KEGG   ENZYME: 2.7.1.78Help
Entry
EC 2.7.1.78                 Enzyme                                 

Name
polynucleotide 5'-hydroxyl-kinase;
ATP:5'-dephosphopolynucleotide 5'-phosphatase;
PNK;
polynucleotide 5'-hydroxyl kinase (phosphorylating);
5'-hydroxyl polynucleotide kinase;
5'-hydroxyl polyribonucleotide kinase;
5'-hydroxyl RNA kinase;
DNA 5'-hydroxyl kinase;
DNA kinase;
polynucleotide kinase;
polynucleotide 5'-hydroxy-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:5'-dephosphopolynucleotide 5'-phosphotransferase
Reaction(IUBMB)
ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA [RN:R03840]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
5'-dephospho-DNA [CPD:C02374]
Product
ADP [CPD:C00008];
5'-phospho-DNA [CPD:C02128]
Comment
Also acts on 5'-dephospho-RNA 3'-mononucleotides.
History
EC 2.7.1.78 created 1972
Orthology
K08073  bifunctional polynucleotide phosphatase/kinase
K14399  polyribonucleotide 5'-hydroxyl-kinase
Genes
HSA: 10978(CLP1) 11284(PNKP)
PTR: 451198(CLP1) 747683(PNKP)
PPS: 100980511(PNKP) 100994100(CLP1)
GGO: 101143287(CLP1) 101152889(PNKP)
PON: 100446807(PNKP) 100460422(CLP1)
NLE: 100584876(CLP1) 100587753(PNKP) 105740322
MCC: 705071(CLP1) 719084(PNKP)
MCF: 102133691(CLP1) 102140873(PNKP)
CSAB: 103235058(PNKP) 103235350(CLP1)
RRO: 104667214(PNKP) 104677688(CLP1)
RBB: 108514865(CLP1) 108535816(PNKP)
CJC: 100386802(CLP1) 100393151(PNKP)
SBQ: 101034804(PNKP) 101048258(CLP1)
MMU: 59047(Pnkp) 98985(Clp1)
RNO: 308576(Pnkp) 311166(Clp1)
CGE: 100755872(Clp1) 100767996(Pnkp)
NGI: 103736636(Clp1) 103743682(Pnkp)
HGL: 101712591(Pnkp) 101723956(Clp1)
CCAN: 109683911(Pnkp) 109688983(Clp1)
OCU: 100350312(CLP1)
TUP: 102486675(PNKP) 102490551(CLP1)
CFA: 484373(PNKP) 610161(CLP1)
AML: 100465832(PNKP) 100478336(CLP1)
UMR: 103657264(PNKP) 103666119(CLP1)
ORO: 101365436(CLP1) 101365837(PNKP)
FCA: 101091047(CLP1) 101093816(PNKP)
PTG: 102960670(CLP1) 102970079(PNKP)
AJU: 106979564(CLP1) 106983117(PNKP)
BTA: 506507(CLP1) 616621(PNKP)
BOM: 102264513(PNKP) 102277848(CLP1)
BIU: 109569885(CLP1) 109572131(PNKP)
PHD: 102332188(PNKP) 102333022(CLP1)
CHX: 102171898(CLP1) 102186043(PNKP)
OAS: 101106031(CLP1) 101114209(PNKP)
SSC: 100520541(CLP1) 100522442(PNKP)
CFR: 102515013(CLP1) 102516230(PNKP)
CDK: 105100187(PNKP) 105101224(CLP1)
BACU: 103001420(PNKP) 103006007(CLP1)
LVE: 103075581(PNKP) 103089865(CLP1)
OOR: 101280708(CLP1) 101290195(PNKP)
ECB: 100052218(PNKP) 100066955(CLP1)
EPZ: 103558224(CLP1) 103558284(PNKP)
EAI: 106822557(CLP1) 106824173(PNKP)
HAI: 109371620(CLP1) 109391028(PNKP)
RSS: 109436669(CLP1) 109452522(PNKP)
PALE: 102890706(CLP1) 102898132(PNKP)
LAV: 100657486(CLP1) 100672018(PNKP)
MDO: 100017655 100022871(CLP1) 100030171(PNKP)
SHR: 100928810(PNKP) 100931522(CLP1)
OAA: 100088944(PNKP) 100092173
GGA: 423131(CLP1)
MGP: 100547570(CLP1)
CJO: 107307754(PNKP) 107314449(CLP1)
APLA: 101799689(CLP1)
ACYG: 106033820(CLP1)
TGU: 100220989(CLP1)
GFR: 102032848(CLP1)
FAB: 101819677(CLP1)
PHI: 102107142(PNKP) 102108463(CLP1)
PMAJ: 107205510(CLP1)
FPG: 101916434(CLP1) 101924800(PNKP)
FCH: 102050209(PNKP) 102056567(CLP1)
CLV: 102091765(CLP1)
EGZ: 104129563(CLP1)
AAM: 106489148(CLP1)
ASN: 102372510(PNKP) 102384463(CLP1)
AMJ: 102558202(PNKP) 102571624(CLP1)
PSS: 102462947(CLP1)
CMY: 102932686(CLP1)
CPIC: 101933800(CLP1) 101940494(PNKP)
ACS: 100556487(clp1) 100558808(pnkp)
PVT: 110078286(CLP1) 110086941(PNKP)
GJA: 107110661(CLP1) 107119268(PNKP)
XLA: 100137702(pnkp.S) 431824(clp1.L)
XTR: 100145800(pnkp) 493364(clp1)
NPR: 108788104(CLP1) 108792103(PNKP)
DRE: 565621(clp1) 569462(pnkp)
IPU: 108268688(clp1) 108278314(pnkp)
AMEX: 103026644(pnkp) 103032393(clp1)
LCO: 104930443(pnkp)
NCC: 104951307(clp1) 104963321(pnkp)
MZE: 101480033(pnkp) 101487618(clp1)
OLA: 101158455(clp1) 101167386(pnkp)
XMA: 102216608(clp1) 102228822(pnkp)
PRET: 103471362(clp1) 103474841(pnkp)
NFU: 107374549(pnkp) 107376815(clp1)
LCF: 108885554(clp1) 108890636(pnkp)
HCQ: 109524444(clp1) 109529349(pnkp)
ELS: 105011239(pnkp) 105028688(clp1)
SFM: 108928645(pnkp) 108935929(clp1)
LCM: 102364593(PNKP) 102366070(CLP1)
CIN: 100182223 100183747(clp1)
DME: Dmel_CG5970(cbc) Dmel_CG9601(CG9601)
DSI: Dsimw501_GD20873(Dsim_GD20873) Dsimw501_GD25757(Dsim_GD25757)
AGA: AgaP_AGAP007701(CLP1_ANOGA)
CEL: CELE_F21D5.5(F21D5.5) CELE_F59A2.4(clpf-1)
ATH: AT3G04680(CLPS3) AT3G14890 AT5G39930(CLPS5)
LJA: Lj0g3v0096039.1(Lj0g3v0096039.1) Lj3g3v0427320.1(Lj3g3v0427320.1) Lj5g3v2290070.1(Lj5g3v2290070.1) Lj5g3v2290070.2(Lj5g3v2290070.2) Lj5g3v2290070.3(Lj5g3v2290070.3)
DOSA: Os01t0737300-00(Os01g0737300) Os02t0217500-01(Os02g0217500)
ATS: 109748167(LOC109748167) 109778679(LOC109778679)
ZMA: 100284798 541878(dnp2)
PDA: 103709610
SCE: YOR250C(CLP1)
ERC: Ecym_2382
KMX: KLMA_30448(CLP1)
NCS: NCAS_0B01210(NCAS0B01210)
NDI: NDAI_0E01090(NDAI0E01090)
TPF: TPHA_0D01350(TPHA0D01350)
TBL: TBLA_0D01320(TBLA0D01320)
TDL: TDEL_0A06350(TDEL0A06350)
KAF: KAFR_0A03930(KAFR0A03930)
CAL: CAALFM_C303840CA(CaO19.6931)
CAUR: QG37_00792
SLB: AWJ20_420(CLP1)
NTE: NEUTE1DRAFT103221(NEUTE1DRAFT_103221) NEUTE1DRAFT79143(NEUTE1DRAFT_79143)
MAW: MAC_01725
BFU: BCIN_04g01720(Bctpp1) BCIN_12g03610(Bcclp1)
ANG: ANI_1_612164(An18g04570) ANI_1_818164(An18g06170)
ABE: ARB_00183(pnk1) ARB_03056
TVE: TRV_03023
ABP: AGABI1DRAFT104404(AGABI1DRAFT_104404) AGABI1DRAFT125354(AGABI1DRAFT_125354)
ABV: AGABI2DRAFT115344(AGABI2DRAFT_115344) AGABI2DRAFT176420(AGABI2DRAFT_176420)
MGL: MGL_1095
DDI: DDB_G0281229(PNKP) DDB_G0285507(clp1)
EHI: EHI_008100(55.t00023) EHI_148430(1.t00112)
PYO: PY17X_0709400(PY04248) PY17X_1140600(PY05803)
PCB: PCHAS_071830(PC000337.04.0) PCHAS_113870
TPV: TP01_0091
BBO: BBOV_IV000690(21.m03011) BBOV_IV008810(23.m06130)
CPV: cgd5_2880
SMIN: v1.2.015573.t1(symbB.v1.2.015573.t1) v1.2.022936.t1(symbB.v1.2.022936.t1)
 » show all
Taxonomy
Reference
1  [PMID:4287929]
  Authors
Novogrodsky A, Hurwitz J.
  Title
The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. I. Phosphorylation at 5'-hydroxyl termini.
  Journal
J Biol Chem 241:2923-32 (1966)
Reference
2  [PMID:4287930]
  Authors
Novogrodsky A, Tal M, Traub A, Hurwitz J.
  Title
The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. II. Further properties of the 5'-hydroxyl polynucleotide kinase.
  Journal
J Biol Chem 241:2933-43 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.78
IUBMB Enzyme Nomenclature: 2.7.1.78
ExPASy - ENZYME nomenclature database: 2.7.1.78
BRENDA, the Enzyme Database: 2.7.1.78
CAS: 37211-65-7

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