KEGG   ENZYME: 2.7.1.172Help
Entry
EC 2.7.1.172                Enzyme                                 

Name
protein-ribulosamine 3-kinase;
Fn3KRP;
FN3K-related protein;
FN3K-RP;
ketosamine 3-kinase 2;
fructosamine-3-kinase-related protein;
ribulosamine/erythrulosamine 3-kinase;
ribulosamine 3-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:[protein]-N6-D-ribulosyl-L-lysine 3-phosphotransferase
Reaction(IUBMB)
ATP + [protein]-N6-D-ribulosyl-L-lysine = ADP + [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine
Substrate
ATP [CPD:C00002];
[protein]-N6-D-ribulosyl-L-lysine
Product
ADP [CPD:C00008];
[protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine
Comment
This enzyme plays a role in freeing proteins from ribulosamines or psicosamines, which might arise from the reaction of amines with glucose and/or glycolytic intermediates. This role is shared by EC 2.7.1.171 (protein-fructosamine 3-kinase), which has, in addition, the unique capacity to phosphorylate fructosamines [1]. The plant enzyme also phosphorylates [protein]-N6-D-erythrulosyl-L-lysine [2]. No activity with [protein]-N6-D-fructosyl-L-lysine [1,2].
History
EC 2.7.1.172 created 2011
Orthology
K15523  protein-ribulosamine 3-kinase
Genes
HSA: 79672(FN3KRP)
PTR: 107969011(FN3KRP)
PPS: 100982920(FN3KRP)
GGO: 101128927(FN3KRP)
PON: 100173348(FN3KRP)
NLE: 100598556(FN3KRP)
MCC: 716431(FN3KRP)
MCF: 101926623(FN3KRP)
CSAB: 103243781(FN3KRP)
RRO: 104654998
RBB: 108534067(FN3KRP)
CJC: 103793436(FN3KRP) 108590074
SBQ: 101053544(FN3KRP)
MMU: 238024(Fn3krp)
RNO: 303755(Fn3krp)
CGE: 100752057(Fn3krp)
NGI: 103739319(Fn3krp)
HGL: 101709333(Fn3krp)
CCAN: 109689328(Fn3krp)
OCU: 100344530(FN3KRP)
TUP: 102476157(FN3KRP)
CFA: 480821(FN3KRP)
AML: 100464438(FN3KRP)
UMR: 103666018(FN3KRP)
ORO: 101368544(FN3KRP)
FCA: 101092971(FN3KRP)
PTG: 102972037(FN3KRP)
AJU: 106986345(FN3KRP)
BTA: 615868(FN3KRP)
BOM: 102281298(FN3KRP)
BIU: 109574261(FN3KRP)
PHD: 102342977(FN3KRP)
CHX: 102184372(FN3KRP)
OAS: 101108669(FN3KRP)
SSC: 100523691(FN3KRP)
CFR: 102524558(FN3KRP)
CDK: 105102231(FN3KRP)
BACU: 102998458(FN3K)
LVE: 103084046(FN3KRP)
OOR: 101282663(FN3KRP)
ECB: 100056107(FN3KRP)
EPZ: 103562261
EAI: 106846292(FN3KRP)
MYB: 102243427(FN3KRP)
MYD: 102772995(FN3KRP)
HAI: 109393079(FN3KRP)
RSS: 109449417(FN3KRP)
PALE: 102898584(FN3KRP)
LAV: 100670171(FN3KRP)
TMU: 101360659
MDO: 100020750(FN3KRP)
SHR: 100913340(FN3KRP)
OAA: 100079591(FN3KRP)
GGA: 417336(FN3KRP)
MGP: 100550464(FN3KRP)
CJO: 107322144
APLA: 101792751(FN3KRP)
ACYG: 106047110
TGU: 100190639(FN3KRP) 100231275
PMAJ: 107198385
FPG: 101910739(FN3KRP)
FCH: 102060101(FN3KRP)
CLV: 102083608
EGZ: 104125362(FN3KRP)
AAM: 106499408
ASN: 102375382
AMJ: 102571809(FN3KRP)
PSS: 102458928
CMY: 102934304(FN3KRP)
CPIC: 101941114(FN3KRP)
ACS: 100552114(fn3krp)
PVT: 110080441(FN3KRP)
PBI: 103055928(FN3KRP)
GJA: 107121874(FN3KRP)
XLA: 444726(fn3krp.S) 779262(fn3k.L)
XTR: 548561(fn3k) 779663(fn3krp)
DRE: 559954(fn3krp)
SRX: 107744985
SANH: 107670452
SGH: 107599346
CCAR: 109064018
IPU: 108256901
AMEX: 103027201
TRU: 101068065
LCO: 104918611
NCC: 104960327
MZE: 101487576
OLA: 101166386
XMA: 102228035
PRET: 103468804
NFU: 107378286
CSEM: 103392706
LCF: 108902705
HCQ: 109532519
BPEC: 110169419
SFM: 108937375
LCM: 102361196(FN3KRP)
CMK: 103175706
CIN: 100175560
APLC: 110976653
SKO: 100375988
API: 100168663
DNX: 107163041
ZNE: 110834669
FCD: 110858520
TUT: 107359867
CEL: CELE_Y116A8C.25(Y116A8C.25)
BMY: Bm1_35645
MYI: 110450645
LAK: 106151239
EPA: 110241378
ADF: 107349801
AQU: 100641712
ATH: AT3G61080
CRB: 17886329
BRP: 103830281
BOE: 106298356
THJ: 104827683
CPAP: 110819567
CIT: 102623897
TCC: 18614223
GRA: 105802641
GHI: 107911946
DZI: 111304671
EGR: 104443493
VRA: 106778982
VAR: 108347511
CCAJ: 109796294
CAM: 101512368
LJA: Lj0g3v0255569.1(Lj0g3v0255569.1) Lj0g3v0255569.2(Lj0g3v0255569.2)
ADU: 107475790
AIP: 107626071
LANG: 109360592
FVE: 101296141
PPER: 18785089
PMUM: 103331969
PAVI: 110769247
MDM: 103439144
PXB: 103935487
ZJU: 107432665
CSV: 101207798
CMO: 103483312
MCHA: 111016237
CMAX: 111479743
CMOS: 111431796
CPEP: 111789914
RCU: 8258509
JCU: 105643054
HBR: 110637026
POP: 7461742
JRE: 108980868
VVI: 100252411
SLY: 101263642
SPEN: 107008193
SOT: 102594708
CANN: 107872803
NSY: 104230356
NTO: 104094265
INI: 109156085
SIND: 105171905
OEU: 111380162
HAN: 110864696
LSV: 111912867
DCR: 108193270
BVG: 104905479
SOE: 110799577
NNU: 104596179
OSA: 4331411
DOSA: Os03t0117800-01(Os03g0117800)
OBR: 102715375
BDI: 100846855
ATS: 109779410(LOC109779410)
SBI: 8077990
ZMA: 100277385
SITA: 101760144
MUS: 103993209
DCT: 110107700
AOF: 109838331
ATR: 18447760
PPP: 112292648
MNG: MNEG_0014
APRO: F751_6551
CMT: CCM_06145
CNB: CNBE0140
MRR: Moror_316
ABP: AGABI1DRAFT67377(AGABI1DRAFT_67377)
ABV: AGABI2DRAFT196782(AGABI2DRAFT_196782)
SMIN: v1.2.031035.t1(symbB.v1.2.031035.t1)
 » show all
Taxonomy
Reference
1  [PMID:14633848]
  Authors
Collard F, Delpierre G, Stroobant V, Matthijs G, Van Schaftingen E
  Title
A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase  acting on psicosamines and ribulosamines but not on fructosamines.
  Journal
Diabetes 52:2888-95 (2003)
  Sequence
[hsa:79672] [mmu:238024]
Reference
2  [PMID:15705060]
  Authors
Fortpied J, Gemayel R, Stroobant V, van Schaftingen E
  Title
Plant ribulosamine/erythrulosamine 3-kinase, a putative protein-repair enzyme.
  Journal
Biochem J 388:795-802 (2005)
DOI:10.1042/BJ20041976
  Sequence
[ath:AT3G61080] [osa:4331411]
Reference
3  [PMID:18637789]
  Authors
Payne LS, Brown PM, Middleditch M, Baker E, Cooper GJ, Loomes KM
  Title
Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein  by affinity labelling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine.
  Journal
Biochem J 416:281-8 (2008)
DOI:10.1042/BJ20080389
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.172
IUBMB Enzyme Nomenclature: 2.7.1.172
ExPASy - ENZYME nomenclature database: 2.7.1.172
BRENDA, the Enzyme Database: 2.7.1.172

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