KEGG   ENZYME: 2.7.1.174Help
Entry
EC 2.7.1.174                Enzyme                                 

Name
diacylglycerol kinase (CTP);
DAG kinase;
CTP-dependent diacylglycerol kinase;
diglyceride kinase (ambiguous);
DGK1 (gene name);
diacylglycerol kinase (CTP dependent)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
CTP:1,2-diacyl-sn-glycerol 3-phosphotransferase
Reaction(IUBMB)
CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate [RN:R09944]
Reaction(KEGG)
Substrate
CTP [CPD:C00063];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
CDP [CPD:C00112];
1,2-diacyl-sn-glycerol 3-phosphate [CPD:C00416]
Comment
Requires Ca2+ or Mg2+ for activity. Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. Unlike the diacylglycerol kinases from bacteria, plants, and animals [cf. EC 2.7.1.107, diacylglycerol kinase (ATP)], the enzyme from Saccharomyces cerevisiae utilizes CTP. The enzyme can also use dCTP, but not ATP, GTP or UTP.
History
EC 2.7.1.174 created 2012, modified 2013
Pathway
ec00564  Glycerophospholipid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K16368  diacylglycerol kinase (CTP)
Genes
MIS: MICPUN_61148
SCE: YOR311C(DGK1)
AGO: AGOS_AFR329C
ERC: Ecym_1490
KLA: KLLA0_F08635g
KMX: KLMA_20319(DGK1)
LTH: KLTH0H15356g
VPO: Kpol_1010p4
ZRO: ZYRO0F12540g
CGR: CAGL0I09812g
NCS: NCAS_0B00880(NCAS0B00880)
NDI: NDAI_0E00540(NDAI0E00540)
TPF: TPHA_0G01150(TPHA0G01150)
TBL: TBLA_0B02820(TBLA0B02820) TBLA_0D00720(TBLA0D00720)
TDL: TDEL_0B01100(TDEL0B01100)
KAF: KAFR_0D01590(KAFR0D01590)
CAL: CAALFM_C200790CA(CaO19.2045)
CAUR: QG37_01917
SLB: AWJ20_3255(DGK1)
NCR: NCU03381
NTE: NEUTE1DRAFT84553(NEUTE1DRAFT_84553)
MGR: MGG_02416
SSCK: SPSK_01155
MAW: MAC_03607
MAJ: MAA_02579
CMT: CCM_00191
MBE: MBM_04096
ANI: AN3177.2
ANG: ANI_1_1322024(An02g09160)
ABE: ARB_05368
TVE: TRV_01710
PTE: PTT_18596
SPO: SPBC3D6.05(ptp4)
CNE: CNA08270
CNB: CNBA8100
ABP: AGABI1DRAFT116813(AGABI1DRAFT_116813)
ABV: AGABI2DRAFT195012(AGABI2DRAFT_195012)
SPAR: SPRG_02163
 » show all
Taxonomy
Reference
1  [PMID:18458075]
  Authors
Han GS, O'Hara L, Carman GM, Siniossoglou S
  Title
An unconventional diacylglycerol kinase that regulates phospholipid synthesis and nuclear membrane growth.
  Journal
J Biol Chem 283:20433-42 (2008)
DOI:10.1074/jbc.M802903200
  Sequence
[sce:YOR311C]
Reference
2  [PMID:18458076]
  Authors
Han GS, O'Hara L, Siniossoglou S, Carman GM
  Title
Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase.
  Journal
J Biol Chem 283:20443-53 (2008)
DOI:10.1074/jbc.M802866200
  Sequence
[sce:YOR311C]
Reference
3  [PMID:21071438]
  Authors
Fakas S, Konstantinou C, Carman GM
  Title
DGK1-encoded diacylglycerol kinase activity is required for phospholipid synthesis during growth resumption from stationary phase in Saccharomyces cerevisiae.
  Journal
J Biol Chem 286:1464-74 (2011)
DOI:10.1074/jbc.M110.194308
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.174
IUBMB Enzyme Nomenclature: 2.7.1.174
ExPASy - ENZYME nomenclature database: 2.7.1.174
BRENDA, the Enzyme Database: 2.7.1.174

DBGET integrated database retrieval system