KEGG   ENZYME: 2.7.11.16Help
Entry
EC 2.7.11.16                Enzyme                                 

Name
G-protein-coupled receptor kinase;
G protein-coupled receptor kinase;
GPCR kinase;
GPCRK;
GRK4;
GRK5;
GRK6;
STK16
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[G-protein-coupled receptor] phosphotransferase
Reaction(IUBMB)
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate
Substrate
ATP [CPD:C00002];
[G-protein-coupled receptor]
Product
ADP [CPD:C00008];
[G-protein-coupled receptor] phosphate
Comment
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.15, beta-adrenergic-receptor kinase).
History
EC 2.7.11.16 created 2005
Orthology
K08291  G protein-coupled receptor kinase
Genes
HSA: 2868(GRK4) 2869(GRK5) 2870(GRK6)
PTR: 461082(GRK4) 466217(GRK5) 471760(GRK6)
PPS: 100972068(GRK6) 100972921(GRK4) 100975050(GRK5)
GGO: 101125204(GRK6) 101142802(GRK5) 101148767(GRK4)
PON: 100171722(GRK5) 100433745(GRK6) 100442141(GRK4)
NLE: 100592067(GRK6) 100593251(GRK5) 100595255(GRK4)
MCC: 100427251(GRK5) 700000(GRK6) 720047(GRK4)
MCF: 102115240(GRK4) 102128844(GRK6) 102132362(GRK5)
CSAB: 103216606(GRK5) 103245054(GRK6) 103246447(GRK4)
RRO: 104672234(GRK5) 104678955(GRK4) 104680460(GRK6)
RBB: 108513853(GRK5) 108522739(GRK4) 108544772(GRK6)
CJC: 100400573(GRK5) 100403264(GRK6) 100403887(GRK4) 108591905
SBQ: 101030769(GRK6) 101037649(GRK5) 101054298(GRK4)
MMU: 14772(Grk4) 14773(Grk5) 26385(Grk6)
MCAL: 110285684(Grk5) 110294130(Grk4) 110307882(Grk6)
MPAH: 110326741(Grk5) 110330568(Grk4) 110333637(Grk6)
RNO: 59075(Grk5) 59076(Grk6) 59077(Grk4)
MUN: 110549769(Grk6) 110552404(Grk4) 110566290(Grk5)
CGE: 100767022(Grk4) 100771151 103161260(Grk6)
NGI: 103729285(Grk5) 103732366(Grk6) 103741150(Grk4)
HGL: 101718249(Grk6) 101718850(Grk5) 101720649(Grk4) 101720846
CCAN: 109676704 109685731(Grk4) 109685760(Grk6) 109700825(Grk5)
OCU: 100351551(GRK4) 100357639(GRK6) 103347166 103351438(GRK5)
TUP: 102474598(GRK6) 102480420(GRK4) 102485965(GRK5)
CFA: 100684653(GRK6) 479075(GRK4) 486915(GRK5)
VVP: 112916590(GRK5) 112920421(GRK4) 112925482(GRK6)
AML: 100466557(GRK4) 100478616(GRK6) 100480732(GRK5)
UMR: 103657694(GRK5) 103664442(GRK6) 103676663(GRK4)
UAH: 113245697(GRK4) 113251993(GRK5) 113264153(GRK6)
ORO: 101366445(GRK4) 101377206(GRK6) 101385208(GRK5)
FCA: 101086226(GRK4) 101087379(GRK6) 101089047(GRK5)
PTG: 102955344(GRK4) 102962153(GRK5) 102968971(GRK6)
PPAD: 109267583(GRK6) 109269752(GRK4) 109272977(GRK5)
AJU: 106969373(GRK5) 106975413(GRK6) 106978855(GRK4)
BTA: 281801(GRK5) 512489(GRK4) 521413(GRK6)
BOM: 102271649(GRK6) 102272970(GRK5) 102283303(GRK4)
BIU: 109553055(GRK5) 109560743(GRK4) 109561904(GRK6)
BBUB: 102389056(GRK5) 102389526(GRK4) 102412507(GRK6)
CHX: 102183500(GRK4) 102186301(GRK6) 102190578(GRK5)
OAS: 101107019(GRK6) 101107151(GRK5) 101120060 101122439(GRK4)
SSC: 100152937(GRK5) 100519668(GRK4) 110259389(GRK6)
CDK: 105099593(GRK6) 105103924(GRK4) 105104188(GRK5)
BACU: 103005786(GRK5) 103011898(GRK4) 103017883(GRK6)
LVE: 103071087(GRK5) 103073492 103082340(GRK6)
OOR: 101275494(GRK5) 101276909(GRK6) 101288363(GRK4)
DLE: 111169865(GRK6) 111172254(GRK5)
PCAD: 102979868 102988242(GRK4) 102988311(GRK6) 114484635(GRK5)
ECB: 100053624(GRK4) 100065919(GRK5) 100068570(GRK6)
EPZ: 103539972(GRK6) 103542954 103554506(GRK5) 103558677(GRK4)
EAI: 106825835(GRK4) 106827137(GRK6) 106836364(GRK5)
MYB: 102246592(GRK5) 102255277(GRK6) 102260906(GRK4)
MYD: 102754944 102757801(GRK6) 102758601(GRK5) 102762532(GRK4)
MNA: 107524071(GRK4) 107529777(GRK6) 107532096(GRK5)
HAI: 109382992(GRK5) 109389794(GRK6) 109390911(GRK4)
DRO: 112300283(GRK5) 112316718(GRK4) 112320363(GRK6)
PALE: 102877766(GRK5) 102881935(GRK6) 102893603(GRK4)
RAY: 107509758(GRK5) 107517532(GRK6) 107517995(GRK4)
MJV: 108396051(GRK5) 108406370(GRK6)
LAV: 100659746 100663377(GRK5) 100663381(GRK6) 100670615(GRK4)
MDO: 100021366(GRK4) 100026232(GRK5) 100031943(GRK6)
PCW: 110209572(GRK5) 110212220(GRK4) 110216761(GRK6)
OAA: 100074050(GRK4) 100084269(GRK5) 100084380(GRK6)
GGA: 416361(GRK6) 422879(GRK4) 423929(GRK5)
MGP: 100539666 100540688(GRK4) 100550765(GRK6)
CJO: 107314005(GRK4) 107316182(GRK5) 107320438(GRK6)
NMEL: 110398045(GRK4) 110399963(GRK5) 110405115(GRK6)
ACYG: 106034651(GRK4) 106042780(GRK6) 106045200(GRK5)
TGU: 100227306(GRK5) 100229994(GRK6) 100232432(GRK4)
LSR: 110469989(GRK5) 110470777(GRK6) 110481866(GRK4)
SCAN: 103814115(GRK5) 103817367(GRK6) 103823915(GRK4)
GFR: 102035414(GRK5) 102036653(GRK4) 102041334(GRK6)
FAB: 101807573(GRK4) 101814948(GRK5) 101818256(GRK6)
PHI: 102106169(GRK5) 102110063(GRK4) 102110395(GRK6)
PMAJ: 107202831(GRK4) 107206946(GRK5) 107210768(GRK6)
CCAE: 111928238(GRK4) 111930967(GRK5) 111935451(GRK6)
CCW: 104689515(GRK6) 104690771(GRK4) 104694850(GRK5)
ETL: 114060962(GRK5) 114061206(GRK4) 114066262(GRK6) 114066479
FPG: 101911963(GRK6) 101912780(GRK4) 101916330(GRK5) 101919471
FCH: 102046997 102048279(GRK4) 102049406(GRK6) 102050182(GRK5)
CLV: 102084153(GRK6) 102084308 102091969(GRK4) 102093957(GRK5)
EGZ: 104128614(GRK5) 104130186(GRK4) 104135895(GRK6)
NNI: 104016063 104018057(GRK4) 104018951(GRK6) 104022391(GRK5)
ACUN: 113479265(GRK4) 113481464(GRK5) 113485270(GRK6)
PADL: 103912228(GRK6) 103918548(GRK5) 103920932(GRK4)
AAM: 106489500(GRK5) 106489905(GRK6) 106498749(GRK4)
ASN: 102381837(GRK4) 102383862 102387634(GRK6) 102388176(GRK5)
AMJ: 102557717(GRK5) 102569938(GRK6) 102572009(GRK4) 102573177
CMY: 102936492(GRK4) 102943434(GRK5) 102944452(GRK6) 102948318
CPIC: 101931530(GRK5) 101936310 101938937(GRK4) 101944859(GRK6)
ACS: 100554970 100564440(grk6) 100568068(grk5)
PVT: 110075170 110075316(GRK5) 110077405(GRK6)
PMUR: 107288606(GRK5) 107291402(GRK6) 107295358
XLA: 108696022 108697324 108711651 108712671 446831(grk4.L) 447337(grk6.S) 474158(grk4.S) 733256(grk5.L)
XTR: 100379796(grk6) 100497344(grk5) 448587(grk4) 550070(grk5)
NPR: 108783744(GRK6) 108785832(GRK4) 108795411 108802218(GRK5)
DRE: 560761(grk4) 560806(grk5) 561288(grk6) 567452(grk5l)
IPU: 108265152 108277214(Grk5) 108278711(grk6)
LCM: 102345414(GRK5) 102358242 102359573(GRK6) 102364205(GRK4)
CMK: 103177327(grk6) 103186330(grk4) 103186576(grk5)
SPU: 756375
APLC: 110988180
SKO: 100374101(GRK5)
DME: Dmel_CG17998(Gprk2)
DER: 6554722
DSI: Dsimw501_GD21578(Dsim_GD21578)
DSR: 110191388
DPE: 6598666
DWI: 6649829
DAZ: 108608671
DNV: 108659601
DHE: 111597155
MDE: 101901760
LCQ: 111682859
AAG: 5567507
AME: 410632
BIM: 100741600
CCAL: 108630771
OBB: 114876758
SOC: 105199349
MPHA: 105829530
AEC: 105146542
ACEP: 105624805
PBAR: 105433159
VEM: 105564122
HST: 105184862
DQU: 106749793
CFO: 105252842
LHU: 105672492
PGC: 109860236
OBO: 105275024
PCF: 106788165
NVI: 100122766
CSOL: 105363233
MDL: 103578293
TCA: 656376
DPA: 109545471
ATD: 109594515
NVL: 108560187
BMOR: 101747093
PRAP: 110998692
HAW: 110377080
TNL: 113495152
API: 100165035
DNX: 107168275
AGS: 114127518
RMD: 113555217
BTAB: 109038990
CLEC: 106662266
FCD: 110858013
DPX: DAPPUDRAFT_127071(Grk1)
PVM: 113817454
TUT: 107369896
DPTE: 113795012
CSCU: 111612737
PTEP: 107452617
CEL: CELE_F19C6.1(grk-1)
CBR: CBG01947(Cbr-grk-1)
PCAN: 112564568
CRG: 105324517
MYI: 110451725
OBI: 106876126
LAK: 106178688
SHX: MS3_10159
EGL: EGR_02568
EPA: 110245004
ADF: 107338742
PDAM: 113682745
SPIS: 111331987
DGT: 114515746
HMG: 100197054
AQU: 100637826
 » show all
Taxonomy
Reference
1  [PMID:8288567]
  Authors
Kunapuli P, Onorato JJ, Hosey MM, Benovic JL.
  Title
Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5.
  Journal
J Biol Chem 269:1099-105 (1994)
  Sequence
[hsa:2869]
Reference
2  [PMID:8120045]
  Authors
Premont RT, Koch WJ, Inglese J, Lefkowitz RJ.
  Title
Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.
  Journal
J Biol Chem 269:6832-41 (1994)
  Sequence
[bta:281801]
Reference
3  [PMID:14654303]
  Authors
Willets JM, Challiss RA, Nahorski SR.
  Title
Non-visual GRKs: are we seeing the whole picture?
  Journal
Trends Pharmacol Sci 24:626-33 (2003)
DOI:10.1016/j.tips.2003.10.003
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.16
IUBMB Enzyme Nomenclature: 2.7.11.16
ExPASy - ENZYME nomenclature database: 2.7.11.16
BRENDA, the Enzyme Database: 2.7.11.16

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