAC_03715
MAJ: MAA_05882
CMT: CCM_01434
MBE: MBM_00301
ANI: AN1854.2
ANG: ANI_1_2022184(An04g07130)
ABE: ARB_04271
TVE: TRV_08153
PTE: PTT_20332
SPO: SPCC4B3.10c(ipk1)
CNE: CND04140
CNB: CNBD2180
ABP: AGABI1DRAFT35200(AGABI1DRAFT_35200)
ABV: AGABI2DRAFT63616(AGABI2DRAFT_63616)
DFA: DFA_10812
SPAR: SPRG_19601
 » show all
Taxonomy
Reference
1  [PMID:10390371]
  Authors
York JD, Odom AR, Murphy R, Ives EB, Wente SR.
  Title
A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.
  Journal
Science 285:96-100 (1999)
DOI:10.1126/science.285.5424.96
  Sequence
[sce:YDR315C]
Reference
2  [PMID:7961779]
  Authors
Phillippy BQ, Ullah AH, Ehrlich KC.
  Title
Purification and some properties of inositol 1,3,4,5,6-Pentakisphosphate 2-kinase from immature soybean seeds.
  Journal
J Biol Chem 269:28393-9 (1994)
Reference
3
  Authors
Phillippy, B.Q., Ullah, A.H. and Ehrlich, K.C.
  Title
Additions and corrections to Purification and some properties of inositol 1,3,4,5,6-pentakisphosphate 2-kinase from immature soybean seeds.
  Journal
J Biol Chem 270:7782 (1997)
Reference
4  [PMID:9794810]
  Authors
Ongusaha PP, Hughes PJ, Davey J, Michell RH.
  Title
Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation.
  Journal
Biochem J 335 ( Pt 3):671-9 (1998)
Reference
5  [PMID:15459192]
  Authors
Miller AL, Suntharalingam M, Johnson SL, Audhya A, Emr SD, Wente SR.
  Title
Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway.
  Journal
J Biol Chem 279:51022-32 (2004)
DOI:10.1074/jbc.M409394200
Reference
6  [PMID:12226109]
  Authors
Stevenson-Paulik J, Odom AR, York JD.
  Title
Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.
  Journal
J Biol Chem 277:42711-8 (2002)
DOI:10.1074/jbc.M209112200
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.158
IUBMB Enzyme Nomenclature: 2.7.1.158
ExPASy - ENZYME nomenclature database: 2.7.1.158
BRENDA, the Enzyme Database: 2.7.1.158

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