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Entry
EC 2.7.4.26                 Enzyme                                 

Name
isopentenyl phosphate kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
BRITE hierarchy
Sysname
ATP:isopentenyl phosphate phosphotransferase
Reaction(IUBMB)
ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate [RN:R10093]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
isopentenyl phosphate [CPD:C20345]
Product
ADP [CPD:C00008];
isopentenyl diphosphate [CPD:C00129]
Comment
The enzyme is involved in the mevalonate pathway in Archaea [1]. The activity has also been identified in the plant Mentha piperita (peppermint) [2]. It is strictly specific for ATP but can use other phosphate acceptors such as dimethylallyl phosphate, geranyl phosphate, or fosfomycin.
History
EC 2.7.4.26 created 2012
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K06981  isopentenyl phosphate kinase
Genes
CVC: BKX93_17520
CHRI: DK842_11805
TUM: CBW65_19615
TAB: CIG75_09860
SVU: B1H20_34165
ACTA: C1701_23150
RRS: RoseRS_2247
RCA: Rcas_4059
CAU: Caur_0506
CHL: Chy400_0542
CAG: Cagg_3216
HAU: Haur_2285
ATM: ANT_15950
MJA: MJ_0044
MMP: MMP1645
MMD: GYY_09080
MAE: Maeo_1031
MVO: Mvol_1261
MTH: MTH_47
METC: MTCT_0046
METE: tca_00047(proB)
MST: Msp_0857
MSI: Msm_1440
MRU: mru_0921
MEB: Abm4_1229
MMIL: sm9_1640
MEYE: TL18_07255
MOL: YLM1_0486
METH: MBMB1_0812
MFC: BRM9_0362
MCUB: MCBB_1337
MFV: Mfer_0896
MKA: MK0777
AFU: AF_2288
FPL: Ferp_1382
GAC: GACE_1301
GAH: GAH_00188
TAC: Ta0103
TVO: TVG0187430(TVG0187430)
PTO: PTO0497
FAI: FAD_1830
CDIV: CPM_0049
MARC: AR505_0192
PHO: PH1623(PH1623)
PAB: PAB0373(argB-like)
PFU: PF1636
PFI: PFC_10425
PYN: PNA2_0206
PYS: Py04_1517
TKO: TK1473
TON: TON_0134
TGA: TGAM_1729(fomA)
TSI: TSIB_1230
THE: GQS_04565
THA: TAM4_1700
THM: CL1_0568
TLT: OCC_01024
THS: TES1_0236
TNU: BD01_2227
TEU: TEU_05465
PPAC: PAP_01960
MAC: MA_0603
MBAR: MSBR2_1898
MBAK: MSBR3_2037
MMA: MM_1763
MMAC: MSMAC_1518
METM: MSMTP_2866
MTHE: MSTHC_1166
MTHR: MSTHT_2118
MHOR: MSHOH_3625
MBU: Mbur_2396
MMET: MCMEM_0542
MMH: Mmah_1550
MPY: Mpsy_0884
MTP: Mthe_0475
MCJ: MCON_2558
MHI: Mhar_0984
MHU: Mhun_2889
MLA: Mlab_0682
MPI: Mpet_0760
MBN: Mboo_2212
MPL: Mpal_2375
MPD: MCP_1638
MEZ: Mtc_2284
RCI: LRC398
HAL: VNG_1148G(argB)
HSL: OE_2647F
HHB: Hhub_2771
HALH: HTSR_0764
HHSR: HSR6_0790
HMA: rrnAC0078(argB1)
HHI: HAH_0835(argB1)
NPH: NP_2852A
NMO: Nmlp_2741
HUT: Huta_2046
HTI: HTIA_1633
HMU: Hmuk_2605
HWA: HQ_2926A
HWC: Hqrw_3337
HVO: HVO_2762
HME: HFX_2774
HLA: Hlac_1830
HTU: Htur_2540
NMG: Nmag_0440
NAT: NJ7G_1104
SALI: L593_01905
ACJ: ACAM_1109
SMR: Smar_0511
IHO: Igni_0566
IIS: EYM_04880
DKA: DKAM_1442
TAG: Tagg_1081
IAG: Igag_0200
HBU: Hbut_0538
SSO: SSO0064
SOL: Ssol_1044
SSOA: SULA_1081
SSOL: SULB_1082
SSOF: SULC_1081
SID: M164_2063
SII: LD85_2323
SIH: SiH_2002
SIR: SiRe_1929
SIC: SiL_1909
MSE: Msed_2137
MCN: Mcup_0152
AHO: Ahos_0653
PAI: PAE1012
PIS: Pisl_1207
PCL: Pcal_0149
PAS: Pars_0180
PYR: P186_2438
POG: Pogu_2299
TNE: Tneu_0164
CMA: Cmaq_1001
TUZ: TUZN_1437
TTN: TTX_2050
VDI: Vdis_1766
VMO: VMUT_0213
TPE: Tpen_0607
ASC: ASAC_0904
ACIA: SE86_05200
NMR: Nmar_0314
NCT: NMSP_1394
NEV: NTE_02263
NCV: NCAV_1517
NBV: T478_0246
NDV: NDEV_0280
MARH: Mia14_0599
KCR: Kcr_1595
BARC: AOA65_2113
BARB: AOA66_1068
 » show all
Taxonomy
Reference
1  [PMID:16621811]
  Authors
Grochowski LL, Xu H, White RH
  Title
Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate.
  Journal
J Bacteriol 188:3192-8 (2006)
DOI:10.1128/JB.188.9.3192-3198.2006
  Sequence
[mja:MJ_0044]
Reference
2  [PMID:10570138]
  Authors
Lange BM, Croteau R
  Title
Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step.
  Journal
Proc Natl Acad Sci U S A 96:13714-9 (1999)
DOI:10.1073/pnas.96.24.13714
Reference
3  [PMID:19928876]
  Authors
Chen M, Poulter CD
  Title
Characterization of thermophilic archaeal isopentenyl phosphate kinases.
  Journal
Biochemistry 49:207-17 (2010)
DOI:10.1021/bi9017957
  Sequence
[mth:MTH_47] [tac:Ta0103]
Reference
4  [PMID:20402538]
  Authors
Mabanglo MF, Schubert HL, Chen M, Hill CP, Poulter CD
  Title
X-ray structures of isopentenyl phosphate kinase.
  Journal
ACS Chem Biol 5:517-27 (2010)
DOI:10.1021/cb100032g
  Sequence
[mth:MTH_47] [tac:Ta0103]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.4.26
IUBMB Enzyme Nomenclature: 2.7.4.26
ExPASy - ENZYME nomenclature database: 2.7.4.26
BRENDA, the Enzyme Database: 2.7.4.26

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