KEGG   ENZYME: 2.7.1.52Help
Entry
EC 2.7.1.52                 Enzyme                                 

Name
fucokinase;
fucokinase (phosphorylating);
fucose kinase;
L-fucose kinase;
L-fucokinase;
ATP:6-deoxy-L-galactose 1-phosphotransferase;
ATP:L-fucose 1-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:beta-L-fucose 1-phosphotransferase
Reaction(IUBMB)
ATP + L-fucose = ADP + beta-L-fucose 1-phosphate [RN:R03161]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
L-fucose [CPD:C01019]
Product
ADP [CPD:C00008];
beta-L-fucose 1-phosphate [CPD:C02985]
Comment
Requires a divalent cation for activity, with Mg2+ and Fe2+ giving rise to the highest enzyme activity. Forms part of a salvage pathway for reutilization of L-fucose. Can also phosphorylate D-arabinose, but more slowly.
History
EC 2.7.1.52 created 1972, modified 2004
Pathway
ec00051  Fructose and mannose metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K05305  fucokinase
Genes
HSA: 197258(FUK)
PTR: 468015(FUK)
PPS: 100981840(FUK)
GGO: 101132289(FUK)
PON: 100454490(FUK)
NLE: 100606422(FUK)
MCC: 709226(FUK)
MCF: 102127748(FUK)
CSAB: 103233158(FUK)
RRO: 104677820(FUK)
RBB: 108527441(FUK)
CJC: 100413891(FUK)
SBQ: 101049340(FUK)
MMU: 234730(Fuk)
RNO: 307848(Fuk)
CGE: 100752219(Fuk)
NGI: 103735635(Fuk)
HGL: 101722039(Fuk)
CCAN: 109684986(Fuk)
OCU: 100348059(FUK)
TUP: 102491737(FUK)
CFA: 489715(FUK)
AML: 100481849(FUK)
UMR: 103673574(FUK)
ORO: 101383814(FUK)
FCA: 101094896(FUK)
PTG: 102956046(FUK)
AJU: 106983746(FUK)
BTA: 519181(FUK)
BOM: 102267499(FUK)
BIU: 109572530(FUK)
PHD: 102319245(FUK)
CHX: 102173959(FUK)
OAS: 101114636(FUK)
SSC: 100625448(FUK)
CFR: 102513917(FUK)
CDK: 105097707(FUK)
BACU: 103019486(FUK)
LVE: 103084623(FUK)
OOR: 101282658(FUK)
ECB: 100054844(FUK)
EPZ: 103552406(FUK)
EAI: 106823440(FUK)
MYB: 102253257(FUK)
MYD: 102756628(FUK)
HAI: 109388833(FUK)
RSS: 109433726(FUK)
PALE: 102895323(FUK)
LAV: 100672550(FUK)
TMU: 101342284
MDO: 100617318(FUK)
OAA: 100075033(FUK)
GGA: 770049(FUK)
MGP: 100546052(FUK)
CJO: 107319068(FUK)
APLA: 101793742(FUK)
ACYG: 106033121(FUK)
TGU: 100228545(FUK)
GFR: 102042406(FUK)
FAB: 101820082(FUK)
PHI: 102104108(FUK)
PMAJ: 107209808(FUK)
CCW: 104687567(FUK)
FPG: 101919068(FUK)
FCH: 102046401(FUK)
CLV: 102092541(FUK)
EGZ: 104130289(FUK)
AAM: 106492724(FUK)
ASN: 102368059(FUK)
AMJ: 102572043(FUK)
CMY: 102943730(FUK)
CPIC: 101941728(FUK)
ACS: 100558701(fuk)
PVT: 110081311(FUK)
PBI: 103061608(FUK)
GJA: 107117655(FUK)
XLA: 100137687(fuk.L)
XTR: 100497304(fuk)
NPR: 108803447(FUK)
DRE: 100150934(fuk)
SRX: 107720764 107740890(fuk)
AMEX: 103035161(fuk)
TRU: 101074270(fuk)
LCO: 104937043(fuk)
NCC: 104956228(fuk)
MZE: 101463615(fuk)
OLA: 101172159(fuk)
XMA: 102237071(fuk)
PRET: 103466785(fuk)
NFU: 107389126(fuk)
CSEM: 103379717(fuk)
LCF: 108893719(fuk)
HCQ: 109518183(fuk)
BPEC: 110155087(fuk)
SASA: 106560702(fuk)
ELS: 105026607(fuk)
SFM: 108934685(fuk)
LCM: 102347730(FUK)
CMK: 103186660(fuk)
CIN: 100182438
SPU: 100892878(fuk)
APLC: 110975638
CRG: 105323794
MYI: 110463342
EPA: 110233424
HMG: 101234558
ATH: AT1G01220(FKGP)
CRB: 17876572
BRP: 103843778
BOE: 106312465
THJ: 104815884
CPAP: 110808528
CIT: 102607405
TCC: 18613941
GRA: 105763919
GHI: 107945905
DZI: 111304857
EGR: 104445349
VRA: 106754135
VAR: 108343062
CCAJ: 109796650
CAM: 101489062
LJA: Lj1g3v5038190.1(Lj1g3v5038190.1) Lj1g3v5038190.2(Lj1g3v5038190.2)
ADU: 107491927
AIP: 107646095
LANG: 109333340
FVE: 101313747
PPER: 18785393
PMUM: 103332228
PAVI: 110757650
MDM: 103439376
PXB: 103927198
ZJU: 107423663
CSV: 101204338
CMO: 103483166
MCHA: 111016303
CMOS: 111441674
CPEP: 111800352
RCU: 8282132
JCU: 105642816
HBR: 110632095
POP: 7486785
JRE: 109010378
VVI: 100258719
SLY: 101258193
SPEN: 107007997
SOT: 102590041
CANN: 107839347
NSY: 104228145
NTO: 104121367
INI: 109150877
SIND: 105173828
OEU: 111409933
HAN: 110937555
LSV: 111894586
DCR: 108209637
BVG: 104907115
SOE: 110786573
NNU: 104604718
OSA: 4331392
DOSA: Os03t0115100-01(Os03g0115100)
OBR: 102713062
BDI: 100826076
ATS: 109785929(LOC109785929)
SBI: 8078003
ZMA: 100381824
SITA: 101773659
PDA: 103719462
EGU: 105043452
MUS: 103970309
DCT: 110094703
AOF: 109825030
ATR: 18447674
PPP: 112278448
DFA: DFA_01669
FCY: FRACYDRAFT_232262(FUK1)
TCR: 508379.10
ROB: CK5_28240
RTO: RTO_22660
SGY: Sgly_1597
SUS: Acid_0569
 » show all
Taxonomy
Reference
1  [PMID:5646161]
  Authors
Ishihara H, Massaro DJ, Heath EC.
  Title
The metabolism of L-fucose. 3. The enzymatic synthesis of beta-L-fucose 1-phosphate.
  Journal
J Biol Chem 243:1103-9 (1968)
Reference
2  [PMID:2986701]
  Authors
Butler W, Serif GS.
  Title
Fucokinase, its anomeric specificity and mechanism of phosphate group transfer.
  Journal
Biochim Biophys Acta 829:238-43 (1985)
DOI:10.1016/0167-4838(85)90193-1
Reference
3  [PMID:9488699]
  Authors
Park SH, Pastuszak I, Drake R, Elbein AD.
  Title
Purification to apparent homogeneity and properties of pig kidney L-fucose kinase.
  Journal
J Biol Chem 273:5685-91 (1998)
DOI:10.1074/jbc.273.10.5685
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.52
IUBMB Enzyme Nomenclature: 2.7.1.52
ExPASy - ENZYME nomenclature database: 2.7.1.52
BRENDA, the Enzyme Database: 2.7.1.52
CAS: 37278-00-5

DBGET integrated database retrieval system