| Entry |
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| Name |
galactokinase;
galactokinase (phosphorylating);
ATP:D-galactose-1-phosphotransferase
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
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| Sysname |
ATP:alpha-D-galactose 1-phosphotransferase
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| Reaction(IUBMB) |
ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate [RN: R01092]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
ADP [CPD: C00008];
alpha-D-galactose 1-phosphate [CPD: C00446]
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| Comment |
Part of the Leloir pathway for galactose metabolism. The enzymes from mammals and from the bacterium Escherichia coli have no activity with N-acetyl-alpha-D-galactosamine [4-6].
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| History |
EC 2.7.1.6 created 1961
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| Pathway |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
CARDINI CE, LELOIR LF. |
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| Title |
Enzymic phosphorylation of galactosamine and galactose. |
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| Journal |
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| Reference |
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| Authors |
NEUFELD EF, FEINGOLD DS, HASSID WZ. |
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| Title |
Phosphorylation of D-galactose and L-arabinose by extracts from Phaseolus aureus seedlings. |
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| Journal |
J Biol Chem 235:906-9 (1960) |
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| Reference |
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| Authors |
Wilkinson JF. |
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| Title |
The pathway of the adaptive fermentation of galactose by yeast. |
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| Journal |
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| Reference |
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| Authors |
Yang J, Fu X, Jia Q, Shen J, Biggins JB, Jiang J, Zhao J, Schmidt JJ, Wang PG, Thorson JS |
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| Title |
Studies on the substrate specificity of Escherichia coli galactokinase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Timson DJ, Reece RJ |
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| Title |
Sugar recognition by human galactokinase. |
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| Journal |
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| Reference |
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| Authors |
Thoden JB, Timson DJ, Reece RJ, Holden HM |
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| Title |
Molecular structure of human galactokinase: implications for type II galactosemia. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.1.6 |
| ExPASy - ENZYME nomenclature database: | 2.7.1.6 |
| BRENDA, the Enzyme Database: | 2.7.1.6 |
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