KEGG   ENZYME: 2.7.1.74Help
Entry
EC 2.7.1.74                 Enzyme                                 

Name
deoxycytidine kinase;
deoxycytidine kinase (phosphorylating);
2'-deoxycytidine kinase;
Ara-C kinase;
arabinofuranosylcytosine kinase;
deoxycytidine-cytidine kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
NTP:deoxycytidine 5'-phosphotransferase
Reaction(IUBMB)
NTP + deoxycytidine = NDP + dCMP [RN:R02321]
Reaction(KEGG)
R02321 > R01666;
(other) R00185
Show
Substrate
NTP [CPD:C00201];
deoxycytidine [CPD:C00881]
Product
NDP [CPD:C00454];
dCMP [CPD:C00239]
Comment
Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors.
History
EC 2.7.1.74 created 1972
Pathway
ec00230  Purine metabolism
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Orthology
K00893  deoxycitidine kinase
K15519  deoxyadenosine/deoxycytidine kinase
Genes
HSA: 1633(DCK)
PTR: 461273(DCK)
PPS: 100990892(DCK)
GGO: 101153698(DCK)
PON: 100459989(DCK)
NLE: 100580396(DCK)
MCC: 705040(DCK)
MCF: 101925611(DCK)
CSAB: 103235762(DCK)
RRO: 104678729(DCK)
RBB: 108534027(DCK)
CJC: 100395055(DCK)
SBQ: 101045176(DCK)
MMU: 13178(Dck)
RNO: 79127(Dck)
CGE: 100751299(Dck)
NGI: 103730983(Dck)
HGL: 101722212(Dck)
CCAN: 109679520(Dck)
OCU: 100348589(DCK)
TUP: 102498967(DCK)
CFA: 482188(DCK)
AML: 100482093(DCK)
UMR: 103665295(DCK)
ORO: 101384844(DCK)
FCA: 101083845(DCK)
PTG: 102949132(DCK)
AJU: 106983696(DCK)
BTA: 530642(DCK)
BOM: 102268258(DCK)
BIU: 109560557(DCK)
PHD: 102324031(DCK)
CHX: 102175015(DCK)
OAS: 101123378(DCK)
SSC: 100517354(DCK)
CFR: 102524113(DCK)
CDK: 105091182(DCK)
BACU: 103015268(DCK)
LVE: 103071330(DCK)
OOR: 101281945(DCK)
ECB: 100054704(DCK)
EPZ: 103560855(DCK)
EAI: 106835100(DCK)
MYB: 102246003 102261934(DCK)
MYD: 102766950(DCK)
HAI: 109393701(DCK)
RSS: 109461108(DCK)
PALE: 102890176(DCK)
LAV: 100667514(DCK)
TMU: 101361286
MDO: 100014536(DCK)
SHR: 100931780(DCK)
OAA: 100078818(DCK)
GGA: 422648(DCK) 770922(DGUOK)
MGP: 100544492(DCK) 100551225
CJO: 107313354(DCK) 107320138
APLA: 101799591(DCK) 101804573
ACYG: 106032673 106043942(DCK)
TGU: 100220427 100223331(DCK)
GFR: 102035084(DCK) 102038779
FAB: 101806066 101811376(DCK)
PHI: 102106204(DCK) 102108269
PMAJ: 107203117(DCK) 107210687
CCAE: 111929482(DCK) 111945349
CCW: 104689701 104696860(DCK)
FPG: 101917700(DCK) 101920025
FCH: 102055990 102056086(DCK)
CLV: 102091484 102092948(DCK)
EGZ: 104125173(DCK) 104128441
AAM: 106491894(DCK) 106493434
ASN: 102381619(DCK) 102382818
AMJ: 102572880(DCK) 102575265
PSS: 102444422(DCK)
CMY: 102946796(DCK)
CPIC: 101948329(DCK)
ACS: 100554557(dck) 100557346
PVT: 110073482 110085258(DCK)
PBI: 103059568(DCK)
GJA: 107123240 107123770(DCK)
XLA: 108710975 446773(dck.2.L) 494987 496391(dck.1.L)
XTR: 549546(dck.2) 594934(dck.1)
NPR: 108784695(DCK) 108797251
DRE: 474325(dck) 541538(zgc:110540)
IPU: 108278442 108279081(dck)
TRU: 101065882(dck)
LCO: 104920317 104922470(dck) 104932480(dguok)
NCC: 104941578 104952207(dck)
PRET: 103459907 103473357(dck)
CSEM: 103389988(dck) 103398651
SDU: 111220806(dck) 111239543
HCQ: 109525557(dck)
BPEC: 110157441(dck) 110175010
MALB: 109969767(dck)
SASA: 100196160(dck) 106603918
OTW: 112220161(dck) 112228262
ELS: 105011305 105027270(dck)
SFM: 108934264 108938663(dck)
LCM: 102355337 102355687(DCK)
CMK: 103186473(dck) 103191301
CIN: 100184470
AQU: 100634027
BRP: 103853852
CANN: 107855796
ASP: AOR13_348
MAI: MICA_1301
BSU: BSU00140(dck)
BSR: I33_0020
BSL: A7A1_1229
BSH: BSU6051_00140(dck)
BSUT: BSUB_00020(dck)
BSUL: BSUA_00020(dck)
BSUS: Q433_00105
BSS: BSUW23_00075(dck)
BST: GYO_0019
BSO: BSNT_06304(dck)
BSQ: B657_00140(dck)
BSX: C663_0016(dck)
BLI: BL02366(dck)
BLD: BLi00023(dck)
BLH: BaLi_c00240(dck)
BAY: RBAM_000190(dcK)
BAQ: BACAU_0015(dck)
BYA: BANAU_0015(dck)
BAMP: B938_00075
BAML: BAM5036_0016(dck)
BAMA: RBAU_0017(dck)
BAMN: BASU_0017(dck)
BAMB: BAPNAU_0015(dck)
BAMT: AJ82_00110
BAMY: V529_00150(dcK)
BMP: NG74_00022(dck)
BAO: BAMF_0015(dck)
BAZ: BAMTA208_00070(dck)
BQL: LL3_00015(dck)
BXH: BAXH7_00016(dcK)
BQY: MUS_0018(dcK)
BAMI: KSO_019335
BAMC: U471_00160
BAMF: U722_00110
BAN: BA_0014
BAR: GBAA_0014
BAT: BAS0017
BAI: BAA_0021
BANT: A16_00180
BANR: A16R_00190
BANS: BAPAT_0015
BANV: DJ46_4407(dck)
BCA: BCE_0015
BCZ: BCE33L0015(dck)
BCQ: BCQ_0021(dck)
BCX: BCA_0021
BAL: BACI_c00210(dck)
BNC: BCN_0015
BCF: bcf_00105
BCER: BCK_07780
BTK: BT9727_0015(dck)
BTL: BALH_0015(dck)
BTT: HD73_0015
BTHI: BTK_00095
BTM: MC28_4734
BTG: BTB_c00200(dck)
BTI: BTG_20810
BTW: BF38_1232(dck)
BWW: bwei_5822(dck)
BMYO: BG05_494
BMYC: DJ92_2604(dck)
BCL: ABC2890(dck)
BPU: BPUM_0511
BPUM: BW16_00115
BPUS: UP12_00110
BPF: BpOF4_04255(dck)
BMQ: BMQ_0019(dck)
BMD: BMD_0019(dck)
BMH: BMWSH_4969(dck)
BMEG: BG04_2295(dck)
BAG: Bcoa_1210
BCOA: BF29_2367(dck)
BJS: MY9_0014
BMET: BMMGA3_00100(dck)
BACW: QR42_00110
BACP: SB24_09640
BACB: OY17_02840
BACO: OXB_0988
BACY: QF06_19060
BACL: BS34A_00220(dck)
BALM: BsLM_0017
BEO: BEH_00105
BGY: BGLY_0018(dck)
BKW: BkAM31D_19295(dck)
BBEV: BBEV_1505(dck)
OIH: OB0015
AFL: Aflv_0014(dck)
AAMY: GFC30_183
LSP: Bsph_0031
VPN: A21D_01450(dck)
BSE: Bsel_2067
SAU: SA0514
SAV: SAV0556
SAW: SAHV_0554
SAM: MW0511
SAS: SAS0514
SAR: SAR0561
SAC: SACOL0603
SAE: NWMN_0518
SAD: SAAV_0519
SUC: ECTR2_510
SUZ: MS7_0546(dck)
SUG: SAPIG0631
SAUA: SAAG_00974
SAUS: SA40_0496
SAUU: SA957_0511
SAUG: SA268_0509
SAUF: X998_0598
SAB: SAB0507c
SAUB: C248_0631
SAUM: BN843_5500
SAUC: CA347_572(dck)
SAUR: SABB_00607(dck)
SAUI: AZ30_02815
SAUD: CH52_02975
SAMS: NI36_02765
SEP: SE0325
SER: SERP0202
SEPP: SEB_00248
SEPS: DP17_1635
SHA: SH2436
SSP: SSP2158
SCA: SCA_0220
SDT: SPSE_2226(dak)
SPAS: STP1_1645
SHU: SHYC_10855(dck)
SCAP: AYP1020_2308(dck)
SSCH: LH95_10445
SSCZ: RN70_11180
SAGQ: EP23_11305
MCL: MCCL_1852
MCAK: MCCS_23990(dck)
ESI: Exig_0015
EAN: Eab7_0016(dck)
BBE: BBR47_21290(dck)
PPY: PPE_00889
PPM: PPSC2_04615(dck)
PPO: PPM_0865(dck)
PPOL: X809_04240
PPOY: RE92_07350
PSAB: PSAB_09380
PRI: PRIO_2447(dck)
SIV: SSIL_0077
JEO: JMA_00270
AMT: Amet_4076
HCR: X271_00459(dck_1) X271_00461(dck_2)
ELJ: ELUMI_v1c07360(dck)
SDI: SDIMI_v3c02370(dck)
STAI: STAIW_v1c02830(dck)
SMIR: SMM_0435
SMIA: P344_02610
SCQ: SCULI_v1c03070(dck)
SATR: SATRI_v1c04920(dck)
SCJ: SCANT_v1c02510(dck)
SHJ: SHELI_v1c02440(dck)
SCLA: SCLARK_001545(dck)
BGA: BG0242(dck)
GBA: J421_0262
MINF: MESINF_0198(dck)
 » show all
Taxonomy
Reference
1  [PMID:5442271]
  Authors
Durham JP, Ives DH.
  Title
Deoxycytidine kinase. II. Purification and general properties of the calf thymus enzyme.
  Journal
J Biol Chem 245:2276-84 (1970)
Reference
2  [PMID:5462538]
  Authors
Ives DH, Durham JP.
  Title
Deoxycytidine kinase. 3. Kinetics and allosteric regulation of the calf thymus enzyme.
  Journal
J Biol Chem 245:2285-94 (1970)
Reference
3  [PMID:5687717]
  Authors
Kessel D.
  Title
Properties of deoxycytidine kinase partially purified from L1210 cells.
  Journal
J Biol Chem 243:4739-44 (1968)
Reference
4  [PMID:5684726]
  Authors
Momparler RL, Fischer GA.
  Title
Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase: purification, properties, and kinetic studies with cytosine arabinoside.
  Journal
J Biol Chem 243:4298-304 (1968)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.74
IUBMB Enzyme Nomenclature: 2.7.1.74
ExPASy - ENZYME nomenclature database: 2.7.1.74
BRENDA, the Enzyme Database: 2.7.1.74
CAS: 9039-45-6

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