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Entry
EC 2.7.11.25                Enzyme                                 

Name
mitogen-activated protein kinase kinase kinase;
cMos;
cRaf;
MAPKKK;
MAP3K;
MAP kinase kinase kinase;
MEKK;
MEKK1;
MEKK2;
MEKK3;
MEK kinase;
Mil/Raf;
MLK-like mitogen-activated protein triple kinase;
MLTK;
MLTKa;
MLTKb;
REKS;
STK28
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (MAPKKKK-activated)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) but requires MAPKKKK for activation. Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway [2]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
History
EC 2.7.11.25 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K04415  mitogen-activated protein kinase kinase kinase 8
K04416  mitogen-activated protein kinase kinase kinase 1
K04417  mitogen-activated protein kinase kinase kinase 9
K04418  mitogen-activated protein kinase kinase kinase 10
K04419  mitogen-activated protein kinase kinase kinase 11
K04420  mitogen-activated protein kinase kinase kinase 2
K04421  mitogen-activated protein kinase kinase kinase 3
K04422  mitogen-activated protein kinase kinase kinase 13
K04423  mitogen-activated protein kinase kinase kinase 12
K04424  sterile alpha motif and leucine zipper containing kinase AZK
K04425  mitogen-activated protein kinase kinase kinase 6
K04426  mitogen-activated protein kinase kinase kinase 5
K04427  mitogen-activated protein kinase kinase kinase 7
K04428  mitogen-activated protein kinase kinase kinase 4
K04466  mitogen-activated protein kinase kinase kinase 14
K11228  mitogen-activated protein kinase kinase kinase
K11229  mitogen-activated protein kinase kinase kinase
K11230  mitogen-activated protein kinase kinase kinase
K13414  mitogen-activated protein kinase kinase kinase 1
K13986  mitogen-activated protein kinase kinase kinase 15
K17533  mitogen-activated protein kinase kinase kinase 19
K17534  mitogen-activated protein kinase kinase kinase MLK4
K20605  mitogen-activated protein kinase kinase kinase 2
K20606  mitogen-activated protein kinase kinase kinase ANP1
K20717  mitogen-activated protein kinase kinase kinase YODA
Genes
HSA: 10746(MAP3K2) 1326(MAP3K8) 389840(MAP3K15) 4214(MAP3K1) 4215(MAP3K3) 4216(MAP3K4) 4217(MAP3K5) 4293(MAP3K9) 4294(MAP3K10) 4296(MAP3K11) 51776(MAP3K20) 6885(MAP3K7) 7786(MAP3K12) 80122(MAP3K19) 84451(MAP3K21) 9020(MAP3K14) 9064(MAP3K6) 9175(MAP3K13)
PTR: 450384(MAP3K8) 451326(MAP3K11) 451940(MAP3K12) 454750(MAP3K14) 456674(MAP3K6) 459745(MAP3K20) 462888(MAP3K7) 463023(MAP3K5) 463119(MAP3K4) 465526(MAP3K15) 467498(MAP3K9) 468286(MAP3K3) 468880(MAP3K10) 469711(MAP3K21) 470547(MAP3K19) 471543(MAP3K1) 736244(MAP3K2) 737524(MAP3K13)
PPS: 100969705(MAP3K3) 100971946(MAP3K21) 100973371(MAP3K2) 100974026(MAP3K7) 100975785(MAP3K15) 100977883(MAP3K10) 100978161(MAP3K8) 100981441(MAP3K4) 100983287(MAP3K12) 100984930(MAP3K14) 100985472(MAP3K13) 100985853(MAP3K11) 100990426(MAP3K9) 100991014(MAP3K5) 100992106(MAP3K19) 100992712(MAP3K6) 100994192(MAP3K20) 100994796(MAP3K1)
GGO: 101128207(MAP3K13) 101129821(MAP3K15) 101130070(MAP3K21) 101132363(MAP3K19) 101133328(MAP3K8) 101135149(MAP3K9) 101136722(MAP3K1) 101137766(MAP3K6) 101144707(MAP3K7) 101147354(MAP3K5) 101147819(MAP3K14) 101148044(MAP3K3) 101148067(MAP3K10) 101148964(MAP3K11) 101149805(MAP3K2) 101151387(MAP3K12) 101152649(MAP3K4) 101154523(MAP3K20)
PON: 100171454(MAP3K7) 100172208(MAP3K12) 100172983(MAP3K13) 100433831(MAP3K9) 100436201(MAP3K14) 100440278(MAP3K20) 100442172(MAP3K4) 100444678(MAP3K3) 100445147(MAP3K6) 100448142(MAP3K19) 100450054(MAP3K2) 100450400(MAP3K21) 100450681(MAP3K10) 100452447(MAP3K15) 100453309(MAP3K1) 100456749(MAP3K11) 100458776(MAP3K5) 103889401(MAP3K8)
NLE: 100579516(MAP3K8) 100583302(MAP3K6) 100587332(MAP3K5) 100587341(MAP3K13) 100588106(MAP3K11) 100588522(MAP3K10) 100589608(MAP3K9) 100590602(MAP3K15) 100595740(MAP3K21) 100596471(MAP3K7) 100596886(MAP3K12) 100599140(MAP3K19) 100600394(MAP3K14) 100601763(MAP3K3) 100601802(MAP3K2) 100602313(MAP3K4) 100603568(MAP3K20) 100606554(MAP3K1)
MCC: 100424131(MAP3K2) 693835(MAP3K9) 695958(MAP3K15) 696936(MAP3K8) 698274(MAP3K20) 700477(MAP3K10) 701085(MAP3K13) 703059(MAP3K12) 703101(MAP3K7) 710360(MAP3K4) 710979(MAP3K1) 711382(MAP3K5) 712728(MAP3K19) 712755(MAP3K21) 715911(MAP3K6) 716038(MAP3K11) 716258(MAP3K14) 717866(MAP3K3)
MCF: 101865276(MAP3K4) 101925622(MAP3K12) 101925657(MAP3K5) 101926191(MAP3K11) 102119428(MAP3K13) 102123041(MAP3K1) 102123979(MAP3K9) 102124252(MAP3K6) 102124587(MAP3K15) 102129200(MAP3K19) 102129741(MAP3K21) 102132095(MAP3K3) 102132262(MAP3K10) 102132599(MAP3K8) 102138136(MAP3K2) 102139881(MAP3K20) 102140498(MAP3K7) 102145584(MAP3K14)
CSAB: 103216879(MAP3K2) 103216980(MAP3K19) 103217331(MAP3K20) 103221113(MAP3K13) 103221701(MAP3K1) 103225290(MAP3K6) 103227627(MAP3K11) 103229274(MAP3K9) 103230770(MAP3K21) 103231683(MAP3K15) 103234697(MAP3K10) 103238400(MAP3K12) 103240115(MAP3K7) 103240310(MAP3K5) 103240840(MAP3K4) 103243225(MAP3K3) 103243289(MAP3K14) 103247459(MAP3K8)
RRO: 104657086(MAP3K1) 104657273(MAP3K8) 104657888(MAP3K7) 104660313(MAP3K9) 104662431(MAP3K2) 104664818(MAP3K11) 104665553(MAP3K19) 104669999(MAP3K4) 104670592(MAP3K12) 104672741(MAP3K13) 104673509(MAP3K20) 104675014(MAP3K5) 104675466(MAP3K3) 104675763(MAP3K6) 104676124(MAP3K10) 104678324(MAP3K21) 104678377(MAP3K14) 104682410(MAP3K15)
RBB: 108514626(MAP3K12) 108518196(MAP3K6) 108518539(MAP3K20) 108518979(MAP3K21) 108522968(MAP3K5) 108525357(MAP3K13) 108527990(MAP3K4) 108528065(MAP3K8) 108530959(MAP3K1) 108532216(MAP3K14) 108533000(MAP3K2) 108536203(MAP3K9) 108536280(MAP3K3) 108538907(MAP3K15) 108539086(MAP3K10) 108539499(MAP3K7) 108539596(MAP3K19) 108543509(MAP3K11)
CJC: 100385107(MAP3K8) 100385131(MAP3K9) 100387775(MAP3K11) 100389500(MAP3K1) 100395753(MAP3K13) 100395802(MAP3K10) 100396743(MAP3K21) 100401112(MAP3K14) 100401384(MAP3K20) 100403175(MAP3K7) 100404784(MAP3K6) 100406322(MAP3K5) 100406711(MAP3K2) 100408788(MAP3K12) 100409244(MAP3K15) 100409608(MAP3K3) 100413660(MAP3K4)
SBQ: 101031938(MAP3K12) 101035755(MAP3K3) 101035799(MAP3K2) 101038273(MAP3K6) 101038631(MAP3K10) 101039966(MAP3K11) 101042401(MAP3K4) 101043045 101043439 101044826(MAP3K14) 101045636(MAP3K7) 101046566(MAP3K8) 101049991(MAP3K13) 101050832(MAP3K15) 101051154(MAP3K9) 101052309 101054366(MAP3K1)
MMU: 22625(Map3k19) 234878(Map3k21) 26401(Map3k1) 26403(Map3k11) 26404(Map3k12) 26405(Map3k2) 26406(Map3k3) 26407(Map3k4) 26408(Map3k5) 26409(Map3k7) 26410(Map3k8) 269881(Map3k10) 270672(Map3k15) 338372(Map3k9) 53608(Map3k6) 53859(Map3k14) 65964(Map3k20) 71751(Map3k13)
MCAL: 110284747(Map3k2) 110284809(Map3k8) 110285269(Map3k20) 110285431(Map3k11) 110286531(Map3k15) 110292293(Map3k7) 110292889(Map3k6) 110298678(Map3k10) 110300557(Map3k21) 110303338(Map3k5) 110304892(Map3k14) 110305762(Map3k3) 110306985(Map3k9) 110307741(Map3k1) 110311026(Map3k12) 110311270(Map3k13) 110312545(Map3k4)
MPAH: 110314161(Map3k15) 110318175(Map3k20) 110322531(Map3k19) 110323270(Map3k6) 110324226(Map3k9) 110327022(Map3k11) 110327052(Map3k10) 110328949(Map3k1) 110329718(Map3k13) 110331495(Map3k3) 110332218(Map3k14) 110333106(Map3k2) 110333248(Map3k8) 110335072(Map3k12) 110337368(Map3k21) 110337870(Map3k5) 110338018(Map3k4) 110338656(Map3k7)
RNO: 100910771 100912399 116596(Map3k8) 116667(Map3k1) 171492(Map3k2) 25579(Map3k12) 289001(Map3k19) 303604(Map3k3) 303823(Map3k13) 307950(Map3k21) 308106(Map3k4) 308463(Map3k10) 309168(Map3k11) 311743(Map3k20) 313022(Map3k6) 313121(Map3k7) 360640(Map3k14) 365057(Map3k5) 500690(Map3k9) 501558(Map3k15)
MUN: 110540249(Map3k15) 110545661(Map3k14) 110546648(Map3k1) 110547048(Map3k3) 110549306(Map3k11) 110552314(Map3k12) 110552483(Map3k6) 110553443 110554363 110554364(Map3k20) 110554862(Map3k4) 110556721(Map3k10) 110558401(Map3k8) 110558804(Map3k9) 110561590(Map3k13) 110565808 110565809
CGE: 100751831(Map3k15) 100752376(Map3k5) 100753508(Map3k3) 100754991(Map3k13) 100759538(Map3k8) 100760135(Map3k6) 100762677(Map3k11) 100762934(Map3k9) 100764060(Map3k4) 100764739(Map3k19) 100765738(Map3k12) 100766459(Map3k14) 100768062(Map3k10) 100769818(Map3k20) 100770540(Map3k1) 100771548(Map3k21) 100772559(Map3k2) 100774341(Map3k7)
NGI: 103724902(Map3k5) 103724991(Map3k11) 103725874(Map3k9) 103732132(Map3k2) 103732670(Map3k13) 103736239(Map3k15) 103737023(Map3k4) 103737078(Map3k6) 103738320(Map3k14) 103738660(Map3k12) 103739547(Map3k7) 103739909(Map3k1) 103743128(Map3k21) 103744757(Map3k3) 103747991(Map3k8) 103750755(Map3k10) 103751744(Map3k20)
HGL: 101696673(Map3k9) 101697616(Map3k6) 101700680(Map3k13) 101701961(Map3k4) 101702332(Map3k12) 101702514(Map3k15) 101703313(Map3k14) 101704125(Map3k21) 101704335(Map3k3) 101707762(Map3k20) 101710286(Map3k8) 101712051(Map3k5) 101718269(Map3k7) 101718471(Map3k10) 101718575(Map3k11) 101720769(Map3k1) 101725578(Map3k19) 101726195(Map3k2)
CCAN: 109675757 109684077(Map3k12) 109687144(Map3k11) 109687931 109688533(Map3k10) 109691665(Map3k14) 109695531(Map3k1) 109695913(Map3k8) 109696078(Map3k6) 109697041(Map3k5) 109698497(Map3k7) 109699113(Map3k2) 109699287(Map3k13) 109700149(Map3k4) 109700426(Map3k9) 109702680 109703189(Map3k3)
OCU: 100340498(MAP3K5) 100341731(MAP3K9) 100343069(MAP3K6) 100343571(MAP3K7) 100343621(MAP3K10) 100345602(MAP3K13) 100345607(MAP3K21) 100348484(MAP3K1) 100351032(MAP3K14) 100351826(MAP3K20) 100355324(MAP3K3) 100355566(MAP3K8) 100355693(MAP3K2) 100356691(MAP3K11) 100357608(MAP3K15) 100358104(MAP3K4) 100358158(MAP3K12)
TUP: 102470721(MAP3K9) 102471323(MAP3K10) 102474694(MAP3K12) 102477331(MAP3K7) 102477673(MAP3K3) 102478254(MAP3K13) 102479529(MAP3K21) 102479582(MAP3K4) 102483890(MAP3K1) 102485186(MAP3K2) 102490022(MAP3K11) 102493021(MAP3K8) 102495244(MAP3K5) 102500729(MAP3K14) 102501118(MAP3K20) 102503019(MAP3K15) 102503262(MAP3K6)
CFA: 100685499(MAP3K13) 100688368(MAP3K21) 102156745(MAP3K7) 476215(MAP3K5) 476262(MAP3K4) 478061(MAP3K1) 478802(MAP3K20) 480481(MAP3K3) 483732(MAP3K11) 483897(MAP3K19) 484504(MAP3K10) 487085(MAP3K8) 487345(MAP3K6) 490765(MAP3K9) 490926(MAP3K14) 491765(MAP3K15) 607170(MAP3K12) 612902(MAP3K2)
VVP: 112910639(MAP3K14) 112916399(MAP3K20) 112919046(MAP3K15) 112919386(MAP3K5) 112920702(MAP3K3) 112921182(MAP3K12) 112921580(MAP3K8) 112923157(MAP3K7) 112924257(MAP3K11) 112926277(MAP3K13) 112927232(MAP3K9) 112927350(MAP3K21) 112928296(MAP3K10) 112931693(MAP3K6) 112932616(MAP3K19) 112932690(MAP3K2) 112932971(MAP3K4) 112935233(MAP3K1)
AML: 100465667(MAP3K4) 100466442(MAP3K1) 100466506(MAP3K7) 100467807(MAP3K13) 100469942(MAP3K12) 100472044(MAP3K9) 100472260(MAP3K14) 100473197(MAP3K10) 100475304(MAP3K5) 100475390(MAP3K21) 100475426(MAP3K2) 100475740(MAP3K3) 100479214(MAP3K6) 100479844(MAP3K20) 100480593(MAP3K8) 100480913(MAP3K11) 100483854(MAP3K19) 105241834(MAP3K15)
UMR: 103656496(MAP3K8) 103658571(MAP3K2) 103659570(MAP3K20) 103659895 103660092(MAP3K7) 103660898(MAP3K4) 103661092(MAP3K10) 103661981(MAP3K21) 103663496(MAP3K5) 103663891(MAP3K1) 103665628(MAP3K3) 103665883(MAP3K14) 103666761(MAP3K6) 103667667(MAP3K19) 103668259(MAP3K15) 103671518(MAP3K9) 103675534(MAP3K12) 103676070(MAP3K13) 103679581(MAP3K11)
UAH: 113242246(MAP3K15) 113243573(MAP3K10) 113244105(MAP3K11) 113244248(MAP3K8) 113250769(MAP3K20) 113254044(MAP3K13) 113255319(MAP3K1) 113257547(MAP3K12) 113259020(MAP3K21) 113259481(MAP3K5) 113259629(MAP3K4) 113263338(MAP3K19) 113263482(MAP3K2) 113264818(MAP3K7) 113265289(MAP3K3) 113265323(MAP3K14) 113268217(MAP3K6) 113270380(MAP3K9)
ORO: 101363246(MAP3K14) 101365423(MAP3K12) 101365627 101366511(MAP3K1) 101368270(MAP3K2) 101370047(MAP3K13) 101374728(MAP3K5) 101374941(MAP3K6) 101375291(MAP3K3) 101375908(MAP3K10) 101376824(MAP3K7) 101377609(MAP3K19) 101379119(MAP3K9) 101379514(MAP3K4) 101381295 101382287(MAP3K11) 101385184(MAP3K8) 101385199(MAP3K15)
FCA: 101081315(MAP3K6) 101082912(MAP3K5) 101083468(MAP3K14) 101083633(MAP3K3) 101084717(MAP3K9) 101087164(MAP3K12) 101087784(MAP3K21) 101089731(MAP3K10) 101089836(MAP3K15) 101090328(MAP3K1) 101090454(MAP3K19) 101090624(MAP3K8) 101093205(MAP3K13) 101094038(MAP3K20) 101095899(MAP3K7) 101096406(MAP3K2) 101097977(MAP3K4) 101098654(MAP3K11)
PTG: 102948678(MAP3K9) 102952700(MAP3K4) 102957300(MAP3K12) 102957925(MAP3K2) 102959520(MAP3K20) 102960317(MAP3K5) 102960849(MAP3K15) 102961042(MAP3K8) 102961509(MAP3K10) 102963341(MAP3K7) 102963818(MAP3K6) 102964388(MAP3K14) 102965107(MAP3K13) 102966576(MAP3K3) 102969655(MAP3K19) 102970826(MAP3K21) 102971191(MAP3K1)
PPAD: 109245401(MAP3K4) 109246346(MAP3K1) 109246746(MAP3K11) 109248910(MAP3K21) 109249200(MAP3K12) 109249879(MAP3K5) 109256395(MAP3K15) 109256635(MAP3K10) 109256795(MAP3K6) 109258173(MAP3K14) 109263420(MAP3K7) 109268227(MAP3K9) 109270158(MAP3K19) 109273104(MAP3K20) 109275247(MAP3K13) 109276338(MAP3K8) 109277107(MAP3K3) 109278797(MAP3K2)
AJU: 106966378(MAP3K2) 106967988(MAP3K13) 106971139(MAP3K11) 106974370(MAP3K9) 106975243(MAP3K1) 106975683(MAP3K19) 106977317(MAP3K8) 106977571(MAP3K6) 106978686(MAP3K3) 106979597(MAP3K10) 106981653(MAP3K21) 106981924(MAP3K15) 106983077(MAP3K7) 106983084(MAP3K12) 106983673(MAP3K5) 106985032(MAP3K4) 106987964(MAP3K20) 106988147(MAP3K14)
BTA: 504592(MAP3K2) 505369(MAP3K13) 505427(MAP3K12) 508367(MAP3K14) 508943(MAP3K3) 511779(MAP3K4) 514210(MAP3K11) 519251(MAP3K20) 523962(MAP3K1) 529146(MAP3K7) 529335(MAP3K15) 535622(MAP3K8) 537380(MAP3K5) 538340(MAP3K9) 538897(MAP3K19) 614598(MAP3K6) 616014(MAP3K21) 781037(MAP3K10)
BOM: 102264669(MAP3K6) 102264816(MAP3K7) 102267592(MAP3K1) 102268339(MAP3K14) 102271481(MAP3K9) 102273125(MAP3K2) 102274075(MAP3K21) 102274152(MAP3K10) 102275307(MAP3K3) 102276849(MAP3K5) 102276927(MAP3K19) 102278856(MAP3K8) 102279268(MAP3K11) 102281279(MAP3K12) 102282362(MAP3K15) 102283969(MAP3K4) 102285655(MAP3K13) 102288137(MAP3K20)
BIU: 109553877(MAP3K21) 109554270(MAP3K11) 109554944(MAP3K15) 109557274(MAP3K13) 109559030(MAP3K12) 109563601(MAP3K4) 109563902(MAP3K7) 109563980(MAP3K5) 109565306(MAP3K9) 109565311(MAP3K2) 109566425(MAP3K20) 109568007(MAP3K8) 109568332(MAP3K19) 109572644(MAP3K10) 109573153(MAP3K6) 109573385(MAP3K3) 109574056(MAP3K14) 109574889(MAP3K1)
BBUB: 102389039(MAP3K15) 102390117(MAP3K19) 102390268(MAP3K21) 102394831(MAP3K12) 102397755(MAP3K14) 102398186(MAP3K20) 102398758(MAP3K9) 102399115(MAP3K11) 102399287(MAP3K8) 102399327(MAP3K1) 102404285(MAP3K6) 102404576(MAP3K13) 102406531(MAP3K2) 102408502(MAP3K5) 102409579(MAP3K10) 102412509(MAP3K4) 102413611(MAP3K3) 102415113(MAP3K7)
CHX: 102168436(MAP3K15) 102172156(MAP3K5) 102172543(MAP3K4) 102172719(MAP3K7) 102172769(MAP3K19) 102173036(MAP3K3) 102173267(MAP3K11) 102174723(MAP3K12) 102175623(MAP3K2) 102178859(MAP3K13) 102180599(MAP3K9) 102183919(MAP3K20) 102186147(MAP3K10) 102186443(MAP3K6) 102187530(MAP3K1) 102188512(MAP3K8) 102189617(MAP3K14) 102191110(MAP3K21) 108634540
OAS: 101102889(MAP3K12) 101103160(MAP3K9) 101104888(MAP3K15) 101106493(MAP3K19) 101108056(MAP3K7) 101108969(MAP3K11) 101109858(MAP3K2) 101111776(MAP3K20) 101112260(MAP3K1) 101113246(MAP3K4) 101113737(MAP3K6) 101115427(MAP3K21) 101117036(MAP3K13) 101117094(MAP3K8) 101118723(MAP3K10) 101118799(MAP3K14) 101121018(MAP3K5) 101122537(MAP3K3) 114113152 114113190
SSC: 100135663(MAP3K7) 100152572(MAP3K20) 100154002(MAP3K21) 100154202(MAP3K4) 100155753(MAP3K9) 100511286(MAP3K19) 100512235(MAP3K6) 100513491(MAP3K3) 100515448(MAP3K13) 100517714(MAP3K12) 100520402(MAP3K14) 100521453(MAP3K10) 100621234(MAP3K2) 100622217(MAP3K8) 100622769(MAP3K5) 100736741(MAP3K11) 100739216(MAP3K15) 396617(MAP3K1)
CFR: 102504523(MAP3K14) 102505073(MAP3K2) 102505358(MAP3K1) 102505759(MAP3K3) 102506410(MAP3K13) 102506717(MAP3K11) 102509143(MAP3K10) 102509815(MAP3K4) 102513589(MAP3K9) 102518335(MAP3K8) 102518433(MAP3K12) 102518953(MAP3K6) 102519538(MAP3K7) 102519731(MAP3K19) 102520465(MAP3K20) 102522243(MAP3K5) 102523391(MAP3K21)
CDK: 105084487(MAP3K2) 105085862(MAP3K13) 105086141(MAP3K9) 105086293(MAP3K4) 105087133(MAP3K1) 105090412(MAP3K3) 105091098(MAP3K20) 105091198(MAP3K21) 105092037(MAP3K5) 105092383(MAP3K19) 105093336(MAP3K10) 105094405(MAP3K14) 105094560(MAP3K12) 105095322 105095522(MAP3K7) 105096296(MAP3K8) 105100707(MAP3K6) 105102638(MAP3K11)
BACU: 102999255(MAP3K3) 103001803(MAP3K21) 103002185(MAP3K1) 103004845(MAP3K11) 103005548(MAP3K10) 103006512(MAP3K4) 103010611(MAP3K8) 103011832(MAP3K12) 103015628(MAP3K6) 103015859(MAP3K14) 103016499(MAP3K15) 103017845(MAP3K2) 103018600(MAP3K20) 103019037(MAP3K9) 103019299(MAP3K7) 103020592(MAP3K13)
LVE: 103070441(MAP3K8) 103073201(MAP3K13) 103075340(MAP3K7) 103075844(MAP3K4) 103076636(MAP3K3) 103079692(MAP3K20) 103081325(MAP3K6) 103082490(MAP3K14) 103083140(MAP3K2) 103083385(MAP3K1) 103083922(MAP3K9) 103085713(MAP3K10) 103089110(MAP3K11) 103089504(MAP3K15) 103089656(MAP3K21)
OOR: 101269437(MAP3K11) 101269575(MAP3K8) 101270119(MAP3K14) 101270305(MAP3K2) 101270573(MAP3K9) 101271000(MAP3K6) 101272330(MAP3K15) 101272930 101273274(MAP3K10) 101273961(MAP3K3) 101277039(MAP3K4) 101277232(MAP3K5) 101278099(MAP3K13) 101282832(MAP3K12) 101283961(MAP3K7) 101285035 101288918(MAP3K1)
DLE: 111163411(MAP3K6) 111163761(MAP3K7) 111163906(MAP3K21) 111166150(MAP3K5) 111168464(MAP3K4) 111170190(MAP3K14) 111170375(MAP3K15) 111172872(MAP3K20) 111173006(MAP3K9) 111173071(MAP3K13) 111173936(MAP3K12) 111178133(MAP3K8) 111180858(MAP3K10) 111182605(MAP3K3) 111183352(MAP3K2) 111183748(MAP3K11) 111186550(MAP3K1)
PCAD: 102973167(MAP3K20) 102973912(MAP3K11) 102976909(MAP3K5) 102977794(MAP3K4) 102979076(MAP3K1) 102979560(MAP3K21) 102985093(MAP3K6) 102985391(MAP3K2) 102985586(MAP3K3) 102988471(MAP3K8) 102989373(MAP3K10) 102989494(MAP3K13) 102991211(MAP3K9) 102991269(MAP3K14) 102994311(MAP3K12) 102995727(MAP3K7)
ECB: 100050140(MAP3K14) 100050587(MAP3K19) 100050628(MAP3K2) 100053153(MAP3K20) 100054289(MAP3K9) 100057319(MAP3K11) 100058153(MAP3K4) 100058434(MAP3K15) 100059237(MAP3K13) 100059834(MAP3K21) 100061688(MAP3K1) 100063602(MAP3K8) 100064002(MAP3K12) 100064751(MAP3K3) 100065841(MAP3K7) 100070933(MAP3K6) 100073186(MAP3K5)
EPZ: 103540552(MAP3K11) 103541518(MAP3K8) 103542532(MAP3K15) 103548212(MAP3K1) 103548805(MAP3K7) 103549765(MAP3K3) 103550526(MAP3K6) 103554685(MAP3K14) 103555565(MAP3K12) 103555750(MAP3K21) 103556184(MAP3K4) 103556363(MAP3K5) 103558546(MAP3K19) 103559591(MAP3K20) 103560489(MAP3K10) 103562194(MAP3K2) 103564958(MAP3K13) 103567590
EAI: 106824083(MAP3K9) 106833665(MAP3K11) 106834092(MAP3K2) 106834499(MAP3K13) 106834739(MAP3K20) 106835292(MAP3K12) 106835501(MAP3K15) 106835525(MAP3K3) 106836478(MAP3K14) 106836538(MAP3K19) 106837968(MAP3K8) 106839092(MAP3K6) 106839676(MAP3K21) 106842047(MAP3K4) 106843249(MAP3K10) 106843371(MAP3K1) 106847421(MAP3K7)
MYB: 102239254(MAP3K13) 102240442(MAP3K10) 102242281(MAP3K6) 102242308(MAP3K3) 102243445(MAP3K9) 102245865(MAP3K2) 102248363(MAP3K8) 102250231(MAP3K19) 102252114(MAP3K12) 102253871(MAP3K11) 102254118(MAP3K7) 102255496(MAP3K15) 102256847(MAP3K5) 102258632(MAP3K1) 102259842(MAP3K21) 102262247(MAP3K14) 102262729(MAP3K4) 102263045(MAP3K20)
MYD: 102751509(MAP3K10) 102753581(MAP3K2) 102753720(MAP3K13) 102753749(MAP3K21) 102756379(MAP3K9) 102757393(MAP3K4) 102762787(MAP3K3) 102762988(MAP3K14) 102763786(MAP3K1) 102763957(MAP3K7) 102770852(MAP3K20) 102770934(MAP3K6) 102771069(MAP3K15) 102771311(MAP3K5) 102771577(MAP3K11) 102773021(MAP3K12) 102774051 102775461(MAP3K8)
MNA: 107524234 107524427(MAP3K8) 107526803(MAP3K15) 107527145(MAP3K1) 107527317(MAP3K13) 107528308(MAP3K12) 107528582(MAP3K2) 107528876(MAP3K14) 107530487(MAP3K3) 107531250 107531997(MAP3K19) 107533446(MAP3K7) 107533546(MAP3K11) 107534150(MAP3K10) 107535728(MAP3K4) 107536244(MAP3K9) 107541967(MAP3K6) 107546566
HAI: 109371277(MAP3K13) 109371823(MAP3K2) 109374860(MAP3K10) 109376677(MAP3K9) 109380266(MAP3K3) 109384179(MAP3K11) 109385705(MAP3K1) 109386678(MAP3K6) 109387711(MAP3K21) 109388733 109388741 109389111(MAP3K8) 109389465(MAP3K7) 109391825(MAP3K12) 109394013(MAP3K4) 109395015(MAP3K14) 109395649(MAP3K15)
DRO: 112296959(MAP3K7) 112297079(MAP3K5) 112297294(MAP3K4) 112298609(MAP3K14) 112299262(MAP3K6) 112305730(MAP3K20) 112306103(MAP3K21) 112308163(MAP3K13) 112311900(MAP3K9) 112313010(MAP3K2) 112313288(MAP3K15) 112315269(MAP3K1) 112316249(MAP3K3) 112316842(MAP3K8) 112317244(MAP3K11) 112318252(MAP3K12) 112320192(MAP3K10)
PALE: 102878894(MAP3K11) 102880315(MAP3K13) 102880422(MAP3K2) 102880725(MAP3K9) 102882452(MAP3K7) 102882855(MAP3K6) 102884946(MAP3K19) 102885138(MAP3K10) 102885530(MAP3K20) 102886741(MAP3K1) 102888506(MAP3K4) 102888994(MAP3K5) 102889570(MAP3K3) 102893121(MAP3K12) 102895694(MAP3K21) 102896654(MAP3K8) 102897183(MAP3K15) 102897751(MAP3K14)
RAY: 107497495(MAP3K11) 107501901(MAP3K3) 107503588(MAP3K6) 107505142 107508165(MAP3K14) 107508239(MAP3K9) 107508648(MAP3K7) 107509857(MAP3K12) 107512002(MAP3K15) 107514741(MAP3K4) 107516884(MAP3K2) 107518243(MAP3K13) 107518617(MAP3K1) 107518939(MAP3K8) 107520012 107520332(MAP3K19) 107521291(MAP3K5) 107521797(MAP3K10)
MJV: 108383459(MAP3K9) 108384016(MAP3K1) 108386996(MAP3K14) 108390480(MAP3K10) 108392181(MAP3K8) 108394776(MAP3K12) 108395540 108399127(MAP3K7) 108400895(MAP3K2) 108400917(MAP3K15) 108401094(MAP3K5) 108401834(MAP3K3) 108402621(MAP3K11) 108403112(MAP3K4) 108404979 108406519(MAP3K6) 108408396(MAP3K19) 108410204(MAP3K13)
LAV: 100655149(MAP3K1) 100655585(MAP3K11) 100658813(MAP3K5) 100660454(MAP3K20) 100660700(MAP3K15) 100661927(MAP3K14) 100662122(MAP3K3) 100662383(MAP3K8) 100664871(MAP3K4) 100665139(MAP3K2) 100665212(MAP3K9) 100667170(MAP3K7) 100672580(MAP3K12) 100673821(MAP3K10) 100673872(MAP3K21) 100674925(MAP3K6) 100677466(MAP3K13)
MDO: 100014185(MAP3K15) 100014282(MAP3K13) 100015818(MAP3K19) 100017378(MAP3K6) 100017495(MAP3K10) 100018494(MAP3K20) 100018684(MAP3K8) 100019975(MAP3K7) 100020082(MAP3K9) 100020668(MAP3K14) 100025970(MAP3K3) 100026735(MAP3K2) 100028987(MAP3K21) 100030111(MAP3K11) 100031527(MAP3K5) 100032065(MAP3K1) 100032495(MAP3K4)
SHR: 100913571(MAP3K1) 100913706(MAP3K12) 100913796(MAP3K13) 100916246(MAP3K9) 100916713(MAP3K2) 100917439(MAP3K5) 100918124(MAP3K14) 100920997(MAP3K7) 100924042(MAP3K21) 100925633(MAP3K8) 100927077(MAP3K6) 100928208(MAP3K4) 100932009(MAP3K10) 100932862(MAP3K15) 100932989(MAP3K11) 100933129(MAP3K19) 100933813(MAP3K20) 100933837(MAP3K3)
PCW: 110192034(MAP3K7) 110194151(MAP3K12) 110194666(MAP3K2) 110195402(MAP3K11) 110202681(MAP3K10) 110206150(MAP3K6) 110208372(MAP3K9) 110208619(MAP3K4) 110208922(MAP3K5) 110210842(MAP3K15) 110211269(MAP3K8) 110211581(MAP3K20) 110215703(MAP3K1) 110215732(MAP3K14) 110215942(MAP3K3) 110217833(MAP3K21) 110221295(MAP3K13) 110223756(MAP3K19)
OAA: 100076215(MAP3K8) 100076229(MAP3K7) 100076612(MAP3K1) 100076986(MAP3K13) 100081079(MAP3K5) 100081562(MAP3K4) 100083301 100083521(MAP3K15) 100084257(MAP3K20) 100085554(MAP3K14) 100086943(MAP3K9) 100087843(MAP3K2) 100088084(MAP3K6) 100089912(MAP3K19) 100092024(MAP3K3) 100092492(MAP3K12) 100092507(MAP3K10) 107547228(MAP3K11)
GGA: 100858193(MAP3K6) 101750513 418609(MAP3K15) 419954(MAP3K3) 419964(MAP3K14) 420419(MAPKKK3L) 420479(MAP3K8) 421579(MAP3K4) 421688(MAP3K5) 421808(MAP3K7) 424149(MAP3K20) 424225(MAP3K2) 424876(MAP3K13) 425792(MAP3K9) 427144(MAP3K1) 428586(MAP3K21) 429048(MAP3K19)
MGP: 100538760(MAP3K14) 100539648(MAP3K21) 100539749(MAP3K7) 100540233(MAP3K19) 100541097(MAP3K8) 100542691 100542719(MAP3K3) 100543830(MAP3K2) 100547994(MAP3K13) 100548383(MAP3K4) 100550623(MAP3K1) 100550901(MAP3K9) 104911778 104914275(MAP3K6)
CJO: 107306009(MAP3K1) 107306938(MAP3K12) 107308787 107308936(MAP3K8) 107311414(MAP3K21) 107311515(MAP3K4) 107311662(MAP3K5) 107311964(MAP3K7) 107314878(MAP3K9) 107316691(MAP3K20) 107316800(MAP3K2) 107316869(MAP3K19) 107317933(MAP3K13) 107324060(MAP3K6) 107325016(MAP3K14) 107325133(MAP3K3) 107325422(MAP3K15)
NMEL: 110387413(MAP3K6) 110388448(MAP3K14) 110388470(MAP3K3) 110390387(MAP3K1) 110390881(MAP3K12) 110393429(MAP3K8) 110394259 110395417(MAP3K4) 110395624(MAP3K7) 110395802(MAP3K5) 110395888(MAP3K21) 110399087(MAP3K13) 110399351(MAP3K19) 110399448(MAP3K20) 110399799(MAP3K2) 110400952(MAP3K9) 110404669(MAP3K15)
APLA: 101791236(MAP3K14) 101791519(MAP3K15) 101791769(MAP3K8) 101792050(MAP3K13) 101793656(MAP3K1) 101795869 101795899(MAP3K4) 101796310(MAP3K9) 101798043(MAP3K2) 101798142(MAP3K19) 101799109(MAP3K5) 101800996 101801284(MAP3K3) 101801810(MAP3K21) 101803181(MAP3K6) 101803306(MAP3K20) 113843279
ACYG: 106030002 106032515(MAP3K5) 106035399(MAP3K7) 106035615(MAP3K1) 106036842 106037849(MAP3K15) 106039243(MAP3K13) 106039351(MAP3K19) 106039514(MAP3K4) 106042342(MAP3K9) 106042681(MAP3K8) 106045922(MAP3K2) 106045975(MAP3K3) 106046936(MAP3K14) 106047891(MAP3K6) 106048621
TGU: 100217837(MAP3K14) 100219311(MAP3K15) 100219827(MAP3K2) 100221443(MAP3K7) 100223633(MAP3K3) 100224192(MAP3K5) 100225400(MAP3K13) 100225825(MAP3K1) 100226503 100228461(MAP3K20) 100228874(MAP3K21) 100229586(MAP3K9) 100229845(MAP3K4) 100230596(MAP3K8) 100232008(MAP3K19) 115491344 115491381
LSR: 110468326(MAP3K2) 110468877(MAP3K21) 110472556(MAP3K1) 110474076(MAP3K13) 110474827(MAP3K3) 110475629(MAP3K14) 110476074(MAP3K9) 110477339(MAP3K8) 110477918(MAP3K4) 110478595(MAP3K7) 110480535(MAP3K12) 110480620(MAP3K19) 110482911(MAP3K20) 110483222(MAP3K15) 110483316(MAP3K5) 110484542
SCAN: 103812700 103812752(MAP3K8) 103814336(MAP3K2) 103814440(MAP3K20) 103814628(MAP3K19) 103815669(MAP3K13) 103815920(MAP3K15) 103818465(MAP3K5) 103818563(MAP3K21) 103819102(MAP3K7) 103821035(MAP3K1) 103821627(MAP3K4) 103821648(MAP3K14) 103821658(MAP3K3) 103826623(MAP3K9)
GFR: 102032306(MAP3K3) 102033648(MAP3K2) 102033703(MAP3K20) 102034507(MAP3K5) 102034934(MAP3K9) 102035976(MAP3K8) 102038763(MAP3K14) 102038921(MAP3K15) 102039929(MAP3K7) 102040792(MAP3K13) 102041684(MAP3K21) 102041779(MAP3K19) 102043718(MAP3K4) 102044243 102044899(MAP3K1)
FAB: 101807474(MAP3K12) 101807669(MAP3K1) 101810116(MAP3K20) 101810453(MAP3K15) 101811653(MAP3K2) 101812702(MAP3K9) 101812912(MAP3K13) 101813386(MAP3K14) 101813633(MAP3K19) 101813992(MAP3K3) 101814532(MAP3K7) 101814940(MAP3K4) 101816945(MAP3K21) 101817004 101819414(MAP3K8)
PHI: 102101107(MAP3K4) 102102554(MAP3K20) 102102657(MAP3K11) 102103765(MAP3K1) 102106417(MAP3K21) 102107403(MAP3K7) 102108460 102111999(MAP3K9) 102112025(MAP3K13) 102112033(MAP3K3) 102112668(MAP3K19) 102113050(MAP3K2) 102113463(MAP3K14) 102113468(MAP3K12) 102113721(MAP3K15) 102114163(MAP3K8)
PMAJ: 107198728(MAP3K12) 107199524 107200237 107200816(MAP3K8) 107201551(MAP3K5) 107201717(MAP3K7) 107201928(MAP3K4) 107201984(MAP3K21) 107206205(MAP3K9) 107207267(MAP3K15) 107207509(MAP3K20) 107207548(MAP3K19) 107207590(MAP3K2) 107208746(MAP3K13) 107215258(MAP3K3) 107215307(MAP3K14) 107216401(MAP3K1)
CCAE: 111922870(MAP3K15) 111924099(MAP3K8) 111925531 111925720(MAP3K7) 111926874(MAP3K21) 111926951(MAP3K4) 111930888(MAP3K9) 111932076(MAP3K20) 111932210(MAP3K2) 111933696(MAP3K13) 111939927(MAP3K3) 111940095(MAP3K14) 111941445(MAP3K1)
CCW: 104683461(MAP3K9) 104684293(MAP3K21) 104684463(MAP3K4) 104686340(MAP3K15) 104686414 104686470(MAP3K8) 104686679(MAP3K1) 104692210(MAP3K7) 104693868(MAP3K20) 104693990(MAP3K2) 104696697(MAP3K13) 104698524(MAP3K14) 104698629(MAP3K3)
ETL: 114054812(MAP3K13) 114054911(MAP3K20) 114055129(MAP3K1) 114055484(MAP3K9) 114055550(MAP3K2) 114055651(MAP3K4) 114057792(MAP3K7) 114058907(MAP3K15) 114059498(MAP3K5) 114060299(MAP3K8) 114064004(MAP3K21) 114065134 114066926(MAP3K3) 114068663(MAP3K14) 114070364(MAP3K11) 114073458(MAP3K12)
FPG: 101910755(MAP3K20) 101911178(MAP3K1) 101911552(MAP3K5) 101911986(MAP3K6) 101912446(MAP3K3) 101914815(MAP3K21) 101915193(MAP3K15) 101916440(MAP3K13) 101917746(MAP3K7) 101918017(MAP3K4) 101918542(MAP3K9) 101919762(MAP3K14) 101921040(MAP3K8) 101921462(MAP3K2) 101921723(MAP3K12) 101923251
FCH: 102045898(MAP3K1) 102046644(MAP3K12) 102047801(MAP3K3) 102048037(MAP3K4) 102048630(MAP3K14) 102050351 102050412(MAP3K13) 102051326(MAP3K20) 102052421(MAP3K21) 102052615(MAP3K15) 102052668(MAP3K2) 102055830(MAP3K8) 102057038(MAP3K5) 102057922(MAP3K9) 102058816(MAP3K7) 102060113(MAP3K6)
CLV: 102085060(MAP3K3) 102085165(MAP3K20) 102086335(MAP3K9) 102086486(MAP3K4) 102087091(MAP3K8) 102087971(MAP3K15) 102088147 102088332(MAP3K14) 102089200(MAP3K21) 102091011(MAP3K13) 102092494(MAP3K2) 102097744(MAP3K1)
EGZ: 104124823(MAP3K4) 104128061 104129655(MAP3K9) 104130961 104131021 104131267(MAP3K13) 104132232(MAP3K14) 104133587(MAP3K8) 104133722(MAP3K2) 104134638(MAP3K3) 104134700(MAP3K1) 104134937(MAP3K6) 104135191(MAP3K15) 104135405(MAP3K7)
NNI: 104009891(MAP3K3) 104010005 104010621(MAP3K13) 104011958(MAP3K1) 104015344 104017546(MAP3K12) 104017829(MAP3K6) 104018435(MAP3K4) 104018900(MAP3K14) 104018989(MAP3K2) 104020321(MAP3K9) 104021753 104021941(MAP3K7) 104022250(MAP3K8) 104022566(MAP3K15)
ACUN: 113476643(MAP3K8) 113477214 113477881(MAP3K4) 113478050(MAP3K7) 113478674(MAP3K21) 113480320(MAP3K9) 113480593(MAP3K15) 113482184(MAP3K20) 113482266(MAP3K2) 113483720(MAP3K13) 113488380(MAP3K6) 113489126(MAP3K3) 113489146(MAP3K14) 113489657(MAP3K1)
PADL: 103912745(MAP3K5) 103912780(MAP3K9) 103913621(MAP3K7) 103913871(MAP3K3) 103914152(MAP3K4) 103916532(MAP3K2) 103916918(MAP3K13) 103918220(MAP3K15) 103918240(MAP3K8) 103919424(MAP3K1) 103921283 103921921(MAP3K14) 103924192 103924744
AAM: 106486799(MAP3K4) 106487372(MAP3K21) 106489690(MAP3K7) 106489958(MAP3K8) 106490809(MAP3K15) 106493178(MAP3K13) 106495649(MAP3K14) 106497426(MAP3K3) 106498093(MAP3K9) 106499249(MAP3K20) 106499278(MAP3K2)
ASN: 102368682(MAP3K15) 102368863 102371337(MAP3K11) 102374958(MAP3K3) 102375647(MAP3K20) 102376392(MAP3K12) 102376941(MAP3K1) 102379177(MAP3K6) 102379289 102380826(MAP3K21) 102381053(MAP3K13) 102381161 102382136(MAP3K4) 102382735(MAP3K9) 102386999(MAP3K7) 102387437(MAP3K8) 102388858(MAP3K14)
AMJ: 102559099(MAP3K21) 102560853(MAP3K6) 102561424(MAP3K12) 102562794(MAP3K1) 102566049(MAP3K13) 102566471(MAP3K8) 102568383(MAP3K20) 102569201(MAP3K7) 102570911(MAP3K11) 102572648 102573024(MAP3K5) 102573918(MAP3K4) 102574412(MAP3K2) 102575720(MAP3K14) 106736664(MAP3K9) 106736858(MAP3K15) 106736961(MAP3K3)
PSS: 102443925(MAP3K11) 102444358(MAP3K20) 102446659(MAP3K4) 102448094(MAP3K2) 102449623(MAP3K8) 102451227(MAP3K5) 102453748(MAP3K13) 102454634(MAP3K3) 102454880 102455384(MAP3K21) 102456989(MAP3K6) 102459971(MAP3K9) 102462962(MAP3K15) 102463619(MAP3K1) 102464024(MAP3K14)
CMY: 102930570(MAP3K3) 102931859 102933894(MAP3K6) 102935713(MAP3K15) 102936052(MAP3K7) 102936228(MAP3K4) 102936511(MAP3K8) 102936755(MAP3K21) 102938448(MAP3K1) 102939329(MAP3K13) 102939834(MAP3K14) 102940369(MAP3K9) 102941356(MAP3K2) 102941563(MAP3K20) 102943511(MAP3K12) 102946051(MAP3K11)
CPIC: 101931315(MAP3K7) 101932285(MAP3K14) 101932636(MAP3K9) 101933464(MAP3K1) 101934711(MAP3K2) 101939688(MAP3K11) 101939982(MAP3K13) 101940564(MAP3K20) 101940960(MAP3K15) 101941097(MAP3K8) 101942215(MAP3K6) 101946795(MAP3K4) 101948589 101948914(MAP3K12) 101950530(MAP3K10) 101951773(MAP3K21) 101953672(MAP3K3)
ACS: 100552553(map3k6) 100553164(map3k12) 100554725(map3k7) 100556486(map3k9) 100557698(map3k3) 100558170(map3k2) 100558270(map3k13) 100558842(map3k21) 100560027(map3k4) 100560190(map3k14) 100561745(map3k1) 100562159 100562883(map3k8) 100565973(map3k10) 100566960(map3k20) 100568169(map3k15)
PVT: 110074404(MAP3K12) 110074609(MAP3K7) 110075498(MAP3K21) 110075665(MAP3K10) 110075834(MAP3K13) 110076402(MAP3K9) 110076740(MAP3K15) 110080317(MAP3K3) 110081369(MAP3K14) 110082918(MAP3K8) 110085271(MAP3K2) 110085400(MAP3K1) 110085837 110087352(MAP3K4) 110088423(MAP3K6) 110088583(MAP3K20) 110089958(MAP3K11)
PBI: 103048285(MAP3K1) 103049938(MAP3K2) 103051131(MAP3K11) 103052010(MAP3K5) 103053098(MAP3K13) 103053351(MAP3K12) 103054161(MAP3K20) 103059578(MAP3K4) 103061668(MAP3K21) 103061999(MAP3K15) 103064348(MAP3K8) 103064885 103065661(MAP3K6) 103066049(MAP3K14) 103066986(MAP3K3) 103067160(MAP3K9) 103067633(MAP3K7) 112541949(MAP3K10)
PMUR: 107282828(MAP3K8) 107284356 107285893(MAP3K13) 107288998(MAP3K11) 107290426(MAP3K20) 107291245(MAP3K12) 107291593(MAP3K21) 107292307(MAP3K1) 107294300(MAP3K9) 107294312(MAP3K6) 107295908(MAP3K15) 107301663 107302054(MAP3K2) 107302364(MAP3K3) 107302815(MAP3K7) 107303029(MAP3K14)
TSR: 106540521(MAP3K3) 106540861(MAP3K1) 106541826 106542520(MAP3K14) 106544597(MAP3K13) 106545629 106546812 106548273(MAP3K6) 106548362(MAP3K8) 106548568(MAP3K2) 106549188(MAP3K4) 106549515(MAP3K7) 106549757(MAP3K12) 106550204 106550493(MAP3K11) 106554087(MAP3K5) 106554168 106554890
PMUA: 114581713(MAP3K3) 114581835(MAP3K14) 114586443(MAP3K11) 114593051(MAP3K12) 114593961(MAP3K7) 114594175(MAP3K5) 114594310(MAP3K4) 114594397(MAP3K21) 114596241(MAP3K15) 114597691(MAP3K13) 114601490(MAP3K6) 114603188(MAP3K10) 114603537(MAP3K2) 114606876(MAP3K20) 114606892(MAP3K1) 114607438 114607849(MAP3K8)
GJA: 107107052(MAP3K20) 107107352(MAP3K21) 107107364(MAP3K10) 107107910(MAP3K8) 107113333(MAP3K4) 107114874(MAP3K7) 107115849(MAP3K15) 107116392 107116647(MAP3K6) 107117647 107117807(MAP3K2) 107119674(MAP3K12) 107121069(MAP3K11) 107122639(MAP3K9) 107123377(MAP3K1) 107123584(MAP3K13) 107125527(MAP3K14)
XLA: 100113430(map3k12.S) 100126613(map3k4.S) 100337576(map3k12.L) 100337577(map3k13.S) 100337578(map3k13.L) 100381159(map3k9.L) 101027300 101027301 108699730(map3k9.S) 108700848(map3k14.L) 108701261(map3k2.L) 108701280(map3k19.L) 108701764 108702551(map3k14.S) 108702560 108702901(map3k2.S) 108702997 108704427(map3k1.S) 108708008 108708885 108717885 108718321(map3k1.L) 108718772(map3k8.L) 108719812 108719849(map3k8.S) 379399(map3k7.S) 398612(map3k10.L) 399459(map3k7.L) 734336(map3k3.L)
XTR: 100101764(map3k7) 100488058(map3k10) 100488307(map3k12) 100488360(map3k22) 100488738(map3k19) 100488949(map3k9) 100489201(map3k14) 100490021(map3k3) 100490504(map3k1) 100493069(map3k8) 100493570(map3k2) 100493878(map3k13) 100495797(map3k20) 100497217(map3k4) 100497692(map3k5)
NPR: 108784622 108785393(MAP3K2) 108785711(MAP3K15) 108785983(MAP3K14) 108786829(MAP3K12) 108788845(MAP3K8) 108792018(MAP3K1) 108794093(MAP3K10) 108795048(MAP3K4) 108795599(MAP3K13) 108800110(MAP3K7) 108800631 108802493(MAP3K3)
DRE: 100004261(map3k14a) 100005496(si:ch211-1i11.3) 100334289(map3k15) 100334486(map3k1) 101886393 325488(map3k4) 404626(map3k12) 553788(map3k7) 555703(map3k5) 558321(map3k2) 559247(zak) 560211(map3k3) 560639(map3k9) 560932(map3k10) 561518(si:ch211-120p12.3) 563727(map3k8) 568412(si:ch211-45c16.2) 572217(map3k19) 795766
IPU: 108256020(map3k3) 108256315(map3k15) 108256334 108256841(map3k7) 108257027(map3k5) 108259239 108260854 108263591 108263809 108264755(map3k10) 108265230(map3k12) 108266646(map3k20) 108266772(map3k13) 108272715(map3k2) 108274187(map3k8) 108277254(map3k1)
PHYP: 113525868(map3k20) 113525928 113526695(map3k10) 113527715(map3k8) 113528261 113528353(map3k3) 113528943(map3k5) 113529033(map3k7) 113533175(map3k12) 113533797 113538380(map3k2) 113541066 113541164(map3k15) 113543563(map3k1) 113544164(map3k21) 113545713
AMEX: 103026704(map3k2) 103026927(map3k15) 103030442(map3k9) 103031091 103031259(map3k8) 103031546(map3k10) 103031965(map3k20) 103032151(map3k13) 103033000(map3k5) 103034596(map3k3) 103039333(map3k7) 103039485 103042517(map3k1) 103042822 103043321 103044968 103046281(map3k4) 103046562(map3k12) 103047161
TRU: 101061432(map3k5) 101061953 101062891(map3k9) 101063413(map3k13) 101063524(map3k7) 101064896(map3k20) 101067596 101068242(map3k10) 101068369 101069247(map3k8) 101069629 101069746(map3k2) 101070474 101072543(map3k3) 101074328(map3k19) 101075070(map3k21) 101076353(map3k15) 101078679 101079141
LCO: 104919956(map3k12) 104923921 104924081(map3k7) 104926153(map3k5) 104927785(map3k20) 104928162 104928756(map3k15) 104928818(map3k8) 104928841(map3k13) 104929782(map3k9) 104930222(map3k3) 104930685 104931530(map3k21) 104931623(map3k10) 104934606(map3k2) 104937092 104938682 109140639 109142828
ONL: 100689877(map3k7) 100689980(map3k21) 100691392(map3k12) 100692507(map3k15) 100692691(map3k3) 100695481(map3k20) 100695488 100699877 100703888(map3k5) 100704108(map3k10) 100704313 100705497(map3k2) 100707432 100707946 100708160(map3k9) 100710682(map3k8) 100711264 100711574(map3k13) 100712512
XCO: 114133159(map3k10) 114133938 114134112(map3k9) 114135267 114136720(map3k15) 114136809 114137073(map3k8) 114138146(map3k21) 114140552(map3k2) 114142698(map3k12) 114147068 114148301(map3k13) 114148676(map3k20) 114151841 114157052 114158518(map3k7) 114158595(map3k5) 114160172(map3k3) 114160257
PRET: 103456566 103456750(map3k15) 103457092(map3k2) 103457283(map3k5) 103457977(map3k7) 103458299(map3k9) 103458400 103458953 103461651(map3k13) 103464416(map3k12) 103467635 103468661 103468920(map3k3) 103474653(map3k10) 103476695 103479332 103480213(map3k11) 103481612 103482391(map3k8)
KMR: 108229597 108230337 108231598(map3k12) 108232129 108233483(map3k5) 108234665(map3k15) 108237522(map3k9) 108237722 108239385 108239514 108239697(map3k20) 108240785(map3k13) 108240940(map3k10) 108245043 108245069 108246150(map3k14) 108246834(map3k2) 108247128(map3k8) 108251536(map3k7)
SDU: 111217270 111217593(map3k3) 111217746 111218353(map3k20) 111218550(map3k13) 111219576 111221016 111222725(map3k2) 111223920(map3k12) 111224356(map3k15) 111225561 111226008 111226905(map3k11) 111228231(map3k8) 111228953 111235336 111237351(map3k5) 111238128(map3k10) 111238781(map3k7)
SLAL: 111645547 111645753(map3k15) 111654131(map3k10) 111654335 111654997 111656266 111660531 111660589(map3k3) 111661471(map3k5) 111661524(map3k7) 111663802 111664391 111668535(map3k20) 111669238(map3k8) 111670210(map3k12) 111670445(map3k11) 111671104 111671514(map3k13) 111672426(map3k2)
HCQ: 109507895(map3k20) 109508417 109510165 109514181(map3k8) 109517251(map3k9) 109518541 109519328 109519483 109520183(map3k2) 109523279(map3k13) 109524703(map3k15) 109526404(map3k10) 109528236 109529244(map3k12) 109529256 109532434(map3k3)
BPEC: 110154967 110156771 110159957(map3k13) 110160986 110161278(map3k15) 110163573(map3k10) 110164496 110165688(map3k2) 110166574(map3k20) 110167886(map3k3) 110168889 110171100(map3k9) 110171200(map3k12) 110171242(map3k7) 110173386 110173792
MALB: 109955638(map3k12) 109955649(map3k2) 109957145(map3k13) 109958042(map3k20) 109959709 109960851 109961492 109962300(map3k5) 109962489(map3k15) 109962735 109963171(map3k3) 109964259 109966142 109967378(map3k7) 109969321 109969442 109973381(map3k9) 109974338(map3k10) 109974520(map3k8)
ELS: 105006267(map3k13) 105007215 105007693 105007974 105011943(map3k10) 105012974(map3k3) 105013210 105015746 105015920(map3k9) 105016206(map3k20) 105017873(map3k7) 105017906(map3k5) 105019416(map3k8) 105019952(map3k2) 105020697(map3k11) 105021218(map3k21) 105021721(map3k1) 105021978(map3k15) 105026325 105030567
LCM: 102347264 102350357 102350566(MAP3K2) 102351315(MAP3K14) 102353974(MAP3K3) 102355070(MAP3K1) 102356869(MAP3K9) 102358159(MAP3K7) 102358237(MAP3K15) 102362205(MAP3K12) 102364487(MAP3K11) 102364913(MAP3K20) 102367402(MAP3K13) 102367513(MAP3K8)
CMK: 103176455(map3k20) 103177506(map3k15) 103177870(map3k1) 103178276(map3k7) 103178584(map3k9) 103179260(map3k21) 103186428(map3k8) 103187711(map3k3) 103189809(map3k2) 103189852 103190243(map3k10) 103190572(map3k13) 103190676(map3k12)
DME: Dmel_CG18492(Tak1) Dmel_CG2272(slpr) Dmel_CG31421(Takl1) Dmel_CG4720(Ask1) Dmel_CG4803(Takl2) Dmel_CG7717(Mekk1) Dmel_CG8789(wnd)
DSI: Dsimw501_GD12264(Dsim_GD12264) Dsimw501_GD18431(Dsim_GD18431) Dsimw501_GD19320(Dsim_GD19320) Dsimw501_GD20035(Dsim_GD20035) Dsimw501_GD20154(Dsim_GD20154) Dsimw501_GD27793(Dsim_GD27793)
CEL: CELE_B0414.7(mtk-1) CELE_F33E2.2(dlk-1) CELE_F52F12.3(mom-4) CELE_F59A6.1(nsy-1) CELE_K11D12.10(mlk-1) CELE_R13F6.6(zak-1) CELE_Y105C5A.24(Y105C5A.24)
CBR: CBG02299(Cbr-nsy-1) CBG03852(Cbr-mom-4) CBG04061(Cbr-mtk-1) CBG08663(Cbr-mlk-1) CBG08707(Cbr-dlk-1) CBG16544(Cbr-zak-1)
ATH: AT1G09000(NP1) AT1G53570(MAP3KA) AT1G54960(NP2) AT1G63700(YDA) AT4G08480(MAPKKK9) AT4G08500(MEKK1) AT5G11850
LJA: Lj1g3v1316910.1(Lj1g3v1316910.1) Lj1g3v1318210.1(Lj1g3v1318210.1) Lj1g3v1318220.1(Lj1g3v1318220.1) Lj1g3v4931570.1(Lj1g3v4931570.1) Lj2g3v0343910.1(Lj2g3v0343910.1) Lj4g3v2742830.1(Lj4g3v2742830.1) Lj4g3v2742850.1(Lj4g3v2742850.1) Lj5g3v1999000.1(Lj5g3v1999000.1)
DOSA: Os02t0220700-01(Os02g0220700) Os02t0666300-01(Os02g0666300) Os03t0262200-00(Os03g0262200) Os03t0703400-01(Os03g0703400) Os04t0437600-01(Os04g0437600) Os04t0559800-01(Os04g0559800) Os08t0421800-01(Os08g0421800) Os11t0207200-01(Os11g0207200)
ATS: 109742220(LOC109742220) 109747125(LOC109747125) 109750728(LOC109750728) 109758282(LOC109758282) 109765252(LOC109765252) 109766114(LOC109766114) 109779305(LOC109779305)
ZMA: 100191147 100191795(MAPKKK) 100194169(si606029c09(535)) 100272734(cl17799_1) 100279294 100304418(pco069828(336)) 100381765 100383481 103627282 103646082 103654795
APRO: F751_0620
SCE: YCR073C(SSK22) YJL095W(BCK1) YLR362W(STE11) YNR031C(SSK2)
KMX: KLMA_30080(STE11) KLMA_70196(SSK2)
NCS: NCAS_0A05370(NCAS0A05370) NCAS_0D04600(NCAS0D04600) NCAS_0J00960(NCAS0J00960)
NDI: NDAI_0I00340(NDAI0I00340) NDAI_0J01990(NDAI0J01990)
TPF: TPHA_0B01010(TPHA0B01010) TPHA_0M01840(TPHA0M01840)
TBL: TBLA_0A08290(TBLA0A08290) TBLA_0I02400(TBLA0I02400)
TDL: TDEL_0A07560(TDEL0A07560) TDEL_0E01710(TDEL0E01710)
KAF: KAFR_0A06190(KAFR0A06190) KAFR_0C04590(KAFR0C04590) KAFR_0F04340(KAFR0F04340)
SLB: AWJ20_3708(STE11) AWJ20_3718(SSK2)
NCR: NCU02234(mik-1) NCU03071(os-4) NCU06182(nrc-1)
NTE: NEUTE1DRAFT121976(NEUTE1DRAFT_121976) NEUTE1DRAFT86337(NEUTE1DRAFT_86337) NEUTE1DRAFT91407(NEUTE1DRAFT_91407)
SMP: SMAC_02801(putative os4) SMAC_03673(mik1) SMAC_05356(putative mik2)
FPU: FPSE_00070 FPSE_03520(FST11)
ANG: ANI_1_450074(An08g03240) ANI_1_456154(An17g01280) ANI_1_938024(An02g06830)
PNO: SNOG_07196(SNOG_07195) SNOG_07664 SNOG_12215
ZTR: MYCGRDRAFT_67344(MgSsk2) MYCGRDRAFT_71128(MgSte11)
SPO: SPAC1006.09(win1) SPAC1F3.02c(mkh1) SPAC9G1.02(wis4) SPBC1D7.05(byr2)
ABP: AGABI1DRAFT117102(AGABI1DRAFT_117102) AGABI1DRAFT32645(AGABI1DRAFT_32645) AGABI1DRAFT68456(AGABI1DRAFT_68456)
ABV: AGABI2DRAFT214884(AGABI2DRAFT_214884) AGABI2DRAFT62685(AGABI2DRAFT_62685)
DDI: DDB_G0281557(drkD)
DFA: DFA_02737(drkD)
SMIN: v1.2.022894.t1(symbB.v1.2.022894.t1)
NGD: NGA_0093910(STE11)
JAG: GJA_3447
 » show all
Taxonomy
Reference
1  [PMID:8940179]
  Authors
Wang XS, Diener K, Jannuzzi D, Trollinger D, Tan TH, Lichenstein H, Zukowski M, Yao Z.
  Title
Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.
  Journal
J Biol Chem 271:31607-11 (1996)
DOI:10.1074/jbc.271.49.31607
  Sequence
[hsa:4217]
Reference
2  [PMID:11042189]
  Authors
Gotoh I, Adachi M, Nishida E.
  Title
Identification and characterization of a novel MAP kinase kinase kinase, MLTK.
  Journal
J Biol Chem 276:4276-86 (2001)
DOI:10.1074/jbc.M008595200
  Sequence
[hsa:51776] [mmu:65964]
Reference
3  [PMID:8334704]
  Authors
Vojtek AB, Hollenberg SM, Cooper JA.
  Title
Mammalian Ras interacts directly with the serine/threonine kinase Raf.
  Journal
Cell 74:205-14 (1993)
DOI:10.1016/0092-8674(93)90307-C
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.25
IUBMB Enzyme Nomenclature: 2.7.11.25
ExPASy - ENZYME nomenclature database: 2.7.11.25
BRENDA, the Enzyme Database: 2.7.11.25
CAS: 146702-84-3

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