KEGG   ENZYME: 2.7.11.8Help
Entry
EC 2.7.11.8                 Enzyme                                 

Name
Fas-activated serine/threonine kinase;
FAST;
FASTK;
STK10
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[Fas-activated serine/threonine protein] phosphotransferase
Reaction(IUBMB)
ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]
Reaction(KEGG)
(other) R00162
Show
Substrate
ATP [CPD:C00002];
[Fas-activated serine/threonine protein]
Product
ADP [CPD:C00008];
[Fas-activated serine/threonine phosphoprotein]
Comment
This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
History
EC 2.7.11.8 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K08290  Fas-activated serine/threonine kinase
Genes
HSA: 10922(FASTK)
PTR: 472626(FASTK)
PPS: 100978359(FASTK)
GGO: 101150125(FASTK)
PON: 100171584(FASTK)
NLE: 100593928(FASTK)
MCC: 714020(FASTK)
MCF: 101926723(FASTK)
CSAB: 103227240(FASTK)
RRO: 104675400(FASTK)
RBB: 108532532(FASTK)
CJC: 100409995(FASTK)
SBQ: 101037716(FASTK)
MMU: 66587(Fastk)
RNO: 296741(Fastk)
CGE: 100762130(Fastk)
NGI: 103745309(Fastk)
HGL: 101707658(Fastk)
CCAN: 109694452(Fastk)
OCU: 100343065(FASTK)
TUP: 102498075(FASTK)
CFA: 482802(FASTK)
AML: 100482824(FASTK)
UMR: 103660954(FASTK)
ORO: 101384446(FASTK)
FCA: 101082140(FASTK)
PTG: 102956491(FASTK)
AJU: 106969574(FASTK)
BTA: 509781(FASTK)
BOM: 102266409(FASTK)
BIU: 109557800(FASTK)
PHD: 102321141(FASTK)
CHX: 102186744 108635865(FASTK)
OAS: 101103314(FASTK)
SSC: 100233181(FASTK)
CFR: 102523278(FASTK)
CDK: 105105644(FASTK)
BACU: 103019324(FASTK)
LVE: 103084660(FASTK)
OOR: 101282680(FASTK)
ECB: 100063473(FASTK)
EPZ: 103564176(FASTK)
EAI: 106823328(FASTK)
MYB: 102254535(FASTK)
MYD: 102755949(FASTK)
HAI: 109389645(FASTK)
RSS: 109435158(FASTK)
PALE: 102878349(FASTK)
LAV: 100672710(FASTK)
TMU: 101358568
GGA: 426636(FASTK)
MGP: 100544059(FASTK)
CJO: 107308708(FASTK)
TGU: 100227496(FASTK)
GFR: 102034598(FASTK)
FAB: 101814009(FASTK)
PHI: 102100505(FASTK)
PMAJ: 107200647(FASTK)
CCAE: 111944798(FASTK)
CCW: 104684261(FASTK)
FPG: 101913183(FASTK)
FCH: 102058389(FASTK)
CLV: 102096109(FASTK)
EGZ: 104127868(FASTK)
AAM: 106491561(FASTK)
ASN: 102382446(FASTK)
AMJ: 102570632(FASTK)
CMY: 102940414(FASTK)
CPIC: 101930899(FASTK)
ACS: 103282002(fastk)
PVT: 110082558(FASTK)
GJA: 107108218(FASTK)
DRE: 564534(fastk)
IPU: 108267814(fastk)
AMEX: 103039878(fastk)
TRU: 101064436(fastk)
LCO: 104932655(fastk)
MZE: 101476418(fastk)
OLA: 111949112(fastk)
XMA: 102236288(fastk)
PRET: 103460488(fastk)
NFU: 107383684(fastk)
KMR: 108228222(fastk)
CSEM: 103398754(fastk)
LCF: 108884940(fastk)
SDU: 111237341(fastk)
BPEC: 110173952(fastk)
MALB: 109965944(fastk)
ELS: 105025013(fastk)
SFM: 108937493(fastk)
LCM: 102349276(FASTK)
CMK: 103190094(fastk)
SKO: 102804167
 » show all
Taxonomy
Reference
1  [PMID:7544399]
  Authors
Tian Q, Taupin J, Elledge S, Robertson M, Anderson P.
  Title
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.
  Journal
J Exp Med 182:865-74 (1995)
  Sequence
[hsa:10922]
Reference
2  [PMID:15572676]
  Authors
Li W, Simarro M, Kedersha N, Anderson P.
  Title
FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression.
  Journal
Mol Cell Biol 24:10718-32 (2004)
DOI:10.1128/MCB.24.24.10718-10732.2004
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.8
IUBMB Enzyme Nomenclature: 2.7.11.8
ExPASy - ENZYME nomenclature database: 2.7.11.8
BRENDA, the Enzyme Database: 2.7.11.8
CAS: 170347-50-9

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