KEGG   ENZYME: 2.7.11.15Help
Entry
EC 2.7.11.15                Enzyme                                 

Name
beta-adrenergic-receptor kinase;
ATP:beta-adrenergic-receptor phosphotransferase;
[beta-adrenergic-receptor] kinase;
beta-adrenergic receptor-specific kinase;
beta-AR kinase;
beta-ARK;
beta-ARK 1;
beta-ARK 2;
beta-receptor kinase;
GRK2;
GRK3;
beta-adrenergic-receptor kinase (phosphorylating);
beta2ARK;
betaARK1;
beta-adrenoceptor kinase;
beta-adrenoceptor kinase 1;
beta-adrenoceptor kinase 2;
ADRBK1;
BARK1;
adrenergic receptor kinase;
STK15
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[beta-adrenergic receptor] phosphotransferase
Reaction(IUBMB)
ATP + [beta-adrenergic receptor] = ADP + phospho-[beta-adrenergic receptor] [RN:R03274]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
[beta-adrenergic receptor] [CPD:C01141]
Product
ADP [CPD:C00008];
phospho-beta-adrenergic receptor [CPD:C04141]
Comment
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
History
EC 2.7.11.15 created 1989 as EC 2.7.1.126, transferred 2005 to EC 2.7.11.15
Orthology
K00910  beta-adrenergic-receptor kinase
Genes
HSA: 156(GRK2) 157(GRK3)
PTR: 100614029(GRK3) 451363(GRK2)
PPS: 100984800(GRK3) 100991802(GRK2)
GGO: 101140574(GRK2) 101148325(GRK3)
PON: 100454669(GRK3) 100461893(GRK2)
NLE: 100582671(GRK3) 100604826(ADRBK1) 105737617
MCC: 714510(GRK3) 721754(GRK2)
MCF: 102141861(GRK2) 102141926(GRK3)
CSAB: 103219132(GRK2) 103223079(GRK3)
RRO: 104664749(GRK2) 104671949(GRK3)
RBB: 108515962(GRK3) 108518610(GRK2)
CJC: 100396838(GRK3)
SBQ: 101027803(ADRBK2) 101049133(ADRBK1)
MMU: 110355(Grk2) 320129(Grk3)
RNO: 25238(Grk2) 25372(Grk3)
CGE: 100761290(Adrbk2) 100762552(Grk2)
NGI: 103725575(Grk2) 103746714(Grk3)
HGL: 101708742(Grk3) 101708906(Grk2)
CCAN: 109684472 109690706(Grk2) 109701375(Grk3)
OCU: 100349708(GRK3) 103345045(GRK2)
TUP: 102482004(GRK2) 102499442(GRK3)
CFA: 483701(GRK2) 486327(GRK3)
AML: 100469854(GRK2) 100475417(GRK3)
UMR: 103659256(GRK3) 103679607(GRK2)
ORO: 101384757(ADRBK1) 101385645(ADRBK2)
FCA: 101090393(GRK3) 101101082(GRK2)
PTG: 102957039(GRK3) 102970752(GRK2)
AJU: 106971185(GRK2) 106982294(GRK3)
BTA: 282136(GRK3) 282682(GRK2)
BOM: 102286310(GRK2) 102288247(GRK3)
BIU: 109554452(GRK2) 109571286(GRK3)
PHD: 102322462(GRK3) 102323551(GRK2)
CHX: 102180735(GRK2) 102185296(GRK3)
OAS: 101108265(ADRBK1) 101117366(ADRBK2)
SSC: 100156449(GRK3) 100513842(GRK2)
CFR: 102505202(GRK3) 102523137(GRK2)
CDK: 105099520(GRK3) 105104436(GRK2)
BACU: 103005732(GRK3) 103015958 103019615(GRK2)
LVE: 103073421(GRK3) 103076247(GRK2)
OOR: 101270842(ADRBK2) 101283682(ADRBK1)
ECB: 100059001(GRK2) 100065495(GRK3) 111767400(GRK3)
EPZ: 103550032(GRK3) 103559830(GRK2)
EAI: 106833505(GRK2) 106841709(GRK3)
MYB: 102243341(GRK2) 102248143(GRK3)
MYD: 102761774(GRK3) 102764962(GRK2)
HAI: 109384296(GRK2) 109394134(GRK3)
RSS: 109450370(GRK2) 109460327(GRK3)
PALE: 102881239(GRK3) 102893733(GRK2)
LAV: 100666578(GRK3) 100671884(GRK2)
MDO: 100009844(GRK3)
SHR: 100913578(GRK3)
GGA: 416904(GRK3) 426000(GRK2)
MGP: 100541374(GRK3) 100545380(GRK2)
CJO: 107314190(GRK2) 107321443(GRK3)
APLA: 101801089(ADRBK1) 101802877(GRK3)
ACYG: 106029321(ADRBK1) 106031075(ADRBK2)
TGU: 100217970(GRK3) 100227701(GRK2)
GFR: 102032477(GRK2) 102036360(GRK3)
FAB: 101810197(GRK3) 101811193(GRK2)
PHI: 102108753(GRK3) 102114443(GRK2)
PMAJ: 107205270(GRK2) 107211779(GRK3)
CCW: 104688799(GRK3)
FPG: 101911656(GRK2) 101916842(GRK3)
FCH: 102048951(GRK3) 102058946(GRK2)
CLV: 102092240(GRK2) 102096658(GRK3)
EGZ: 104128318(ADRBK2) 104129654
ASN: 102367979(GRK2) 102378654(GRK3)
AMJ: 102563874(GRK2) 106737118(GRK3)
PSS: 102443539(GRK2) 102454375
CMY: 102946005(GRK3) 102947181(GRK2)
CPIC: 101944586(GRK2) 101953922(GRK3)
ACS: 100555775(grk2) 103282961
PVT: 110083438(GRK3) 110085629(GRK2)
PBI: 103064129(GRK2) 103066055(GRK3)
GJA: 107116822(GRK2) 107123215(GRK3)
XTR: 100379889(grk3)
NPR: 108790542
DRE: 569403(grk3)
IPU: 108276813(ADRBK2)
AMEX: 103046030
TRU: 101073064(grk3)
MZE: 101476711(grk3)
OLA: 111948284(grk3)
XMA: 102224709(grk3)
PRET: 103473184
NFU: 107396329
KMR: 108245400
CSEM: 103389928(grk3)
LCF: 108895613(grk3)
SDU: 111224273(grk3)
HCQ: 109527953(grk3)
BPEC: 110166677(grk3)
MALB: 109974750(grk3)
ELS: 105015221(grk3)
SFM: 108930044(grk3)
LCM: 102362780(GRK2) 102365333(ADRBK2)
CMK: 103184070
CIN: 100184862(adrbk2)
SPU: 100888242(adrbk2)
APLC: 110987558
DME: Dmel_CG40129(Gprk1)
DSI: Dsimw501_GD17695(Dsim_GD17695) Dsimw501_GD28815(Dsim_GD28815)
AAG: 5568458
AME: 413197
BIM: 100748232
BTER: 100651375
SOC: 105194556
AEC: 105153411
ACEP: 105619512
PBAR: 105422796
HST: 105181552
DQU: 106746819
CFO: 105258109
LHU: 105678424
PGC: 109856349
PCF: 106783861
NVI: 100121113
MDL: 103575167
TCA: 654946
DPA: 109537817
NVL: 108568789
BMOR: 101741546
PMAC: 106717955
PRAP: 110992337
HAW: 110372807
API: 100166085(Gprk1)
ZNE: 110841237
FCD: 110856660
DPX: DAPPUDRAFT_194156(Grk2)
TUT: 107361145
CEL: CELE_W02B3.2(grk-2)
CBR: CBG15249(Cbr-grk-2)
TSP: Tsp_00495
CRG: 105319304
MYI: 110461337
OBI: 106871981
LAK: 106181894
SHX: MS3_04047
ADF: 107338012
HMG: 100214170
AQU: 100638292
 » show all
Taxonomy
Reference
1  [PMID:3036840]
  Authors
Benovic JL, Mayor F Jr, Staniszewski C, Lefkowitz RJ, Caron MG
  Title
Purification and characterization of the beta-adrenergic receptor kinase.
  Journal
J Biol Chem 262:9026-32 (1987)
Reference
2  [PMID:8394172]
  Authors
Kim CM, Dion SB, Onorato JJ, Benovic JL.
  Title
Expression and characterization of two beta-adrenergic receptor kinase isoforms using the baculovirus expression system.
  Journal
Receptor 3:39-55 (1993)
Reference
3  [PMID:9349395]
  Authors
Laugwitz KL, Kronsbein K, Schmitt M, Hoffmann K, Seyfarth M, Schomig A, Ungerer M.
  Title
Characterization and inhibition of beta-adrenergic receptor kinase in intact myocytes.
  Journal
Cardiovasc Res 35:324-33 (1997)
Reference
4  [PMID:7559596]
  Authors
Ferguson SS, Menard L, Barak LS, Koch WJ, Colapietro AM, Caron MG.
  Title
Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1.
  Journal
J Biol Chem 270:24782-9 (1995)
DOI:10.1074/jbc.270.42.24782
Reference
5  [PMID:14654303]
  Authors
Willets JM, Challiss RA, Nahorski SR.
  Title
Non-visual GRKs: are we seeing the whole picture?
  Journal
Trends Pharmacol Sci 24:626-33 (2003)
DOI:10.1016/j.tips.2003.10.003
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.15
IUBMB Enzyme Nomenclature: 2.7.11.15
ExPASy - ENZYME nomenclature database: 2.7.11.15
BRENDA, the Enzyme Database: 2.7.11.15
CAS: 102925-39-3

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