KEGG   ENZYME: 2.7.1.168Help
Entry
EC 2.7.1.168                Enzyme                                 

Name
D-glycero-alpha-D-manno-heptose-7-phosphate kinase;
D-alpha-D-heptose-7-phosphate kinase;
hdda (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:D-glycero-alpha-D-manno-heptose 7-phosphate 1-phosphotransferase
Reaction(IUBMB)
D-glycero-alpha-D-manno-heptose 7-phosphate + ATP = D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + ADP [RN:R09770]
Reaction(KEGG)
Substrate
D-glycero-alpha-D-manno-heptose 7-phosphate [CPD:C19878];
ATP [CPD:C00002]
Product
D-glycero-alpha-D-manno-heptose 1,7-bisphosphate [CPD:C19879];
ADP [CPD:C00008]
Comment
The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in Gram-positive bacteria. The enzyme is specific for the alpha-anomer.
History
EC 2.7.1.168 created 2010
Pathway
ec00540  Lipopolysaccharide biosynthesis
Orthology
K07031  D-glycero-alpha-D-manno-heptose-7-phosphate kinase
Genes
YPB: YPTS_1055
YPQ: DJ40_1348
YPU: BZ21_254
YPR: BZ20_1035
YPC: BZ23_530
PLU: plu4822(wblW)
PLUM: A4R40_23985
PGB: H744_1c0473 H744_2c2398
PPB: PPUBIRD1_1475
PEN: PSEEN2467
AMAG: I533_13340
HCH: HCH_06166
TOL: TOL_2206
BMA: BMA2296(hddA)
BMV: BMASAVP1_A0532(hddA)
BML: BMA10229_A1068(hddA)
BMN: BMA10247_2174(hddA)
BMAL: DM55_1488
BMAE: DM78_2666
BMAQ: DM76_1466
BMAI: DM57_1071
BMAF: DM51_1937
BMAZ: BM44_1067
BMAB: BM45_2462
BPS: BPSL2796(wcbL)
BPM: BURPS1710b_3292(wcbL)
BPSE: BDL_2649
BPSM: BBQ_513
BPSU: BBN_641
BPSD: BBX_1047
BPZ: BP1026B_I0514(wcbL)
BPK: BBK_2134
BPSH: DR55_1722
BPSA: BBU_2766
BPSO: X996_1362
BUT: X994_3360
BTD: BTI_920
BTHA: DR62_529
BCEW: DM40_4219
BLAT: WK25_23460
PAPI: SG18_07840
NET: Neut_0157
MEH: M301_2248
CJE: Cj1425c(hddA)
CJB: BN148_1425c(hddA)
CJS: CJS3_1518
CJEJ: N564_01422
CJEU: N565_01462
CJEN: N755_01459
CJEI: N135_01515
CJER: H730_08145
CJY: QZ67_01564(hddA)
CJQ: UC78_1366(hddA)
CJR: CJE1610
CCF: YSQ_01735
CIS: CINS_0292
CCUN: CCUN_1153
CLX: CLAN_0156
GLO: Glov_0793
DAS: Daes_0075
DPI: BN4_12080
PPRF: DPRO_PA0008(hddA)
LIP: LIA008(mvaK1) LIC011(mvaK1)
DOL: Dole_1710
SCL: sce3746
BBA: Bd1027(lmbP)
BBAT: Bdt_0972(lmbP)
BBW: BDW_03545
BBAC: EP01_15225
BEX: A11Q_821
BMX: BMS_0715
BJA: blr5970
MOR: MOC_1454
CAK: Caul_4922
JAN: Jann_4245
KVU: EIO_0807
KVL: KVU_0341(lmbP)
RSU: NHU_00146
SSAN: NX02_24820
MAG: amb1073
MAGX: XM1_1802
MAGN: WV31_16785
MAGQ: MGMAQ_1158
MGM: Mmc1_0617
ASOC: CB4_00632(hddA)
LLK: LLKF_2314
LLM: llmg_2347
LLR: llh_12025
LLW: kw2_2126
CAC: CA_C3055
CAE: SMB_G3091(mvk)
CAY: CEA_G3061
FPA: FPR_02560
RTO: RTO_07330
CSO: CLS_35520
SGY: Sgly_1518
HMO: HM1_1146
BPRM: CL3_13500
BPRS: CK3_00760
PUF: UFO1_1095
AOC: Aocu_04590(hddA)
MTU: Rv0115(hddA)
MTV: RVBD_0115
MTC: MT0123
MRA: MRA_0121(hddA)
MTUR: CFBS_0124(hddA)
MTO: MTCTRI2_0118(hddA)
MTD: UDA_0115(hddA)
MTN: ERDMAN_0133(hddA)
MTUC: J113_00815
MTUE: J114_00635
MTUH: I917_00875
MTUL: TBHG_00115
MTUT: HKBT1_0124(hddA)
MTUU: HKBT2_0124(hddA)
MTQ: HKBS1_0124(hddA)
MBO: BQ2027_MB0119(hdda)
MBB: BCG_0149
MBT: JTY_0119
MBX: BCGT_3912
MMIC: RN08_0133
MCE: MCAN_01181(hddA)
MPA: MAP_0935
MAO: MAP4_2925
MAVI: RC58_14520
MAVU: RE97_14545
MAV: MAV_1118
MIT: OCO_09890
MIA: OCU_09910
MID: MIP_01627
MYO: OEM_10070
MIR: OCQ_10000
MMM: W7S_04930
SRN: A4G23_00465(hddA)
LMOI: VV02_14415
CFL: Cfla_3600
CWO: Cwoe_5465
SYN: slr0862(lmbP)
SYZ: MYO_112400(lmbP)
SYY: SYNGTS_1229(lmbP)
SYT: SYNGTI_1229(lmbP)
SYS: SYNPCCN_1228(lmbP)
SYQ: SYNPCCP_1228(lmbP)
SYJ: D082_22800(lmbP)
PRC: EW14_1456
MAR: MAE_55670
MPK: VL20_390
CYT: cce_0966(lmbP)
CEO: ETSB_0016(lmbP)
DET: DET0206
DMD: dcmb_209
HAU: Haur_3668
ATM: ANT_19990
TRA: Trad_1639
OTE: Oter_3977
GES: VT84_07095(hddA_1) VT84_15600(hddA_2)
KST: KSMBR1_2293(mvk)
ACA: ACP_0827
ABAS: ACPOL_2477
SUS: Acid_0418
GAU: GAU_0471
GBA: J421_2375
BTH: BT_0474
BTHO: Btheta7330_02888(hddA_2)
BOA: Bovatus_04910(hddA_2)
CPI: Cpin_3115
FLN: FLA_6276
WIN: WPG_0814
PAA: Paes_1742
MARN: LN42_06525
NDE: NIDE2328 NIDE3425(hddA)
TVO: TVG0491501(TVG0491501) TVG0927911(TVG0927911)
PTO: PTO1352
MEAR: Mpt1_c11480(mvk2) Mpt1_c11600(galK)
MARC: AR505_1771
MPI: Mpet_1390
NBV: T478_0176
MARH: Mia14_0639
LOKI: Lokiarch_02870(hddA)
 » show all
Taxonomy
Reference
1  [PMID:11279237]
  Authors
Kneidinger B, Graninger M, Puchberger M, Kosma P, Messner P
  Title
Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose.
  Journal
J Biol Chem 276:20935-44 (2001)
DOI:10.1074/jbc.M100378200
  Sequence
Reference
2  [PMID:12101286]
  Authors
Valvano MA, Messner P, Kosma P
  Title
Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides.
  Journal
Microbiology 148:1979-89 (2002)
DOI:10.1099/00221287-148-7-1979
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.168
IUBMB Enzyme Nomenclature: 2.7.1.168
ExPASy - ENZYME nomenclature database: 2.7.1.168
BRENDA, the Enzyme Database: 2.7.1.168

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