KEGG   ENZYME: 2.7.11.4Help
Entry
EC 2.7.11.4                 Enzyme                                 

Name
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase;
BCK;
BCKD kinase;
BCODH kinase;
branched-chain alpha-ketoacid dehydrogenase kinase;
branched-chain 2-oxo acid dehydrogenase kinase;
branched-chain keto acid dehydrogenase kinase;
branched-chain oxo acid dehydrogenase kinase (phosphorylating);
STK2
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphotransferase
Reaction(IUBMB)
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] = ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
Reaction(KEGG)
(other) R03516
Show
Substrate
ATP [CPD:C00002];
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]
Product
ADP [CPD:C00008];
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
Comment
The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the branched-chain 2-oxoacid dehydrogenase complex. Phosphorylation inactivates EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring).
History
EC 2.7.11.4 created 1986 as EC 2.7.1.115, transferred 2005 to EC 2.7.11.4
Orthology
K00905  [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase
Genes
HSA: 10295(BCKDK)
PTR: 741960(BCKDK)
PPS: 100988171(BCKDK)
PON: 100435349(BCKDK)
NLE: 100592408(BCKDK)
MCC: 712985(BCKDK)
MCF: 102135926(BCKDK)
CSAB: 103231287(BCKDK)
RRO: 104661569(BCKDK)
RBB: 108529119(BCKDK)
CJC: 100386931(BCKDK)
SBQ: 101039806(BCKDK)
MMU: 12041(Bckdk)
RNO: 29603(Bckdk)
CGE: 100755998(Bckdk)
NGI: 103726326(Bckdk)
HGL: 101715390(Bckdk)
CCAN: 109682760(Bckdk)
OCU: 100341990(BCKDK)
TUP: 102488075(BCKDK)
CFA: 479776(BCKDK)
AML: 100476243(BCKDK)
UMR: 103657884(BCKDK)
ORO: 101379705(BCKDK)
FCA: 101089414(BCKDK)
PTG: 102964750(BCKDK)
AJU: 106979116(BCKDK)
BTA: 505005(BCKDK)
BOM: 102272790(BCKDK)
BIU: 109578528(BCKDK)
PHD: 102327700(BCKDK)
CHX: 102178232(BCKDK)
OAS: 101104290(BCKDK)
SSC: 100522544(BCKDK)
CFR: 102514896(BCKDK)
CDK: 105102713(BCKDK)
BACU: 103002138(BCKDK)
LVE: 103076626(BCKDK)
OOR: 101285430(BCKDK)
ECB: 100063321(BCKDK)
EPZ: 103547243(BCKDK)
EAI: 106831884(BCKDK)
MYB: 102256163(BCKDK)
MYD: 102771109(BCKDK)
HAI: 109374188(BCKDK)
RSS: 109437778(BCKDK)
PALE: 102887175(BCKDK)
LAV: 100663738(BCKDK)
TMU: 101356582
MDO: 100013633(BCKDK)
SHR: 100930326(BCKDK)
OAA: 100080324(BCKDK)
FAB: 101807123(BCKDK)
PHI: 102106406(BCKDK)
PMAJ: 107199235(BCKDK)
FPG: 101920590(BCKDK)
FCH: 102046178(BCKDK)
CLV: 106146054(BCKDK)
ASN: 102385742(BCKDK)
AMJ: 102557785(BCKDK)
PSS: 102450847(BCKDK)
CMY: 102940861
CPIC: 101952608(BCKDK)
ACS: 100555810(bckdk)
PVT: 110086395(BCKDK)
PBI: 103051605(BCKDK)
GJA: 107106646(BCKDK)
XLA: 108703947(bckdk.L) 432076(bckdk.S)
XTR: 100380070(bckdk)
NPR: 108803576(BCKDK)
DRE: 282677(bckdk)
SRX: 107710731(bckdk) 107712146
IPU: 108260303(bckdk)
AMEX: 103026403(bckdk)
TRU: 101071747(bckdk)
LCO: 104921106(bckdk)
MZE: 101470802(bckdk)
OLA: 101172677(bckdk)
XMA: 102232910(bckdk)
PRET: 103476315(bckdk)
NFU: 107387216(bckdk)
KMR: 108238069(bckdk)
CSEM: 103395393(bckdk)
LCF: 108893638(bckdk)
SDU: 111217087(bckdk)
HCQ: 109517958(bckdk)
BPEC: 110166962(bckdk)
MALB: 109959266(bckdk)
SASA: 106567669(BCKD) 106603456
ELS: 105011092(bckdk)
SFM: 108928236(bckdk)
LCM: 102360605(BCKDK)
CMK: 103180529(bckdk)
SPU: 574737(bckdk)
APLC: 110976612
SKO: 100369777
FCD: 110862028
TUT: 107368956
CRG: 105328662
MYI: 110455574
OBI: 106879645
LAK: 106155712
EPA: 110252284
ADF: 107358500
HMG: 100214984
APRO: F751_3531
SMIN: v1.2.008918.t1(symbB.v1.2.008918.t1) v1.2.010686.t1(symbB.v1.2.010686.t1) v1.2.010686.t2(symbB.v1.2.010686.t2) v1.2.012337.t1(symbB.v1.2.012337.t1)
 » show all
Taxonomy
Reference
1  [PMID:7142221]
  Authors
Paxton R, Harris RA.
  Title
Isolation of rabbit liver branched chain alpha-ketoacid dehydrogenase and regulation by phosphorylation.
  Journal
J Biol Chem 257:14433-9 (1982)
Reference
2  [PMID:10903321]
  Authors
Wynn RM, Chuang JL, Cote CD, Chuang DT.
  Title
Tetrameric assembly and conservation in the ATP-binding domain of rat branched-chain alpha-ketoacid dehydrogenase kinase.
  Journal
J Biol Chem 275:30512-9 (2000)
DOI:10.1074/jbc.M005075200
Reference
3  [PMID:12189132]
  Authors
Chuang JL, Wynn RM, Chuang DT.
  Title
The C-terminal hinge region of lipoic acid-bearing domain of E2b is essential for domain interaction with branched-chain alpha-keto acid dehydrogenase kinase.
  Journal
J Biol Chem 277:36905-8 (2002)
DOI:10.1074/jbc.C200430200
Reference
4  [PMID:9344245]
  Authors
Popov KM, Hawes JW, Harris RA.
  Title
Mitochondrial alpha-ketoacid dehydrogenase kinases: a new family of protein kinases.
  Journal
Adv Second Messenger Phosphoprotein Res 31:105-11 (1997)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.4
IUBMB Enzyme Nomenclature: 2.7.11.4
ExPASy - ENZYME nomenclature database: 2.7.11.4
BRENDA, the Enzyme Database: 2.7.11.4
CAS: 82391-38-6

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