KEGG   ENZYME: 2.7.1.171Help
Entry
EC 2.7.1.171                Enzyme                                 

Name
protein-fructosamine 3-kinase;
FN3K;
fructosamine 3-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:[protein]-N6-D-fructosyl-L-lysine 3-phosphotransferase
Reaction(IUBMB)
ATP + [protein]-N6-D-fructosyl-L-lysine = ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine
Substrate
ATP [CPD:C00002];
[protein]-N6-D-fructosyl-L-lysine
Product
ADP [CPD:C00008];
[protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine
Comment
Non-enzymic glycation is an important factor in the pathogenesis of diabetic complications. Key early intermediates in this process are fructosamines, such as [protein]-N6-D-fructosyl-L-lysine. Fructosamine-3-kinase is part of an ATP-dependent system for removing carbohydrates from non-enzymically glycated proteins. The phosphorylation destablilizes the [protein]-N6-D-fructosyl-L-lysine adduct and leads to its spontaneous decomposition. cf. EC 2.7.1.172, protein-ribulosamine 3-kinase.
History
EC 2.7.1.171 created 2011
Orthology
K15522  protein-fructosamine 3-kinase
Genes
HSA: 64122(FN3K)
PTR: 454999(FN3K)
PPS: 100983475(FN3K)
GGO: 101129274(FN3K)
PON: 100432964(FN3K)
NLE: 100601146(FN3K)
MCC: 106994166(FN3K)
MCF: 102132233(FN3K)
CSAB: 103243881(FN3K)
RBB: 108534066(FN3K)
CJC: 100397627(FN3K)
SBQ: 101053226(FN3K)
MMU: 63828(Fn3k)
RNO: 498034(Fn3k)
CGE: 100751771(Fn3k)
NGI: 103739318(Fn3k)
HGL: 101712216(Fn3k)
CCAN: 109689327(Fn3k)
OCU: 100346330(FN3K)
TUP: 102490564(FN3K)
CFA: 608337(FN3K)
AML: 100466189(FN3K)
UMR: 103666019(FN3K)
ORO: 101368258(FN3K)
FCA: 101093222(FN3K)
PTG: 102972520(FN3K)
AJU: 106986324(FN3K)
BTA: 539709(FN3K)
BOM: 102280823(FN3K)
BIU: 109574437(FN3K)
PHD: 102343329(FN3K)
CHX: 102184090(FN3K)
OAS: 101108403(FN3K)
SSC: 100523990(FN3K)
CFR: 102524293(FN3K)
CDK: 105102232(FN3K)
LVE: 103083772(FN3K)
OOR: 101282913(FN3K)
ECB: 100056532(FN3K)
EPZ: 103562257(FN3K)
EAI: 106846356(FN3K)
MYB: 102254271(FN3K)
MYD: 102773280(FN3K)
HAI: 109393083(FN3K)
RSS: 109449418(FN3K)
PALE: 102898341(FN3K)
LAV: 100669036(FN3K)
TMU: 101360399
OAA: 100079558(FN3K)
GGA: 417335(FN3K)
MGP: 100547749(FN3K)
CJO: 107322145(FN3K)
APLA: 101790399(FN3K)
ACYG: 106047109(FN3K)
TGU: 100226491(FN3K)
GFR: 102032280(FN3K)
FAB: 101809933(FN3K)
PHI: 102111398(FN3K)
PMAJ: 107212391(FN3K)
CCW: 104695651(FN3K)
FPG: 101910565(FN3K)
FCH: 102059933(FN3K)
CLV: 102083783
EGZ: 104125361(FN3K)
AAM: 106499386(FN3K)
ASN: 102371989(FN3K)
AMJ: 102571431(FN3K)
PSS: 102448713(FN3K)
CMY: 102934080(FN3K)
CPIC: 101941575(FN3K)
ACS: 100556240
PVT: 110075083(FN3K)
PBI: 103060185
GJA: 107123117(FN3K)
MYI: 110450667
OBI: 106874220
 » show all
Taxonomy
Reference
1  [PMID:11522682]
  Authors
Szwergold BS, Howell S, Beisswenger PJ
  Title
Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo.
  Journal
Diabetes 50:2139-47 (2001)
  Sequence
[hsa:64122]
Reference
2  [PMID:11016445]
  Authors
Delpierre G, Rider MH, Collard F, Stroobant V, Vanstapel F, Santos H, Van Schaftingen E
  Title
Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase.
  Journal
Diabetes 49:1627-34 (2000)
  Sequence
[hsa:64122] [mmu:63828]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.171
IUBMB Enzyme Nomenclature: 2.7.1.171
ExPASy - ENZYME nomenclature database: 2.7.1.171
BRENDA, the Enzyme Database: 2.7.1.171

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