KEGG   ENZYME: 2.7.7.10Help
Entry
EC 2.7.7.10                 Enzyme                                 

Name
UTP---hexose-1-phosphate uridylyltransferase;
galactose-1-phosphate uridylyltransferase;
galactose 1-phosphate uridylyltransferase;
alpha-D-galactose 1-phosphate uridylyltransferase;
galactose 1-phosphate uridyltransferase;
UDPgalactose pyrophosphorylase;
uridine diphosphate galactose pyrophosphorylase;
uridine diphosphogalactose pyrophosphorylase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
UTP:alpha-D-hexose-1-phosphate uridylyltransferase
Reaction(IUBMB)
UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-alpha-D-galactose [RN:R00502]
Reaction(KEGG)
Substrate
UTP [CPD:C00075];
alpha-D-galactose 1-phosphate [CPD:C00446]
Product
diphosphate [CPD:C00013];
UDP-alpha-D-galactose [CPD:C00052]
Comment
alpha-D-Glucose 1-phosphate can also act as acceptor, but more slowly.
History
EC 2.7.7.10 created 1961
Pathway
ec00052  Galactose metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:13549431]
  Authors
ISSELBACHER KJ.
  Title
A mammalian uridinediphosphate galactose pyrophosphorylase.
  Journal
J Biol Chem 232:429-44 (1958)
Reference
2  [PMID:13115434]
  Authors
KALCKAR HM.
  Title
The role of phosphoglycosyl compounds in the biosynthesis of nucleosides and nucleotides.
  Journal
Biochim Biophys Acta 12:250-64 (1953)
DOI:10.1016/0006-3002(53)90144-9
Reference
3  [PMID:500588]
  Authors
Lee L, Kimura A, Tochikura T.
  Title
Purification and properties of UDP-glucose (UDP-galactose) pyrophosphorylase from Bifidobacterium bifidum.
  Journal
J Biochem (Tokyo) 86:923-8 (1979)
Reference
4  [PMID:6304512]
  Authors
Lobelle-Rich PA, Reeves RE.
  Title
Separation and characterization of two UTP-utilizing hexose phosphate uridylyltransferases from Entamoeba histolytica.
  Journal
Mol Biochem Parasitol 7:173-82 (1983)
DOI:10.1016/0166-6851(83)90043-9
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.10
IUBMB Enzyme Nomenclature: 2.7.7.10
ExPASy - ENZYME nomenclature database: 2.7.7.10
BRENDA, the Enzyme Database: 2.7.7.10
CAS: 9016-11-9

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