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Entry
EC 2.7.11.20                Enzyme                                 

Name
elongation factor 2 kinase;
Ca/CaM-kinase III;
calmodulin-dependent protein kinase III;
CaM kinase III;
eEF2 kinase;
eEF2K;
EF2K;
STK19
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[elongation factor 2] phosphotransferase
Reaction(IUBMB)
ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate
Substrate
ATP [CPD:C00002];
[elongation factor 2]
Product
ADP [CPD:C00008];
[elongation factor 2] phosphate
Comment
Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC 2.7.11.11, cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+ [1,2].
History
EC 2.7.11.20 created 2005
Orthology
K08292  elongation factor 2 kinase
Genes
HSA: 29904(EEF2K)
PTR: 454350(EEF2K)
PPS: 100974702(EEF2K)
GGO: 101135987(EEF2K)
PON: 100457763(EEF2K)
NLE: 100591954(EEF2K)
MCC: 698604(EEF2K)
MCF: 102136849(EEF2K)
CSAB: 103229593(EEF2K)
RRO: 104682093(EEF2K)
RBB: 108514252(EEF2K)
CJC: 100390187(EEF2K)
SBQ: 101029579(EEF2K)
MMU: 13631(Eef2k)
RNO: 25435(Eef2k)
CGE: 100765385(Eef2k)
NGI: 103742746(Eef2k)
HGL: 101709310(Eef2k)
CCAN: 109686284(Eef2k)
OCU: 100347896(EEF2K)
TUP: 102470788(EEF2K)
CFA: 479812(EEF2K)
AML: 100482707(EEF2K)
UMR: 103668877(EEF2K)
ORO: 101363112(EEF2K)
FCA: 101101433(EEF2K)
PTG: 102960729(EEF2K)
AJU: 106970506(EEF2K)
BTA: 521730(EEF2K)
BOM: 102283488(EEF2K) 106701273
BIU: 109578373(EEF2K)
PHD: 102324564(EEF2K)
CHX: 102168229(EEF2K)
OAS: 101103447(EEF2K)
SSC: 100523723(EEF2K)
CFR: 102515399(EEF2K)
CDK: 105092290(EEF2K)
BACU: 102997361(EEF2K)
LVE: 103084838(EEF2K)
OOR: 101270520(EEF2K)
ECB: 100058387(EEF2K)
EPZ: 103567577(EEF2K)
EAI: 106841742(EEF2K)
MYB: 102240849(EEF2K) 102245848
MYD: 102761531(EEF2K)
HAI: 109386570(EEF2K)
RSS: 109458204(EEF2K)
PALE: 102897678(EEF2K)
LAV: 100669506(EEF2K)
TMU: 101351746
MDO: 100019979(EEF2K)
SHR: 100917051(EEF2K) 105749596
OAA: 100077045(EEF2K)
GGA: 416619(EEF2K)
MGP: 100547079(EEF2K)
CJO: 107320867(EEF2K)
APLA: 101798747(EEF2K)
ACYG: 106033497(EEF2K)
TGU: 100226037(EEF2K)
GFR: 102034166(EEF2K)
FAB: 101818070(EEF2K)
PHI: 102109650(EEF2K)
PMAJ: 107211299(EEF2K)
CCAE: 111936015(EEF2K)
CCW: 104684860(EEF2K)
FPG: 101920273(EEF2K)
FCH: 102054348(EEF2K)
CLV: 102091136(EEF2K)
EGZ: 104135860(EEF2K)
AAM: 106491361(EEF2K)
ASN: 102383218(EEF2K)
AMJ: 102562118(EEF2K)
PSS: 102444339(EEF2K)
CMY: 102948272(EEF2K)
CPIC: 101933737(EEF2K)
ACS: 100568209(eef2k)
PVT: 110082197(EEF2K)
PBI: 103061498(EEF2K)
GJA: 107123036(EEF2K)
XTR: 100145184(eef2k)
NPR: 108796493(EEF2K)
DRE: 437013(eef2k)
SRX: 107745669 107753299(eef2k)
CCAR: 109053861
IPU: 108273921(eef2k)
AMEX: 103031207(eef2k)
TRU: 105418917
LCO: 104918854(eef2k)
MZE: 101477580(eef2k)
OLA: 101158311(eef2k)
XMA: 102232849(eef2k)
PRET: 103481520(eef2k)
NFU: 107387735(eef2k)
KMR: 108248519(eef2k)
CSEM: 103381767(eef2k)
LCF: 108876059(eef2k)
SDU: 111219818(eef2k)
HCQ: 109527545(eef2k)
BPEC: 110166447(eef2k)
MALB: 109963045(eef2k)
SASA: 106589523 106609006(eef2k)
ELS: 105025068(eef2k)
SFM: 108940089(eef2k)
LCM: 102345198(EEF2K) 102355739
CMK: 103178713(eef2k)
CIN: 100186164
SPU: 583067(eef2k)
SKO: 100376880
CEL: CELE_F42A10.4(efk-1)
CBR: CBG21103(Cbr-efk-1)
BMY: Bm1_35010
TSP: Tsp_07620
CRG: 105321018
MYI: 110466934
OBI: 106875963
EGL: EGR_01890
ADF: 107331965
HMG: 100208670
AQU: 100639147
CRE: CHLREDRAFT_192430(SSA16)
VCN: VOLCADRAFT_33453(ssa16)
SMIN: v1.2.015467.t1(symbB.v1.2.015467.t1)
 » show all
Taxonomy
Reference
1  [PMID:8514778]
  Authors
Mitsui K, Brady M, Palfrey HC, Nairn AC.
  Title
Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas.
  Journal
J Biol Chem 268:13422-33 (1993)
  Sequence
[rno:25435]
Reference
2  [PMID:1372803]
  Authors
Hincke MT, Nairn AC.
  Title
Phosphorylation of elongation factor 2 during Ca(2+)-mediated secretion from rat parotid acini.
  Journal
Biochem J 282 ( Pt 3):877-82 (1992)
Reference
3  [PMID:11500363]
  Authors
Knebel A, Morrice N, Cohen P.
  Title
A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.
  Journal
EMBO J 20:4360-9 (2001)
DOI:10.1093/emboj/20.16.4360
Reference
4  [PMID:15158453]
  Authors
Sans MD, Xie Q, Williams JA.
  Title
Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini.
  Journal
Biochem Biophys Res Commun 319:144-51 (2004)
DOI:10.1016/j.bbrc.2004.04.164
Reference
5  [PMID:14709557]
  Authors
Browne GJ, Finn SG, Proud CG.
  Title
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.
  Journal
J Biol Chem 279:12220-31 (2004)
DOI:10.1074/jbc.M309773200
  Sequence
[hsa:29904]
Reference
6  [PMID:11904175]
  Authors
Ryazanov AG.
  Title
Elongation factor-2 kinase and its newly discovered relatives.
  Journal
FEBS Lett 514:26-9 (2002)
DOI:10.1016/S0014-5793(02)02299-8
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.20
IUBMB Enzyme Nomenclature: 2.7.11.20
ExPASy - ENZYME nomenclature database: 2.7.11.20
BRENDA, the Enzyme Database: 2.7.11.20
CAS: 116283-83-1

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