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Entry
EC 2.7.4.10                 Enzyme                                 

Name
nucleoside-triphosphate---adenylate kinase;
guanosine triphosphate-adenylate kinase;
nucleoside triphosphate-adenosine monophosphate transphosphorylase;
GTP:AMP phosphotransferase;
isozyme 3 of adenylate kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
BRITE hierarchy
Sysname
nucleoside-triphosphate:AMP phosphotransferase
Reaction(IUBMB)
nucleoside triphosphate + AMP = nucleoside diphosphate + ADP [RN:R00333]
Reaction(KEGG)
Substrate
nucleoside triphosphate [CPD:C00201];
AMP [CPD:C00020]
Product
nucleoside diphosphate [CPD:C00454];
ADP [CPD:C00008]
Comment
Many nucleoside triphosphates can act as donors.
History
EC 2.7.4.10 created 1965
Pathway
ec00230  Purine metabolism
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K00944  nucleoside-triphosphate--adenylate kinase
Genes
HSA: 50808(AK3)
PTR: 464977(AK3)
PPS: 100978520(AK3)
GGO: 101147145(AK3)
PON: 100174279(AK3)
NLE: 100587551(AK3)
MCC: 694714(AK3)
MCF: 102120283(AK3)
CSAB: 103219499(AK3)
RRO: 104682433(AK3)
RBB: 108514950(AK3)
CJC: 100411941(AK3)
SBQ: 101028212(AK3)
MMU: 56248(Ak3)
RNO: 26956(Ak3)
CGE: 100760312(Ak3)
NGI: 103740983(Ak3)
HGL: 101716319(Ak3)
CCAN: 109697541(Ak3)
OCU: 100008827(AK3)
TUP: 102473823(AK3)
CFA: 476342(AK3) 480491
AML: 100464676(AK3)
UMR: 103663216(AK3)
ORO: 101375590(AK3) 101381565
FCA: 101099336(AK3)
PTG: 102951330(AK3)
AJU: 106968148(AK3)
BTA: 281613(AK3)
BOM: 102279433(AK3)
BIU: 109562909(AK3)
PHD: 102338294(AK3)
CHX: 102176121(AK3)
OAS: 101113201(AK3)
SSC: 100155691(AK3)
CFR: 102519747(AK3)
CDK: 105101969(AK3)
BACU: 103013601 103018485(AK3)
LVE: 103076093(AK3)
OOR: 101274454(AK3)
ECB: 100059240(AK3)
EPZ: 103563067(AK3)
EAI: 106843618(AK3)
MYB: 102245652 102253310(AK3)
MYD: 102761509(AK3)
HAI: 109384497(AK3)
RSS: 109446477(AK3)
PALE: 102882331(AK3)
LAV: 100670938(AK3)
TMU: 101359179
MDO: 100014818(AK3)
SHR: 100926548(AK3)
OAA: 100073575(AK3)
GGA: 426534(AK3)
MGP: 100548417(AK3)
CJO: 107306088(AK3)
APLA: 101797995(AK3)
ACYG: 106046388(AK3)
TGU: 100190159(AK3)
GFR: 102037617(AK3)
FAB: 101808054(AK3)
PHI: 102111260(AK3)
PMAJ: 107198317(AK3)
CCAE: 111940769(AK3)
CCW: 104685170(AK3)
FPG: 101916720(AK3)
FCH: 102051291(AK3)
CLV: 102090510(AK3)
EGZ: 104135724(AK3)
AAM: 106496772(AK3)
ASN: 102371482(AK3)
AMJ: 102572133(AK3)
PSS: 102454862(AK3)
CMY: 102932160(AK3)
CPIC: 101951335(AK3)
ACS: 100567310(ak3)
PVT: 110083248(AK3)
PBI: 103050139(AK3)
GJA: 107107210(AK3)
XLA: 414511(ak3.S) 734496(ak3.L)
XTR: 100170447(ak3)
NPR: 108791539(AK3)
DRE: 406404(ak3)
CCAR: 109097537
IPU: 108276759(ak3)
AMEX: 103033473(ak3)
TRU: 101068198(ak3)
LCO: 104936365(ak3)
NCC: 104967885(ak3)
MZE: 101484351(ak3)
OLA: 101160331(ak3)
XMA: 102230187(ak3)
PRET: 103473615(ak3)
NFU: 107397386(ak3)
KMR: 108232553(ak3)
CSEM: 103389215(ak3)
LCF: 108879212(ak3)
SDU: 111238945(ak3)
HCQ: 109509873(ak3)
BPEC: 110174129(ak3)
MALB: 109963435(ak3)
SASA: 106561494(ak3) 106568444(KAD4)
ELS: 105014790(ak3)
SFM: 108932610(ak3)
LCM: 102364891(AK3)
CMK: 103191334(ak3)
CIN: 100182043
SPU: 583479
APLC: 110989635
SKO: 102802370
DME: Dmel_CG6612(Adk3)
DSI: Dsimw501_GD20690(Dsim_GD20690)
MDE: 101892611
AAG: 5564849
AME: 552511
BIM: 100742201
BTER: 100643739
SOC: 105202362
AEC: 105144591
ACEP: 105623641
PBAR: 105426460
HST: 105183562
DQU: 106742849
CFO: 105254231
LHU: 105676787
PGC: 109856446
PCF: 106789377
NVI: 100119962(AK3)
MDL: 103577439
TCA: 659658
DPA: 109537901
NVL: 108562448
BMOR: 101742093
PMAC: 106712415
PRAP: 110998483
HAW: 110371419
PXY: 105382459
API: 100161031
DNX: 107165968
CLEC: 106672533
ZNE: 110827628
FCD: 110857975
TUT: 107362549
CRG: 105330382
MYI: 110442802
OBI: 106874656
LAK: 106176498
ADF: 107352295
AQU: 100632777
SMIN: v1.2.025282.t1(symbB.v1.2.025282.t1)
 » show all
Taxonomy
Reference
1  [PMID:5423264]
  Authors
Albrecht GJ.
  Title
Purification and properties of nucleoside triphosphate-adenosine monophosphate transphosphorylase from beef heart mitochondria.
  Journal
Biochemistry 9:2462-70 (1970)
Reference
2  [PMID:13693071]
  Authors
CHIGA M, ROGERS AE, PLAUT GW.
  Title
Nucleotide transphosphorylases from liver. II. Purification and properties of a 6-oxypurine nucleoside triphosphate-adenosine monophosphate transphosphorylase from swine liver.
  Journal
J Biol Chem 236:1800-5 (1961)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.4.10
IUBMB Enzyme Nomenclature: 2.7.4.10
ExPASy - ENZYME nomenclature database: 2.7.4.10
BRENDA, the Enzyme Database: 2.7.4.10
CAS: 9026-74-8

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