Entry |
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Name |
protein kinase C;
calcium-dependent protein kinase C;
calcium-independent protein kinase C;
calcium/phospholipid dependent protein kinase;
cPKCalpha;
cPKCbeta;
cPKCgamma;
nPKCdelta;
nPKCepsilon;
nPKC;
nPKC;
PKC;
PKCalpha;
PKCbeta;
PKCgamma;
PKCdelta;
PKCepsilon;
PKCzeta;
Pkc1p;
protein kinase Cepsilon;
STK24
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Class |
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
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Sysname |
ATP:protein phosphotransferase (diacylglycerol-dependent)
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Reaction(IUBMB) |
ATP + a protein = ADP + a phosphoprotein [RN: R00162]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters.
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History |
EC 2.7.11.13 created 2005 (EC 2.7.1.37 part-incorporated 2005)
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Orthology |
K02677 | classical protein kinase C alpha type |
K06068 | novel protein kinase C delta type |
K06069 | atypical protein kinase C iota type |
K06071 | serine/threonine-protein kinase N1 |
K18050 | novel protein kinase C epsilon type |
K18051 | novel protein kinase C eta type |
K18052 | novel protein kinase C theta type |
K18952 | atypical protein kinase C zeta type |
K19662 | classical protein kinase C beta type |
K19663 | classical protein kinase C gamma type |
K23691 | serine/threonine-protein kinase N2 |
K23692 | serine/threonine-protein kinase N3 |
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Genes |
» show all
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Reference |
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Authors |
Jaken S. |
Title |
Protein kinase C and tumor promoters. |
Journal |
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Reference |
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Authors |
Parekh DB, Ziegler W, Parker PJ. |
Title |
Multiple pathways control protein kinase C phosphorylation. |
Journal |
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Reference |
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Authors |
Valledor AF, Xaus J, Comalada M, Soler C, Celada A. |
Title |
Protein kinase C epsilon is required for the induction of mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. |
Journal |
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Reference |
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Authors |
Lendenfeld T, Kubicek CP. |
Title |
Characterization and properties of protein kinase C from the filamentous fungus Trichoderma reesei. |
Journal |
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Reference |
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Authors |
Brooks SP, Storey KB. |
Title |
Protein kinase C from rainbow trout brain: identification and characterization of three isozymes. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.7.11.13 |
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